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The map label for this gene is glcD [H]

Identifier: 21227393

GI number: 21227393

Start: 1532465

End: 1533847

Strand: Reverse

Name: glcD [H]

Synonym: MM_1291

Alternate gene names: 21227393

Gene position: 1533847-1532465 (Counterclockwise)

Preceding gene: 21227396

Following gene: 21227392

Centisome position: 37.44

GC content: 50.47

Gene sequence:

>1383_bases
TTGAGGTCTATAATGAATATAACTGAAGAGCTTAGAAAAATCGTTGGTGGGCGGCTCTCGGTCTCGCCTTCTGAACTTTA
TTGTTATTCTTCTGACGCATCCCAGGTCAAGGGGATGCCTGATTACGTGGTGCGTCCTGAAAGCACCGACGAGGTCAGCC
GCATTTTGAGGCTTGCCTATGAAAATGAAATCCCGGTTACTGCAAGGGGCGCAGGCACAGGTCTTGCCGGCGGAGCTGTC
CCGGTCAGTGGGGGCATTGTGCTGGATATGTCGGGAATGAATCGTATTCTCGAAATTGATATTGACAATATCCAGGTAGT
CGTGGAGCCCGGAATGATCCAGGACGCCCTTAACGACGCTTTAAAACCATACGGATTTTTCTTTCCCCCTAACCCGGGCA
GCTCTGCAATGTGCACCATCGGGGGCATGATAGCTTATAATGCAAGTGGGATGCGCTGCGTTAAGTACGGAACAACCAGA
AACTACGTCCGCGACCTTGAAGTGGTGCTTGCGGACGGGACTGTTATCCACACAGGCTCAAAAATGCTAAAATCAGCTGC
CGGGTATGACCTGACACAGCTTATAATAGGATCTGAAGGCACGCTTGGAATTGTCACGAAAGCCAGCCTGAAGATCGCCC
CTCTTCCGAAGACACGCAAACTTGTGATCGCCTCCTTTAAAAGTGCGGAGGTTGCAGGACAGGCAGTTGTAAAGACTTTT
TCAAACGGAGTTATTCCATCAGCCTGTGAGATCCTTGACCGGGTTTCCCTGCAGGTGCTTAAACGTTATGACCCGAAACT
TGTGCTCCCCTCTGAAGGTGATGTCATCCTTTTCGAGGTCGACGGCACTGAAAACTCGGCTCGTGAGGCAGCAGAGCAGA
TAATAGAAGTTTGCTCTCCTCTGACCCTTTCCATAAAGCTTGCAGAAAGCGAAAAGGAAATGGCAGATATCTGGGCAGCA
AGGAAGCTGGTAGGCGCAGCAGTTTCTCGCCTTGACCCTACAAAAACCAGGATTTATGTAGGTGAAGATGTAGGGGTTCC
TATTAAGAAGATCCCGGAACTGCTCAGGAGGGCACAGGAGATTTCCGAGAAATTTAACCTGCCTGCAATGAAATACGGGC
ATATAGGAGACGGAAACCTTCACCTAGCCCTTTTCATTGATGTCCTGAATGAAGATGAGTGGGACCGCCTTAACCGGGCT
GCAGATCTTGTCCACAGGACTGCAATAGAGCTTGGGGGCACGGTCAGTTCCGAACACGGTGTCGGTGCAGCCAGAGCCGA
ATACATGGAAGCCCAGTGGGGACCTGCTATTGAAGTGATGCGTGCAATTAAGAAAGCCCTTGACCCAAAGGGAATCCTGA
ATCCGGGTAAACTGGGGCTGTAA

Upstream 100 bases:

>100_bases
ATTCTTATATATTATTAATATTGATTATCTGCTGCAAATTATCTCTCATTTCTGTCCCAACCGTGACAGACTTTCTATTT
TTCACATCTGAATTCTACAT

Downstream 100 bases:

>100_bases
AAATTATGAAAAACGAAGTAAAAAATGAAGAAGTAAAAAATGAAACCGGGAGGGCAGAGAAATTGAACAAAAAAGAAACA
GGCGAGAAAAGCAAAAAGCT

Product: (S)-2-hydroxy-acid dehydrogenase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MRSIMNITEELRKIVGGRLSVSPSELYCYSSDASQVKGMPDYVVRPESTDEVSRILRLAYENEIPVTARGAGTGLAGGAV
PVSGGIVLDMSGMNRILEIDIDNIQVVVEPGMIQDALNDALKPYGFFFPPNPGSSAMCTIGGMIAYNASGMRCVKYGTTR
NYVRDLEVVLADGTVIHTGSKMLKSAAGYDLTQLIIGSEGTLGIVTKASLKIAPLPKTRKLVIASFKSAEVAGQAVVKTF
SNGVIPSACEILDRVSLQVLKRYDPKLVLPSEGDVILFEVDGTENSAREAAEQIIEVCSPLTLSIKLAESEKEMADIWAA
RKLVGAAVSRLDPTKTRIYVGEDVGVPIKKIPELLRRAQEISEKFNLPAMKYGHIGDGNLHLALFIDVLNEDEWDRLNRA
ADLVHRTAIELGGTVSSEHGVGAARAEYMEAQWGPAIEVMRAIKKALDPKGILNPGKLGL

Sequences:

>Translated_460_residues
MRSIMNITEELRKIVGGRLSVSPSELYCYSSDASQVKGMPDYVVRPESTDEVSRILRLAYENEIPVTARGAGTGLAGGAV
PVSGGIVLDMSGMNRILEIDIDNIQVVVEPGMIQDALNDALKPYGFFFPPNPGSSAMCTIGGMIAYNASGMRCVKYGTTR
NYVRDLEVVLADGTVIHTGSKMLKSAAGYDLTQLIIGSEGTLGIVTKASLKIAPLPKTRKLVIASFKSAEVAGQAVVKTF
SNGVIPSACEILDRVSLQVLKRYDPKLVLPSEGDVILFEVDGTENSAREAAEQIIEVCSPLTLSIKLAESEKEMADIWAA
RKLVGAAVSRLDPTKTRIYVGEDVGVPIKKIPELLRRAQEISEKFNLPAMKYGHIGDGNLHLALFIDVLNEDEWDRLNRA
ADLVHRTAIELGGTVSSEHGVGAARAEYMEAQWGPAIEVMRAIKKALDPKGILNPGKLGL
>Mature_460_residues
MRSIMNITEELRKIVGGRLSVSPSELYCYSSDASQVKGMPDYVVRPESTDEVSRILRLAYENEIPVTARGAGTGLAGGAV
PVSGGIVLDMSGMNRILEIDIDNIQVVVEPGMIQDALNDALKPYGFFFPPNPGSSAMCTIGGMIAYNASGMRCVKYGTTR
NYVRDLEVVLADGTVIHTGSKMLKSAAGYDLTQLIIGSEGTLGIVTKASLKIAPLPKTRKLVIASFKSAEVAGQAVVKTF
SNGVIPSACEILDRVSLQVLKRYDPKLVLPSEGDVILFEVDGTENSAREAAEQIIEVCSPLTLSIKLAESEKEMADIWAA
RKLVGAAVSRLDPTKTRIYVGEDVGVPIKKIPELLRRAQEISEKFNLPAMKYGHIGDGNLHLALFIDVLNEDEWDRLNRA
ADLVHRTAIELGGTVSSEHGVGAARAEYMEAQWGPAIEVMRAIKKALDPKGILNPGKLGL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=462, Percent_Identity=34.8484848484849, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI37595754, Length=485, Percent_Identity=32.9896907216495, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI119964728, Length=459, Percent_Identity=32.0261437908497, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4501993, Length=233, Percent_Identity=30.0429184549356, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1789351, Length=437, Percent_Identity=34.324942791762, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1787977, Length=532, Percent_Identity=28.9473684210526, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI48994907, Length=482, Percent_Identity=25.9336099585062, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI48994914, Length=140, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71992373, Length=459, Percent_Identity=33.5511982570806, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71992381, Length=459, Percent_Identity=32.4618736383442, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71992392, Length=359, Percent_Identity=34.5403899721448, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17534361, Length=454, Percent_Identity=30.3964757709251, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17556096, Length=468, Percent_Identity=25.2136752136752, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320027, Length=473, Percent_Identity=30.2325581395349, Blast_Score=215, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6320023, Length=460, Percent_Identity=30.8695652173913, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6320764, Length=483, Percent_Identity=29.6066252587992, Blast_Score=182, Evalue=9e-47,
Organism=Drosophila melanogaster, GI18921117, Length=435, Percent_Identity=30.1149425287356, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24639277, Length=435, Percent_Identity=30.1149425287356, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24639275, Length=435, Percent_Identity=30.1149425287356, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24653753, Length=206, Percent_Identity=33.0097087378641, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 49552; Mature: 49552

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSIMNITEELRKIVGGRLSVSPSELYCYSSDASQVKGMPDYVVRPESTDEVSRILRLAY
CCHHHHHHHHHHHHHCCCEECCCCCEEEECCCHHHHCCCCCEEECCCCHHHHHHHHHHHH
ENEIPVTARGAGTGLAGGAVPVSGGIVLDMSGMNRILEIDIDNIQVVVEPGMIQDALNDA
CCCCCEEECCCCCCCCCCCEEECCCEEEEECCCCEEEEEEECCEEEEECCCHHHHHHHHH
LKPYGFFFPPNPGSSAMCTIGGMIAYNASGMRCVKYGTTRNYVRDLEVVLADGTVIHTGS
HCCCCEEECCCCCCCCEEEECCEEEECCCCCEEEEECCCHHHHHEEEEEEECCEEEECCH
KMLKSAAGYDLTQLIIGSEGTLGIVTKASLKIAPLPKTRKLVIASFKSAEVAGQAVVKTF
HHHHHHCCCCEEEEEECCCCCEEEEEECCEEEECCCCCCEEEEEECCCHHHHHHHHHHHH
SNGVIPSACEILDRVSLQVLKRYDPKLVLPSEGDVILFEVDGTENSAREAAEQIIEVCSP
HCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
LTLSIKLAESEKEMADIWAARKLVGAAVSRLDPTKTRIYVGEDVGVPIKKIPELLRRAQE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
ISEKFNLPAMKYGHIGDGNLHLALFIDVLNEDEWDRLNRAADLVHRTAIELGGTVSSEHG
HHHHHCCCCEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VGAARAEYMEAQWGPAIEVMRAIKKALDPKGILNPGKLGL
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRSIMNITEELRKIVGGRLSVSPSELYCYSSDASQVKGMPDYVVRPESTDEVSRILRLAY
CCHHHHHHHHHHHHHCCCEECCCCCEEEECCCHHHHCCCCCEEECCCCHHHHHHHHHHHH
ENEIPVTARGAGTGLAGGAVPVSGGIVLDMSGMNRILEIDIDNIQVVVEPGMIQDALNDA
CCCCCEEECCCCCCCCCCCEEECCCEEEEECCCCEEEEEEECCEEEEECCCHHHHHHHHH
LKPYGFFFPPNPGSSAMCTIGGMIAYNASGMRCVKYGTTRNYVRDLEVVLADGTVIHTGS
HCCCCEEECCCCCCCCEEEECCEEEECCCCCEEEEECCCHHHHHEEEEEEECCEEEECCH
KMLKSAAGYDLTQLIIGSEGTLGIVTKASLKIAPLPKTRKLVIASFKSAEVAGQAVVKTF
HHHHHHCCCCEEEEEECCCCCEEEEEECCEEEECCCCCCEEEEEECCCHHHHHHHHHHHH
SNGVIPSACEILDRVSLQVLKRYDPKLVLPSEGDVILFEVDGTENSAREAAEQIIEVCSP
HCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCC
LTLSIKLAESEKEMADIWAARKLVGAAVSRLDPTKTRIYVGEDVGVPIKKIPELLRRAQE
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
ISEKFNLPAMKYGHIGDGNLHLALFIDVLNEDEWDRLNRAADLVHRTAIELGGTVSSEHG
HHHHHCCCCEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
VGAARAEYMEAQWGPAIEVMRAIKKALDPKGILNPGKLGL
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]