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The map label for this gene is purE [H]

Identifier: 21228251

GI number: 21228251

Start: 2552548

End: 2553057

Strand: Direct

Name: purE [H]

Synonym: MM_2149

Alternate gene names: 21228251

Gene position: 2552548-2553057 (Clockwise)

Preceding gene: 21228250

Following gene: 21228252

Centisome position: 62.31

GC content: 48.04

Gene sequence:

>510_bases
ATGACTGATGTTGTAATAATCCTTGGCAGCAAATCCGATAAAGAAGTAGCAAGAAAGGCAACCGAAGTCTTTGACAGGTT
TGGTATTGAATATACCATCACTGTTGCATCCGCACACAGGACCCCTGCGAGGCTTGCTGAAATAATTGAAACTGCGCATA
AAACCGACGTAAAGGCATTTATTGCTATTGCCGGGCTCTCAGCCCATCTTCCAGGAGTTGTGGCTTCAAGCACTATAAAA
CCTGTAATCGGAGTCCCTGTAAACTCAGCACTTGATGGGATTGACGCCCTCCTGTCTATTGCCCAGATGCCTACGGGAAT
TCCGGTTGCCTGTGTGGGAATCGGAAGAGGGGATAATGCTGCAATTCTTGCCGTTCAGCTGCTGGCAGTGGAAAACGGGG
AGCTTGCGGAAAAGCTTTCGAATTATCGAAAAGAGCTTGTCGAGATGATTGAGAAGGACGCAGAAAGCTTGATGGATGAG
CTTGTCACTGAAGGCAGGGCAGCAAGCTGA

Upstream 100 bases:

>100_bases
TTTGGTTTTTTACTCCTTGATTGAATTCTCTTAAGGTAAAAGCTTAAATAATTTCTCATATATTACCATATATTCTCATA
CACATGATTGCGGAGTATAC

Downstream 100 bases:

>100_bases
TTCTCTCCTCAGGACAGCAAGCTGATAATCTATTACAGAGGCTGAATTGATAGGTAACAGGAAAGATCGGGAACCAAGCT
GTTTTTCTGTAACAGGGGCT

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MTDVVIILGSKSDKEVARKATEVFDRFGIEYTITVASAHRTPARLAEIIETAHKTDVKAFIAIAGLSAHLPGVVASSTIK
PVIGVPVNSALDGIDALLSIAQMPTGIPVACVGIGRGDNAAILAVQLLAVENGELAEKLSNYRKELVEMIEKDAESLMDE
LVTEGRAAS

Sequences:

>Translated_169_residues
MTDVVIILGSKSDKEVARKATEVFDRFGIEYTITVASAHRTPARLAEIIETAHKTDVKAFIAIAGLSAHLPGVVASSTIK
PVIGVPVNSALDGIDALLSIAQMPTGIPVACVGIGRGDNAAILAVQLLAVENGELAEKLSNYRKELVEMIEKDAESLMDE
LVTEGRAAS
>Mature_168_residues
TDVVIILGSKSDKEVARKATEVFDRFGIEYTITVASAHRTPARLAEIIETAHKTDVKAFIAIAGLSAHLPGVVASSTIKP
VIGVPVNSALDGIDALLSIAQMPTGIPVACVGIGRGDNAAILAVQLLAVENGELAEKLSNYRKELVEMIEKDAESLMDEL
VTEGRAAS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=144, Percent_Identity=45.8333333333333, Blast_Score=104, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=138, Percent_Identity=48.5507246376812, Blast_Score=124, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17764; Mature: 17633

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIILGSKSDKEVARKATEVFDRFGIEYTITVASAHRTPARLAEIIETAHKTDVKAF
CCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IAIAGLSAHLPGVVASSTIKPVIGVPVNSALDGIDALLSIAQMPTGIPVACVGIGRGDNA
HHHHHHHHHCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCH
AILAVQLLAVENGELAEKLSNYRKELVEMIEKDAESLMDELVTEGRAAS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDVVIILGSKSDKEVARKATEVFDRFGIEYTITVASAHRTPARLAEIIETAHKTDVKAF
CCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IAIAGLSAHLPGVVASSTIKPVIGVPVNSALDGIDALLSIAQMPTGIPVACVGIGRGDNA
HHHHHHHHHCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCH
AILAVQLLAVENGELAEKLSNYRKELVEMIEKDAESLMDELVTEGRAAS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]