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The map label for this gene is gpsA

Identifier: 21240996

GI number: 21240996

Start: 268756

End: 269781

Strand: Direct

Name: gpsA

Synonym: XAC0222

Alternate gene names: 21240996

Gene position: 268756-269781 (Clockwise)

Preceding gene: 21240995

Following gene: 21240998

Centisome position: 5.19

GC content: 67.06

Gene sequence:

>1026_bases
ATGAGCGATTTGACCCACAAGATCGCCGTTCTCGGCGCCGGTTCCTGGGGCACGGCCCTGGCCGCGCTGCTCGCCAGGCA
TGGTCACCCGACCGTGCTCTGGGGGCGCGACGCGGCGATGGTGGATACCATCGACCGCACCCACGAGAACGCGCGCTATC
TGCCGGGCATTGCACTGCCCGACAGCCTGCGTGCCACCACCGACCTGCAGGCGGCGGTCGCTGACGCCACTTGGATCCTG
GTGGTGGTGCCCTCGCATGCGTTCACCGAGACGATCCGGCTGATCGCACCGCTGCGCCCGCCCGGTGCCGGCGTTGCGTG
GGCGACCAAAGGCTTCGAACCCGGTTCCGGGCGGTTTCTGCATGAAGTGGCGCGTGACATCCTCGGCCCCAGCGTTCCGC
TGGCCGTGGTGACCGGACCTTCCTTCGCCAAGGAAGTCACGCTCGGCCTGCCGACCGCCATCACCGTGCACGGCGACGAT
GCGGCGTTTGCGCAAGTGGTGGCCGACGCGATGCATGGCCCCACTTTCCGCGCCTACACCGGCGACGACATGGTGGGCGC
CGAGCTCGGCGGGGCGATGAAGAACGTGCTGGCGGTGGCCACCGGCGTGGCCGATGGCATGCAGCTTGGTCTCAATGCAC
GTGCCGGTTTGATCACACGTGGCTTGAACGAGATGCTGCGTCTGGCGGCGGTGATCGGCGCTCGTCCGGAGACCTTGATG
GGCCTGGCCGGGTTGGGCGATCTGGTGCTCACCTGCACCGGCGATCTGTCGCGCAACCGTCGCCTGGGTCTGGCCTTGGG
GCGCGGGCAGAGCTTGGACGAGGCGATCCGCGAGATCGGTCAGGTGGTCGAATCGGTGCAGACGGCCGATGAAGTCATGC
GTCAGGCCGAACACCACGGCATCGAACTGCCGATCTCCAATGCCGTGCGTGCGGTATTGCACGGCGAAATCACCCCGGAA
GCAGGCTTGAAGGAATTGCTGGCACGCGAGCGCAAGCCAGAGTACCCGCAGACCTTGTTCACCTGA

Upstream 100 bases:

>100_bases
CGAAGCCCTGTATGCGGAAACCCTGCGTCAGCGTCAGAACGAAGGGACCTCGCTGGCCGATTCCGAGCCGGCTGGCAACG
CCTAAGCGTTGATTGCGCCG

Downstream 100 bases:

>100_bases
GAACAGCTGACAAAACGCTTCGCTCACCACCAGGCCTGCGTGGCCGGTGCTCGGAATCTCGCGTACCACTCTTTCACTGT
GGTTCCGCGCGCACCGTCCA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSDLTHKIAVLGAGSWGTALAALLARHGHPTVLWGRDAAMVDTIDRTHENARYLPGIALPDSLRATTDLQAAVADATWIL
VVVPSHAFTETIRLIAPLRPPGAGVAWATKGFEPGSGRFLHEVARDILGPSVPLAVVTGPSFAKEVTLGLPTAITVHGDD
AAFAQVVADAMHGPTFRAYTGDDMVGAELGGAMKNVLAVATGVADGMQLGLNARAGLITRGLNEMLRLAAVIGARPETLM
GLAGLGDLVLTCTGDLSRNRRLGLALGRGQSLDEAIREIGQVVESVQTADEVMRQAEHHGIELPISNAVRAVLHGEITPE
AGLKELLARERKPEYPQTLFT

Sequences:

>Translated_341_residues
MSDLTHKIAVLGAGSWGTALAALLARHGHPTVLWGRDAAMVDTIDRTHENARYLPGIALPDSLRATTDLQAAVADATWIL
VVVPSHAFTETIRLIAPLRPPGAGVAWATKGFEPGSGRFLHEVARDILGPSVPLAVVTGPSFAKEVTLGLPTAITVHGDD
AAFAQVVADAMHGPTFRAYTGDDMVGAELGGAMKNVLAVATGVADGMQLGLNARAGLITRGLNEMLRLAAVIGARPETLM
GLAGLGDLVLTCTGDLSRNRRLGLALGRGQSLDEAIREIGQVVESVQTADEVMRQAEHHGIELPISNAVRAVLHGEITPE
AGLKELLARERKPEYPQTLFT
>Mature_340_residues
SDLTHKIAVLGAGSWGTALAALLARHGHPTVLWGRDAAMVDTIDRTHENARYLPGIALPDSLRATTDLQAAVADATWILV
VVPSHAFTETIRLIAPLRPPGAGVAWATKGFEPGSGRFLHEVARDILGPSVPLAVVTGPSFAKEVTLGLPTAITVHGDDA
AFAQVVADAMHGPTFRAYTGDDMVGAELGGAMKNVLAVATGVADGMQLGLNARAGLITRGLNEMLRLAAVIGARPETLMG
LAGLGDLVLTCTGDLSRNRRLGLALGRGQSLDEAIREIGQVVESVQTADEVMRQAEHHGIELPISNAVRAVLHGEITPEA
GLKELLARERKPEYPQTLFT

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=334, Percent_Identity=30.8383233532934, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI24307999, Length=333, Percent_Identity=29.4294294294294, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1790037, Length=336, Percent_Identity=50, Blast_Score=320, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI17507425, Length=367, Percent_Identity=29.4277929155313, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI32564399, Length=339, Percent_Identity=28.9085545722714, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32564403, Length=349, Percent_Identity=28.080229226361, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193210136, Length=349, Percent_Identity=28.080229226361, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193210134, Length=334, Percent_Identity=25.4491017964072, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324513, Length=347, Percent_Identity=29.3948126801153, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320181, Length=345, Percent_Identity=28.695652173913, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17136202, Length=361, Percent_Identity=28.808864265928, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17136204, Length=341, Percent_Identity=28.7390029325513, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17136200, Length=341, Percent_Identity=28.7390029325513, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI22026922, Length=347, Percent_Identity=27.6657060518732, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45551945, Length=348, Percent_Identity=26.1494252873563, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281362270, Length=240, Percent_Identity=29.1666666666667, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24648969, Length=304, Percent_Identity=25.9868421052632, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_XANAC (Q8PQU9)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640578.1
- ProteinModelPortal:   Q8PQU9
- SMR:   Q8PQU9
- GeneID:   1154293
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0222
- NMPDR:   fig|190486.1.peg.222
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   XAXO190486:XAC0222-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35826; Mature: 35694

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 194-194 BINDING 110-110 BINDING 110-110 BINDING 143-143 BINDING 258-258 BINDING 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLTHKIAVLGAGSWGTALAALLARHGHPTVLWGRDAAMVDTIDRTHENARYLPGIALP
CCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCC
DSLRATTDLQAAVADATWILVVVPSHAFTETIRLIAPLRPPGAGVAWATKGFEPGSGRFL
CCCCHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHH
HEVARDILGPSVPLAVVTGPSFAKEVTLGLPTAITVHGDDAAFAQVVADAMHGPTFRAYT
HHHHHHHCCCCCCEEEEECCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEC
GDDMVGAELGGAMKNVLAVATGVADGMQLGLNARAGLITRGLNEMLRLAAVIGARPETLM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
GLAGLGDLVLTCTGDLSRNRRLGLALGRGQSLDEAIREIGQVVESVQTADEVMRQAEHHG
HHHCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IELPISNAVRAVLHGEITPEAGLKELLARERKPEYPQTLFT
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCC
>Mature Secondary Structure 
SDLTHKIAVLGAGSWGTALAALLARHGHPTVLWGRDAAMVDTIDRTHENARYLPGIALP
CCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCC
DSLRATTDLQAAVADATWILVVVPSHAFTETIRLIAPLRPPGAGVAWATKGFEPGSGRFL
CCCCHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHH
HEVARDILGPSVPLAVVTGPSFAKEVTLGLPTAITVHGDDAAFAQVVADAMHGPTFRAYT
HHHHHHHCCCCCCEEEEECCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEC
GDDMVGAELGGAMKNVLAVATGVADGMQLGLNARAGLITRGLNEMLRLAAVIGARPETLM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
GLAGLGDLVLTCTGDLSRNRRLGLALGRGQSLDEAIREIGQVVESVQTADEVMRQAEHHG
HHHCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IELPISNAVRAVLHGEITPEAGLKELLARERKPEYPQTLFT
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217