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The map label for this gene is ilvD

Identifier: 21241119

GI number: 21241119

Start: 411090

End: 412928

Strand: Reverse

Name: ilvD

Synonym: XAC0345

Alternate gene names: 21241119

Gene position: 412928-411090 (Counterclockwise)

Preceding gene: 21241122

Following gene: 21241117

Centisome position: 7.98

GC content: 64.82

Gene sequence:

>1839_bases
ATGCCCGAGTACCGTTCCAAAACCTCCACCCACGGCCGCAACATGGCCGGCGCCCGCGCCCTGTGGCGTGCCACCGGCAT
GCGCGATGGCGACTTCCACAAGCCCATCATCGCCATCGCCAACTCGTTCACGCAGTTCGTGCCCGGGCATGTACACCTGA
AGGATCTTGGCCAGCTGGTCGCGCGCGAGATCGAACGCGTCGGCGGCGTGGCCAAAGAGTTCGACACCATCGCCGTGGAC
GACGGCATCGCGATGGGCCATGACGGCATGCTGTATTCGCTGCCCAGCCGCGAGATCATCGCCGACTCGGTCGAATACAT
GGTCAACGCGCATTGCGCCGACGCGCTGGTGTGCATCTCCAACTGCGACAAGATCACCCCCGGCATGTTGATGGCCGCGC
TGCGGCTCAATATCCCCACCGTGTTCGTCTCCGGCGGCCCGATGGAAGCCGGCAAGACCAAGCTGGCCGAGCACAAGCTC
GACCTGATCGATGCGATGGTGATTGCCGCCGACGACAGCGCCTCCGACGAAAAAGTGGCCGAGTTCGAACGCAGCGCCTG
CCCCACCTGCGGCTCGTGCTCGGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAAGCGCTGGGCCTGTCGCTGC
CGGGCAACGGCACCGTGGTCGCCACGCACGCGGACCGCGAGCAACTGTTTCTGCGCGCCGGACGCGTGGCGGTGGAACTG
TGTCACCGCTGGTACGGCGGCGAAGATCCCACCGCCCTGCCGCGCGGCATCGCCACCTTCGAAGCCTTCGAAAATGCGAT
GACCCTGGACATCGCCATGGGTGGCTCGACCAATACCATCCTGCACCTGCTCGCCGCCGCGCAGGAAGGCGAGGTTGCCT
TCGGCATGCAGGATATCGACCGCTTGTCCAAGCGCGTGCCGCAACTGTGCAAGGTCGCACCGAATACGCCCAAGTACCAC
ATCGAAGATGTGCATCGCGCCGGCGGCATCATGGCCATTCTCGGTGAACTCGCACGCGGCGGCCTGCTGCATACCAACGC
CGCCACCGTGCACGCACGCACGCTGGCCGATGCCATCGCGCAATGGGATGTCACCCAGACCGACGATGAAAACGTACACA
CGTTCTACAAAGCCGGCCCGGCCGGCATTCCCACGCAGATCGCCTTCAGCCAGGCAACGCGTTGGGACAGCCTGGATACC
GACCGCAGCGACGGCTGCATCCGCGATGTCGCACATGCGTTCTCGCAGGAAGGCGGCCTGGCCGTGCTGTACGGCAATAT
CGCCCGCGACGGCTGCGTGGTGAAGACTGCAGGCGTGGACGAATCCATCCACGTGTTCGAAGGCACTGCCCGCGTGTTCG
AGAGCCAGGATGCTGCTGTGAAAGGCATCCTCGCCGATGAGGTGGTCGCAGGTGATGTGGTGGTCATCCGCTACGAAGGC
CCCAAGGGCGGCCCCGGCATGCAGGAAATGCTCTACCCCACCAGCTATCTCAAATCCAAGGGCCTGGGCAAACAATGCGC
CCTGCTCACCGACGGCCGCTTCTCCGGCGGCACCTCGGGGTTATCGATTGGTCACGCATCGCCGGAAGCCGCCGCAGGCG
GCGCGATCGGCCTGGTGCGCGAAGGCGACAGGATCCTGATCGACATTCCCAATCGTTCGATCAACCTGCTGATTTCGGAC
GAGGAACTCGCGCTTCGTCGCGCCGAGCAGGACGCCAAGGGCTGGAAGCCGGTGGAGGTGCGCCCACGCAAGGTCACCAC
CGCGTTGAAGGCGTATGCGTTGCTGGCGACCAGTGCGGACAAGGGTGCGGTCCGGGATAAGGCGCTGCTGGACGGTTAG

Upstream 100 bases:

>100_bases
AACGTGCGGACCCTGCGCGTGCGGTGACGGTTGCAGCAGCAACAGTCACGACGCGCTCTAATTGCCAGCCACCGCTCGCC
AATCAGCCGTCGAATTCGCC

Downstream 100 bases:

>100_bases
TGCCAGCGATCGCGGCGTGGTGAGCTGGCTTCTTGTGGTAAGCGCAATGCGACGCATCGGTGGGCCATGCTGATGCAACG
CAGTTATCGCCGCTTGCTTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKL
DLIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMQDIDRLSKRVPQLCKVAPNTPKYH
IEDVHRAGGIMAILGELARGGLLHTNAATVHARTLADAIAQWDVTQTDDENVHTFYKAGPAGIPTQIAFSQATRWDSLDT
DRSDGCIRDVAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVREGDRILIDIPNRSINLLISD
EELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKALLDG

Sequences:

>Translated_612_residues
MPEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKL
DLIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMQDIDRLSKRVPQLCKVAPNTPKYH
IEDVHRAGGIMAILGELARGGLLHTNAATVHARTLADAIAQWDVTQTDDENVHTFYKAGPAGIPTQIAFSQATRWDSLDT
DRSDGCIRDVAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVREGDRILIDIPNRSINLLISD
EELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKALLDG
>Mature_611_residues
PEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERVGGVAKEFDTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKLD
LIDAMVIAADDSASDEKVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVELC
HRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMQDIDRLSKRVPQLCKVAPNTPKYHI
EDVHRAGGIMAILGELARGGLLHTNAATVHARTLADAIAQWDVTQTDDENVHTFYKAGPAGIPTQIAFSQATRWDSLDTD
RSDGCIRDVAHAFSQEGGLAVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEGP
KGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVREGDRILIDIPNRSINLLISDE
ELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSADKGAVRDKALLDG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=72.2852512155592, Blast_Score=919, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=503, Percent_Identity=33.0019880715706, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1786464, Length=516, Percent_Identity=31.7829457364341, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=30.0556586270872, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=37.2131147540984, Blast_Score=353, Evalue=3e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_XANAC (Q8PQI0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640701.1
- GeneID:   1154416
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0345
- NMPDR:   fig|190486.1.peg.345
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   XAXO190486:XAC0345-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65135; Mature: 65004

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERVGGVAKEFDTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKLDLIDAMVIAADDSASDEKVA
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHH
EFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMQDID
HHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEECHHHHH
RLSKRVPQLCKVAPNTPKYHIEDVHRAGGIMAILGELARGGLLHTNAATVHARTLADAIA
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
QWDVTQTDDENVHTFYKAGPAGIPTQIAFSQATRWDSLDTDRSDGCIRDVAHAFSQEGGL
HCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
AVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
EEEECCCCCCCEEEEECCCCCCEEEEECHHHHHCCCCHHHHHHHHHHEEECCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
EGDRILIDIPNRSINLLISDEELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCC
KGAVRDKALLDG
CCCCCCHHHCCC
>Mature Secondary Structure 
PEYRSKTSTHGRNMAGARALWRATGMRDGDFHKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERVGGVAKEFDTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPTVFVSGGPMEAGKTKLAEHKLDLIDAMVIAADDSASDEKVA
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHH
EFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFLRAGRVAVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
CHRWYGGEDPTALPRGIATFEAFENAMTLDIAMGGSTNTILHLLAAAQEGEVAFGMQDID
HHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEECHHHHH
RLSKRVPQLCKVAPNTPKYHIEDVHRAGGIMAILGELARGGLLHTNAATVHARTLADAIA
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
QWDVTQTDDENVHTFYKAGPAGIPTQIAFSQATRWDSLDTDRSDGCIRDVAHAFSQEGGL
HCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
AVLYGNIARDGCVVKTAGVDESIHVFEGTARVFESQDAAVKGILADEVVAGDVVVIRYEG
EEEECCCCCCCEEEEECCCCCCEEEEECHHHHHCCCCHHHHHHHHHHEEECCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKQCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
EGDRILIDIPNRSINLLISDEELALRRAEQDAKGWKPVEVRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCC
KGAVRDKALLDG
CCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217