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The map label for this gene is dut [H]

Identifier: 21227730

GI number: 21227730

Start: 1941048

End: 1941563

Strand: Reverse

Name: dut [H]

Synonym: MM_1628

Alternate gene names: 21227730

Gene position: 1941563-1941048 (Counterclockwise)

Preceding gene: 21227738

Following gene: 21227729

Centisome position: 47.4

GC content: 42.44

Gene sequence:

>516_bases
ATGGCTCTTTTATCCAGCAATGAACTGAGAAAATTAATAAAAGCAAATCCCCCTTTACTTGAAAACGCAGTAGACACCGA
AACCCAGATACAGCCAAATGGGCTTGAGCTCACCCTGAAAGAGATAAAAACAATAGAAGGTGCGGGAGCTGTTGATTTTG
ACAATTCCGAAAGAAAAGTTCCGGACGCAAAACCCCTGGAATTTGGAAAAGACGGATGGATCCACCTTCCGGAGGGGATT
TATAAAGTTATATTTAACGAAATCGTCAATATTCCAATGAACCTTGCTGCAATCGCAAAACCAAGATCAAGCCTTATTCG
GTGCGGGGCAACTCTTGAAACTGCAGTATGGGATGCAGGTTACAGGGGACGAAGCGAATCCATGCTTGTAGTTTATAACC
CTGCAGGCTTTAAGTTGAAGAAAAACGCCAGGATAATGCAGCTCCTTTTCTATACCCTTAATACCGAAGTAGAGGAAGGC
TATTCTGGAGTTTACCAGAACGAAAATACAAACTGA

Upstream 100 bases:

>100_bases
TAAGAAGAAAATAAAACAAAAAGAGAAACAAATATAAGAAAAGAATAAAGTTTGAAAAGCCCGAAATAGTAATAAAGAAT
ACACACAATTACAGTTTTTC

Downstream 100 bases:

>100_bases
ATTTATAAAAAATATGGAATAAAATAACTAAAATTGTAAAAGAATTTGAGGTAGAATGGACAGTGTAACATAAGTTCTGT
AAAATCACAAATCTCAAGAA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MALLSSNELRKLIKANPPLLENAVDTETQIQPNGLELTLKEIKTIEGAGAVDFDNSERKVPDAKPLEFGKDGWIHLPEGI
YKVIFNEIVNIPMNLAAIAKPRSSLIRCGATLETAVWDAGYRGRSESMLVVYNPAGFKLKKNARIMQLLFYTLNTEVEEG
YSGVYQNENTN

Sequences:

>Translated_171_residues
MALLSSNELRKLIKANPPLLENAVDTETQIQPNGLELTLKEIKTIEGAGAVDFDNSERKVPDAKPLEFGKDGWIHLPEGI
YKVIFNEIVNIPMNLAAIAKPRSSLIRCGATLETAVWDAGYRGRSESMLVVYNPAGFKLKKNARIMQLLFYTLNTEVEEG
YSGVYQNENTN
>Mature_170_residues
ALLSSNELRKLIKANPPLLENAVDTETQIQPNGLELTLKEIKTIEGAGAVDFDNSERKVPDAKPLEFGKDGWIHLPEGIY
KVIFNEIVNIPMNLAAIAKPRSSLIRCGATLETAVWDAGYRGRSESMLVVYNPAGFKLKKNARIMQLLFYTLNTEVEEGY
SGVYQNENTN

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0717

COG function: function code F; Deoxycytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 19028; Mature: 18897

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLSSNELRKLIKANPPLLENAVDTETQIQPNGLELTLKEIKTIEGAGAVDFDNSERKV
CCCCCHHHHHHHHHCCCCHHHCCCCCCCEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCC
PDAKPLEFGKDGWIHLPEGIYKVIFNEIVNIPMNLAAIAKPRSSLIRCGATLETAVWDAG
CCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCHHHHHHHCCC
YRGRSESMLVVYNPAGFKLKKNARIMQLLFYTLNTEVEEGYSGVYQNENTN
CCCCCCCEEEEECCCCCEEECCCHHHHHHHHHHCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ALLSSNELRKLIKANPPLLENAVDTETQIQPNGLELTLKEIKTIEGAGAVDFDNSERKV
CCCCHHHHHHHHHCCCCHHHCCCCCCCEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCC
PDAKPLEFGKDGWIHLPEGIYKVIFNEIVNIPMNLAAIAKPRSSLIRCGATLETAVWDAG
CCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCHHHHHHHCCC
YRGRSESMLVVYNPAGFKLKKNARIMQLLFYTLNTEVEEGYSGVYQNENTN
CCCCCCCEEEEECCCCCEEECCCHHHHHHHHHHCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]