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The map label for this gene is xapA [C]

Identifier: 21228481

GI number: 21228481

Start: 2836547

End: 2837323

Strand: Direct

Name: xapA [C]

Synonym: MM_2379

Alternate gene names: 21228481

Gene position: 2836547-2837323 (Clockwise)

Preceding gene: 21228480

Following gene: 21228482

Centisome position: 69.25

GC content: 45.3

Gene sequence:

>777_bases
ATGGATAAGATAGATGAGATTGCAGAAATTGCAGTTCTCGGAGGTGTGGGTTTTAACTCACACAGGGACTGCGAAAATTA
TCCTGTAAAGACTCCCTATGGGAGTGTTACTGCATATATTACCCGCATAAATGGAAAAGATATTGCAATAATTCCCAGAC
ACGCTAAAGAAGTTCATATTCCTCCTCACAGGGTCAACTACAGGGCAAATATATGGGCTGTGCGTTCCCTCGGAGTAAAA
CGTGTAATTTCCACAAATTCGGTCGGGTCAATGCGCGGGCACCCTGCAGGCAGTTTTGTCGTGCTTGACGATTTCATAGA
TTTTACCCGCAGCAGGCCTTCTACTTTTTATGATGATAATACCGTGCATGTTGATGTCGCTGAACCTTACTGCCCTGAAA
TTAAGGAAGCCCTCAAATATTCCCTGAATAAACACGGTTTTTCTTACACCGAAGGGATCTACGCCTGCACGGAAGGCCCT
CGTTTTGAAACCAGGGCTGAAATACGCATGATGAGCCAGTTCGCAGACGTTGTTGGTATGACCGGTATACCCGAGGTGGT
CCTTGCAAAAGAACTCGGCCTTTGCTACGCTTCCCTTGCCATTGTTACAAACCAGGCATGTGGGATGACAACACAAAAAT
TAACAGCAGACGAAGTGACAGAAGTTGTCGGAAAAGCTCAGGACTCGATCTCCGAAATCATCTCTGAAACAATCAGAAAT
ATTCCTGAGACAAGGAAATGCATGTGCAGATTTGCAAAGGAAGGAGCCTGCCTTTAA

Upstream 100 bases:

>100_bases
AGTGTGAGAGGAAGAAAAAGTAAAAAGATCGCATGAACCTGTGTCCCATCAGCCGGAAATTATGAATTTTCATTAAAAAC
GCAGGAACGGAGACCCAAAA

Downstream 100 bases:

>100_bases
TATTTTTGAGAATAAGTTGATATATGCACCGGCATGAAACTAACCAGAATCTGATTGAAAGTATCAGCCTGAAATCTCAA
CCTTATTCTTAACTTCCTTC

Product: 5'-methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MDKIDEIAEIAVLGGVGFNSHRDCENYPVKTPYGSVTAYITRINGKDIAIIPRHAKEVHIPPHRVNYRANIWAVRSLGVK
RVISTNSVGSMRGHPAGSFVVLDDFIDFTRSRPSTFYDDNTVHVDVAEPYCPEIKEALKYSLNKHGFSYTEGIYACTEGP
RFETRAEIRMMSQFADVVGMTGIPEVVLAKELGLCYASLAIVTNQACGMTTQKLTADEVTEVVGKAQDSISEIISETIRN
IPETRKCMCRFAKEGACL

Sequences:

>Translated_258_residues
MDKIDEIAEIAVLGGVGFNSHRDCENYPVKTPYGSVTAYITRINGKDIAIIPRHAKEVHIPPHRVNYRANIWAVRSLGVK
RVISTNSVGSMRGHPAGSFVVLDDFIDFTRSRPSTFYDDNTVHVDVAEPYCPEIKEALKYSLNKHGFSYTEGIYACTEGP
RFETRAEIRMMSQFADVVGMTGIPEVVLAKELGLCYASLAIVTNQACGMTTQKLTADEVTEVVGKAQDSISEIISETIRN
IPETRKCMCRFAKEGACL
>Mature_258_residues
MDKIDEIAEIAVLGGVGFNSHRDCENYPVKTPYGSVTAYITRINGKDIAIIPRHAKEVHIPPHRVNYRANIWAVRSLGVK
RVISTNSVGSMRGHPAGSFVVLDDFIDFTRSRPSTFYDDNTVHVDVAEPYCPEIKEALKYSLNKHGFSYTEGIYACTEGP
RFETRAEIRMMSQFADVVGMTGIPEVVLAKELGLCYASLAIVTNQACGMTTQKLTADEVTEVVGKAQDSISEIISETIRN
IPETRKCMCRFAKEGACL

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=251, Percent_Identity=35.8565737051793, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI1788746, Length=176, Percent_Identity=31.8181818181818, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71980569, Length=249, Percent_Identity=30.5220883534137, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323045, Length=267, Percent_Identity=28.4644194756554, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221459247, Length=227, Percent_Identity=33.920704845815, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI20130079, Length=272, Percent_Identity=31.9852941176471, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 28545; Mature: 28545

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIDEIAEIAVLGGVGFNSHRDCENYPVKTPYGSVTAYITRINGKDIAIIPRHAKEVHI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCEECC
PPHRVNYRANIWAVRSLGVKRVISTNSVGSMRGHPAGSFVVLDDFIDFTRSRPSTFYDDN
CCCCCCEEEEEEEEHHCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCC
TVHVDVAEPYCPEIKEALKYSLNKHGFSYTEGIYACTEGPRFETRAEIRMMSQFADVVGM
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCC
TGIPEVVLAKELGLCYASLAIVTNQACGMTTQKLTADEVTEVVGKAQDSISEIISETIRN
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
IPETRKCMCRFAKEGACL
CCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDKIDEIAEIAVLGGVGFNSHRDCENYPVKTPYGSVTAYITRINGKDIAIIPRHAKEVHI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCEECC
PPHRVNYRANIWAVRSLGVKRVISTNSVGSMRGHPAGSFVVLDDFIDFTRSRPSTFYDDN
CCCCCCEEEEEEEEHHCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCC
TVHVDVAEPYCPEIKEALKYSLNKHGFSYTEGIYACTEGPRFETRAEIRMMSQFADVVGM
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCC
TGIPEVVLAKELGLCYASLAIVTNQACGMTTQKLTADEVTEVVGKAQDSISEIISETIRN
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
IPETRKCMCRFAKEGACL
CCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]