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The map label for this gene is MCM [H]

Identifier: 21227938

GI number: 21227938

Start: 2186497

End: 2188602

Strand: Reverse

Name: MCM [H]

Synonym: MM_1836

Alternate gene names: 21227938

Gene position: 2188602-2186497 (Counterclockwise)

Preceding gene: 21227939

Following gene: 21227937

Centisome position: 53.43

GC content: 47.25

Gene sequence:

>2106_bases
ATGACTGAAACAGAAAGCAAATGGGACGAGAAATTAAAGAGATTCTTTAAAGATTATTACTGGAATGAAATCCTTCAGCT
GGCAAACGAATACCCGGACCAGCGTAGCCTTGCAGTTGATTTCACGGATATAGAAAAATTTGACAGGGATCTTTCAAGGG
AATTTCTTGAGCATCCCGGAGAACTTATATCCGCAGCTGAAGCCGCTCTGAAAGAAATTGACCTGCCTGTAGAAAAGAAC
CTTGAGCAGGCCCATGTAAGGGTCATAAAAATTCCTAACAGGATTCCTATCAGGGAACTGAGAAGCAAACACCTCACACG
TTTTGTTGCTATCGAGGGCATGATAAGAAAGGCAACAGAGGTCAGGCCAAGGATCACAAAAGCTGCCTTCCAGTGTTTAA
GATGTGGGCACCTGACCATAGTGGAGCAGAACAGTTTCAAGTTCGAAGAGCCTTTTGCAGGATGTGAAGAGGAGACCTGC
GGGAAGAAAGGGCCATTCAAGGTTTCAATTGAAGATTCAACTTTTATCGATGCCCAGAAACTACAGATCCAGGAGTCCCC
GGAAAACCTGAAAGGAGGGTCGCAACCCCAGAGCCTGGAAGTGGACTCTGAAGATGACCTTACGGGGAATGTTACTCCGG
GGGACCGTGTTATAATCAACGGAGTCCTGAAGTCAAGGCAGCGCACCCTCAAGGACGGGAAATCCACTTTCTACGACCTT
ATACTGGAAGCGAATTCCATCGAGCGCCTGGACAAAGATTATGATGAGCTTGAAATATCTGCCGAAGAAGAGGAACAGAT
CCTTGAGCTTTCCCGTGACCCGGCAATTTATGAAAAAATCATAAGCTCCATTGCGCCCTCTATTTACGGATACGAGGATA
TCAAAGAAGCCCTTGCACTCCAGTTATTTTCAGGGGTTGTGAAGAACCTTCCTGACGGCTCGAGGACGAGGGGCGATATC
CACATGATGCTTGTAGGTGACCCCGGAATTGCAAAAAGCCAGCTTCTCCGTTATGTTGTCAAACTATCTCCAAGAGGCGT
CTTTGCTTCAGGGAGGAGCGCGTCTGCGAGCGGTTTGACTGCGGCTGCCGTAAAAGACGACATGAACGACGGCAGGTGGA
CGATAGAAGGCGGAGCACTTGTCATGGCTGATATGGGAGTTGCTGCAGTTGACGAAATGGACAAGATGAGGACAGAGGAC
AAGAGTGCCCTCCACGAGGCAATGGAACAGCAGACCATAAGCATAGCCAAAGCAGGGATTATTGCAACTTTAAAGTCCAG
GTGTGCCCTTCTTGGAGCTGCAAATCCGAAATACGGCCGCTTTGACCGGTATGAAGGGCTTGCAGATCAAATAAATATGC
CTCCGGCTCTGCTTTCTCGTTTCGACCTGATCTTCGTTTTGCTCGATACCCCAAACCATTCCCTGGACAGCAGGATAGCA
AACCACATTCTGCAGTCGCATTATGCGGGAGAACTCTCCGAGCAAAGGCAAAAACTTCCAGGGTCTACAATTTCTGAAGA
ATTTGTTGATGCTGAAATGGAAATAATTGAGCCTGTTATTGCACCGGAATTTATGCGGAAGTATATCGCATTTGCACGAA
AAAATGTTTATCCGGTAATGGAAGAAGATACAAGACATCACCTTATTAACTTTTATACGGACCTCAGGAGAAGCGGAGAA
GGCAAGAATACGCCCGTGCCCGTAACAGCCAGGCAGCTCGAAGCGCTGGTTCGCCTCTCCGAAGCCAGTGCACGTGTCCG
CCTCAGTAATATAGTCACCCTTGAGGACGCAAAACGGACCATCAGAATAGTAATGAACTGCCTTAAAAACGTAGGAGTCG
ATCCAGAAACAGGAGCTCTTGACGCAGACATACTTGCTTCGGGTACAAGCATGAGCCAGAGGAATAAAATAAAACTCCTC
AAAGACATAATAAAAAAAGTCAGTGATAGACACCCGGGTTCCAAAGCTCCTCTTGAAGAGGTCTATGCAGAGGCTGAAAG
CGAGCACGGCATAGATAGAGGACATGCAGAGGAATACATAAAGAAGATGAAACAGAGAGGCGACATTCTTTCTCCGGACC
AGACCCATATCAGGCTCATTAATTAA

Upstream 100 bases:

>100_bases
TATATCTTATACGTTTTTTTACTTTTTTAAAATCGTTTTCATGTAAAAACAACCTGATCGAAGATAGAAATTTTCATAAA
AGCCAACTTTTGAGAATGTT

Downstream 100 bases:

>100_bases
GTCAAAAAACAGCGGATTCTCGCAACTGAAACTGTTACTGTACACCAGGAAGCTCCCGAAGGAAAAAACAGTGTACCCGC
AAACAAAATAATGATGGTTA

Product: cell division control protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 701; Mature: 700

Protein sequence:

>701_residues
MTETESKWDEKLKRFFKDYYWNEILQLANEYPDQRSLAVDFTDIEKFDRDLSREFLEHPGELISAAEAALKEIDLPVEKN
LEQAHVRVIKIPNRIPIRELRSKHLTRFVAIEGMIRKATEVRPRITKAAFQCLRCGHLTIVEQNSFKFEEPFAGCEEETC
GKKGPFKVSIEDSTFIDAQKLQIQESPENLKGGSQPQSLEVDSEDDLTGNVTPGDRVIINGVLKSRQRTLKDGKSTFYDL
ILEANSIERLDKDYDELEISAEEEEQILELSRDPAIYEKIISSIAPSIYGYEDIKEALALQLFSGVVKNLPDGSRTRGDI
HMMLVGDPGIAKSQLLRYVVKLSPRGVFASGRSASASGLTAAAVKDDMNDGRWTIEGGALVMADMGVAAVDEMDKMRTED
KSALHEAMEQQTISIAKAGIIATLKSRCALLGAANPKYGRFDRYEGLADQINMPPALLSRFDLIFVLLDTPNHSLDSRIA
NHILQSHYAGELSEQRQKLPGSTISEEFVDAEMEIIEPVIAPEFMRKYIAFARKNVYPVMEEDTRHHLINFYTDLRRSGE
GKNTPVPVTARQLEALVRLSEASARVRLSNIVTLEDAKRTIRIVMNCLKNVGVDPETGALDADILASGTSMSQRNKIKLL
KDIIKKVSDRHPGSKAPLEEVYAEAESEHGIDRGHAEEYIKKMKQRGDILSPDQTHIRLIN

Sequences:

>Translated_701_residues
MTETESKWDEKLKRFFKDYYWNEILQLANEYPDQRSLAVDFTDIEKFDRDLSREFLEHPGELISAAEAALKEIDLPVEKN
LEQAHVRVIKIPNRIPIRELRSKHLTRFVAIEGMIRKATEVRPRITKAAFQCLRCGHLTIVEQNSFKFEEPFAGCEEETC
GKKGPFKVSIEDSTFIDAQKLQIQESPENLKGGSQPQSLEVDSEDDLTGNVTPGDRVIINGVLKSRQRTLKDGKSTFYDL
ILEANSIERLDKDYDELEISAEEEEQILELSRDPAIYEKIISSIAPSIYGYEDIKEALALQLFSGVVKNLPDGSRTRGDI
HMMLVGDPGIAKSQLLRYVVKLSPRGVFASGRSASASGLTAAAVKDDMNDGRWTIEGGALVMADMGVAAVDEMDKMRTED
KSALHEAMEQQTISIAKAGIIATLKSRCALLGAANPKYGRFDRYEGLADQINMPPALLSRFDLIFVLLDTPNHSLDSRIA
NHILQSHYAGELSEQRQKLPGSTISEEFVDAEMEIIEPVIAPEFMRKYIAFARKNVYPVMEEDTRHHLINFYTDLRRSGE
GKNTPVPVTARQLEALVRLSEASARVRLSNIVTLEDAKRTIRIVMNCLKNVGVDPETGALDADILASGTSMSQRNKIKLL
KDIIKKVSDRHPGSKAPLEEVYAEAESEHGIDRGHAEEYIKKMKQRGDILSPDQTHIRLIN
>Mature_700_residues
TETESKWDEKLKRFFKDYYWNEILQLANEYPDQRSLAVDFTDIEKFDRDLSREFLEHPGELISAAEAALKEIDLPVEKNL
EQAHVRVIKIPNRIPIRELRSKHLTRFVAIEGMIRKATEVRPRITKAAFQCLRCGHLTIVEQNSFKFEEPFAGCEEETCG
KKGPFKVSIEDSTFIDAQKLQIQESPENLKGGSQPQSLEVDSEDDLTGNVTPGDRVIINGVLKSRQRTLKDGKSTFYDLI
LEANSIERLDKDYDELEISAEEEEQILELSRDPAIYEKIISSIAPSIYGYEDIKEALALQLFSGVVKNLPDGSRTRGDIH
MMLVGDPGIAKSQLLRYVVKLSPRGVFASGRSASASGLTAAAVKDDMNDGRWTIEGGALVMADMGVAAVDEMDKMRTEDK
SALHEAMEQQTISIAKAGIIATLKSRCALLGAANPKYGRFDRYEGLADQINMPPALLSRFDLIFVLLDTPNHSLDSRIAN
HILQSHYAGELSEQRQKLPGSTISEEFVDAEMEIIEPVIAPEFMRKYIAFARKNVYPVMEEDTRHHLINFYTDLRRSGEG
KNTPVPVTARQLEALVRLSEASARVRLSNIVTLEDAKRTIRIVMNCLKNVGVDPETGALDADILASGTSMSQRNKIKLLK
DIIKKVSDRHPGSKAPLEEVYAEAESEHGIDRGHAEEYIKKMKQRGDILSPDQTHIRLIN

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein) [H]

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain [H]

Homologues:

Organism=Homo sapiens, GI33469919, Length=630, Percent_Identity=35.7142857142857, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI33469917, Length=630, Percent_Identity=35.7142857142857, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI33356547, Length=580, Percent_Identity=33.9655172413793, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI23510448, Length=628, Percent_Identity=33.2802547770701, Blast_Score=324, Evalue=2e-88,
Organism=Homo sapiens, GI33469968, Length=660, Percent_Identity=33.6363636363636, Blast_Score=322, Evalue=8e-88,
Organism=Homo sapiens, GI7427519, Length=660, Percent_Identity=32.7272727272727, Blast_Score=316, Evalue=5e-86,
Organism=Homo sapiens, GI19923727, Length=675, Percent_Identity=30.962962962963, Blast_Score=302, Evalue=7e-82,
Organism=Homo sapiens, GI6631095, Length=630, Percent_Identity=32.8571428571429, Blast_Score=299, Evalue=6e-81,
Organism=Homo sapiens, GI33469922, Length=488, Percent_Identity=38.5245901639344, Blast_Score=298, Evalue=2e-80,
Organism=Homo sapiens, GI33469924, Length=661, Percent_Identity=31.3161875945537, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI310128402, Length=277, Percent_Identity=35.7400722021661, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI310119838, Length=277, Percent_Identity=35.7400722021661, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI310115110, Length=277, Percent_Identity=35.7400722021661, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI23397546, Length=394, Percent_Identity=24.8730964467005, Blast_Score=136, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17554306, Length=612, Percent_Identity=35.7843137254902, Blast_Score=357, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI71997752, Length=589, Percent_Identity=33.276740237691, Blast_Score=353, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17508417, Length=642, Percent_Identity=32.8660436137072, Blast_Score=351, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17562700, Length=551, Percent_Identity=36.2976406533575, Blast_Score=309, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI17562702, Length=512, Percent_Identity=33.984375, Blast_Score=298, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71997563, Length=629, Percent_Identity=31.7965023847377, Blast_Score=288, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI71997571, Length=357, Percent_Identity=40.0560224089636, Blast_Score=230, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6325276, Length=638, Percent_Identity=33.5423197492163, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319448, Length=558, Percent_Identity=37.4551971326165, Blast_Score=356, Evalue=7e-99,
Organism=Saccharomyces cerevisiae, GI6323304, Length=696, Percent_Identity=32.4712643678161, Blast_Score=329, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6319679, Length=540, Percent_Identity=35.9259259259259, Blast_Score=311, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6320803, Length=712, Percent_Identity=31.7415730337079, Blast_Score=302, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6321237, Length=357, Percent_Identity=40.8963585434174, Blast_Score=274, Evalue=4e-74,
Organism=Drosophila melanogaster, GI17137242, Length=683, Percent_Identity=32.6500732064422, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI17137132, Length=614, Percent_Identity=31.5960912052117, Blast_Score=332, Evalue=8e-91,
Organism=Drosophila melanogaster, GI17530827, Length=626, Percent_Identity=33.5463258785943, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24645774, Length=646, Percent_Identity=33.9009287925697, Blast_Score=328, Evalue=9e-90,
Organism=Drosophila melanogaster, GI24639835, Length=537, Percent_Identity=37.8026070763501, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI17647617, Length=552, Percent_Identity=34.963768115942, Blast_Score=304, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24647251, Length=575, Percent_Identity=24.5217391304348, Blast_Score=166, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF00493 MCM [H]

EC number: NA

Molecular weight: Translated: 78714; Mature: 78582

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50051 MCM_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETESKWDEKLKRFFKDYYWNEILQLANEYPDQRSLAVDFTDIEKFDRDLSREFLEHPG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCHH
ELISAAEAALKEIDLPVEKNLEQAHVRVIKIPNRIPIRELRSKHLTRFVAIEGMIRKATE
HHHHHHHHHHHHCCCCHHCCHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VRPRITKAAFQCLRCGHLTIVEQNSFKFEEPFAGCEEETCGKKGPFKVSIEDSTFIDAQK
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEECHHH
LQIQESPENLKGGSQPQSLEVDSEDDLTGNVTPGDRVIINGVLKSRQRTLKDGKSTFYDL
HEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ILEANSIERLDKDYDELEISAEEEEQILELSRDPAIYEKIISSIAPSIYGYEDIKEALAL
HHCCHHHHHHHCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHCCHHHHHHHHHH
QLFSGVVKNLPDGSRTRGDIHMMLVGDPGIAKSQLLRYVVKLSPRGVFASGRSASASGLT
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCC
AAAVKDDMNDGRWTIEGGALVMADMGVAAVDEMDKMRTEDKSALHEAMEQQTISIAKAGI
HHHHHCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATLKSRCALLGAANPKYGRFDRYEGLADQINMPPALLSRFDLIFVLLDTPNHSLDSRIA
HHHHHHHHHHHCCCCCCCCCCHHHCCCHHHCCCCHHHHHHHCEEEEEECCCCCCHHHHHH
NHILQSHYAGELSEQRQKLPGSTISEEFVDAEMEIIEPVIAPEFMRKYIAFARKNVYPVM
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCC
EEDTRHHLINFYTDLRRSGEGKNTPVPVTARQLEALVRLSEASARVRLSNIVTLEDAKRT
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEHHHEEEHHHHHHH
IRIVMNCLKNVGVDPETGALDADILASGTSMSQRNKIKLLKDIIKKVSDRHPGSKAPLEE
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
VYAEAESEHGIDRGHAEEYIKKMKQRGDILSPDQTHIRLIN
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEC
>Mature Secondary Structure 
TETESKWDEKLKRFFKDYYWNEILQLANEYPDQRSLAVDFTDIEKFDRDLSREFLEHPG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCHH
ELISAAEAALKEIDLPVEKNLEQAHVRVIKIPNRIPIRELRSKHLTRFVAIEGMIRKATE
HHHHHHHHHHHHCCCCHHCCHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VRPRITKAAFQCLRCGHLTIVEQNSFKFEEPFAGCEEETCGKKGPFKVSIEDSTFIDAQK
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEEECCCCEECHHH
LQIQESPENLKGGSQPQSLEVDSEDDLTGNVTPGDRVIINGVLKSRQRTLKDGKSTFYDL
HEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ILEANSIERLDKDYDELEISAEEEEQILELSRDPAIYEKIISSIAPSIYGYEDIKEALAL
HHCCHHHHHHHCCHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHCCHHHHHHHHHH
QLFSGVVKNLPDGSRTRGDIHMMLVGDPGIAKSQLLRYVVKLSPRGVFASGRSASASGLT
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCC
AAAVKDDMNDGRWTIEGGALVMADMGVAAVDEMDKMRTEDKSALHEAMEQQTISIAKAGI
HHHHHCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATLKSRCALLGAANPKYGRFDRYEGLADQINMPPALLSRFDLIFVLLDTPNHSLDSRIA
HHHHHHHHHHHCCCCCCCCCCHHHCCCHHHCCCCHHHHHHHCEEEEEECCCCCCHHHHHH
NHILQSHYAGELSEQRQKLPGSTISEEFVDAEMEIIEPVIAPEFMRKYIAFARKNVYPVM
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCC
EEDTRHHLINFYTDLRRSGEGKNTPVPVTARQLEALVRLSEASARVRLSNIVTLEDAKRT
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEHHHEEEHHHHHHH
IRIVMNCLKNVGVDPETGALDADILASGTSMSQRNKIKLLKDIIKKVSDRHPGSKAPLEE
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
VYAEAESEHGIDRGHAEEYIKKMKQRGDILSPDQTHIRLIN
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]