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The map label for this gene is dhaA [H]

Identifier: 21241009

GI number: 21241009

Start: 283259

End: 284161

Strand: Direct

Name: dhaA [H]

Synonym: XAC0235

Alternate gene names: 21241009

Gene position: 283259-284161 (Clockwise)

Preceding gene: 21241008

Following gene: 77748519

Centisome position: 5.47

GC content: 64.78

Gene sequence:

>903_bases
ATGAACTACCCCGGCTATCCCTTTCCCCCCAAGCGCCTTGAGGTGCGCCCCGGCGTTGCGATGTCGTATCTGGACGAAGG
CCCGCGCGATGGCGAGGTGGTTGTCATGCTGCACGGCAATCCGTCGTGGAGCTATTTGTGGCGGCATCTGGTGAGCGGCC
TGTCCGATCGCTACCGCTGTATCGTGCCCGATCACATCGGCATGGGGCTGTCCGACAAGCCCGACGATGCGCCCGACGCG
CAGCCGCGCTACGACTACACGCTGCAATCCCGCGTGGACGATCTGGACACCTTGTTGCGGCATCTGGGCATCACCGGGCC
GGTGACGCTGGCGGTGCACGATTGGGGCGGCATGATCGGTTTCGGCTGGGCGTTGTCGCATCACGCGCAGGTCAAGCGGC
TGGTCATCACCAACACGGCTGCGTTCCCGCTGCCGGCGGAGAAGCCGATGCCATGGCAGATTGCGATGGGTCGGCACTGG
CGGCCGGGCGAGTGGTTTATCCGCACGTTCAATGCGTTTTCGTCCGGCGCGTCGTGGTTTGGCGTCTCGCGGCGCATGCC
GGCCGATGTGCGCCGCGCTTACGTGGCGCCGTACAACAACTGGCGCAACCGCATCTCCACCATCCGCTTCATGCAGGACA
TACCCCTGTCGCCGGCCGACCAGGGCTGGTCGTTGCTGGAGCGCTCGGCGCAGGCATTGCCCGCGTTCGCCGACCGCCCG
GCCTTTATCGCCTGGGGCCTGCGTGATATCTGTTTCGACAAGCACTTTCTGGCCGGCTTTCGCAGGGCGCTGCCGCAGGC
CGAAGTGACTGCATTCAACGATGCCAATCACTACGTGCTGGAAGACAAGCACGAGGTGCTGGTGCCGGCGATTCGCGCGT
TTCTGGAGCGCAATCCGCTGTAA

Upstream 100 bases:

>100_bases
ACCACTGTTGCAAACAGTTCAACCTTGCAGCGATGGTGAGGTGCGATGTCTTAGACGAATCGCCAGACGCATTTCAGTCC
CTGCTTTACATCGAGAGATC

Downstream 100 bases:

>100_bases
CGCCTCGCAGATGGCAGCGCGCCGCGGCGCGTTAGCCATGCCGCACTCAAGGGCTGAAATTCCTGAAGTGGATCCCGATG
CAGCGCACCGGTCATGCCGG

Product: haloalkane dehalogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MNYPGYPFPPKRLEVRPGVAMSYLDEGPRDGEVVVMLHGNPSWSYLWRHLVSGLSDRYRCIVPDHIGMGLSDKPDDAPDA
QPRYDYTLQSRVDDLDTLLRHLGITGPVTLAVHDWGGMIGFGWALSHHAQVKRLVITNTAAFPLPAEKPMPWQIAMGRHW
RPGEWFIRTFNAFSSGASWFGVSRRMPADVRRAYVAPYNNWRNRISTIRFMQDIPLSPADQGWSLLERSAQALPAFADRP
AFIAWGLRDICFDKHFLAGFRRALPQAEVTAFNDANHYVLEDKHEVLVPAIRAFLERNPL

Sequences:

>Translated_300_residues
MNYPGYPFPPKRLEVRPGVAMSYLDEGPRDGEVVVMLHGNPSWSYLWRHLVSGLSDRYRCIVPDHIGMGLSDKPDDAPDA
QPRYDYTLQSRVDDLDTLLRHLGITGPVTLAVHDWGGMIGFGWALSHHAQVKRLVITNTAAFPLPAEKPMPWQIAMGRHW
RPGEWFIRTFNAFSSGASWFGVSRRMPADVRRAYVAPYNNWRNRISTIRFMQDIPLSPADQGWSLLERSAQALPAFADRP
AFIAWGLRDICFDKHFLAGFRRALPQAEVTAFNDANHYVLEDKHEVLVPAIRAFLERNPL
>Mature_300_residues
MNYPGYPFPPKRLEVRPGVAMSYLDEGPRDGEVVVMLHGNPSWSYLWRHLVSGLSDRYRCIVPDHIGMGLSDKPDDAPDA
QPRYDYTLQSRVDDLDTLLRHLGITGPVTLAVHDWGGMIGFGWALSHHAQVKRLVITNTAAFPLPAEKPMPWQIAMGRHW
RPGEWFIRTFNAFSSGASWFGVSRRMPADVRRAYVAPYNNWRNRISTIRFMQDIPLSPADQGWSLLERSAQALPAFADRP
AFIAWGLRDICFDKHFLAGFRRALPQAEVTAFNDANHYVLEDKHEVLVPAIRAFLERNPL

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity, which includes mono- and di- chlorinated

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=311, Percent_Identity=22.8295819935691, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562298, Length=159, Percent_Identity=31.4465408805031, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17554012, Length=303, Percent_Identity=22.1122112211221, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.5 [H]

Molecular weight: Translated: 34159; Mature: 34159

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYPGYPFPPKRLEVRPGVAMSYLDEGPRDGEVVVMLHGNPSWSYLWRHLVSGLSDRYRC
CCCCCCCCCCCCEEECCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEE
IVPDHIGMGLSDKPDDAPDAQPRYDYTLQSRVDDLDTLLRHLGITGPVTLAVHDWGGMIG
EECHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCH
FGWALSHHAQVKRLVITNTAAFPLPAEKPMPWQIAMGRHWRPGEWFIRTFNAFSSGASWF
HHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCC
GVSRRMPADVRRAYVAPYNNWRNRISTIRFMQDIPLSPADQGWSLLERSAQALPAFADRP
CCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCC
AFIAWGLRDICFDKHFLAGFRRALPQAEVTAFNDANHYVLEDKHEVLVPAIRAFLERNPL
CEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNYPGYPFPPKRLEVRPGVAMSYLDEGPRDGEVVVMLHGNPSWSYLWRHLVSGLSDRYRC
CCCCCCCCCCCCEEECCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEE
IVPDHIGMGLSDKPDDAPDAQPRYDYTLQSRVDDLDTLLRHLGITGPVTLAVHDWGGMIG
EECHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCH
FGWALSHHAQVKRLVITNTAAFPLPAEKPMPWQIAMGRHWRPGEWFIRTFNAFSSGASWF
HHHHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCC
GVSRRMPADVRRAYVAPYNNWRNRISTIRFMQDIPLSPADQGWSLLERSAQALPAFADRP
CCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCC
AFIAWGLRDICFDKHFLAGFRRALPQAEVTAFNDANHYVLEDKHEVLVPAIRAFLERNPL
CEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10094681; 10735862 [H]