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The map label for this gene is 21227708

Identifier: 21227708

GI number: 21227708

Start: 1917092

End: 1918015

Strand: Direct

Name: 21227708

Synonym: MM_1606

Alternate gene names: NA

Gene position: 1917092-1918015 (Clockwise)

Preceding gene: 21227707

Following gene: 21227709

Centisome position: 46.8

GC content: 47.62

Gene sequence:

>924_bases
ATGAAAGAAGTTCAGGAAACCGCAGAAAAGATCCGGACAATGGAAATCCGGGGTGCAGGCAGGATTGCAAAAGCTGCAGC
TGAAGTAATCAGGGACTATGCTGCAGGGCTCGAGGCTGCTTCTATTGAGGAATTTGCAGCCGGGATCACGGAAGTCTCCA
ATTACCTTATCAGCACACGCCCTACAGCCGTATCCCTCCCTAACGCCGTAAAGCTCTCTTCCAGATATTCTTCTGATAAT
GTAGAGAACGCCAGGAAGGAGGTCATCAATAACGCCAACCTCTTTATCGAGAGGGCAGATAAAGCTCTTGGAAGAATTGG
AAAAATTGGAGCAGGGAGAGTTCAGGACGGGGACGTAATAATGACTCACTGCAATTCCCATGCCGCCCTTTCCATAATTA
CAACGGCTTTTGAAGACGGAAAAAATATTTCAGTTATCGCAACTGAAAGCCGCCCCAGGCGCCAGGGGTTGCTGACAGTC
AGGCGCCTTAACGGCTTTGGAATCCCCACAACCCTTATTGTGGACTCTGCTGTGCGCTACTATATGAAAGATGTGGATAA
AGTGATAGTCGGAGCTGATGCGATTGCAGCAAACGGAGCCCTTGTAAACAAAATAGGGACTTCCCAGCTCGCCCTTGCTG
CCCACGAAGCCAGAAAAAGTTTCATGGTAGCTGCCGAGACCTTCAAATTCAGCCCGAGCACTATCCTGGGAATACCTATA
GAAATCGAAGAAAGGTCCACAGATGAAGTTGTCGACCCTTCGGTTCTGGCAGAACTCCCTCATGTGCAGGTGAAAAATCC
GGCTTTTGACTTTACTCCCTCTGAATACATCGATATGATAGTAACTGATATAGGAATTATTCCGCCTGCAATGGCGTATA
TAGTAATAAAAGAACACCTTGGATGGGAGTTTGAAGAGATCTAG

Upstream 100 bases:

>100_bases
TAACCAGATCAATTCCGGTCTTTGTCCTCCTCCGGTCTTTCAATGAGAGAAGGAGAGCTGAAAGATAGCTATAAATCAGG
CGCTGACTATCCCTTATATT

Downstream 100 bases:

>100_bases
GGTGTATAAAGAGATTATAAGCATATAGAGACTTCACTAAATAACAGGAAGGAAAAAACATGATTAATGTTGAGTATACC
GATGGTGCTCAGGAATCACT

Product: translation initiation factor IF-2B subunit delta

Products: NA

Alternate protein names: eIF-2B GDP-GTP exchange factor [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKEVQETAEKIRTMEIRGAGRIAKAAAEVIRDYAAGLEAASIEEFAAGITEVSNYLISTRPTAVSLPNAVKLSSRYSSDN
VENARKEVINNANLFIERADKALGRIGKIGAGRVQDGDVIMTHCNSHAALSIITTAFEDGKNISVIATESRPRRQGLLTV
RRLNGFGIPTTLIVDSAVRYYMKDVDKVIVGADAIAANGALVNKIGTSQLALAAHEARKSFMVAAETFKFSPSTILGIPI
EIEERSTDEVVDPSVLAELPHVQVKNPAFDFTPSEYIDMIVTDIGIIPPAMAYIVIKEHLGWEFEEI

Sequences:

>Translated_307_residues
MKEVQETAEKIRTMEIRGAGRIAKAAAEVIRDYAAGLEAASIEEFAAGITEVSNYLISTRPTAVSLPNAVKLSSRYSSDN
VENARKEVINNANLFIERADKALGRIGKIGAGRVQDGDVIMTHCNSHAALSIITTAFEDGKNISVIATESRPRRQGLLTV
RRLNGFGIPTTLIVDSAVRYYMKDVDKVIVGADAIAANGALVNKIGTSQLALAAHEARKSFMVAAETFKFSPSTILGIPI
EIEERSTDEVVDPSVLAELPHVQVKNPAFDFTPSEYIDMIVTDIGIIPPAMAYIVIKEHLGWEFEEI
>Mature_307_residues
MKEVQETAEKIRTMEIRGAGRIAKAAAEVIRDYAAGLEAASIEEFAAGITEVSNYLISTRPTAVSLPNAVKLSSRYSSDN
VENARKEVINNANLFIERADKALGRIGKIGAGRVQDGDVIMTHCNSHAALSIITTAFEDGKNISVIATESRPRRQGLLTV
RRLNGFGIPTTLIVDSAVRYYMKDVDKVIVGADAIAANGALVNKIGTSQLALAAHEARKSFMVAAETFKFSPSTILGIPI
EIEERSTDEVVDPSVLAELPHVQVKNPAFDFTPSEYIDMIVTDIGIIPPAMAYIVIKEHLGWEFEEI

Specific function: Catalyzes the exchange of initiation factor 2-bound GDP for GTP [H]

COG id: COG1184

COG function: function code J; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family [H]

Homologues:

Organism=Homo sapiens, GI78000156, Length=293, Percent_Identity=26.962457337884, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI78000158, Length=293, Percent_Identity=26.962457337884, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI187607323, Length=293, Percent_Identity=26.962457337884, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4503503, Length=225, Percent_Identity=31.1111111111111, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI72534748, Length=314, Percent_Identity=32.484076433121, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI23943880, Length=294, Percent_Identity=30.6122448979592, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7657058, Length=192, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17557123, Length=263, Percent_Identity=28.1368821292776, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17557462, Length=309, Percent_Identity=32.0388349514563, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322878, Length=249, Percent_Identity=34.5381526104418, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6325375, Length=356, Percent_Identity=28.3707865168539, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321520, Length=250, Percent_Identity=25.2, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21358605, Length=214, Percent_Identity=32.2429906542056, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281364091, Length=307, Percent_Identity=29.9674267100977, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24659399, Length=307, Percent_Identity=29.9674267100977, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24659407, Length=307, Percent_Identity=29.9674267100977, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922816, Length=307, Percent_Identity=29.9674267100977, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357667, Length=273, Percent_Identity=32.2344322344322, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24651647, Length=273, Percent_Identity=32.2344322344322, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005250
- InterPro:   IPR000649
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: NA

Molecular weight: Translated: 33299; Mature: 33299

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVQETAEKIRTMEIRGAGRIAKAAAEVIRDYAAGLEAASIEEFAAGITEVSNYLISTR
CCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PTAVSLPNAVKLSSRYSSDNVENARKEVINNANLFIERADKALGRIGKIGAGRVQDGDVI
CCEECCCCCEEHHCCCCCCCHHHHHHHHHCCCHHEEEHHHHHHHHHCCCCCCCCCCCCEE
MTHCNSHAALSIITTAFEDGKNISVIATESRPRRQGLLTVRRLNGFGIPTTLIVDSAVRY
EEECCCCCEEHEEEEHHCCCCCEEEEEECCCCCHHHCEEEEECCCCCCCHHHHHHHHHHH
YMKDVDKVIVGADAIAANGALVNKIGTSQLALAAHEARKSFMVAAETFKFSPSTILGIPI
HHHHHHHHHHCCCHHHCCCCCEECCCCHHHHHHHHHHHHHHEEEEHHEECCCCEEEEEEE
EIEERSTDEVVDPSVLAELPHVQVKNPAFDFTPSEYIDMIVTDIGIIPPAMAYIVIKEHL
EECCCCCCCCCCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GWEFEEI
CCCHHCC
>Mature Secondary Structure
MKEVQETAEKIRTMEIRGAGRIAKAAAEVIRDYAAGLEAASIEEFAAGITEVSNYLISTR
CCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PTAVSLPNAVKLSSRYSSDNVENARKEVINNANLFIERADKALGRIGKIGAGRVQDGDVI
CCEECCCCCEEHHCCCCCCCHHHHHHHHHCCCHHEEEHHHHHHHHHCCCCCCCCCCCCEE
MTHCNSHAALSIITTAFEDGKNISVIATESRPRRQGLLTVRRLNGFGIPTTLIVDSAVRY
EEECCCCCEEHEEEEHHCCCCCEEEEEECCCCCHHHCEEEEECCCCCCCHHHHHHHHHHH
YMKDVDKVIVGADAIAANGALVNKIGTSQLALAAHEARKSFMVAAETFKFSPSTILGIPI
HHHHHHHHHHCCCHHHCCCCCEECCCCHHHHHHHHHHHHHHEEEEHHEECCCCEEEEEEE
EIEERSTDEVVDPSVLAELPHVQVKNPAFDFTPSEYIDMIVTDIGIIPPAMAYIVIKEHL
EECCCCCCCCCCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GWEFEEI
CCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]