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The map label for this gene is vllY [H]

Identifier: 21241225

GI number: 21241225

Start: 541545

End: 542615

Strand: Direct

Name: vllY [H]

Synonym: XAC0452

Alternate gene names: 21241225

Gene position: 541545-542615 (Clockwise)

Preceding gene: 21241223

Following gene: 21241226

Centisome position: 10.46

GC content: 61.53

Gene sequence:

>1071_bases
ATGCAGGTCACCACCTTCGACAATCCGATGGGCATCGACGGCTTCGAATTCGTCGAATTCGCCGCACCGGCCGGCCAGGG
GGAGCAACTGCACGATTATTTCCGCAAGATGGGCTTCAGCGCGGTGCTGCGTCATCGCAGCCGCCCCATTACCGTCTATC
GCCAGGGCGGGGTCAACTTCCTGCTCAACGAAGATCCCGATTCGTTCGCTGCCGATTTCGCCGCCGCGCACGGCCCCTGC
GCCTGCGGCTTTGCCATCCGCTTCCGCACCCCGTCCGAGACCGTGCTGCAGACGGTGCTGGGCAACGGCGGCGAAGCCGT
GCAGAACAAGCCCGACACCCGCGCGGTCCCGGCGCCGGTGGTCAAGGGGATCGGCGATTGCATGCTGTACCTGGTGGACC
GTTATGGCGAGGCCGGCAGCATCTATGACGCCGATTTCGAGCCGATCGACGGTGCCGACCAGCACCCGGCCGGCTTCGGA
CTGACCTTCATCGACCACCTGACCCATAACCTGTATTTCGGCAACATGCAGCGCTGGTCGGACTATTACGAGCGCCTGTT
CAACTTCCGCGAGATCCGCTATTTCGACATCAAGGGCGCCAAGACCGGCCTGGTGTCCAAGGCGATGACCGCGCCGGACG
GCATCGTGCGCATCCCGCTCAACGAATCCTCCGACCCCAAGAGCCAGATCAACGAGTATCTGGATGCGTACCAGGGCGAA
GGTATCCAGCACATCGCCTGTTTTACCGACGACATCTACACCAGCGTGGAAAAGATGCGCGCCGCCGGCGTGAGTTTCCT
GGATACGCCGGACACGTATTTCGATGTGGTGGACCTGCGCATCCCCGCGCATGGCGAAGATGTCGAACGCCTGCGCCGCA
ACAAGATCCTGATCGACGCCGACCCCGATACCAAACAGCGCAAACTGCTGCAGATCTTCACCACCAACTGCATCGGCCCG
ATCTTCTTCGAGATCATCCAGCGCAAGGGAAACGAAGGCTTTGGCGAAGGCAATTTCCAGGCGCTGTTCGAAAGCATCGA
GCGCGATCAGATGAAGCGTGGGGTGCTTTGA

Upstream 100 bases:

>100_bases
GGTCTTCTGCTACTCCGCATAGCCCTGCGGCCCCCCCAAGCGTGGAGAAACGACGATGAGCGCACAACCGAACACCACTG
CGACCCGCCCGGATCCTGGC

Downstream 100 bases:

>100_bases
GGGCTGGGATTAGGGATTGGTGATTCGCTTAAGGCAAGATCTTGATGCGTCACTTCAGCGGGCCTTGGTTGTCTGACAAG
AGAATCCGTAAGACCGCACG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MQVTTFDNPMGIDGFEFVEFAAPAGQGEQLHDYFRKMGFSAVLRHRSRPITVYRQGGVNFLLNEDPDSFAADFAAAHGPC
ACGFAIRFRTPSETVLQTVLGNGGEAVQNKPDTRAVPAPVVKGIGDCMLYLVDRYGEAGSIYDADFEPIDGADQHPAGFG
LTFIDHLTHNLYFGNMQRWSDYYERLFNFREIRYFDIKGAKTGLVSKAMTAPDGIVRIPLNESSDPKSQINEYLDAYQGE
GIQHIACFTDDIYTSVEKMRAAGVSFLDTPDTYFDVVDLRIPAHGEDVERLRRNKILIDADPDTKQRKLLQIFTTNCIGP
IFFEIIQRKGNEGFGEGNFQALFESIERDQMKRGVL

Sequences:

>Translated_356_residues
MQVTTFDNPMGIDGFEFVEFAAPAGQGEQLHDYFRKMGFSAVLRHRSRPITVYRQGGVNFLLNEDPDSFAADFAAAHGPC
ACGFAIRFRTPSETVLQTVLGNGGEAVQNKPDTRAVPAPVVKGIGDCMLYLVDRYGEAGSIYDADFEPIDGADQHPAGFG
LTFIDHLTHNLYFGNMQRWSDYYERLFNFREIRYFDIKGAKTGLVSKAMTAPDGIVRIPLNESSDPKSQINEYLDAYQGE
GIQHIACFTDDIYTSVEKMRAAGVSFLDTPDTYFDVVDLRIPAHGEDVERLRRNKILIDADPDTKQRKLLQIFTTNCIGP
IFFEIIQRKGNEGFGEGNFQALFESIERDQMKRGVL
>Mature_356_residues
MQVTTFDNPMGIDGFEFVEFAAPAGQGEQLHDYFRKMGFSAVLRHRSRPITVYRQGGVNFLLNEDPDSFAADFAAAHGPC
ACGFAIRFRTPSETVLQTVLGNGGEAVQNKPDTRAVPAPVVKGIGDCMLYLVDRYGEAGSIYDADFEPIDGADQHPAGFG
LTFIDHLTHNLYFGNMQRWSDYYERLFNFREIRYFDIKGAKTGLVSKAMTAPDGIVRIPLNESSDPKSQINEYLDAYQGE
GIQHIACFTDDIYTSVEKMRAAGVSFLDTPDTYFDVVDLRIPAHGEDVERLRRNKILIDADPDTKQRKLLQIFTTNCIGP
IFFEIIQRKGNEGFGEGNFQALFESIERDQMKRGVL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=351, Percent_Identity=28.2051282051282, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI285002264, Length=208, Percent_Identity=33.6538461538462, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI14249394, Length=377, Percent_Identity=26.790450928382, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17555220, Length=235, Percent_Identity=40.4255319148936, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17550752, Length=227, Percent_Identity=33.920704845815, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667510, Length=286, Percent_Identity=34.965034965035, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21356105, Length=286, Percent_Identity=34.965034965035, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 39906; Mature: 39906

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTTFDNPMGIDGFEFVEFAAPAGQGEQLHDYFRKMGFSAVLRHRSRPITVYRQGGVNF
CEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEE
LLNEDPDSFAADFAAAHGPCACGFAIRFRTPSETVLQTVLGNGGEAVQNKPDTRAVPAPV
EECCCCHHHHHHHHHCCCCEEECEEEEECCCHHHHHHHHHCCCCHHHCCCCCCCCCCHHH
VKGIGDCMLYLVDRYGEAGSIYDADFEPIDGADQHPAGFGLTFIDHLTHNLYFGNMQRWS
HHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCHHHHH
DYYERLFNFREIRYFDIKGAKTGLVSKAMTAPDGIVRIPLNESSDPKSQINEYLDAYQGE
HHHHHHHCHHHEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCC
GIQHIACFTDDIYTSVEKMRAAGVSFLDTPDTYFDVVDLRIPAHGEDVERLRRNKILIDA
CCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECCCCHHHHHHHHCCEEEEC
DPDTKQRKLLQIFTTNCIGPIFFEIIQRKGNEGFGEGNFQALFESIERDQMKRGVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQVTTFDNPMGIDGFEFVEFAAPAGQGEQLHDYFRKMGFSAVLRHRSRPITVYRQGGVNF
CEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEE
LLNEDPDSFAADFAAAHGPCACGFAIRFRTPSETVLQTVLGNGGEAVQNKPDTRAVPAPV
EECCCCHHHHHHHHHCCCCEEECEEEEECCCHHHHHHHHHCCCCHHHCCCCCCCCCCHHH
VKGIGDCMLYLVDRYGEAGSIYDADFEPIDGADQHPAGFGLTFIDHLTHNLYFGNMQRWS
HHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECCHHHHH
DYYERLFNFREIRYFDIKGAKTGLVSKAMTAPDGIVRIPLNESSDPKSQINEYLDAYQGE
HHHHHHHCHHHEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCC
GIQHIACFTDDIYTSVEKMRAAGVSFLDTPDTYFDVVDLRIPAHGEDVERLRRNKILIDA
CCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECCCCHHHHHHHHCCEEEEC
DPDTKQRKLLQIFTTNCIGPIFFEIIQRKGNEGFGEGNFQALFESIERDQMKRGVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA