Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 21227679

GI number: 21227679

Start: 1878709

End: 1879581

Strand: Reverse

Name: nadC [H]

Synonym: MM_1577

Alternate gene names: 21227679

Gene position: 1879581-1878709 (Counterclockwise)

Preceding gene: 21227680

Following gene: 21227678

Centisome position: 45.88

GC content: 45.82

Gene sequence:

>873_bases
ATGTTAAAGATCCGCAGTAAAGAAAATATCAGAAAAACATCAAAAATAGAAACAAAAAGTAAGGAATTTTCGAGGCAAAA
CATGATAGACCTTTTTGATCTCTACTTTTACGAAGACTGCCCCTATCAGGATGAAAGCGCAGAACTGCTCAGGCTTGTGG
GCAGGGGGAAAATGAGGATTGTTTCGAGGGAGAACGGGACCTCTGCCTGTGCCGGCGACCTTGCAGGATATTATGAGAAA
AAAGGGCTGAAAGTCCTGAATTACTTCAGGGACGGGGAAAATTTCAAGCCCGGAGATGCAATTTTCGAAGCAGAAGGAGA
CATCAAACTTATATTCAGATTCTGGAGAGTTTCCCAGACATTTCTGACCATGATGTGCGCCATTGCCACGAAAACAGCCT
CTATGGTCAGTGAGGCCCGAAGAACTAATCCTGATATTATTATTGCAACGAGCCGGAAGACGCACCCAGGGGCCCGGATA
TTTGAGCTTAAAGCAGTCCGGGCAGGCGGAGGAGATATCCACAGGAATTCCCTCAGCGACTCCATTCAGATAAGCCAGAA
CCACCTGGAAGTTGCAGGGGAACTGGGAAAGCTCAGGGCTATGAAAAAGATAGAAATCGAGCCCAGATCGAGAGAAGAAG
CATTCAAATATGCTGAAATGTCGGACATAATGCTCCTTGATCATCTTTCCCCGGAAGAACTGAGGGAACTCGGACCAGAA
CTCAAGGAACTTAACCCTGAACTCGAGCTTGCAGTGGGAGGAATCGAGGCAAAAAGAATCCCCGAATACGCTCCCTTTGT
TGATATTATTGTCATAAGTGCTCCCTATTACGCAAATCCTCTTGACTTTACAACGAAGATCGAAAGGCTGTAA

Upstream 100 bases:

>100_bases
AATAAGGTGAATAAGTAAGGTGAATAAGTAAGGGGAATAAGTAAGGAGAATAATGACAGGAAACAGAGAAAAAGATGTGA
AAAGCTCGTAATAAAAGAAA

Downstream 100 bases:

>100_bases
GCTGATAAATAAAAGGTGAACGCATGCCAGAAATCAAAAACATACAGGAAACCGAAAAAGAAGAAAACGGAACCCTGCCT
GTCCTCGTAACCGCGCTAAA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MLKIRSKENIRKTSKIETKSKEFSRQNMIDLFDLYFYEDCPYQDESAELLRLVGRGKMRIVSRENGTSACAGDLAGYYEK
KGLKVLNYFRDGENFKPGDAIFEAEGDIKLIFRFWRVSQTFLTMMCAIATKTASMVSEARRTNPDIIIATSRKTHPGARI
FELKAVRAGGGDIHRNSLSDSIQISQNHLEVAGELGKLRAMKKIEIEPRSREEAFKYAEMSDIMLLDHLSPEELRELGPE
LKELNPELELAVGGIEAKRIPEYAPFVDIIVISAPYYANPLDFTTKIERL

Sequences:

>Translated_290_residues
MLKIRSKENIRKTSKIETKSKEFSRQNMIDLFDLYFYEDCPYQDESAELLRLVGRGKMRIVSRENGTSACAGDLAGYYEK
KGLKVLNYFRDGENFKPGDAIFEAEGDIKLIFRFWRVSQTFLTMMCAIATKTASMVSEARRTNPDIIIATSRKTHPGARI
FELKAVRAGGGDIHRNSLSDSIQISQNHLEVAGELGKLRAMKKIEIEPRSREEAFKYAEMSDIMLLDHLSPEELRELGPE
LKELNPELELAVGGIEAKRIPEYAPFVDIIVISAPYYANPLDFTTKIERL
>Mature_290_residues
MLKIRSKENIRKTSKIETKSKEFSRQNMIDLFDLYFYEDCPYQDESAELLRLVGRGKMRIVSRENGTSACAGDLAGYYEK
KGLKVLNYFRDGENFKPGDAIFEAEGDIKLIFRFWRVSQTFLTMMCAIATKTASMVSEARRTNPDIIIATSRKTHPGARI
FELKAVRAGGGDIHRNSLSDSIQISQNHLEVAGELGKLRAMKKIEIEPRSREEAFKYAEMSDIMLLDHLSPEELRELGPE
LKELNPELELAVGGIEAKRIPEYAPFVDIIVISAPYYANPLDFTTKIERL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=273, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786299, Length=266, Percent_Identity=27.0676691729323, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321162, Length=227, Percent_Identity=29.0748898678414, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32996; Mature: 32996

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIRSKENIRKTSKIETKSKEFSRQNMIDLFDLYFYEDCPYQDESAELLRLVGRGKMRI
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEE
VSRENGTSACAGDLAGYYEKKGLKVLNYFRDGENFKPGDAIFEAEGDIKLIFRFWRVSQT
EECCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCCCCEEHHHHHHHHHH
FLTMMCAIATKTASMVSEARRTNPDIIIATSRKTHPGARIFELKAVRAGGGDIHRNSLSD
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCC
SIQISQNHLEVAGELGKLRAMKKIEIEPRSREEAFKYAEMSDIMLLDHLSPEELRELGPE
CEEECHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCEECCCCHHHHHHHCCH
LKELNPELELAVGGIEAKRIPEYAPFVDIIVISAPYYANPLDFTTKIERL
HHHCCCCEEEEECCCCHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MLKIRSKENIRKTSKIETKSKEFSRQNMIDLFDLYFYEDCPYQDESAELLRLVGRGKMRI
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEE
VSRENGTSACAGDLAGYYEKKGLKVLNYFRDGENFKPGDAIFEAEGDIKLIFRFWRVSQT
EECCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEECCCCCEEHHHHHHHHHH
FLTMMCAIATKTASMVSEARRTNPDIIIATSRKTHPGARIFELKAVRAGGGDIHRNSLSD
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCC
SIQISQNHLEVAGELGKLRAMKKIEIEPRSREEAFKYAEMSDIMLLDHLSPEELRELGPE
CEEECHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHCCCEECCCCHHHHHHHCCH
LKELNPELELAVGGIEAKRIPEYAPFVDIIVISAPYYANPLDFTTKIERL
HHHCCCCEEEEECCCCHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]