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The map label for this gene is gyrA [H]

Identifier: 21228522

GI number: 21228522

Start: 2883276

End: 2885978

Strand: Direct

Name: gyrA [H]

Synonym: MM_2420

Alternate gene names: 21228522

Gene position: 2883276-2885978 (Clockwise)

Preceding gene: 21228521

Following gene: 21228523

Centisome position: 70.39

GC content: 49.02

Gene sequence:

>2703_bases
ATGGACACCGGTCCTGAAGAGCCTGAAGATGAGGAGCCTGTAAGAGCAGGAGTTACTCCCATCCTTATTGACGACGAGAT
GAAACGCTCTTACATCAATTATGCGATGAGCGTAATTGTCGGAAGGGCTCTCCCGGATGCCCGTGACGGCTTAAAGCCTG
TCCACCGCAGGATCCTTTTCTCCATGAATGAGTCAGGGATCACTCATGACAAGCCTTACAAAAAATCCGCACGTATTGTG
GGAGACGTTCTTGGTAAGTACCACCCTCATGGGGATTCTGCAGTTTATGACACTATTGTGCGCATGGTCCAGGACTTCTC
TCTCAGGTACCCTCTGATCGACGGGCAGGGTAACTTCGGGTCAATTGACGGAGACTCGGCTGCTGCGATGCGTTACACTG
AAGTCCGTATGGACAGGATCGCGGAAGAGATGCTGGTTGATATTGAGAAAGAAACCGTTCCTTTCATTCCTAACTATGAC
GGGTCCCTGAAAGAGCCGGAAGTCCTTCCAGCCAGGCTTCCAAACCTCCTTATAAATGGTTCAACCGGCATTGCCGTCGG
AATGGCAACAAACATGCCTCCTCACAATATCAGCGAGGTTATCGACGGAATTCTGATGCTTATCGAAAACCCCGAAACAC
AGATTTCGGAACTGATGACCGTTATCAAGGGTCCTGACTTCCCCACAGGCGCACACATACTCGGGACAGCGGGTATAAGG
TCTGCATACATGACAGGCAGAGGCCCTATAAGGATGAGGGCAGTTGCCGAAATTCAGGAGCTTAAAAAAGACAGGCAGCA
GATTATAGTAACCGAACTCCCTTATCAGGTAAACAAGGCAAAGTTGATTGAAAACATCGCCCAGCTTGTAAGGGAAAAGG
TGATTAACGGAATTTCCGACCTGCGTGATGAGTCTGACAGGGAAGGGATCAGGGTTGTAGTCGAGCTTTCAAGAGGTGTA
AACCCCAACGTCGTCCTGAACCAGCTTTATAAACACACTCAGATGGCAACCACTTTTGGTGTTATCAACCTCGCCCTTGT
TGACGGAAAGCCCAAAGAGCTGAACCTGAAACAGCTTCTCGAGATCTACCTGGAATACAGGATGGAAATTATCCAGAAGA
GGACACTCTATGATCTGAGGAAGAGCGAAGAAAGGGCTCACATCCTGGAAGGGTTAAGGATTGCCCTTGACAATATAGAT
GCAGTTGTTGCCCTTATTAAGGGTTCTGCAAACGCCGATCAGGCAAAGCAGGGCTTAATAGACAACTTTGCTCTTGACGA
GGTCCAGGCAAAAGCTATCCTTGAGATGCGCCTCCAGAGGCTTACCGGTCTTGAAACCCGGAAGATCCTTGATGAACTTG
AGGCTCTCGTAAAACAGATTGAAGAACTGAGGAAGATCCTGGCAAGTGATGAACTGAAGTACGAAATTATCAGGACGGAA
CTTTCTGAGCTCAAGGATAAATACGGGGACATCCGCAGGACAAGGATTGTGCATAACACGGAAAATGTGACTGATGAAGA
CCTTATCCCTGAAGAAGATGTTGTAGTTACGATCACAAACAGCGGCTACATAAAGCGCATTCCTCTTGACACCTATACCA
TGCAGCGCCGTGGAGGCAGAGGGATTATCGGCATGGAAATGAAGGAGGAAGATTTTGTTGAAAACCTCTTCATTTCGTCA
ACCCATAACTATATCCTTTTCTTCACAAACAGGGGCAGGCTCTACTGGCAGAAGGTCTATGAGATCCCCGAGGGCTCCCG
CCAGTCGAGAGGCAAAGCCATAGTCAACCTGCTTGAGCTTCAGGAAGGCGAAATGGTCAATGCCATGATTTCCGTTGAAG
AATTTGCCGAAGACAAATACCTCTTTATGGCAACAAGGGCAGGGACGGTCAAGAAGACTCCACTGTCCGAGTTCAGGAAC
CCGAGAAGAGCAGGCATCATTGCGGTCAGCCTGGACGAAGGTGACGAGCTTGTTAAAGTCCTCCTTACCGACGGAAAGCA
GGAAATCATGATGGTCTCGAAAAAAGGCAAAGCCATCCGCTTCTCAGAAGAAGATGTCCGCCCGATGGGCAGGACTGCAA
GAGGAGTCCGGGGTATGACCCTTGAAGGACCGGATGACGAGGTGGTCAGCCTTGACCTGGTGGACGAGACCACAACTCTC
CTTACAGTCACCGATAACGGCTTCGGGAAAAGGACGGAATACTCGCAGTACCCTGTGCACCGCCGCGGTGGAAAAGGCGT
GATCACGATCGTCACAAACCTCAGGAACGGATTTGTCTCCAACGTCAAATCAGTTGCTGAAGACGATGAACTCATGTTTA
CGAGTGCAGAAGGAATCATTATCCGGATCCCCGCAAAAGACATCTCCATCCAGGGCAGAAACACCCAGGGTGTACGGGTT
ATGAACATTAAGTCCGGAGACAAAGTCGGCGGCATGGCAAGGATCAAAAACGGAAAAGAAGACGAAAAGCTGAAACTGAC
CGCCCTTGCTAAAAAAGCAGCAAAAGAAAAGGTACCTGGATCAGAATCCGAAGAAGACGAATCCGAAGACCTCGATGAAT
TCGAAGGCTCAGACGAGTTCGGGGAAGAACCGGAAAAGGAAGAATTCGAAGACTCAGAATCCGAAGACTCAGAATCCGAA
GACTCAGAAGAGGAAGAAGAGGAAGAAGAGGAAGAAGAGGAAGAAAAGGAAGAGGAGTATTAA

Upstream 100 bases:

>100_bases
ATACCAGGCAACTCTTATTCCTGAAAGTCCAGTAGAAAATACCACTGAAGATCCAGTAGAAAATACCACTGAAGATTCTG
AATTAGAAGATGAAACCGAA

Downstream 100 bases:

>100_bases
GAGAGGAATAAAAGTATTAAATTACAGAAATGAGTGAAGGATTATCTCCTTCACTCGACTTCCATTTTGCCGGAATTAAC
CTATTGGGGATTGGTTCCCG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 900; Mature: 900

Protein sequence:

>900_residues
MDTGPEEPEDEEPVRAGVTPILIDDEMKRSYINYAMSVIVGRALPDARDGLKPVHRRILFSMNESGITHDKPYKKSARIV
GDVLGKYHPHGDSAVYDTIVRMVQDFSLRYPLIDGQGNFGSIDGDSAAAMRYTEVRMDRIAEEMLVDIEKETVPFIPNYD
GSLKEPEVLPARLPNLLINGSTGIAVGMATNMPPHNISEVIDGILMLIENPETQISELMTVIKGPDFPTGAHILGTAGIR
SAYMTGRGPIRMRAVAEIQELKKDRQQIIVTELPYQVNKAKLIENIAQLVREKVINGISDLRDESDREGIRVVVELSRGV
NPNVVLNQLYKHTQMATTFGVINLALVDGKPKELNLKQLLEIYLEYRMEIIQKRTLYDLRKSEERAHILEGLRIALDNID
AVVALIKGSANADQAKQGLIDNFALDEVQAKAILEMRLQRLTGLETRKILDELEALVKQIEELRKILASDELKYEIIRTE
LSELKDKYGDIRRTRIVHNTENVTDEDLIPEEDVVVTITNSGYIKRIPLDTYTMQRRGGRGIIGMEMKEEDFVENLFISS
THNYILFFTNRGRLYWQKVYEIPEGSRQSRGKAIVNLLELQEGEMVNAMISVEEFAEDKYLFMATRAGTVKKTPLSEFRN
PRRAGIIAVSLDEGDELVKVLLTDGKQEIMMVSKKGKAIRFSEEDVRPMGRTARGVRGMTLEGPDDEVVSLDLVDETTTL
LTVTDNGFGKRTEYSQYPVHRRGGKGVITIVTNLRNGFVSNVKSVAEDDELMFTSAEGIIIRIPAKDISIQGRNTQGVRV
MNIKSGDKVGGMARIKNGKEDEKLKLTALAKKAAKEKVPGSESEEDESEDLDEFEGSDEFGEEPEKEEFEDSESEDSESE
DSEEEEEEEEEEEEEKEEEY

Sequences:

>Translated_900_residues
MDTGPEEPEDEEPVRAGVTPILIDDEMKRSYINYAMSVIVGRALPDARDGLKPVHRRILFSMNESGITHDKPYKKSARIV
GDVLGKYHPHGDSAVYDTIVRMVQDFSLRYPLIDGQGNFGSIDGDSAAAMRYTEVRMDRIAEEMLVDIEKETVPFIPNYD
GSLKEPEVLPARLPNLLINGSTGIAVGMATNMPPHNISEVIDGILMLIENPETQISELMTVIKGPDFPTGAHILGTAGIR
SAYMTGRGPIRMRAVAEIQELKKDRQQIIVTELPYQVNKAKLIENIAQLVREKVINGISDLRDESDREGIRVVVELSRGV
NPNVVLNQLYKHTQMATTFGVINLALVDGKPKELNLKQLLEIYLEYRMEIIQKRTLYDLRKSEERAHILEGLRIALDNID
AVVALIKGSANADQAKQGLIDNFALDEVQAKAILEMRLQRLTGLETRKILDELEALVKQIEELRKILASDELKYEIIRTE
LSELKDKYGDIRRTRIVHNTENVTDEDLIPEEDVVVTITNSGYIKRIPLDTYTMQRRGGRGIIGMEMKEEDFVENLFISS
THNYILFFTNRGRLYWQKVYEIPEGSRQSRGKAIVNLLELQEGEMVNAMISVEEFAEDKYLFMATRAGTVKKTPLSEFRN
PRRAGIIAVSLDEGDELVKVLLTDGKQEIMMVSKKGKAIRFSEEDVRPMGRTARGVRGMTLEGPDDEVVSLDLVDETTTL
LTVTDNGFGKRTEYSQYPVHRRGGKGVITIVTNLRNGFVSNVKSVAEDDELMFTSAEGIIIRIPAKDISIQGRNTQGVRV
MNIKSGDKVGGMARIKNGKEDEKLKLTALAKKAAKEKVPGSESEEDESEDLDEFEGSDEFGEEPEKEEFEDSESEDSESE
DSEEEEEEEEEEEEEKEEEY
>Mature_900_residues
MDTGPEEPEDEEPVRAGVTPILIDDEMKRSYINYAMSVIVGRALPDARDGLKPVHRRILFSMNESGITHDKPYKKSARIV
GDVLGKYHPHGDSAVYDTIVRMVQDFSLRYPLIDGQGNFGSIDGDSAAAMRYTEVRMDRIAEEMLVDIEKETVPFIPNYD
GSLKEPEVLPARLPNLLINGSTGIAVGMATNMPPHNISEVIDGILMLIENPETQISELMTVIKGPDFPTGAHILGTAGIR
SAYMTGRGPIRMRAVAEIQELKKDRQQIIVTELPYQVNKAKLIENIAQLVREKVINGISDLRDESDREGIRVVVELSRGV
NPNVVLNQLYKHTQMATTFGVINLALVDGKPKELNLKQLLEIYLEYRMEIIQKRTLYDLRKSEERAHILEGLRIALDNID
AVVALIKGSANADQAKQGLIDNFALDEVQAKAILEMRLQRLTGLETRKILDELEALVKQIEELRKILASDELKYEIIRTE
LSELKDKYGDIRRTRIVHNTENVTDEDLIPEEDVVVTITNSGYIKRIPLDTYTMQRRGGRGIIGMEMKEEDFVENLFISS
THNYILFFTNRGRLYWQKVYEIPEGSRQSRGKAIVNLLELQEGEMVNAMISVEEFAEDKYLFMATRAGTVKKTPLSEFRN
PRRAGIIAVSLDEGDELVKVLLTDGKQEIMMVSKKGKAIRFSEEDVRPMGRTARGVRGMTLEGPDDEVVSLDLVDETTTL
LTVTDNGFGKRTEYSQYPVHRRGGKGVITIVTNLRNGFVSNVKSVAEDDELMFTSAEGIIIRIPAKDISIQGRNTQGVRV
MNIKSGDKVGGMARIKNGKEDEKLKLTALAKKAAKEKVPGSESEEDESEDLDEFEGSDEFGEEPEKEEFEDSESEDSESE
DSEEEEEEEEEEEEEKEEEY

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=357, Percent_Identity=24.9299719887955, Blast_Score=84, Evalue=8e-16,
Organism=Homo sapiens, GI19913406, Length=392, Percent_Identity=24.234693877551, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=881, Percent_Identity=49.0351872871737, Blast_Score=837, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=669, Percent_Identity=37.9671150971599, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17535065, Length=296, Percent_Identity=26.0135135135135, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=280, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=396, Percent_Identity=23.7373737373737, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136538, Length=287, Percent_Identity=26.1324041811847, Blast_Score=73, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 101312; Mature: 101312

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTGPEEPEDEEPVRAGVTPILIDDEMKRSYINYAMSVIVGRALPDARDGLKPVHRRILF
CCCCCCCCCCCCCHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHH
SMNESGITHDKPYKKSARIVGDVLGKYHPHGDSAVYDTIVRMVQDFSLRYPLIDGQGNFG
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCC
SIDGDSAAAMRYTEVRMDRIAEEMLVDIEKETVPFIPNYDGSLKEPEVLPARLPNLLING
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEEC
STGIAVGMATNMPPHNISEVIDGILMLIENPETQISELMTVIKGPDFPTGAHILGTAGIR
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEECHHHH
SAYMTGRGPIRMRAVAEIQELKKDRQQIIVTELPYQVNKAKLIENIAQLVREKVINGISD
HHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRDESDREGIRVVVELSRGVNPNVVLNQLYKHTQMATTFGVINLALVDGKPKELNLKQLL
HCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHH
EIYLEYRMEIIQKRTLYDLRKSEERAHILEGLRIALDNIDAVVALIKGSANADQAKQGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DNFALDEVQAKAILEMRLQRLTGLETRKILDELEALVKQIEELRKILASDELKYEIIRTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSELKDKYGDIRRTRIVHNTENVTDEDLIPEEDVVVTITNSGYIKRIPLDTYTMQRRGGR
HHHHHHHHCCHHHHEEEECCCCCCCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHCCCC
GIIGMEMKEEDFVENLFISSTHNYILFFTNRGRLYWQKVYEIPEGSRQSRGKAIVNLLEL
CEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHCCCCCCHHHHHHHHHHHHH
QEGEMVNAMISVEEFAEDKYLFMATRAGTVKKTPLSEFRNPRRAGIIAVSLDEGDELVKV
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEEEEEECCCHHHHHH
LLTDGKQEIMMVSKKGKAIRFSEEDVRPMGRTARGVRGMTLEGPDDEVVSLDLVDETTTL
HHHCCCCCEEEEECCCCEEEECHHHCCHHHHHHCCCCCCCCCCCCCCEEEEEEECCCEEE
LTVTDNGFGKRTEYSQYPVHRRGGKGVITIVTNLRNGFVSNVKSVAEDDELMFTSAEGII
EEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCEE
IRIPAKDISIQGRNTQGVRVMNIKSGDKVGGMARIKNGKEDEKLKLTALAKKAAKEKVPG
EEECCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SESEEDESEDLDEFEGSDEFGEEPEKEEFEDSESEDSESEDSEEEEEEEEEEEEEKEEEY
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTGPEEPEDEEPVRAGVTPILIDDEMKRSYINYAMSVIVGRALPDARDGLKPVHRRILF
CCCCCCCCCCCCCHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHH
SMNESGITHDKPYKKSARIVGDVLGKYHPHGDSAVYDTIVRMVQDFSLRYPLIDGQGNFG
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCC
SIDGDSAAAMRYTEVRMDRIAEEMLVDIEKETVPFIPNYDGSLKEPEVLPARLPNLLING
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEEC
STGIAVGMATNMPPHNISEVIDGILMLIENPETQISELMTVIKGPDFPTGAHILGTAGIR
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEECHHHH
SAYMTGRGPIRMRAVAEIQELKKDRQQIIVTELPYQVNKAKLIENIAQLVREKVINGISD
HHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRDESDREGIRVVVELSRGVNPNVVLNQLYKHTQMATTFGVINLALVDGKPKELNLKQLL
HCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCHHHHH
EIYLEYRMEIIQKRTLYDLRKSEERAHILEGLRIALDNIDAVVALIKGSANADQAKQGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DNFALDEVQAKAILEMRLQRLTGLETRKILDELEALVKQIEELRKILASDELKYEIIRTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSELKDKYGDIRRTRIVHNTENVTDEDLIPEEDVVVTITNSGYIKRIPLDTYTMQRRGGR
HHHHHHHHCCHHHHEEEECCCCCCCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHCCCC
GIIGMEMKEEDFVENLFISSTHNYILFFTNRGRLYWQKVYEIPEGSRQSRGKAIVNLLEL
CEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHCCCCCCHHHHHHHHHHHHH
QEGEMVNAMISVEEFAEDKYLFMATRAGTVKKTPLSEFRNPRRAGIIAVSLDEGDELVKV
CCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEEEEEECCCHHHHHH
LLTDGKQEIMMVSKKGKAIRFSEEDVRPMGRTARGVRGMTLEGPDDEVVSLDLVDETTTL
HHHCCCCCEEEEECCCCEEEECHHHCCHHHHHHCCCCCCCCCCCCCCEEEEEEECCCEEE
LTVTDNGFGKRTEYSQYPVHRRGGKGVITIVTNLRNGFVSNVKSVAEDDELMFTSAEGII
EEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCEE
IRIPAKDISIQGRNTQGVRVMNIKSGDKVGGMARIKNGKEDEKLKLTALAKKAAKEKVPG
EEECCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SESEEDESEDLDEFEGSDEFGEEPEKEEFEDSESEDSESEDSEEEEEEEEEEEEEKEEEY
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]