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The map label for this gene is ubiA

Identifier: 21241164

GI number: 21241164

Start: 460839

End: 461744

Strand: Reverse

Name: ubiA

Synonym: XAC0390

Alternate gene names: 21241164

Gene position: 461744-460839 (Counterclockwise)

Preceding gene: 21241165

Following gene: 21241162

Centisome position: 8.92

GC content: 67.55

Gene sequence:

>906_bases
ATGAGCAAGCATGGTGTCGAACAACTGCCCGCAGCGCGCGCGCTGACGTGGCCGCAGCGATTGGGCCAGTACTGGAAGCT
GGTCCGTGGCGACCGCCCGATCGGAAGCCTGCTGCTGCTCTGGCCCACCTGGTGGGCGTTGTGGCTGGCCGCCGACGGCC
TGCCGCCGCTGTGGACGCTCTTCGTGTTCACCGCCGGGGTGTGGCTGACCCGCTCGGCCGGTTGCGTGATCAACGATTAC
GCCGACCGCTGGCTGGATCCGCACGTGGAGCGCACCAAATCGCGTCCGCTGGCCACCGGCGCGGTCTCCGGGCGCGAGGC
ATTATGGGTATTCGTGGCGCTGATGCTGGTGGCCTTCGCGCTGGTGCTCACGCTCAACTGGCTGACCGTGATGCTGAGCG
TGCCCGGCGTCTTCCTGGCCGCCAGCTACCCCTATCTCAAGCGCCATACCCACCTGCCGCAGGTCTATCTGGGCATGGCG
TTCGGCTGGGGCATCCCGATGGCCTTCGCCGCCGTGCAAGGCAGCGTGCCGTTGCTGGGCTGGCTGCTGTATGCCGCCAA
CATCCTGTGGGCCACCGCCTACGACACCTGGTACGCCATGGTCGACCGCGACGACGATATCCGCATGGGCAGCAAGTCCA
CCGCCATCCTGTTCGGCAGATTCGATCTGATCGCGCAAGGCATCCTGTATGCGCTGATGGCCGCGACGCTGGTAATGGTC
GGCCTGCGCGCTGATCTCGGCGCTGCGTACTGGGCCGGCCTGGGCGCTGCAGCGCTGCTGGTCGCCTACGAATTCCGCAT
CGCCCGCCACCGCGAGCGCGGCCCCTGCTTCCGCGCCTTCCTGCACAACAACTGGGTTGGCCTGGCGATCTTCGTCGGCA
TCGCAGTGGCGGTGGCAGGGCGTTAG

Upstream 100 bases:

>100_bases
TGCCATCGCGGACGCAGGGCTTTCCCAGAATTGCCGCCCGGGCAGCGCCCACCTCGCGCCCACATGACCACGGCCAAGCC
GCGCTGCTACCCTTTGCAGC

Downstream 100 bases:

>100_bases
ATGCGGGATCGGGGATTGGGGATGGGAAATTCGTCGATTGAAGGTCAGATCTTGAAATTGCGAGCAAGGATTCAAGCCCG
CCACCAGCTTCAACTGCTCT

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLFVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVALMLVAFALVLTLNWLTVMLSVPGVFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMAFAAVQGSVPLLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVMV
GLRADLGAAYWAGLGAAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAGR

Sequences:

>Translated_301_residues
MSKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLFVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVALMLVAFALVLTLNWLTVMLSVPGVFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMAFAAVQGSVPLLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVMV
GLRADLGAAYWAGLGAAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAGR
>Mature_300_residues
SKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLFVFTAGVWLTRSAGCVINDYA
DRWLDPHVERTKSRPLATGAVSGREALWVFVALMLVAFALVLTLNWLTVMLSVPGVFLAASYPYLKRHTHLPQVYLGMAF
GWGIPMAFAAVQGSVPLLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVMVG
LRADLGAAYWAGLGAAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAGR

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=284, Percent_Identity=34.8591549295775, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1790473, Length=280, Percent_Identity=57.1428571428571, Blast_Score=305, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17553718, Length=302, Percent_Identity=34.7682119205298, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI32565247, Length=303, Percent_Identity=34.6534653465347, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17553720, Length=359, Percent_Identity=30.08356545961, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32565245, Length=161, Percent_Identity=40.9937888198758, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32565243, Length=160, Percent_Identity=40.625, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324370, Length=293, Percent_Identity=33.1058020477816, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21355567, Length=278, Percent_Identity=37.0503597122302, Blast_Score=177, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_XANAC (Q8PQD5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640746.1
- GeneID:   1154461
- GenomeReviews:   AE008923_GR
- NMPDR:   fig|190486.1.peg.390
- HOGENOM:   HBG324383
- OMA:   PWAMGWH
- ProtClustDB:   PRK12848
- BioCyc:   XAXO190486:XAC0390-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33376; Mature: 33244

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbdb2cc8)-; HASH(0xc4a2ac8)-; HASH(0xb230504)-; HASH(0xce81834)-; HASH(0xc3d55c8)-; HASH(0xce7cb58)-; HASH(0xce7f520)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTL
CCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVALMLVAFA
HHHHHHHHHHCCCCCEEEHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVLTLNWLTVMLSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGSVPLLG
HHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVMV
HHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
GLRADLGAAYWAGLGAAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC
R
H
>Mature Secondary Structure 
SKHGVEQLPAARALTWPQRLGQYWKLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTL
CCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVALMLVAFA
HHHHHHHHHHCCCCCEEEHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVLTLNWLTVMLSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGSVPLLG
HHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLIAQGILYALMAATLVMV
HHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
GLRADLGAAYWAGLGAAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCC
R
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217