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The map label for this gene is pgaC [H]

Identifier: 21227756

GI number: 21227756

Start: 1972985

End: 1975075

Strand: Reverse

Name: pgaC [H]

Synonym: MM_1654

Alternate gene names: 21227756

Gene position: 1975075-1972985 (Counterclockwise)

Preceding gene: 21227757

Following gene: 21227755

Centisome position: 48.22

GC content: 39.89

Gene sequence:

>2091_bases
ATGGTTAAAGAACGTATCGGAGATTTTGTAAAATTTCAAAAAACAGAAGTAATAAATCGACCGGAGACTATATTTGGAAG
AAAAGAGAAGAGCGATAAAAAATTCTCTGATTCTTCCGGCAATAGCGTAAATAAATTGATACCTGTTGCCTCATTAATTC
TGGCTGTATTAATCACTCTTTCAATCGGATTATTTCTTTACGAGGGAATTAACCACTTAAATAATGGTACTCCCGGCAGT
GTTACTATCCTGGAAGAACCAGAGCTTCTTGACGCACTGAGGAATGCGCAGGATAGAGGAGTTCTTCTTGCAATGCATGG
ATGGGCACATGAAGATTATTCAACTCTAACGCCATTGCAGATAAAAGAAAATATAGAAAAAGGAAAATACGTCTTTGAAA
AAGCCGGGATTGTTCCTGTGGCATTCATCCTTCCAGAAGAACCTATTCATGGAACAATAGATGCATCACTAAAACGGGAA
ATAGAGAGCAACGGGATCCCAACAGAGTTACCTGTGCTCGAAACCGATGGAACCTACAGGAACGAATATACATGGAACTG
GCGTGAAATGGAAAGTTTAGAAGATTCCCGATACCAGGAGGCTTCTGAGCAAATAAGGGAGGATAATCCGACAACGATTC
TGCTCCATGCACAGGACTGGAATCCTTATACGAAGCAGTTTATCACTGATTACTTATCATCGACCAATGAGAGAAATGTC
ACCATCAGGGTAGATGATGTCGAGGTGAATACCAGACCAGAAATGGTCTCTGACATGGCCCAGTTGACCCAATACGAATC
AGTTGGACAGGTTGCATTTGCAGTAATTCCTGCGGGAGCAGGAAAAGGAGACAACCCTGCTATCGGGAACATAAATATAA
ACAGGATTATGGGGGTTTACTTCTGGTTCTTTATCATAACCTCATTGTTGCCACTTTCATTTTTTGCAACATGGAAATTG
TTATCGAAGTGGCACAAAAATAGGAAACAAAACAGGTATTTACTTGAGGATGGCCGAGATCCAAAAGATCCAAACACGAA
AGGTCCAATATTAGTCTCCGTTATTTCCCCGGCTTATAATGAAGAGAAATCAATAGGGAAATGCCTTCAATCTATTCTTA
ATCAAGACTATAAGGGAAAAATGGAAGTGATCGCTGTTAATGACGGCTCCAGCGATCGAACTGCAGAGATTATTTCAAAG
TATCCTGTAAAACTTCTCGACCTTAAAGTTAACGGAGGAAAAGCAAACGCTCTTAATAAAGCTATTGAGATTGCAAAAGG
AGACATTCTGATCTTTACGGATTCAGATTCTTATATGGCACCGAATGCTGTGAGTTCTCTGGTGAAATGTCTCAATGAGA
ATGAAGAAGCCCAGATGGTGGCAGGAAACGTGTTTATTCATGATAACCGGGGAAAAAAAGGAATCATGAAGTATTTCCAG
ATGATTGAATATCGTACCGAACAGGAGATTATCCGCCACCTTCAGGGCTTGTCAGGCAGCATCCTTGTATGCCCTGGCCC
TCTCACTGCTGTCAGGCGCAAAGTGTGTGATGTAATTAGCTTCAGTAACGAGACCATAGTTGAAGATGCTGACTTTACGA
TTAAGGCTCTTAAAAACTCAATTAAAATTATTCAAGAACCAGAAGCAATAGTCTACACTGACGCACCTGAGACTGTTAAA
GGGTGGTATAAACAGAGGAAGAGATGGTGGTATGGAAATCTCCAGTTATGGAGACTCCACAAAAAATGGGCAATGAAGAA
TCCGTGGATGATATTCAATTATTCAGGATATATAACAGGGATTTGTTCAATCATCCTGATCATGTCAATACCATACTTAA
TCCTTCAGTATGACAACATTCCAATGATACTGATGAGTGGAATCCTGTGCCTTGCATTCTCTATAATGCTGTACATTATA
TATATTGGCCCATTATTTGCCACAGACAAAAGATTATTACTAATGTTGATACCTTATGTATTGATCTATGCAACAATAAA
AGTAGTAGTAATCAGCAGCCTTTTCCTGTGCTACCTGACAGGTAAAGGAGTAAAAGTTAAATTCGGTGCAAAGAGCTTTG
TGGTGAGGTAA

Upstream 100 bases:

>100_bases
AAAACAGATGCCTGCTATCATAGGTTTGCGTTAAAATTTCCCTTTAAAATCTGTTACCAATTGAGCAGTCAGCTCAGTAA
GATGCTTGGTGGGGTTCGAG

Downstream 100 bases:

>100_bases
TGAAAAAAGACTACAAAAAATATTTTTTAGCAGGGCCAATACCCTTAATTTTAGTTATAATTCTATTTTATTTACACCCG
GTTAACGAAGGTCCTCCGCG

Product: glycosyltransferase

Products: NA

Alternate protein names: PGA synthase; Poly-beta-1,6-GlcNAc synthase; Biofilm PGA synthesis protein PgaC; N-acetylglucosaminyltransferase PgaC [H]

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MVKERIGDFVKFQKTEVINRPETIFGRKEKSDKKFSDSSGNSVNKLIPVASLILAVLITLSIGLFLYEGINHLNNGTPGS
VTILEEPELLDALRNAQDRGVLLAMHGWAHEDYSTLTPLQIKENIEKGKYVFEKAGIVPVAFILPEEPIHGTIDASLKRE
IESNGIPTELPVLETDGTYRNEYTWNWREMESLEDSRYQEASEQIREDNPTTILLHAQDWNPYTKQFITDYLSSTNERNV
TIRVDDVEVNTRPEMVSDMAQLTQYESVGQVAFAVIPAGAGKGDNPAIGNININRIMGVYFWFFIITSLLPLSFFATWKL
LSKWHKNRKQNRYLLEDGRDPKDPNTKGPILVSVISPAYNEEKSIGKCLQSILNQDYKGKMEVIAVNDGSSDRTAEIISK
YPVKLLDLKVNGGKANALNKAIEIAKGDILIFTDSDSYMAPNAVSSLVKCLNENEEAQMVAGNVFIHDNRGKKGIMKYFQ
MIEYRTEQEIIRHLQGLSGSILVCPGPLTAVRRKVCDVISFSNETIVEDADFTIKALKNSIKIIQEPEAIVYTDAPETVK
GWYKQRKRWWYGNLQLWRLHKKWAMKNPWMIFNYSGYITGICSIILIMSIPYLILQYDNIPMILMSGILCLAFSIMLYII
YIGPLFATDKRLLLMLIPYVLIYATIKVVVISSLFLCYLTGKGVKVKFGAKSFVVR

Sequences:

>Translated_696_residues
MVKERIGDFVKFQKTEVINRPETIFGRKEKSDKKFSDSSGNSVNKLIPVASLILAVLITLSIGLFLYEGINHLNNGTPGS
VTILEEPELLDALRNAQDRGVLLAMHGWAHEDYSTLTPLQIKENIEKGKYVFEKAGIVPVAFILPEEPIHGTIDASLKRE
IESNGIPTELPVLETDGTYRNEYTWNWREMESLEDSRYQEASEQIREDNPTTILLHAQDWNPYTKQFITDYLSSTNERNV
TIRVDDVEVNTRPEMVSDMAQLTQYESVGQVAFAVIPAGAGKGDNPAIGNININRIMGVYFWFFIITSLLPLSFFATWKL
LSKWHKNRKQNRYLLEDGRDPKDPNTKGPILVSVISPAYNEEKSIGKCLQSILNQDYKGKMEVIAVNDGSSDRTAEIISK
YPVKLLDLKVNGGKANALNKAIEIAKGDILIFTDSDSYMAPNAVSSLVKCLNENEEAQMVAGNVFIHDNRGKKGIMKYFQ
MIEYRTEQEIIRHLQGLSGSILVCPGPLTAVRRKVCDVISFSNETIVEDADFTIKALKNSIKIIQEPEAIVYTDAPETVK
GWYKQRKRWWYGNLQLWRLHKKWAMKNPWMIFNYSGYITGICSIILIMSIPYLILQYDNIPMILMSGILCLAFSIMLYII
YIGPLFATDKRLLLMLIPYVLIYATIKVVVISSLFLCYLTGKGVKVKFGAKSFVVR
>Mature_696_residues
MVKERIGDFVKFQKTEVINRPETIFGRKEKSDKKFSDSSGNSVNKLIPVASLILAVLITLSIGLFLYEGINHLNNGTPGS
VTILEEPELLDALRNAQDRGVLLAMHGWAHEDYSTLTPLQIKENIEKGKYVFEKAGIVPVAFILPEEPIHGTIDASLKRE
IESNGIPTELPVLETDGTYRNEYTWNWREMESLEDSRYQEASEQIREDNPTTILLHAQDWNPYTKQFITDYLSSTNERNV
TIRVDDVEVNTRPEMVSDMAQLTQYESVGQVAFAVIPAGAGKGDNPAIGNININRIMGVYFWFFIITSLLPLSFFATWKL
LSKWHKNRKQNRYLLEDGRDPKDPNTKGPILVSVISPAYNEEKSIGKCLQSILNQDYKGKMEVIAVNDGSSDRTAEIISK
YPVKLLDLKVNGGKANALNKAIEIAKGDILIFTDSDSYMAPNAVSSLVKCLNENEEAQMVAGNVFIHDNRGKKGIMKYFQ
MIEYRTEQEIIRHLQGLSGSILVCPGPLTAVRRKVCDVISFSNETIVEDADFTIKALKNSIKIIQEPEAIVYTDAPETVK
GWYKQRKRWWYGNLQLWRLHKKWAMKNPWMIFNYSGYITGICSIILIMSIPYLILQYDNIPMILMSGILCLAFSIMLYII
YIGPLFATDKRLLLMLIPYVLIYATIKVVVISSLFLCYLTGKGVKVKFGAKSFVVR

Specific function: Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1,6- N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide [H]

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family [H]

Homologues:

Organism=Homo sapiens, GI57770468, Length=104, Percent_Identity=39.4230769230769, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1787259, Length=325, Percent_Identity=28.3076923076923, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786560, Length=222, Percent_Identity=27.9279279279279, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: NA

Molecular weight: Translated: 78827; Mature: 78827

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKERIGDFVKFQKTEVINRPETIFGRKEKSDKKFSDSSGNSVNKLIPVASLILAVLITL
CCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SIGLFLYEGINHLNNGTPGSVTILEEPELLDALRNAQDRGVLLAMHGWAHEDYSTLTPLQ
HHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHH
IKENIEKGKYVFEKAGIVPVAFILPEEPIHGTIDASLKREIESNGIPTELPVLETDGTYR
HHHHHHHHHEEHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCC
NEYTWNWREMESLEDSRYQEASEQIREDNPTTILLHAQDWNPYTKQFITDYLSSTNERNV
CCCEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEE
TIRVDDVEVNTRPEMVSDMAQLTQYESVGQVAFAVIPAGAGKGDNPAIGNININRIMGVY
EEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHH
FWFFIITSLLPLSFFATWKLLSKWHKNRKQNRYLLEDGRDPKDPNTKGPILVSVISPAYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCEEEEEECCCCC
EEKSIGKCLQSILNQDYKGKMEVIAVNDGSSDRTAEIISKYPVKLLDLKVNGGKANALNK
CHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEEEECCCCCHHHHH
AIEIAKGDILIFTDSDSYMAPNAVSSLVKCLNENEEAQMVAGNVFIHDNRGKKGIMKYFQ
HHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHHH
MIEYRTEQEIIRHLQGLSGSILVCPGPLTAVRRKVCDVISFSNETIVEDADFTIKALKNS
HHHHCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHH
IKIIQEPEAIVYTDAPETVKGWYKQRKRWWYGNLQLWRLHKKWAMKNPWMIFNYSGYITG
HHEEECCCEEEEECCCHHHHHHHHHHCCEEECCEEEEEEEHHHCCCCCEEEEECCCHHHH
ICSIILIMSIPYLILQYDNIPMILMSGILCLAFSIMLYIIYIGPLFATDKRLLLMLIPYV
HHHHHHHHHCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LIYATIKVVVISSLFLCYLTGKGVKVKFGAKSFVVR
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MVKERIGDFVKFQKTEVINRPETIFGRKEKSDKKFSDSSGNSVNKLIPVASLILAVLITL
CCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SIGLFLYEGINHLNNGTPGSVTILEEPELLDALRNAQDRGVLLAMHGWAHEDYSTLTPLQ
HHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHH
IKENIEKGKYVFEKAGIVPVAFILPEEPIHGTIDASLKREIESNGIPTELPVLETDGTYR
HHHHHHHHHEEHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCC
NEYTWNWREMESLEDSRYQEASEQIREDNPTTILLHAQDWNPYTKQFITDYLSSTNERNV
CCCEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEE
TIRVDDVEVNTRPEMVSDMAQLTQYESVGQVAFAVIPAGAGKGDNPAIGNININRIMGVY
EEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHH
FWFFIITSLLPLSFFATWKLLSKWHKNRKQNRYLLEDGRDPKDPNTKGPILVSVISPAYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCEEEEEECCCCC
EEKSIGKCLQSILNQDYKGKMEVIAVNDGSSDRTAEIISKYPVKLLDLKVNGGKANALNK
CHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEEEECCCCCHHHHH
AIEIAKGDILIFTDSDSYMAPNAVSSLVKCLNENEEAQMVAGNVFIHDNRGKKGIMKYFQ
HHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHHH
MIEYRTEQEIIRHLQGLSGSILVCPGPLTAVRRKVCDVISFSNETIVEDADFTIKALKNS
HHHHCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHH
IKIIQEPEAIVYTDAPETVKGWYKQRKRWWYGNLQLWRLHKKWAMKNPWMIFNYSGYITG
HHEEECCCEEEEECCCHHHHHHHHHHCCEEECCEEEEEEEHHHCCCCCEEEEECCCHHHH
ICSIILIMSIPYLILQYDNIPMILMSGILCLAFSIMLYIIYIGPLFATDKRLLLMLIPYV
HHHHHHHHHCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LIYATIKVVVISSLFLCYLTGKGVKVKFGAKSFVVR
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]