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The map label for this gene is 21227689

Identifier: 21227689

GI number: 21227689

Start: 1886322

End: 1888661

Strand: Direct

Name: 21227689

Synonym: MM_1587

Alternate gene names: NA

Gene position: 1886322-1888661 (Clockwise)

Preceding gene: 21227688

Following gene: 21227692

Centisome position: 46.05

GC content: 47.22

Gene sequence:

>2340_bases
ATGATGCAAAAGAATGGATACATGCGATATTTTACAAAAAAAAGCTGCTACCCAAATCAGTCAGAGGCTATGGATAAAAT
TCATTCTGCCCTCCAGAATGAGAAAATAGTGCTCTTTGAAGGGGCATGCGGTACGGGCAAGACTTTAAGTGCACTTGCTC
CTGCACTGCATGCGGGAAAGAAGCTCAATAAGGTCGTAATTATAGTCACGAATGTCCACCAGCAGATGGTCCAGTTCATA
AATGAAGCAAGAGACATCAACAGGGACAACAGCATAAAAACAATCGTTTTTAAAGGTAAAGCTTCGATGTGCCCTGATAA
TCTTGACTACGAGGAATGCAGGCTCAAAGGGGAAAACACCTATGACCTTCTTGATTTTGAAAGGGAGGTCTCTTCAAAGG
AAAAAGAACTCAAAGACGCCTTCGAAAAACACAAGAAATCAAAAGATCCTGCCCTTTACATCCTCAGGAACGAGCTCGAA
AAAGAACTCGATGAAGCCCGAAAAAAGGCTCAGTCCTTAAGGAACCATTCCTGCTCCAGGCTTTATGAAGTCCTCAAGTT
CGAAAGCAGCGAGTTTTCTTCCTGGCTCTTTTCGGACGTCAGGAGTCCGGAAGAAATTATGGAGTATGCAGAAGACCGGG
GAATGTGCGGGTATGAGCTGCTTAAAAAGGAACTTAAAAATACTGAGCTCCTTATCTGTAATTTCCATCATGTATTAAGT
GCTGACATCTTCATGACTCTCCTCAAATGGCTTGAGAGAGACCCTGAAGACGTCATCCTCATCTTTGACGAAGCCCACAA
TATCGAGGCTTCAGCACGTTCCCATTCCTCAATAATGCTTTCTGAACTGACCGTTGAAAAAGCCCTTTCTGAAGTGGGAG
AAATTCCTGAGCCTGAAAGCTCTCCCGTATTCGGGGGAGGTTCATTCTCCGGTACAGGGATCCCTCTTGACGAAGATTAC
GCTTCAAGGATTTATGCCAGAAGGCTCTTTTCCTGTCTTCTTACCGCAATCAGGGATACTTATGACTCAAAGCTGAAGTT
CGGGGAAAGGAACAGGCTTGGAAAACACTGGCAGGATATCCAGATAAGCGACCCCTATGAACGCCATGACGTCCTGAAAG
CCCGCTTTTTGCGGGACGCACAGAAGGAGGGTTTTGCAGACGAAGAAACGGTTCTTACAAGGCTGCGTGAAATCGGGGAG
TTCGGAGGCAGGCTTGAAGAGATTTATGCTGAGAACTACAAAAAAGGGCTTCTTTCCGTGCCCAAGCGTTCCCAGATCCG
TTATGTTGCAGATTTCCTTTCTTCTTACCTTGTGCTTTCGGACAGGCAGAACTATTATCCGATCCTGAACATGCGCAGGG
ACTTTAAAAGTGACAGGGTTGTAGGCAGGCTTGAACTCTTCACCTGCATCCCGAAAAATGTGACCCAGCCATTGCTTGAC
TCCGTTTATTCCGCGGTGCTAATGTCTGCCACTCTCCGTCCTTTCGAAATGGTCAGGTCCACACTGGGCATTAGCCGGGA
AGTGGAGGAAATTACCTATGGGACAACTTTCCCACAGGAAAGAAGACTCACTCTCGCAGTCTCAGTTCCTCCCCTCTTTG
CAAAAAACAGGGACAGCCCTGAGACCCTTGAAGGTTTGAGAGAGGCTCTTCTTGCTGCCACTGCTGCCTCCCCCGGGAAT
GTAATCATTTATTTCCAGAGCTATGCCGAAGCACTCAGATATACGAAACTCCTTGAGCCTGAACTCTCAATTCCTATTTT
CCTTGATGAGGTTGGGGTATCAGCTCAGGAGATAAGGCCGAAGTTTTTCAAAATAGGGGAGCAGGGAGGAAAAGCTGTGC
TCATAACCTACCTCTGGGGAACATTGAGCGAAGGAGTAGATTTCCGGGACTCCCGCGGCAGGACCGTAATTGTAGTGGGC
GTGGGATACCCTGCTCTGAATGACAGGATAAAAGCTGTCGAGTCGGCATACGATACTGTCTTTGGGTGCGGGGAAGGCTG
GGAATTTGCAGTCCAGGTGCCTACAATAAGGAAAGTGAGGCAGGCAATGGGAAGGGTTGTCCGCTCTCCGGGAGATTTTG
GGGTAAGGATTCTTCTTGACGCCCGCTACCAGGGTTCTCAGGTGCGAAAACTGGGGAAATTTTCTGTTTTTGGATACTTC
CCACCTGAAGAAAGCAGGGAATTCATTGATGTAGCCCCAAAAGATGTAGGAAGCCTGGTAGAAGAGTTCTTCGCAAACAC
ATTGCCTTATAATCCCGAAAAAATTGAAACTGAAAAAAAAGAGCCGGAATCTCCGGCTTCAGGCCGGCTAGAGTTCGGGA
GCCTTGCAGAAAAACTCTAA

Upstream 100 bases:

>100_bases
TAAATTAAAAGAAACTGCAATTTGTGCTGTATTGCAATAAGCGTAATAATAGCTATAACTACAGAGCTCTGGAAACCGTA
GAGACCTCAGGATTAAGCGT

Downstream 100 bases:

>100_bases
TGGGGAAATGGCTCCTTTACTTCAGCCGAACCCTTTATGTTTATTATTTAACTCCGTCTTTTCCTTTCTCTTATTTTCTT
GTTATTTTTGTTTTTCTCGT

Product: DNA repair helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MMQKNGYMRYFTKKSCYPNQSEAMDKIHSALQNEKIVLFEGACGTGKTLSALAPALHAGKKLNKVVIIVTNVHQQMVQFI
NEARDINRDNSIKTIVFKGKASMCPDNLDYEECRLKGENTYDLLDFEREVSSKEKELKDAFEKHKKSKDPALYILRNELE
KELDEARKKAQSLRNHSCSRLYEVLKFESSEFSSWLFSDVRSPEEIMEYAEDRGMCGYELLKKELKNTELLICNFHHVLS
ADIFMTLLKWLERDPEDVILIFDEAHNIEASARSHSSIMLSELTVEKALSEVGEIPEPESSPVFGGGSFSGTGIPLDEDY
ASRIYARRLFSCLLTAIRDTYDSKLKFGERNRLGKHWQDIQISDPYERHDVLKARFLRDAQKEGFADEETVLTRLREIGE
FGGRLEEIYAENYKKGLLSVPKRSQIRYVADFLSSYLVLSDRQNYYPILNMRRDFKSDRVVGRLELFTCIPKNVTQPLLD
SVYSAVLMSATLRPFEMVRSTLGISREVEEITYGTTFPQERRLTLAVSVPPLFAKNRDSPETLEGLREALLAATAASPGN
VIIYFQSYAEALRYTKLLEPELSIPIFLDEVGVSAQEIRPKFFKIGEQGGKAVLITYLWGTLSEGVDFRDSRGRTVIVVG
VGYPALNDRIKAVESAYDTVFGCGEGWEFAVQVPTIRKVRQAMGRVVRSPGDFGVRILLDARYQGSQVRKLGKFSVFGYF
PPEESREFIDVAPKDVGSLVEEFFANTLPYNPEKIETEKKEPESPASGRLEFGSLAEKL

Sequences:

>Translated_779_residues
MMQKNGYMRYFTKKSCYPNQSEAMDKIHSALQNEKIVLFEGACGTGKTLSALAPALHAGKKLNKVVIIVTNVHQQMVQFI
NEARDINRDNSIKTIVFKGKASMCPDNLDYEECRLKGENTYDLLDFEREVSSKEKELKDAFEKHKKSKDPALYILRNELE
KELDEARKKAQSLRNHSCSRLYEVLKFESSEFSSWLFSDVRSPEEIMEYAEDRGMCGYELLKKELKNTELLICNFHHVLS
ADIFMTLLKWLERDPEDVILIFDEAHNIEASARSHSSIMLSELTVEKALSEVGEIPEPESSPVFGGGSFSGTGIPLDEDY
ASRIYARRLFSCLLTAIRDTYDSKLKFGERNRLGKHWQDIQISDPYERHDVLKARFLRDAQKEGFADEETVLTRLREIGE
FGGRLEEIYAENYKKGLLSVPKRSQIRYVADFLSSYLVLSDRQNYYPILNMRRDFKSDRVVGRLELFTCIPKNVTQPLLD
SVYSAVLMSATLRPFEMVRSTLGISREVEEITYGTTFPQERRLTLAVSVPPLFAKNRDSPETLEGLREALLAATAASPGN
VIIYFQSYAEALRYTKLLEPELSIPIFLDEVGVSAQEIRPKFFKIGEQGGKAVLITYLWGTLSEGVDFRDSRGRTVIVVG
VGYPALNDRIKAVESAYDTVFGCGEGWEFAVQVPTIRKVRQAMGRVVRSPGDFGVRILLDARYQGSQVRKLGKFSVFGYF
PPEESREFIDVAPKDVGSLVEEFFANTLPYNPEKIETEKKEPESPASGRLEFGSLAEKL
>Mature_779_residues
MMQKNGYMRYFTKKSCYPNQSEAMDKIHSALQNEKIVLFEGACGTGKTLSALAPALHAGKKLNKVVIIVTNVHQQMVQFI
NEARDINRDNSIKTIVFKGKASMCPDNLDYEECRLKGENTYDLLDFEREVSSKEKELKDAFEKHKKSKDPALYILRNELE
KELDEARKKAQSLRNHSCSRLYEVLKFESSEFSSWLFSDVRSPEEIMEYAEDRGMCGYELLKKELKNTELLICNFHHVLS
ADIFMTLLKWLERDPEDVILIFDEAHNIEASARSHSSIMLSELTVEKALSEVGEIPEPESSPVFGGGSFSGTGIPLDEDY
ASRIYARRLFSCLLTAIRDTYDSKLKFGERNRLGKHWQDIQISDPYERHDVLKARFLRDAQKEGFADEETVLTRLREIGE
FGGRLEEIYAENYKKGLLSVPKRSQIRYVADFLSSYLVLSDRQNYYPILNMRRDFKSDRVVGRLELFTCIPKNVTQPLLD
SVYSAVLMSATLRPFEMVRSTLGISREVEEITYGTTFPQERRLTLAVSVPPLFAKNRDSPETLEGLREALLAATAASPGN
VIIYFQSYAEALRYTKLLEPELSIPIFLDEVGVSAQEIRPKFFKIGEQGGKAVLITYLWGTLSEGVDFRDSRGRTVIVVG
VGYPALNDRIKAVESAYDTVFGCGEGWEFAVQVPTIRKVRQAMGRVVRSPGDFGVRILLDARYQGSQVRKLGKFSVFGYF
PPEESREFIDVAPKDVGSLVEEFFANTLPYNPEKIETEKKEPESPASGRLEFGSLAEKL

Specific function: Unknown

COG id: COG1199

COG function: function code KL; Rad3-related DNA helicases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17506821, Length=577, Percent_Identity=22.3570190641248, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321019, Length=258, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24639946, Length=282, Percent_Identity=26.5957446808511, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI18543219, Length=308, Percent_Identity=25, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010614
- InterPro:   IPR014013
- InterPro:   IPR006555
- InterPro:   IPR001650 [H]

Pfam domain/function: PF06733 DEAD_2 [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 88557; Mature: 88557

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQKNGYMRYFTKKSCYPNQSEAMDKIHSALQNEKIVLFEGACGTGKTLSALAPALHAGK
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCC
KLNKVVIIVTNVHQQMVQFINEARDINRDNSIKTIVFKGKASMCPDNLDYEECRLKGENT
CCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCC
YDLLDFEREVSSKEKELKDAFEKHKKSKDPALYILRNELEKELDEARKKAQSLRNHSCSR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHH
LYEVLKFESSEFSSWLFSDVRSPEEIMEYAEDRGMCGYELLKKELKNTELLICNFHHVLS
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEHHHHHH
ADIFMTLLKWLERDPEDVILIFDEAHNIEASARSHSSIMLSELTVEKALSEVGEIPEPES
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SPVFGGGSFSGTGIPLDEDYASRIYARRLFSCLLTAIRDTYDSKLKFGERNRLGKHWQDI
CCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
QISDPYERHDVLKARFLRDAQKEGFADEETVLTRLREIGEFGGRLEEIYAENYKKGLLSV
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKRSQIRYVADFLSSYLVLSDRQNYYPILNMRRDFKSDRVVGRLELFTCIPKNVTQPLLD
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHH
SVYSAVLMSATLRPFEMVRSTLGISREVEEITYGTTFPQERRLTLAVSVPPLFAKNRDSP
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECCCHHCCCCCCH
ETLEGLREALLAATAASPGNVIIYFQSYAEALRYTKLLEPELSIPIFLDEVGVSAQEIRP
HHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHCH
KFFKIGEQGGKAVLITYLWGTLSEGVDFRDSRGRTVIVVGVGYPALNDRIKAVESAYDTV
HHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
FGCGEGWEFAVQVPTIRKVRQAMGRVVRSPGDFGVRILLDARYQGSQVRKLGKFSVFGYF
EECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCEEEEECC
PPEESREFIDVAPKDVGSLVEEFFANTLPYNPEKIETEKKEPESPASGRLEFGSLAEKL
CCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MMQKNGYMRYFTKKSCYPNQSEAMDKIHSALQNEKIVLFEGACGTGKTLSALAPALHAGK
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCC
KLNKVVIIVTNVHQQMVQFINEARDINRDNSIKTIVFKGKASMCPDNLDYEECRLKGENT
CCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCCC
YDLLDFEREVSSKEKELKDAFEKHKKSKDPALYILRNELEKELDEARKKAQSLRNHSCSR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHH
LYEVLKFESSEFSSWLFSDVRSPEEIMEYAEDRGMCGYELLKKELKNTELLICNFHHVLS
HHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEHHHHHH
ADIFMTLLKWLERDPEDVILIFDEAHNIEASARSHSSIMLSELTVEKALSEVGEIPEPES
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SPVFGGGSFSGTGIPLDEDYASRIYARRLFSCLLTAIRDTYDSKLKFGERNRLGKHWQDI
CCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
QISDPYERHDVLKARFLRDAQKEGFADEETVLTRLREIGEFGGRLEEIYAENYKKGLLSV
CCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKRSQIRYVADFLSSYLVLSDRQNYYPILNMRRDFKSDRVVGRLELFTCIPKNVTQPLLD
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHH
SVYSAVLMSATLRPFEMVRSTLGISREVEEITYGTTFPQERRLTLAVSVPPLFAKNRDSP
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEEECCCHHCCCCCCH
ETLEGLREALLAATAASPGNVIIYFQSYAEALRYTKLLEPELSIPIFLDEVGVSAQEIRP
HHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHCH
KFFKIGEQGGKAVLITYLWGTLSEGVDFRDSRGRTVIVVGVGYPALNDRIKAVESAYDTV
HHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
FGCGEGWEFAVQVPTIRKVRQAMGRVVRSPGDFGVRILLDARYQGSQVRKLGKFSVFGYF
EECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHCEEEEECC
PPEESREFIDVAPKDVGSLVEEFFANTLPYNPEKIETEKKEPESPASGRLEFGSLAEKL
CCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11029001 [H]