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The map label for this gene is cobB [H]

Identifier: 21227496

GI number: 21227496

Start: 1677516

End: 1678868

Strand: Direct

Name: cobB [H]

Synonym: MM_1394

Alternate gene names: 21227496

Gene position: 1677516-1678868 (Clockwise)

Preceding gene: 21227493

Following gene: 21227497

Centisome position: 40.95

GC content: 47.23

Gene sequence:

>1353_bases
TTGATATATATTAATCTGTACAATAGTAACCAAATGACAAAAGGAATACTTATTGCAGGAACCCATAGCGGTGTTGGAAA
AACAACAGTCTCAATGGGTATTATGGCTGCCCTCAAGCACAGGCAGTTAAAAGTCCAGCCCTATAAAGTAGGCCCTGATT
ACATTGACCCTTCCCATCACACTGCCATTTGCGGGCGCCCCTCCCGAAACCTGGATACTTACCTGATGGGCACGGAAGGT
GTCAGGCAGACAGTTGCCCGCACATCTGCAGACGCTGATATTGCTGTCGTTGAAGGGGTTATGGGTCTTTTTGACGGAAT
TGATTCTACGGAAGTTGCGAGCTCAGCTCACGTAGCAAAGACTCTGGACATACCTGTCATACTGGTAATCAATGTCCATG
GTATGTCCAGAAGTGCCGCAGCCCTTCTGAAAGGTTATTCCGAGTTCGATCCAGAAGTCCGGGTTGCAGGTGTCATCCTG
AACCAGGTAGGAAGCCCCCGCCATGCCGAACTTGTAAAAAATTCGCTTCCTGGCAACATTCCGATTATCGGAACAATTCC
CAGAAGAAAGGATATTGAAGTCCCTTCAAGGCACCTTGGGCTTTATATGGCACACGAAAAGGACTACAATACCGCAGAAA
TGGCAGCATTTATTGAAGAAAACGTTGACCTGGATGCAGTTCTTGAACTTGCTGAACCCTGTTCTGTTTCTGAAGCCGAA
GTAGTCCAGAGTCTGGATACGGATCTAAAGATCGGAGTTGCCTGGGACCCTGCTTTCTGTTTCTACTACCGTGATATGTT
TGACGCATTTAGAGATAACGGCGGAGAAGTTGTATTTTTTAGCCCTATGACAGGGGAAGTCCCGGATGTTGATGGAATTT
ATCTCGGGGGAGGCTATCCAGAGCTTTACGCAGAAACTCTCGAGAATTCGGAGACTACACAGAAATTAAAAGGGCTTGCA
GCTGATGGTTTGCCTATCTATGCAGAATGCGGTGGCTTGCTCTATCTCTGCGGGACCTACGAGGTCGATGACCGCTTTTA
TAAACTGGCTGATGTCGTGCCCGCAAATACTCGCATGACAAACCGGCTGAAAGCTCTCGGATATACCGAAGCCCGACCTC
TTGACAAAAATTTCTCTTCGCGCAATATCAGGGGCCATGAGTTCCATTACTCCATTACGGAGTGCGACAGGGATGCAAAA
TTCGCATATGAAATGATCCGCGGGAAAGGTATACAGGACGGCTTTGACGGTCTTATAGAGCACAATACCCTTGCGGGGTA
TATGCATTCTCATCCTGCCAGCTTCCCTGTAGATAAATTCGTGCAAAAATGCAGGGAATACAGAAAAAGGTAA

Upstream 100 bases:

>100_bases
TCTGGTTCTATTCTCTCTGTTTTTTAAGTTTGCTTTTCCAGGTTTACTCCTTAATATTTGTCTTTTCGGTAAACGGTTGC
TGTTCTCCTTAACAGCCGAA

Downstream 100 bases:

>100_bases
AGTGAAAGAAAAAAGGTAAAATGAAGGAAAAAAGGTAAAATGAAGGAAAAAAGTAAAAAAACCTTTTTTAAATTTCCTCT
TCAAATCTTTTTCTTTAAAT

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIYINLYNSNQMTKGILIAGTHSGVGKTTVSMGIMAALKHRQLKVQPYKVGPDYIDPSHHTAICGRPSRNLDTYLMGTEG
VRQTVARTSADADIAVVEGVMGLFDGIDSTEVASSAHVAKTLDIPVILVINVHGMSRSAAALLKGYSEFDPEVRVAGVIL
NQVGSPRHAELVKNSLPGNIPIIGTIPRRKDIEVPSRHLGLYMAHEKDYNTAEMAAFIEENVDLDAVLELAEPCSVSEAE
VVQSLDTDLKIGVAWDPAFCFYYRDMFDAFRDNGGEVVFFSPMTGEVPDVDGIYLGGGYPELYAETLENSETTQKLKGLA
ADGLPIYAECGGLLYLCGTYEVDDRFYKLADVVPANTRMTNRLKALGYTEARPLDKNFSSRNIRGHEFHYSITECDRDAK
FAYEMIRGKGIQDGFDGLIEHNTLAGYMHSHPASFPVDKFVQKCREYRKR

Sequences:

>Translated_450_residues
MIYINLYNSNQMTKGILIAGTHSGVGKTTVSMGIMAALKHRQLKVQPYKVGPDYIDPSHHTAICGRPSRNLDTYLMGTEG
VRQTVARTSADADIAVVEGVMGLFDGIDSTEVASSAHVAKTLDIPVILVINVHGMSRSAAALLKGYSEFDPEVRVAGVIL
NQVGSPRHAELVKNSLPGNIPIIGTIPRRKDIEVPSRHLGLYMAHEKDYNTAEMAAFIEENVDLDAVLELAEPCSVSEAE
VVQSLDTDLKIGVAWDPAFCFYYRDMFDAFRDNGGEVVFFSPMTGEVPDVDGIYLGGGYPELYAETLENSETTQKLKGLA
ADGLPIYAECGGLLYLCGTYEVDDRFYKLADVVPANTRMTNRLKALGYTEARPLDKNFSSRNIRGHEFHYSITECDRDAK
FAYEMIRGKGIQDGFDGLIEHNTLAGYMHSHPASFPVDKFVQKCREYRKR
>Mature_450_residues
MIYINLYNSNQMTKGILIAGTHSGVGKTTVSMGIMAALKHRQLKVQPYKVGPDYIDPSHHTAICGRPSRNLDTYLMGTEG
VRQTVARTSADADIAVVEGVMGLFDGIDSTEVASSAHVAKTLDIPVILVINVHGMSRSAAALLKGYSEFDPEVRVAGVIL
NQVGSPRHAELVKNSLPGNIPIIGTIPRRKDIEVPSRHLGLYMAHEKDYNTAEMAAFIEENVDLDAVLELAEPCSVSEAE
VVQSLDTDLKIGVAWDPAFCFYYRDMFDAFRDNGGEVVFFSPMTGEVPDVDGIYLGGGYPELYAETLENSETTQKLKGLA
ADGLPIYAECGGLLYLCGTYEVDDRFYKLADVVPANTRMTNRLKALGYTEARPLDKNFSSRNIRGHEFHYSITECDRDAK
FAYEMIRGKGIQDGFDGLIEHNTLAGYMHSHPASFPVDKFVQKCREYRKR

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 49641; Mature: 49641

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYINLYNSNQMTKGILIAGTHSGVGKTTVSMGIMAALKHRQLKVQPYKVGPDYIDPSHH
CEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCC
TAICGRPSRNLDTYLMGTEGVRQTVARTSADADIAVVEGVMGLFDGIDSTEVASSAHVAK
EEECCCCCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCHHHHE
TLDIPVILVINVHGMSRSAAALLKGYSEFDPEVRVAGVILNQVGSPRHAELVKNSLPGNI
ECCCCEEEEEEECCCCHHHHHHHHCHHHCCCCCEEHHHHHHHCCCCHHHHHHHHCCCCCC
PIIGTIPRRKDIEVPSRHLGLYMAHEKDYNTAEMAAFIEENVDLDAVLELAEPCSVSEAE
CEEEECCCCCCCCCCHHHCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
VVQSLDTDLKIGVAWDPAFCFYYRDMFDAFRDNGGEVVFFSPMTGEVPDVDGIYLGGGYP
HHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEECCCCH
ELYAETLENSETTQKLKGLAADGLPIYAECGGLLYLCGTYEVDDRFYKLADVVPANTRMT
HHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCEEEEEECEEHHHHHHHHHHCCCCCCHHH
NRLKALGYTEARPLDKNFSSRNIRGHEFHYSITECDRDAKFAYEMIRGKGIQDGFDGLIE
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
HNTLAGYMHSHPASFPVDKFVQKCREYRKR
CCHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIYINLYNSNQMTKGILIAGTHSGVGKTTVSMGIMAALKHRQLKVQPYKVGPDYIDPSHH
CEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCC
TAICGRPSRNLDTYLMGTEGVRQTVARTSADADIAVVEGVMGLFDGIDSTEVASSAHVAK
EEECCCCCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCHHHHE
TLDIPVILVINVHGMSRSAAALLKGYSEFDPEVRVAGVILNQVGSPRHAELVKNSLPGNI
ECCCCEEEEEEECCCCHHHHHHHHCHHHCCCCCEEHHHHHHHCCCCHHHHHHHHCCCCCC
PIIGTIPRRKDIEVPSRHLGLYMAHEKDYNTAEMAAFIEENVDLDAVLELAEPCSVSEAE
CEEEECCCCCCCCCCHHHCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
VVQSLDTDLKIGVAWDPAFCFYYRDMFDAFRDNGGEVVFFSPMTGEVPDVDGIYLGGGYP
HHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEECCCCH
ELYAETLENSETTQKLKGLAADGLPIYAECGGLLYLCGTYEVDDRFYKLADVVPANTRMT
HHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCEEEEEECEEHHHHHHHHHHCCCCCCHHH
NRLKALGYTEARPLDKNFSSRNIRGHEFHYSITECDRDAKFAYEMIRGKGIQDGFDGLIE
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCHHHHHHH
HNTLAGYMHSHPASFPVDKFVQKCREYRKR
CCHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA