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The map label for this gene is 21227868

Identifier: 21227868

GI number: 21227868

Start: 2106303

End: 2107646

Strand: Direct

Name: 21227868

Synonym: MM_1766

Alternate gene names: NA

Gene position: 2106303-2107646 (Clockwise)

Preceding gene: 21227867

Following gene: 21227869

Centisome position: 51.42

GC content: 49.78

Gene sequence:

>1344_bases
ATGACTGAAATAGGTATTGTTGCAGTCGGCGGCTATAATGAAATGGGCCGCAATATGACTGCCATAATTATAGGTGAAGA
TATTGTCATTCTTGATATGGGGCTCAGGCTCGACAGGGTCCAGATCCATGAGGACGTTGAGATTGACAAAATGCATTCTC
TTGAACTGATCGAGATGGGTGCAATTCCTGATGATACTATCATGAAAGAAATCAACGGGACTGTGAGGGCGATCGTCTGT
ACTCACGGGCACCTTGACCATATAGGTGCGATTCCGAAGCTTGCCCACAGGTATAACGCCCCTATACTTGCTACCCCCTA
TACTGCAGCTATTATCAGGCAGCAGATAGAGTCCGAGCGTAAGTTTGAGGTTTGCAACAGGGTTATCCCTCTGCAGGCAG
GCGGGACCTACCAGGTTACGGAAGATATTTCCATAGAGTTCATCAGGGTCCAGCACAGCATCATCGACTGTGTACTTGCA
GCCGTACACACTCCGGCAGGTGCTGTCCTGTATGCCTGTGACTTCAAGCTGGACAGGACTCCGACAATGGGAGAAGCTCC
TGACTTTGACCGCTTCAAATCCCTCGGGAAGGAAGGGGTTATTGCAATGATCACGGAGAGCACTAATGCCGGGCGCTCAG
GCAAGACTCCCTCGGAACAGATAGCAAAAGACATGGTAAGGGATGTCCTGCTCGGAACTGAGGAATCAGGTGTCGGGATG
ATTGTTACAACTTTTGCTTCCCATATTGCCAGGCTTAAAGCGATTATCGAGGCTGCCGAAGAGATGGGCAGAATTCCTGT
GCTTATGGGCCGCTCCATGGAACGCTATGTGGGTGCTGCCAGGGACATCGGTTATCTTGATCTTCCCTCGAATGTTGAGA
TTTACGGTACAAGAAAAGATGTCGACAGGGCATTTAAGCGCATCATGCAGGAAGGCAAAAACAAATACCTGCCTATCGTC
ACAGGACACCAGGGAGAGCCGGGTTCCATTCTTGTGAGGGTCGCAAACGGGGAAACTCCGTATACTATTGACCCCGGGGA
CAGGATTATTTTCTCTGCAAATGTAATCCCGAGCCCGATGACTCAGGCTAACCGCTACGCCCTTGAGACCAAACTCAGGA
TGAAGGGCGGGAGGATCTATGATGATGTCCATGTATCAGGCCACGCTTATAGGGAAGACCACTGGGAGCTTCTTCGCATG
GTGAATCCCGAACATGTGATTCCTGCTCATGGAGACATGGAGATGCATGGGCATTACATCGAAATGGCAGAAGATGCGGG
GTATGTACTCGGAGATACCGTACACCTTCTCAGAAATGGCGAAGTGTTATATATAGAGGAGTAA

Upstream 100 bases:

>100_bases
ACATTCATGCTCATTGGTATAAGACCGTCACCGAATCTGTTTTTGAGGTTTCGGTTTTTACAAGGATAAGATATTCAAAT
TAAATAAGAGGTTAAAAAAT

Downstream 100 bases:

>100_bases
CTCTATAATGAAAATCCCGTGTTCTTGTGATGCTTATGACGCTTGTTGATGAAATTAAAAATCGAAGTTCCCATGTTGAT
GCTGCAATCGACGAATTGCT

Product: Zn-dependent hydrolase

Products: NA

Alternate protein names: RNase J [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTEIGIVAVGGYNEMGRNMTAIIIGEDIVILDMGLRLDRVQIHEDVEIDKMHSLELIEMGAIPDDTIMKEINGTVRAIVC
THGHLDHIGAIPKLAHRYNAPILATPYTAAIIRQQIESERKFEVCNRVIPLQAGGTYQVTEDISIEFIRVQHSIIDCVLA
AVHTPAGAVLYACDFKLDRTPTMGEAPDFDRFKSLGKEGVIAMITESTNAGRSGKTPSEQIAKDMVRDVLLGTEESGVGM
IVTTFASHIARLKAIIEAAEEMGRIPVLMGRSMERYVGAARDIGYLDLPSNVEIYGTRKDVDRAFKRIMQEGKNKYLPIV
TGHQGEPGSILVRVANGETPYTIDPGDRIIFSANVIPSPMTQANRYALETKLRMKGGRIYDDVHVSGHAYREDHWELLRM
VNPEHVIPAHGDMEMHGHYIEMAEDAGYVLGDTVHLLRNGEVLYIEE

Sequences:

>Translated_447_residues
MTEIGIVAVGGYNEMGRNMTAIIIGEDIVILDMGLRLDRVQIHEDVEIDKMHSLELIEMGAIPDDTIMKEINGTVRAIVC
THGHLDHIGAIPKLAHRYNAPILATPYTAAIIRQQIESERKFEVCNRVIPLQAGGTYQVTEDISIEFIRVQHSIIDCVLA
AVHTPAGAVLYACDFKLDRTPTMGEAPDFDRFKSLGKEGVIAMITESTNAGRSGKTPSEQIAKDMVRDVLLGTEESGVGM
IVTTFASHIARLKAIIEAAEEMGRIPVLMGRSMERYVGAARDIGYLDLPSNVEIYGTRKDVDRAFKRIMQEGKNKYLPIV
TGHQGEPGSILVRVANGETPYTIDPGDRIIFSANVIPSPMTQANRYALETKLRMKGGRIYDDVHVSGHAYREDHWELLRM
VNPEHVIPAHGDMEMHGHYIEMAEDAGYVLGDTVHLLRNGEVLYIEE
>Mature_446_residues
TEIGIVAVGGYNEMGRNMTAIIIGEDIVILDMGLRLDRVQIHEDVEIDKMHSLELIEMGAIPDDTIMKEINGTVRAIVCT
HGHLDHIGAIPKLAHRYNAPILATPYTAAIIRQQIESERKFEVCNRVIPLQAGGTYQVTEDISIEFIRVQHSIIDCVLAA
VHTPAGAVLYACDFKLDRTPTMGEAPDFDRFKSLGKEGVIAMITESTNAGRSGKTPSEQIAKDMVRDVLLGTEESGVGMI
VTTFASHIARLKAIIEAAEEMGRIPVLMGRSMERYVGAARDIGYLDLPSNVEIYGTRKDVDRAFKRIMQEGKNKYLPIVT
GHQGEPGSILVRVANGETPYTIDPGDRIIFSANVIPSPMTQANRYALETKLRMKGGRIYDDVHVSGHAYREDHWELLRMV
NPEHVIPAHGDMEMHGHYIEMAEDAGYVLGDTVHLLRNGEVLYIEE

Specific function: Unknown

COG id: COG0595

COG function: function code R; Predicted hydrolase of the metallo-beta-lactamase superfamily

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. RNase J subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR011108
- InterPro:   IPR004613
- InterPro:   IPR001587 [H]

Pfam domain/function: PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49552; Mature: 49421

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01292 UPF0036

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIGIVAVGGYNEMGRNMTAIIIGEDIVILDMGLRLDRVQIHEDVEIDKMHSLELIEMG
CCCEEEEEECCCHHHCCCEEEEEEECCEEEEECCCEECEEEECCCCCCCHHCCEEEEEEC
AIPDDTIMKEINGTVRAIVCTHGHLDHIGAIPKLAHRYNAPILATPYTAAIIRQQIESER
CCCCHHHHHHCCCCEEEEEEECCCHHHHCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHH
KFEVCNRVIPLQAGGTYQVTEDISIEFIRVQHSIIDCVLAAVHTPAGAVLYACDFKLDRT
HHHHHCCEEEEECCCCEEEECCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEEEEEECCC
PTMGEAPDFDRFKSLGKEGVIAMITESTNAGRSGKTPSEQIAKDMVRDVLLGTEESGVGM
CCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE
IVTTFASHIARLKAIIEAAEEMGRIPVLMGRSMERYVGAARDIGYLDLPSNVEIYGTRKD
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEECCCCEEEEECHHH
VDRAFKRIMQEGKNKYLPIVTGHQGEPGSILVRVANGETPYTIDPGDRIIFSANVIPSPM
HHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCEEECCCCEEEEECCCCCCCC
TQANRYALETKLRMKGGRIYDDVHVSGHAYREDHWELLRMVNPEHVIPAHGDMEMHGHYI
HHHHHEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHCCCCEECCCCCCCEECCEEE
EMAEDAGYVLGDTVHLLRNGEVLYIEE
EEECCCCEECCCEEEEEECCCEEEEEC
>Mature Secondary Structure 
TEIGIVAVGGYNEMGRNMTAIIIGEDIVILDMGLRLDRVQIHEDVEIDKMHSLELIEMG
CCEEEEEECCCHHHCCCEEEEEEECCEEEEECCCEECEEEECCCCCCCHHCCEEEEEEC
AIPDDTIMKEINGTVRAIVCTHGHLDHIGAIPKLAHRYNAPILATPYTAAIIRQQIESER
CCCCHHHHHHCCCCEEEEEEECCCHHHHCCHHHHHHHCCCCEEECCHHHHHHHHHHHHHH
KFEVCNRVIPLQAGGTYQVTEDISIEFIRVQHSIIDCVLAAVHTPAGAVLYACDFKLDRT
HHHHHCCEEEEECCCCEEEECCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEEEEEECCC
PTMGEAPDFDRFKSLGKEGVIAMITESTNAGRSGKTPSEQIAKDMVRDVLLGTEESGVGM
CCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE
IVTTFASHIARLKAIIEAAEEMGRIPVLMGRSMERYVGAARDIGYLDLPSNVEIYGTRKD
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEECCCCEEEEECHHH
VDRAFKRIMQEGKNKYLPIVTGHQGEPGSILVRVANGETPYTIDPGDRIIFSANVIPSPM
HHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCEEECCCCEEEEECCCCCCCC
TQANRYALETKLRMKGGRIYDDVHVSGHAYREDHWELLRMVNPEHVIPAHGDMEMHGHYI
HHHHHEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHCCCCEECCCCCCCEECCEEE
EMAEDAGYVLGDTVHLLRNGEVLYIEE
EEECCCCEECCCEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]