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The map label for this gene is ycgO [H]

Identifier: 21228407

GI number: 21228407

Start: 2758132

End: 2759796

Strand: Reverse

Name: ycgO [H]

Synonym: MM_2305

Alternate gene names: 21228407

Gene position: 2759796-2758132 (Counterclockwise)

Preceding gene: 21228408

Following gene: 21228403

Centisome position: 67.37

GC content: 46.61

Gene sequence:

>1665_bases
ATGGTCTTTATGGCAATCAGTACTTCAACTCTTATCCTGTTTGTAATTATTTATCTTGCAGCCACTTTCTATGTCGCTTA
CCTGGGATACAGGAAGAACTCCCAGACAGACGGGTATATGCTTGCAGGTAGAGGAGTTCACCCTGCGATCATGGCACTCT
CGTATGGAGCTGCGTTTATCAGTACTTCCGCAATAATCGGGTTTGGAGGAGTAGCCGCTTCGTTAGGGATGGGGCTCCTG
TGGCTTGTGTTTATGAATATCTTTTTTGGAATCTTCATTGCTTTCGTAGTTTTTGGTCCCCCAACACGCCGCATGGGACT
GAACCTGGGAGCCATAACGTATCCCGAATTTATAGGAAAGCGTTTCCAGTCAAAGTTTATTCAGGCATTTTCCGGGATTT
TGATAGGCATTTTCATGCCTCTTTACGCTGCAAGCGTTATAATAGGAGCCGGAAGATTTCTTGAGACCAGTCTTGGAATC
AATTACAATATTGCCCTTATAATTTTCACCATTATAATCGCTTCTTATGTGATTAAGGGCGGTCTTCTCTCGGTAATGTA
TGTGGATGCCATGCAGGCTATTCTTATGTTGCTTGGAATGGGTTTCCTGCTTGTCTTTACTTACGTTAAGCTTGGAGGAG
TTGTTGAAGCCCACCAGGCTCTTACAAGTATGACAAACCTTGTCCCTCAAGCACTTATAGATCAGGGACACAGGGGATGG
ACTTCAATGCCTGAAGCTGGCTCCCCTATATGGTGGAACATGATTTCGACGATCATAATGGGAGTCGGAATAGGTGTTCT
TGCGCAGCCCCAGCTCGCAGTCAGGTTCATGACTGTAAAGGATGACCGTTCCCTGAAAAGAGCGGTTGCTGTTGGAGGTC
CCTTCATCCTGATGATGGCAGGAGTCGCTTACGTTGTAGGAGCTCTTTCAAATGTGTATTTCTACAGGACTACAGGCATG
ATTTCACTTCAGGTCGTGCCGGATGGAAACACCGACCTGATAATGCCCACTTTCCTGAACCATGCCATGCCTGAAATGTT
TGTAACGCTCTTCATGCTCAGCCTGCTTTCAGCTGCAATGTCCACAGCAGCCGCCCAGTTCCATACAATGGGTACAGCCA
TAGGATATGATGTCTACCAGCAGAGCATTATGAAAGGCAAGTCCACAGCGACCGTCCACGTTACAAGAATAGGGATCACC
TTTACCATCCTGATAGCGGTTGTTCTGGCATATATTCTCCCGATAAGCATTATTGCCAGGGCTACTGCCATGTTCATGGG
CCTTTGCACTTCTGCCTTCCTGCCCCTATTCATAGGAGCACTTTTCTGGAAGCGCACGACGAAAGCAGGAGCAACTGCAA
GCCTTGTAATAGGAACTTTAAGCAGCCTCTTCTGGCTGACTTTTGTACATGCAAAAGAAGCAGTACCTCTCAAGATTTGC
ATGGCAATCTTCGGCAAGGAAACACTACTTTCAGGCACCTGGACCGTCGTAGACCCAATACTGATCGCAACCCCTCTCTC
GCTCCTTGCACTGATCGCTGTAAGCCTTATGACACCCCAGTTTTCATCCGAATTCCTGAAGAAAGCTTTCAGTAGAAGGT
TTGAAGACGAAGAGGAAAAGTCAGAAGCAGCATCACAAAAGAAGGTTGAATCTACAGGCGTTTAA

Upstream 100 bases:

>100_bases
AACTCAGGATCAAAATATCGATCCCGGGCTAAACTTAACTCTCGAGTTCAGGCGATCTTTTTAATATGCCTGTGAAAAAC
AGCAGTTAATCTATTCTGGA

Downstream 100 bases:

>100_bases
ACCTGTATCTTAAGAAGCAGGCGTATTTTTATACGTCTATTCTTTTTCAATTTCATGCTATTTTAGTCTGGCTTTTATTC
TAATTTTAGTCTGGTTTTTA

Product: sodium/proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MVFMAISTSTLILFVIIYLAATFYVAYLGYRKNSQTDGYMLAGRGVHPAIMALSYGAAFISTSAIIGFGGVAASLGMGLL
WLVFMNIFFGIFIAFVVFGPPTRRMGLNLGAITYPEFIGKRFQSKFIQAFSGILIGIFMPLYAASVIIGAGRFLETSLGI
NYNIALIIFTIIIASYVIKGGLLSVMYVDAMQAILMLLGMGFLLVFTYVKLGGVVEAHQALTSMTNLVPQALIDQGHRGW
TSMPEAGSPIWWNMISTIIMGVGIGVLAQPQLAVRFMTVKDDRSLKRAVAVGGPFILMMAGVAYVVGALSNVYFYRTTGM
ISLQVVPDGNTDLIMPTFLNHAMPEMFVTLFMLSLLSAAMSTAAAQFHTMGTAIGYDVYQQSIMKGKSTATVHVTRIGIT
FTILIAVVLAYILPISIIARATAMFMGLCTSAFLPLFIGALFWKRTTKAGATASLVIGTLSSLFWLTFVHAKEAVPLKIC
MAIFGKETLLSGTWTVVDPILIATPLSLLALIAVSLMTPQFSSEFLKKAFSRRFEDEEEKSEAASQKKVESTGV

Sequences:

>Translated_554_residues
MVFMAISTSTLILFVIIYLAATFYVAYLGYRKNSQTDGYMLAGRGVHPAIMALSYGAAFISTSAIIGFGGVAASLGMGLL
WLVFMNIFFGIFIAFVVFGPPTRRMGLNLGAITYPEFIGKRFQSKFIQAFSGILIGIFMPLYAASVIIGAGRFLETSLGI
NYNIALIIFTIIIASYVIKGGLLSVMYVDAMQAILMLLGMGFLLVFTYVKLGGVVEAHQALTSMTNLVPQALIDQGHRGW
TSMPEAGSPIWWNMISTIIMGVGIGVLAQPQLAVRFMTVKDDRSLKRAVAVGGPFILMMAGVAYVVGALSNVYFYRTTGM
ISLQVVPDGNTDLIMPTFLNHAMPEMFVTLFMLSLLSAAMSTAAAQFHTMGTAIGYDVYQQSIMKGKSTATVHVTRIGIT
FTILIAVVLAYILPISIIARATAMFMGLCTSAFLPLFIGALFWKRTTKAGATASLVIGTLSSLFWLTFVHAKEAVPLKIC
MAIFGKETLLSGTWTVVDPILIATPLSLLALIAVSLMTPQFSSEFLKKAFSRRFEDEEEKSEAASQKKVESTGV
>Mature_554_residues
MVFMAISTSTLILFVIIYLAATFYVAYLGYRKNSQTDGYMLAGRGVHPAIMALSYGAAFISTSAIIGFGGVAASLGMGLL
WLVFMNIFFGIFIAFVVFGPPTRRMGLNLGAITYPEFIGKRFQSKFIQAFSGILIGIFMPLYAASVIIGAGRFLETSLGI
NYNIALIIFTIIIASYVIKGGLLSVMYVDAMQAILMLLGMGFLLVFTYVKLGGVVEAHQALTSMTNLVPQALIDQGHRGW
TSMPEAGSPIWWNMISTIIMGVGIGVLAQPQLAVRFMTVKDDRSLKRAVAVGGPFILMMAGVAYVVGALSNVYFYRTTGM
ISLQVVPDGNTDLIMPTFLNHAMPEMFVTLFMLSLLSAAMSTAAAQFHTMGTAIGYDVYQQSIMKGKSTATVHVTRIGIT
FTILIAVVLAYILPISIIARATAMFMGLCTSAFLPLFIGALFWKRTTKAGATASLVIGTLSSLFWLTFVHAKEAVPLKIC
MAIFGKETLLSGTWTVVDPILIATPLSLLALIAVSLMTPQFSSEFLKKAFSRRFEDEEEKSEAASQKKVESTGV

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=469, Percent_Identity=26.4392324093817, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI14140236, Length=562, Percent_Identity=23.6654804270463, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI110835708, Length=479, Percent_Identity=23.1732776617954, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4507031, Length=591, Percent_Identity=22.165820642978, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI206597483, Length=371, Percent_Identity=24.5283018867925, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI206597487, Length=371, Percent_Identity=24.5283018867925, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI109659836, Length=373, Percent_Identity=23.0563002680965, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787251, Length=470, Percent_Identity=25.3191489361702, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87082237, Length=457, Percent_Identity=26.0393873085339, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1790503, Length=466, Percent_Identity=22.5321888412017, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115533094, Length=459, Percent_Identity=25.0544662309368, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 59911; Mature: 59911

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCC
>Mature Secondary Structure
MVFMAISTSTLILFVIIYLAATFYVAYLGYRKNSQTDGYMLAGRGVHPAIMALSYGAAFI
CEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHH
STSAIIGFGGVAASLGMGLLWLVFMNIFFGIFIAFVVFGPPTRRMGLNLGAITYPEFIGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHH
RFQSKFIQAFSGILIGIFMPLYAASVIIGAGRFLETSLGINYNIALIIFTIIIASYVIKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
GLLSVMYVDAMQAILMLLGMGFLLVFTYVKLGGVVEAHQALTSMTNLVPQALIDQGHRGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
TSMPEAGSPIWWNMISTIIMGVGIGVLAQPQLAVRFMTVKDDRSLKRAVAVGGPFILMMA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCHHHHHHHHCCCHHHHHHH
GVAYVVGALSNVYFYRTTGMISLQVVPDGNTDLIMPTFLNHAMPEMFVTLFMLSLLSAAM
HHHHHHHHHHHEEEEEECCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
STAAAQFHTMGTAIGYDVYQQSIMKGKSTATVHVTRIGITFTILIAVVLAYILPISIIAR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ATAMFMGLCTSAFLPLFIGALFWKRTTKAGATASLVIGTLSSLFWLTFVHAKEAVPLKIC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
MAIFGKETLLSGTWTVVDPILIATPLSLLALIAVSLMTPQFSSEFLKKAFSRRFEDEEEK
HHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHH
SEAASQKKVESTGV
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]