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The map label for this gene is kefC [H]

Identifier: 21228011

GI number: 21228011

Start: 2266870

End: 2268885

Strand: Direct

Name: kefC [H]

Synonym: MM_1909

Alternate gene names: 21228011

Gene position: 2266870-2268885 (Clockwise)

Preceding gene: 21228010

Following gene: 21228012

Centisome position: 55.34

GC content: 45.78

Gene sequence:

>2016_bases
ATGGATCTCTCTGTGCTGGCGCATGTCGATGTAATTCTGGGTTTTGCCATTCTTATCCTTACCATATTCTCCAAATTTGA
AGTCCCTCCTGTGCTGGGGTTTCTTGTAACCGGGGTGCTGATAGGCCCTCACGGGCTTGGGATTATGGACAGCGGGCAAA
ACATGGAAATAAATGCCGAACTGGGCGTCATTTTTCTGCTATTTACGATCGGAGTCGATCTCTCTTTAAAAGACCTCTGG
AATATGAAAAAGGCTGTACTGGTGGGAGGTGCTCTTCAGATCCTCTTTACAACAGGAATTGTGCTGGCTGTCTGCACAAA
TCTTGGTTTCAGTCATTCTGCATCCTTATTTACAGGCCTCCTGATCTCACTTAGCAGCACTGCAATAGTTCTCAAGGTCC
TTCAGGACAGAAATGAGGTTTATACTCCGCACGGAAAAACCTCGCTTGCAATTCTTATATTTCAGGACCTTGCTATCGTG
CCCCTTATCCTGATCACTCCGATACTTGCAGGAAGTTCTGTGAGTTTTGAGGGGGCTCTTCCGAACATTTTCTTCAAGGG
CTCCCTGATTATTCTGACTTTTATCCTGAGCGCCAAGTTTGTTGTCCCCGCGATATTTTACCATGTAGGTAAGACGGGCA
GCAAACAGCTTTTCTTCGTCAGCGTCGTTTTCATCTGCCTTTCAGCAGCCGTCTTCACTTACAGTATAGGGCTTTCCCTG
GCACTGGGAGCTTTTTTAGCCGGGATAGTCATCTCAGGGTCCCAGTACAGCCAGCAGGCAATAGGTAATATCATGCCTTT
AAAAGACATGTTCATGAGCTTCTTTTTCGTGTCCGTAGGAATGCTTCTGGATCTCCACTACCTGCTTGACAACCTTTCTG
TTATTATTCTTGCCACGATCAGCCTCATCATCATAAAACTGATCGCCGGAAGTCTTGTGACCTTCCTTCTTGGCTGCCCC
CTCCGCACCACTATACTTACAGGACTTGCCCTTTCTCAGGTAGGGGAATTCTCCTTTGTCCTTTCCAGGCTGGGGCTGGA
GTACTCCCTTCTTGAAGAAGAAACCTATCAGACATTTCTGGCAGTTTCAATCCTCACCATGGGAGTTACACCTTTCCTGA
TCAATGCCTCTTACAGGCCTGCAGATTTCATTGTCAAAAAGGTCTCAGATACGACTCATGGCATGAAGCTGATAAATGGC
ATTTATTCCGAGCCCCTTTATAATGAAGAGATGACCGAGCCCCAGATTAAAGACCATCTTATTATAGTGGGGTTTGGCTT
TTCCGGAAAGACGATCTCAAAGGCAGCAAAAGCCGCTGGCATCCCCTATCTTATAATTGAAATGAATCCCGAAATTGTGC
AGCATGAGAAAGCAAAAGGGGAGAAAATCCAGTATGGGGATGCAACCTTCGGAGCTGTCCTGGAACATGCAGGAATTAAA
AATGCAAGGGTCCTTGTAACAGGAATAGCTGATTCTTCCTCCACAGGGAAAATTGTAGAGAAAGCAAAAGAGCTGAATCC
CAATATCTGTGTAATTGTAAAAGTGCATGACCTGCAGGAAATGAAAAGACTCAACTCCATGGGCGCAGATGAAATCATTC
CTGAAGAATACGAAACCTCAGTGGAAATTTTTGTCCGCCTGCTTGAAAAATACCTTGTCCCCAGGGAAAATATTGAAAAA
ATGGTAAACGATTTGAGGGCTAATGGTTACAGAAGACTGAGAAAACTGGTTGTCGAGCCGGGAATTGACAGTGGGTTCAG
TATAAAGGACGGGCTTCCTGGAATTGATATTCAGGTCCTCAAGGTAGGAGAGGGTTCGAGTTTCCAGGAAAAAACCCTTT
CAGAACTGGATTTCAGAAGAAGGCATGGAGTGACGATAATATCTGTGCGCAGAGGCACGGATATGTTCCATACCCCGGCA
GGAGACTTCCTTCTTCACGCAAAAGATGCCTGCGTCCTCCTCGGAAAAACCGAAGACCTCTACAATGTCCGGAAGTTCTT
TGAAAGCATTCAGTAG

Upstream 100 bases:

>100_bases
TTCATGAACTTCACTCTGTAATGTTCTTTGAAAATTTGAGAAACTTCAATTTAGAAATCTGTAAGTATTTTTGTTTTGAT
TTCCAGAGGAGTAAAACGAA

Downstream 100 bases:

>100_bases
TGAATGAAAACTTGTTTTTCATGGAATTTACCTTTTCATGGAACTTACCTTTTCATGGATAGTGATATATCCTATCCATC
CAGATTTTTCTCCATGCGCA

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MDLSVLAHVDVILGFAILILTIFSKFEVPPVLGFLVTGVLIGPHGLGIMDSGQNMEINAELGVIFLLFTIGVDLSLKDLW
NMKKAVLVGGALQILFTTGIVLAVCTNLGFSHSASLFTGLLISLSSTAIVLKVLQDRNEVYTPHGKTSLAILIFQDLAIV
PLILITPILAGSSVSFEGALPNIFFKGSLIILTFILSAKFVVPAIFYHVGKTGSKQLFFVSVVFICLSAAVFTYSIGLSL
ALGAFLAGIVISGSQYSQQAIGNIMPLKDMFMSFFFVSVGMLLDLHYLLDNLSVIILATISLIIIKLIAGSLVTFLLGCP
LRTTILTGLALSQVGEFSFVLSRLGLEYSLLEEETYQTFLAVSILTMGVTPFLINASYRPADFIVKKVSDTTHGMKLING
IYSEPLYNEEMTEPQIKDHLIIVGFGFSGKTISKAAKAAGIPYLIIEMNPEIVQHEKAKGEKIQYGDATFGAVLEHAGIK
NARVLVTGIADSSSTGKIVEKAKELNPNICVIVKVHDLQEMKRLNSMGADEIIPEEYETSVEIFVRLLEKYLVPRENIEK
MVNDLRANGYRRLRKLVVEPGIDSGFSIKDGLPGIDIQVLKVGEGSSFQEKTLSELDFRRRHGVTIISVRRGTDMFHTPA
GDFLLHAKDACVLLGKTEDLYNVRKFFESIQ

Sequences:

>Translated_671_residues
MDLSVLAHVDVILGFAILILTIFSKFEVPPVLGFLVTGVLIGPHGLGIMDSGQNMEINAELGVIFLLFTIGVDLSLKDLW
NMKKAVLVGGALQILFTTGIVLAVCTNLGFSHSASLFTGLLISLSSTAIVLKVLQDRNEVYTPHGKTSLAILIFQDLAIV
PLILITPILAGSSVSFEGALPNIFFKGSLIILTFILSAKFVVPAIFYHVGKTGSKQLFFVSVVFICLSAAVFTYSIGLSL
ALGAFLAGIVISGSQYSQQAIGNIMPLKDMFMSFFFVSVGMLLDLHYLLDNLSVIILATISLIIIKLIAGSLVTFLLGCP
LRTTILTGLALSQVGEFSFVLSRLGLEYSLLEEETYQTFLAVSILTMGVTPFLINASYRPADFIVKKVSDTTHGMKLING
IYSEPLYNEEMTEPQIKDHLIIVGFGFSGKTISKAAKAAGIPYLIIEMNPEIVQHEKAKGEKIQYGDATFGAVLEHAGIK
NARVLVTGIADSSSTGKIVEKAKELNPNICVIVKVHDLQEMKRLNSMGADEIIPEEYETSVEIFVRLLEKYLVPRENIEK
MVNDLRANGYRRLRKLVVEPGIDSGFSIKDGLPGIDIQVLKVGEGSSFQEKTLSELDFRRRHGVTIISVRRGTDMFHTPA
GDFLLHAKDACVLLGKTEDLYNVRKFFESIQ
>Mature_671_residues
MDLSVLAHVDVILGFAILILTIFSKFEVPPVLGFLVTGVLIGPHGLGIMDSGQNMEINAELGVIFLLFTIGVDLSLKDLW
NMKKAVLVGGALQILFTTGIVLAVCTNLGFSHSASLFTGLLISLSSTAIVLKVLQDRNEVYTPHGKTSLAILIFQDLAIV
PLILITPILAGSSVSFEGALPNIFFKGSLIILTFILSAKFVVPAIFYHVGKTGSKQLFFVSVVFICLSAAVFTYSIGLSL
ALGAFLAGIVISGSQYSQQAIGNIMPLKDMFMSFFFVSVGMLLDLHYLLDNLSVIILATISLIIIKLIAGSLVTFLLGCP
LRTTILTGLALSQVGEFSFVLSRLGLEYSLLEEETYQTFLAVSILTMGVTPFLINASYRPADFIVKKVSDTTHGMKLING
IYSEPLYNEEMTEPQIKDHLIIVGFGFSGKTISKAAKAAGIPYLIIEMNPEIVQHEKAKGEKIQYGDATFGAVLEHAGIK
NARVLVTGIADSSSTGKIVEKAKELNPNICVIVKVHDLQEMKRLNSMGADEIIPEEYETSVEIFVRLLEKYLVPRENIEK
MVNDLRANGYRRLRKLVVEPGIDSGFSIKDGLPGIDIQVLKVGEGSSFQEKTLSELDFRRRHGVTIISVRRGTDMFHTPA
GDFLLHAKDACVLLGKTEDLYNVRKFFESIQ

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=373, Percent_Identity=26.8096514745308, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1786232, Length=583, Percent_Identity=29.5025728987993, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1786685, Length=535, Percent_Identity=29.9065420560748, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1789749, Length=569, Percent_Identity=26.5377855887522, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6322367, Length=432, Percent_Identity=22.9166666666667, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 73227; Mature: 73227

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSVLAHVDVILGFAILILTIFSKFEVPPVLGFLVTGVLIGPHGLGIMDSGQNMEINAE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEECH
LGVIFLLFTIGVDLSLKDLWNMKKAVLVGGALQILFTTGIVLAVCTNLGFSHSASLFTGL
HHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LISLSSTAIVLKVLQDRNEVYTPHGKTSLAILIFQDLAIVPLILITPILAGSSVSFEGAL
HHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEECCCC
PNIFFKGSLIILTFILSAKFVVPAIFYHVGKTGSKQLFFVSVVFICLSAAVFTYSIGLSL
CCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAFLAGIVISGSQYSQQAIGNIMPLKDMFMSFFFVSVGMLLDLHYLLDNLSVIILATI
HHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIIIKLIAGSLVTFLLGCPLRTTILTGLALSQVGEFSFVLSRLGLEYSLLEEETYQTFL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AVSILTMGVTPFLINASYRPADFIVKKVSDTTHGMKLINGIYSEPLYNEEMTEPQIKDHL
HHHHHHHCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
IIVGFGFSGKTISKAAKAAGIPYLIIEMNPEIVQHEKAKGEKIQYGDATFGAVLEHAGIK
EEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEECCCHHHHHHHHCCCC
NARVLVTGIADSSSTGKIVEKAKELNPNICVIVKVHDLQEMKRLNSMGADEIIPEEYETS
CCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCHHHHH
VEIFVRLLEKYLVPRENIEKMVNDLRANGYRRLRKLVVEPGIDSGFSIKDGLPGIDIQVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
KVGEGSSFQEKTLSELDFRRRHGVTIISVRRGTDMFHTPAGDFLLHAKDACVLLGKTEDL
EECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCEEEEEECCHHH
YNVRKFFESIQ
HHHHHHHHHCC
>Mature Secondary Structure
MDLSVLAHVDVILGFAILILTIFSKFEVPPVLGFLVTGVLIGPHGLGIMDSGQNMEINAE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEECH
LGVIFLLFTIGVDLSLKDLWNMKKAVLVGGALQILFTTGIVLAVCTNLGFSHSASLFTGL
HHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LISLSSTAIVLKVLQDRNEVYTPHGKTSLAILIFQDLAIVPLILITPILAGSSVSFEGAL
HHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEECCCC
PNIFFKGSLIILTFILSAKFVVPAIFYHVGKTGSKQLFFVSVVFICLSAAVFTYSIGLSL
CCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAFLAGIVISGSQYSQQAIGNIMPLKDMFMSFFFVSVGMLLDLHYLLDNLSVIILATI
HHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIIIKLIAGSLVTFLLGCPLRTTILTGLALSQVGEFSFVLSRLGLEYSLLEEETYQTFL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AVSILTMGVTPFLINASYRPADFIVKKVSDTTHGMKLINGIYSEPLYNEEMTEPQIKDHL
HHHHHHHCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
IIVGFGFSGKTISKAAKAAGIPYLIIEMNPEIVQHEKAKGEKIQYGDATFGAVLEHAGIK
EEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEECCCHHHHHHHHCCCC
NARVLVTGIADSSSTGKIVEKAKELNPNICVIVKVHDLQEMKRLNSMGADEIIPEEYETS
CCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCCCCCCHHHHH
VEIFVRLLEKYLVPRENIEKMVNDLRANGYRRLRKLVVEPGIDSGFSIKDGLPGIDIQVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
KVGEGSSFQEKTLSELDFRRRHGVTIISVRRGTDMFHTPAGDFLLHAKDACVLLGKTEDL
EECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCEEEEEECCHHH
YNVRKFFESIQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA