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The map label for this gene is tyrS [H]

Identifier: 21228065

GI number: 21228065

Start: 2332947

End: 2333900

Strand: Reverse

Name: tyrS [H]

Synonym: MM_1963

Alternate gene names: 21228065

Gene position: 2333900-2332947 (Counterclockwise)

Preceding gene: 21228066

Following gene: 21228064

Centisome position: 56.98

GC content: 44.55

Gene sequence:

>954_bases
ATGGACAGACTTGAGCTTATAAAAAGGAATGTTCAGGAAATTGTAACAGAAGAAGAACTTGAAGGACTGCTGAATAAAAA
AGAAACTCCGCGCGCTTATGTAGGATACGAGCCAAGCGGAAAAATCCACATGGGGCATGTCCTTACCGTAAACAAGTTAA
TAGATTTGCAAAAAGCAGGGTTCAAGATCACTGTCCTGCTTGCAGATGTACACGCTTATCTGAACAGAAAAGGCACTCTG
GAAGAGGTCAGGAAGATTGCAGACTACAACAGGCGCTGCTTTATTGCTCTCGGGCTTGATGAAGAACAGACTGATTTCGT
TTACGGGTCGGATTTCCAGCTGGGAGCAGAATACATGTTAAATGTGCTCAAACTCTCAAGGGCAGTCACCCTTAACAGGG
CAAAGAGGAGCATGGACGAAGTGGGGCGTGCAATGGACGACCCTACGGTTTCCCAGATGGTTTACCCTCTCATGCAGGCT
ATTGATATTGCCCTCCTTGAAGTGGATGTGGCAGTGGGCGGGATTGACCAGAGGAAAATCCACATGCTTGCCCGTGAAAA
CCTTAAAAGCCTCGGATTTGAGACTCCGATCTGTATTCACACACCTATCCTTCTCGGGCTTGACGGGACCAAAATGGCTT
CCTCAAAGGACAATTTTATTTCGGTAGACGATACTGAAGAAGAGATTTACAGGAAGTTTAAGAAAGCTTTCTGCAAGATG
GGAGATGTGGAAGAGAATCCTATTCTTGCCCTTTTCCGTTACCATATCTTCCCGAGATATGAGACCATAGTTATTGAAAG
GCCGGAGAAATTCGGTGGCAACCTTGTATACAACAGTTATTCAGAGATGGAAAGTGGCTTTGCAGAAGAAAAAGTCCACC
CAATGGATCTTAAAAATTCGGCTGCAAAATACATAAACGAAATTCTGGACCCTGTCCGAAAAGTTCTTCTTTAA

Upstream 100 bases:

>100_bases
TTCCAAAATTCAAATCCGAAGAAGGAATTACCTTTTTAGAGAAACTTATTAATAGAAACTAAGTTTTTCAGAGTAAGAAA
AGAAAAGGAATGTAGATGCA

Downstream 100 bases:

>100_bases
ATTCAGGAAGGGAAAAGTCCCTTCCAAAAACTTTAGGAAATTCGGGGGAAAAGAATTTTTCTGGGGAAAGGGGTGCATTA
CTTAAGAATGCCTGAAGATC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MDRLELIKRNVQEIVTEEELEGLLNKKETPRAYVGYEPSGKIHMGHVLTVNKLIDLQKAGFKITVLLADVHAYLNRKGTL
EEVRKIADYNRRCFIALGLDEEQTDFVYGSDFQLGAEYMLNVLKLSRAVTLNRAKRSMDEVGRAMDDPTVSQMVYPLMQA
IDIALLEVDVAVGGIDQRKIHMLARENLKSLGFETPICIHTPILLGLDGTKMASSKDNFISVDDTEEEIYRKFKKAFCKM
GDVEENPILALFRYHIFPRYETIVIERPEKFGGNLVYNSYSEMESGFAEEKVHPMDLKNSAAKYINEILDPVRKVLL

Sequences:

>Translated_317_residues
MDRLELIKRNVQEIVTEEELEGLLNKKETPRAYVGYEPSGKIHMGHVLTVNKLIDLQKAGFKITVLLADVHAYLNRKGTL
EEVRKIADYNRRCFIALGLDEEQTDFVYGSDFQLGAEYMLNVLKLSRAVTLNRAKRSMDEVGRAMDDPTVSQMVYPLMQA
IDIALLEVDVAVGGIDQRKIHMLARENLKSLGFETPICIHTPILLGLDGTKMASSKDNFISVDDTEEEIYRKFKKAFCKM
GDVEENPILALFRYHIFPRYETIVIERPEKFGGNLVYNSYSEMESGFAEEKVHPMDLKNSAAKYINEILDPVRKVLL
>Mature_317_residues
MDRLELIKRNVQEIVTEEELEGLLNKKETPRAYVGYEPSGKIHMGHVLTVNKLIDLQKAGFKITVLLADVHAYLNRKGTL
EEVRKIADYNRRCFIALGLDEEQTDFVYGSDFQLGAEYMLNVLKLSRAVTLNRAKRSMDEVGRAMDDPTVSQMVYPLMQA
IDIALLEVDVAVGGIDQRKIHMLARENLKSLGFETPICIHTPILLGLDGTKMASSKDNFISVDDTEEEIYRKFKKAFCKM
GDVEENPILALFRYHIFPRYETIVIERPEKFGGNLVYNSYSEMESGFAEEKVHPMDLKNSAAKYINEILDPVRKVLL

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507947, Length=318, Percent_Identity=39.622641509434, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71992775, Length=316, Percent_Identity=34.1772151898734, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6321624, Length=325, Percent_Identity=39.3846153846154, Blast_Score=223, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21357223, Length=320, Percent_Identity=36.875, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 36156; Mature: 36156

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLELIKRNVQEIVTEEELEGLLNKKETPRAYVGYEPSGKIHMGHVLTVNKLIDLQKAG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEECCEEEHHHHHHHHHCC
FKITVLLADVHAYLNRKGTLEEVRKIADYNRRCFIALGLDEEQTDFVYGSDFQLGAEYML
CEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCHHHHHHHH
NVLKLSRAVTLNRAKRSMDEVGRAMDDPTVSQMVYPLMQAIDIALLEVDVAVGGIDQRKI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEHHCCCCCHHHH
HMLARENLKSLGFETPICIHTPILLGLDGTKMASSKDNFISVDDTEEEIYRKFKKAFCKM
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
GDVEENPILALFRYHIFPRYETIVIERPEKFGGNLVYNSYSEMESGFAEEKVHPMDLKNS
CCCCCCCHHHHHHHHHCCCEEEEEEECCHHHCCCEEECCHHHHHCCHHHCCCCCCCCHHH
AAKYINEILDPVRKVLL
HHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDRLELIKRNVQEIVTEEELEGLLNKKETPRAYVGYEPSGKIHMGHVLTVNKLIDLQKAG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEECCEEEHHHHHHHHHCC
FKITVLLADVHAYLNRKGTLEEVRKIADYNRRCFIALGLDEEQTDFVYGSDFQLGAEYML
CEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCHHHHHHHH
NVLKLSRAVTLNRAKRSMDEVGRAMDDPTVSQMVYPLMQAIDIALLEVDVAVGGIDQRKI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEHHCCCCCHHHH
HMLARENLKSLGFETPICIHTPILLGLDGTKMASSKDNFISVDDTEEEIYRKFKKAFCKM
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
GDVEENPILALFRYHIFPRYETIVIERPEKFGGNLVYNSYSEMESGFAEEKVHPMDLKNS
CCCCCCCHHHHHHHHHCCCEEEEEEECCHHHCCCEEECCHHHHHCCHHHCCCCCCCCHHH
AAKYINEILDPVRKVLL
HHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]