Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 21227518

GI number: 21227518

Start: 1697977

End: 1699029

Strand: Reverse

Name: purM [H]

Synonym: MM_1416

Alternate gene names: 21227518

Gene position: 1699029-1697977 (Counterclockwise)

Preceding gene: 21227519

Following gene: 21227515

Centisome position: 41.48

GC content: 47.2

Gene sequence:

>1053_bases
ATGGAAATGGAATTGAAAAAAAGCTGTAAAGCTTGCAGGAATGGTCACAGAATGAGTGAAAAGCACTTAACATACGCGGA
TTCGGGCGTGGATATTAAAGAGGAAGAAAAAACTGTCAAAACCCTTATCGACAAATTAAGTTATGTTCGAAAAGGTATAG
GAGCCCCACTTACAGGAATAGGGCACTATGCAGGGCTTCTCGACTTCGGAGAGTATGCCCTGGCAATGACAACTGACGGA
GTCGGCTCAAAAGTACTTATTGCTAATGAGATGCAGCGCTGGAACACCGTCGGAATAGACTGCATCGCAATGAATGTTAA
CGACCTTCTTGCAATAGGGGCCGAACCTGTAGCCTTTGTGGACTATCTTGCCCTGGAGAAGCATGAAGAAGGCTTTGCCG
AACAGATCGGAGAGGGACTGCTGAAAGGAGCCGAAATCTCCAGGATGTCCATTGTAGGCGGAGAGACCGCTACTCTTCCC
GATATAATTAAAGGTTTTGACCTGGCAGGCACCTGTCTCGGATACCTTAAAAAAGAGGATATTATCGAAGGAGGAAGGGT
CCGGGTAGGCGACGTAATTGTCGGCATCCCGAGTACAGGCGTCCACAGTAACGGTTACACCCTTGTGAGAAAAATCATAC
AGGAATCCGGGTACTCCTATCACGACCCCTGCCCCTATGACAGTTCAAAAACCATAGGAGATGACCTTCTTGAGCCCACG
AGGATCTATATTGAAGTCCTTGATGTCCTTAAAGCGTGTGAAGTCCACGGGCTTGCTCACATAACCGGAAGCGGGCTTTT
GAAACTGAGAAGGGTTACAAAACTCGGTTTTGATTTCTACGACCCCCTGGAGCCCCAGGAGATTTTCAAATTCCTGCGGA
AAGAAGGCGGAGTCGATGACCTTGAGATGTACAGGACCTTCAATATGGGAATGGGCTTTTTGATCATCCTTCCGGAAAAA
GACGCCGAGAAAGCTGCAGAAATAACAGGTGGAAAAATCGTAGGCAAAATCGTGGAAAGCGGGATCAGGGTTAAAGACCT
GGTAATAGAGTAA

Upstream 100 bases:

>100_bases
ATAAGCCAGGGCTCTTCCCAGTACAATATCTCTTTCGTTGTCAGGGAAGATGACGCATTTGCCGCAGTCAAGACACTGCA
CGACGAATTCGAACTTTATA

Downstream 100 bases:

>100_bases
AAATGTAAAACTTAATCCTGTATCAACTTAGAGGGAAAGAAAAGAAAAATGCTCTTTTCCCCTACGTTGAAATCTTTTCT
GCTTCTCTGCTGTGATAGCC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MEMELKKSCKACRNGHRMSEKHLTYADSGVDIKEEEKTVKTLIDKLSYVRKGIGAPLTGIGHYAGLLDFGEYALAMTTDG
VGSKVLIANEMQRWNTVGIDCIAMNVNDLLAIGAEPVAFVDYLALEKHEEGFAEQIGEGLLKGAEISRMSIVGGETATLP
DIIKGFDLAGTCLGYLKKEDIIEGGRVRVGDVIVGIPSTGVHSNGYTLVRKIIQESGYSYHDPCPYDSSKTIGDDLLEPT
RIYIEVLDVLKACEVHGLAHITGSGLLKLRRVTKLGFDFYDPLEPQEIFKFLRKEGGVDDLEMYRTFNMGMGFLIILPEK
DAEKAAEITGGKIVGKIVESGIRVKDLVIE

Sequences:

>Translated_350_residues
MEMELKKSCKACRNGHRMSEKHLTYADSGVDIKEEEKTVKTLIDKLSYVRKGIGAPLTGIGHYAGLLDFGEYALAMTTDG
VGSKVLIANEMQRWNTVGIDCIAMNVNDLLAIGAEPVAFVDYLALEKHEEGFAEQIGEGLLKGAEISRMSIVGGETATLP
DIIKGFDLAGTCLGYLKKEDIIEGGRVRVGDVIVGIPSTGVHSNGYTLVRKIIQESGYSYHDPCPYDSSKTIGDDLLEPT
RIYIEVLDVLKACEVHGLAHITGSGLLKLRRVTKLGFDFYDPLEPQEIFKFLRKEGGVDDLEMYRTFNMGMGFLIILPEK
DAEKAAEITGGKIVGKIVESGIRVKDLVIE
>Mature_350_residues
MEMELKKSCKACRNGHRMSEKHLTYADSGVDIKEEEKTVKTLIDKLSYVRKGIGAPLTGIGHYAGLLDFGEYALAMTTDG
VGSKVLIANEMQRWNTVGIDCIAMNVNDLLAIGAEPVAFVDYLALEKHEEGFAEQIGEGLLKGAEISRMSIVGGETATLP
DIIKGFDLAGTCLGYLKKEDIIEGGRVRVGDVIVGIPSTGVHSNGYTLVRKIIQESGYSYHDPCPYDSSKTIGDDLLEPT
RIYIEVLDVLKACEVHGLAHITGSGLLKLRRVTKLGFDFYDPLEPQEIFKFLRKEGGVDDLEMYRTFNMGMGFLIILPEK
DAEKAAEITGGKIVGKIVESGIRVKDLVIE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=318, Percent_Identity=39.3081761006289, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI209869995, Length=318, Percent_Identity=39.3081761006289, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI209869993, Length=318, Percent_Identity=39.3081761006289, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1788845, Length=324, Percent_Identity=39.8148148148148, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17567511, Length=319, Percent_Identity=35.7366771159875, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321203, Length=334, Percent_Identity=36.8263473053892, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24582400, Length=261, Percent_Identity=36.7816091954023, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38310; Mature: 38310

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMELKKSCKACRNGHRMSEKHLTYADSGVDIKEEEKTVKTLIDKLSYVRKGIGAPLTGI
CCCHHHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
GHYAGLLDFGEYALAMTTDGVGSKVLIANEMQRWNTVGIDCIAMNVNDLLAIGAEPVAFV
HHHHHHHHHCCEEEEEEECCCCCEEEEHHHHHHCCCCCEEEEEECHHHHHHCCCCHHHHH
DYLALEKHEEGFAEQIGEGLLKGAEISRMSIVGGETATLPDIIKGFDLAGTCLGYLKKED
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHH
IIEGGRVRVGDVIVGIPSTGVHSNGYTLVRKIIQESGYSYHDPCPYDSSKTIGDDLLEPT
HCCCCCEEECEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCHH
RIYIEVLDVLKACEVHGLAHITGSGLLKLRRVTKLGFDFYDPLEPQEIFKFLRKEGGVDD
HHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCH
LEMYRTFNMGMGFLIILPEKDAEKAAEITGGKIVGKIVESGIRVKDLVIE
HHHHHHHCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHCCCCHHHEECC
>Mature Secondary Structure
MEMELKKSCKACRNGHRMSEKHLTYADSGVDIKEEEKTVKTLIDKLSYVRKGIGAPLTGI
CCCHHHHHHHHHHCCCCCCHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
GHYAGLLDFGEYALAMTTDGVGSKVLIANEMQRWNTVGIDCIAMNVNDLLAIGAEPVAFV
HHHHHHHHHCCEEEEEEECCCCCEEEEHHHHHHCCCCCEEEEEECHHHHHHCCCCHHHHH
DYLALEKHEEGFAEQIGEGLLKGAEISRMSIVGGETATLPDIIKGFDLAGTCLGYLKKED
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHH
IIEGGRVRVGDVIVGIPSTGVHSNGYTLVRKIIQESGYSYHDPCPYDSSKTIGDDLLEPT
HCCCCCEEECEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCHH
RIYIEVLDVLKACEVHGLAHITGSGLLKLRRVTKLGFDFYDPLEPQEIFKFLRKEGGVDD
HHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCH
LEMYRTFNMGMGFLIILPEKDAEKAAEITGGKIVGKIVESGIRVKDLVIE
HHHHHHHCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]