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The map label for this gene is dppA [H]

Identifier: 21228562

GI number: 21228562

Start: 2934380

End: 2936059

Strand: Reverse

Name: dppA [H]

Synonym: MM_2460

Alternate gene names: 21228562

Gene position: 2936059-2934380 (Counterclockwise)

Preceding gene: 21228564

Following gene: 21228561

Centisome position: 71.68

GC content: 46.85

Gene sequence:

>1680_bases
ATGGAGAAAAAAAAGTTACTGACATTATTTTCTGTTTTCCTGACAGCCCTGGTCGTAATTACGGCTGGCTGTTCTGATAA
GGACAGTGCTCAGGCTGGAACAATGGGTGGAAATTCGCTGGCAGAGGAAACAGTGGTTGAGAATGGTGATGAAGGTTCAC
AGCATGTTGATGTTGTTTATCTGAGCGGCGGAGACTGCGGCTATCCACAGCCGTTCACAATATATCCGAGAGGTCCGGGG
TCATCAAAAGTTGGGATGATCTTTGACAGCCTGTTAGAAAGAGATGAAATTGGCATAATCCCCTGGCTGGCTGAAAGCTG
GGATGTCAGCCCTGATGGAACAGAATATACGGTTCATCTCCGCGAAGGTGTCGTGTGGAGTGATGGAGAACCTTTCACGG
CAAATGATGTTAAATTTACTTTTGATTATGAGCAGAAGAATGTGCCTATCTCAGGTGGAATTGAGGCAGGAGTTGTAAAT
AATGTTCAGGTTGTGGATCCCGGTACGGTCAAATTCGTACTTAACCAGCCTGTTTCAACCTTCCTGTACAAGCTTACCGG
TTTTAGAATCATACCCGAGCACATATACAAAGATGTATCGGACCCTGCCAGTTTCCTTGATCCAGAAGCGGTTACCGGTA
CCGGCCCGTTCATCCTTGACCAGTACAACAAAGAACATGGGACATACCGTTTTGTAGCAAATGAGAATTTCTGGGGACCG
GAAGCTACCGTTAAATCCGTGGAATTTATTCCGGTCAGCGACCCGCTTGTAGCTTTTGAACAGGGAAAAATAGATTTCAC
AGGGGTATCACCCGATACTCTTGACCGGTTCAAATCGGACTCTGACATAAGAATTGTGCAGCAGCCAGCTTTCTGGGGTT
ACCAGTTTTATTTCAACATGAAAAAATGTCCTGAGCTTAATGACAGCCTGGTAAGACAGGCTTTTGCTTACGCCATTGAC
CGTGATGAACTGGTAGAAAAGATCGCAAGAGGTGCCGGAAAAGCCGGGAAAATGGGAATCCTCTCAGAAGACCACGTCTG
GTATAACCCTGACCAGCCCGGGTACAGCTATGACCCGGATAAAGCCGGAGCATTGCTCGAAGAGGCAGGATGGTCTGATA
CGGACGGGGATGGAATACGTGACAAAGGCGGAGAAAAACTGTCATATGTACTATCCCTTAGCAGCGGCGAAGTCCGTATA
GGCGAACTTATAAAAGAAAGGCTGAGTGAAGTGGGAATTGATGTTCAGGTGAAGTCCCTCGAGAGCAAATCCCGCGATTC
CAACCTGAAGAACGGAGACTTTGAGCTTCTGATCAGCGGCTTTGGAGGCTGGGGACAGGATGCAGATTATCTCCGTACAA
GGTACTGTGATACGGATTCACAGTCATCAAACAGTGTGTCATCCGGAGCAGCAGTGTATGGTTACCACAATGACACCCTG
AACGCCCTTGGTACCCGGGAACTGCAGGAACTTGACGATGATAAACGTAAAGAAATAGTATATGAGATGCAAACCGTAAT
TGCGAATGATGTGCCTGCAATACCGCTCTATTATACCACATCGTACGATGCATGGAGAATTTCAAAATATGACGGCTGGA
TGAATATGTACGACCACCATGCGAGGACACACAGCATTCTGTCGTATCTTGAGAGGGATGGGATTGCAGAAAAAAGATAA

Upstream 100 bases:

>100_bases
ATACTCATATATGTTTAGGTATTAACACCTACGTGCTATCAGTATTATTATTCATATTACAGGTTATTTGTAGTAATTTA
CAAAAATAGGGTGTTCTTTA

Downstream 100 bases:

>100_bases
CCTCAATAACCTGATCGAATGCTGGAAAAAAACTGCCAGCGATGCTCTTAACATCCGGGATGAGGGCAGGATGGCAGATT
TCTGGAATAAGCGTTCCGAG

Product: dipeptide/oligopeptide-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MEKKKLLTLFSVFLTALVVITAGCSDKDSAQAGTMGGNSLAEETVVENGDEGSQHVDVVYLSGGDCGYPQPFTIYPRGPG
SSKVGMIFDSLLERDEIGIIPWLAESWDVSPDGTEYTVHLREGVVWSDGEPFTANDVKFTFDYEQKNVPISGGIEAGVVN
NVQVVDPGTVKFVLNQPVSTFLYKLTGFRIIPEHIYKDVSDPASFLDPEAVTGTGPFILDQYNKEHGTYRFVANENFWGP
EATVKSVEFIPVSDPLVAFEQGKIDFTGVSPDTLDRFKSDSDIRIVQQPAFWGYQFYFNMKKCPELNDSLVRQAFAYAID
RDELVEKIARGAGKAGKMGILSEDHVWYNPDQPGYSYDPDKAGALLEEAGWSDTDGDGIRDKGGEKLSYVLSLSSGEVRI
GELIKERLSEVGIDVQVKSLESKSRDSNLKNGDFELLISGFGGWGQDADYLRTRYCDTDSQSSNSVSSGAAVYGYHNDTL
NALGTRELQELDDDKRKEIVYEMQTVIANDVPAIPLYYTTSYDAWRISKYDGWMNMYDHHARTHSILSYLERDGIAEKR

Sequences:

>Translated_559_residues
MEKKKLLTLFSVFLTALVVITAGCSDKDSAQAGTMGGNSLAEETVVENGDEGSQHVDVVYLSGGDCGYPQPFTIYPRGPG
SSKVGMIFDSLLERDEIGIIPWLAESWDVSPDGTEYTVHLREGVVWSDGEPFTANDVKFTFDYEQKNVPISGGIEAGVVN
NVQVVDPGTVKFVLNQPVSTFLYKLTGFRIIPEHIYKDVSDPASFLDPEAVTGTGPFILDQYNKEHGTYRFVANENFWGP
EATVKSVEFIPVSDPLVAFEQGKIDFTGVSPDTLDRFKSDSDIRIVQQPAFWGYQFYFNMKKCPELNDSLVRQAFAYAID
RDELVEKIARGAGKAGKMGILSEDHVWYNPDQPGYSYDPDKAGALLEEAGWSDTDGDGIRDKGGEKLSYVLSLSSGEVRI
GELIKERLSEVGIDVQVKSLESKSRDSNLKNGDFELLISGFGGWGQDADYLRTRYCDTDSQSSNSVSSGAAVYGYHNDTL
NALGTRELQELDDDKRKEIVYEMQTVIANDVPAIPLYYTTSYDAWRISKYDGWMNMYDHHARTHSILSYLERDGIAEKR
>Mature_559_residues
MEKKKLLTLFSVFLTALVVITAGCSDKDSAQAGTMGGNSLAEETVVENGDEGSQHVDVVYLSGGDCGYPQPFTIYPRGPG
SSKVGMIFDSLLERDEIGIIPWLAESWDVSPDGTEYTVHLREGVVWSDGEPFTANDVKFTFDYEQKNVPISGGIEAGVVN
NVQVVDPGTVKFVLNQPVSTFLYKLTGFRIIPEHIYKDVSDPASFLDPEAVTGTGPFILDQYNKEHGTYRFVANENFWGP
EATVKSVEFIPVSDPLVAFEQGKIDFTGVSPDTLDRFKSDSDIRIVQQPAFWGYQFYFNMKKCPELNDSLVRQAFAYAID
RDELVEKIARGAGKAGKMGILSEDHVWYNPDQPGYSYDPDKAGALLEEAGWSDTDGDGIRDKGGEKLSYVLSLSSGEVRI
GELIKERLSEVGIDVQVKSLESKSRDSNLKNGDFELLISGFGGWGQDADYLRTRYCDTDSQSSNSVSSGAAVYGYHNDTL
NALGTRELQELDDDKRKEIVYEMQTVIANDVPAIPLYYTTSYDAWRISKYDGWMNMYDHHARTHSILSYLERDGIAEKR

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=463, Percent_Identity=29.8056155507559, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789887, Length=381, Percent_Identity=29.6587926509186, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787052, Length=442, Percent_Identity=24.4343891402715, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787762, Length=427, Percent_Identity=25.7611241217799, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789397, Length=478, Percent_Identity=24.4769874476987, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081878, Length=396, Percent_Identity=23.7373737373737, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 62089; Mature: 62089

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKKLLTLFSVFLTALVVITAGCSDKDSAQAGTMGGNSLAEETVVENGDEGSQHVDVVY
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEE
LSGGDCGYPQPFTIYPRGPGSSKVGMIFDSLLERDEIGIIPWLAESWDVSPDGTEYTVHL
ECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEE
REGVVWSDGEPFTANDVKFTFDYEQKNVPISGGIEAGVVNNVQVVDPGTVKFVLNQPVST
ECCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCHHH
FLYKLTGFRIIPEHIYKDVSDPASFLDPEAVTGTGPFILDQYNKEHGTYRFVANENFWGP
HHHHHCCCEEEHHHHHHCCCCHHHHCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCC
EATVKSVEFIPVSDPLVAFEQGKIDFTGVSPDTLDRFKSDSDIRIVQQPAFWGYQFYFNM
CCHHCEEEEEECCCCEEEEECCCEEEECCCHHHHHHHCCCCCEEEEECCCCEEEEEEECC
KKCPELNDSLVRQAFAYAIDRDELVEKIARGAGKAGKMGILSEDHVWYNPDQPGYSYDPD
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCH
KAGALLEEAGWSDTDGDGIRDKGGEKLSYVLSLSSGEVRIGELIKERLSEVGIDVQVKSL
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECH
ESKSRDSNLKNGDFELLISGFGGWGQDADYLRTRYCDTDSQSSNSVSSGAAVYGYHNDTL
HCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCH
NALGTRELQELDDDKRKEIVYEMQTVIANDVPAIPLYYTTSYDAWRISKYDGWMNMYDHH
HHHCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCHHHHHHHH
ARTHSILSYLERDGIAEKR
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEKKKLLTLFSVFLTALVVITAGCSDKDSAQAGTMGGNSLAEETVVENGDEGSQHVDVVY
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEE
LSGGDCGYPQPFTIYPRGPGSSKVGMIFDSLLERDEIGIIPWLAESWDVSPDGTEYTVHL
ECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEE
REGVVWSDGEPFTANDVKFTFDYEQKNVPISGGIEAGVVNNVQVVDPGTVKFVLNQPVST
ECCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCHHH
FLYKLTGFRIIPEHIYKDVSDPASFLDPEAVTGTGPFILDQYNKEHGTYRFVANENFWGP
HHHHHCCCEEEHHHHHHCCCCHHHHCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCC
EATVKSVEFIPVSDPLVAFEQGKIDFTGVSPDTLDRFKSDSDIRIVQQPAFWGYQFYFNM
CCHHCEEEEEECCCCEEEEECCCEEEECCCHHHHHHHCCCCCEEEEECCCCEEEEEEECC
KKCPELNDSLVRQAFAYAIDRDELVEKIARGAGKAGKMGILSEDHVWYNPDQPGYSYDPD
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCH
KAGALLEEAGWSDTDGDGIRDKGGEKLSYVLSLSSGEVRIGELIKERLSEVGIDVQVKSL
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECH
ESKSRDSNLKNGDFELLISGFGGWGQDADYLRTRYCDTDSQSSNSVSSGAAVYGYHNDTL
HCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCH
NALGTRELQELDDDKRKEIVYEMQTVIANDVPAIPLYYTTSYDAWRISKYDGWMNMYDHH
HHHCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCHHHHHHHH
ARTHSILSYLERDGIAEKR
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]