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The map label for this gene is hdrD [H]

Identifier: 21227392

GI number: 21227392

Start: 1531296

End: 1532459

Strand: Reverse

Name: hdrD [H]

Synonym: MM_1290

Alternate gene names: 21227392

Gene position: 1532459-1531296 (Counterclockwise)

Preceding gene: 21227393

Following gene: 21227391

Centisome position: 37.41

GC content: 48.8

Gene sequence:

>1164_bases
ATGAAAAACGAAGTAAAAAATGAAGAAGTAAAAAATGAAACCGGGAGGGCAGAGAAATTGAACAAAAAAGAAACAGGCGA
GAAAAGCAAAAAGCTGCCCTTTGAAGTTGACCGCCGTTCGGTTTATAAATGCGTGCAGTGCGGAACCTGTCGTTCAGTCT
GTCCTGTCTTTGACGTTGTCGGCTGGGAGTCTGCCAACACACGTGGAAGAATGCTTATTATTAAAAGCCTGATCGAAGGG
AGGCCGCCGTCTGAAGATGTCCTTTCGAGCCTTGCTTCCTGCACTACCTGCGGGATCTGCGCTGCTAAATGCCCTGCCGG
AGCCAATCCTCCAGAAGTAGTGGAAGCTGCCCGTGCCCAGCTGGTAAAATGCGGTGTGACAACAGATGCCCAGGAAAAAT
TGAGGTCAGCAGTTGCGACCAGCGGCAATTCGTTCGGTGAAACCAGAAGCCGACTACACTGGCTTTCTGATTCGGAACGC
TCAACACTCCCTGAGAAGTCGGATTACGTGTACTTTGTAGGTTGTTTTGACTCTTACCGCTATCCGGAATTTGCAAAAAA
GACCTTTGAGGTTTTGCAGCACTTTGGGGTAACCCTCCTGCCGGATGAGCAGTGCTGTTCATCTCCCCTTCTCCGCACCG
GTTTCCGGGAAGACGCGGAAAAGATTATGGAGCACAACCTTGAGCAGATAAGAAATGTGGGAGCACACACCCTTATTACA
GGCTGTGCAGGCTGCTACACCACCCTCAAGAACAATTATCCTGAAGAATTGAGAGTCATCAGTCTACCTGAGTTCCTTGC
CGAGCACCTTGAAGAACTCAACCTGAAACGCCTTGACCTTTCAGTTACATATCATGACCCCTGCCACCTGGGCAGGCATA
ATAAGGTCTATGATGCTCCCAGAAAAGTTATTCAGGCAATCTGCAATCTTAAGGAAATGAAAAACATCAAAGAAAACTCC
CGCTGCTGCGGCGGTGGGGGCGGAGTCAGGATAGGATATCCGGATATCTCCCTAGAACTTGCCAGAAACAGGCTCGACGA
TGTGCCTGAAGGCGTTGACTACATAGTGACATCCTGTCCTCTCTGTGTGAGGAATCTCAGAGATGCAGGCGGAAATATCG
AGATAATCGATATTATAGAACTCGTGGCAATGGCGATGCAATAA

Upstream 100 bases:

>100_bases
AAGCCCAGTGGGGACCTGCTATTGAAGTGATGCGTGCAATTAAGAAAGCCCTTGACCCAAAGGGAATCCTGAATCCGGGT
AAACTGGGGCTGTAAAAATT

Downstream 100 bases:

>100_bases
GGTCGGTTCTTCATTGTTTAGCCACTCTGATTTCAGTTATGGCTTTGAGCTGTTGTTTTCTCTCAGCTCCACCTTAACTC
CGGGCCGGTTTTGTCCGGCT

Product: Fe-S oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKNEVKNEEVKNETGRAEKLNKKETGEKSKKLPFEVDRRSVYKCVQCGTCRSVCPVFDVVGWESANTRGRMLIIKSLIEG
RPPSEDVLSSLASCTTCGICAAKCPAGANPPEVVEAARAQLVKCGVTTDAQEKLRSAVATSGNSFGETRSRLHWLSDSER
STLPEKSDYVYFVGCFDSYRYPEFAKKTFEVLQHFGVTLLPDEQCCSSPLLRTGFREDAEKIMEHNLEQIRNVGAHTLIT
GCAGCYTTLKNNYPEELRVISLPEFLAEHLEELNLKRLDLSVTYHDPCHLGRHNKVYDAPRKVIQAICNLKEMKNIKENS
RCCGGGGGVRIGYPDISLELARNRLDDVPEGVDYIVTSCPLCVRNLRDAGGNIEIIDIIELVAMAMQ

Sequences:

>Translated_387_residues
MKNEVKNEEVKNETGRAEKLNKKETGEKSKKLPFEVDRRSVYKCVQCGTCRSVCPVFDVVGWESANTRGRMLIIKSLIEG
RPPSEDVLSSLASCTTCGICAAKCPAGANPPEVVEAARAQLVKCGVTTDAQEKLRSAVATSGNSFGETRSRLHWLSDSER
STLPEKSDYVYFVGCFDSYRYPEFAKKTFEVLQHFGVTLLPDEQCCSSPLLRTGFREDAEKIMEHNLEQIRNVGAHTLIT
GCAGCYTTLKNNYPEELRVISLPEFLAEHLEELNLKRLDLSVTYHDPCHLGRHNKVYDAPRKVIQAICNLKEMKNIKENS
RCCGGGGGVRIGYPDISLELARNRLDDVPEGVDYIVTSCPLCVRNLRDAGGNIEIIDIIELVAMAMQ
>Mature_387_residues
MKNEVKNEEVKNETGRAEKLNKKETGEKSKKLPFEVDRRSVYKCVQCGTCRSVCPVFDVVGWESANTRGRMLIIKSLIEG
RPPSEDVLSSLASCTTCGICAAKCPAGANPPEVVEAARAQLVKCGVTTDAQEKLRSAVATSGNSFGETRSRLHWLSDSER
STLPEKSDYVYFVGCFDSYRYPEFAKKTFEVLQHFGVTLLPDEQCCSSPLLRTGFREDAEKIMEHNLEQIRNVGAHTLIT
GCAGCYTTLKNNYPEELRVISLPEFLAEHLEELNLKRLDLSVTYHDPCHLGRHNKVYDAPRKVIQAICNLKEMKNIKENS
RCCGGGGGVRIGYPDISLELARNRLDDVPEGVDYIVTSCPLCVRNLRDAGGNIEIIDIIELVAMAMQ

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Loosely Bound To The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Escherichia coli, GI1788576, Length=383, Percent_Identity=26.6318537859008, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI48994913, Length=385, Percent_Identity=24.4155844155844, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR004017
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: PF02754 CCG [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 43061; Mature: 43061

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00071 GAPDH ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEVKNEEVKNETGRAEKLNKKETGEKSKKLPFEVDRRSVYKCVQCGTCRSVCPVFDVV
CCCCCCHHHHHHHCCHHHHCCHHHCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
GWESANTRGRMLIIKSLIEGRPPSEDVLSSLASCTTCGICAAKCPAGANPPEVVEAARAQ
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVKCGVTTDAQEKLRSAVATSGNSFGETRSRLHWLSDSERSTLPEKSDYVYFVGCFDSYR
HHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCC
YPEFAKKTFEVLQHFGVTLLPDEQCCSSPLLRTGFREDAEKIMEHNLEQIRNVGAHTLIT
CHHHHHHHHHHHHHCCCEECCCHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHH
GCAGCYTTLKNNYPEELRVISLPEFLAEHLEELNLKRLDLSVTYHDPCHLGRHNKVYDAP
HHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHCCCEEEEEEEEECCCHHCCCCCCHHHHH
RKVIQAICNLKEMKNIKENSRCCGGGGGVRIGYPDISLELARNRLDDVPEGVDYIVTSCP
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHH
LCVRNLRDAGGNIEIIDIIELVAMAMQ
HHHHHHHHCCCCEEHHHHHHHHHHHCC
>Mature Secondary Structure
MKNEVKNEEVKNETGRAEKLNKKETGEKSKKLPFEVDRRSVYKCVQCGTCRSVCPVFDVV
CCCCCCHHHHHHHCCHHHHCCHHHCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
GWESANTRGRMLIIKSLIEGRPPSEDVLSSLASCTTCGICAAKCPAGANPPEVVEAARAQ
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVKCGVTTDAQEKLRSAVATSGNSFGETRSRLHWLSDSERSTLPEKSDYVYFVGCFDSYR
HHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCC
YPEFAKKTFEVLQHFGVTLLPDEQCCSSPLLRTGFREDAEKIMEHNLEQIRNVGAHTLIT
CHHHHHHHHHHHHHCCCEECCCHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHH
GCAGCYTTLKNNYPEELRVISLPEFLAEHLEELNLKRLDLSVTYHDPCHLGRHNKVYDAP
HHHHHHHHHHCCCHHHHEEECCHHHHHHHHHHCCCEEEEEEEEECCCHHCCCCCCHHHHH
RKVIQAICNLKEMKNIKENSRCCGGGGGVRIGYPDISLELARNRLDDVPEGVDYIVTSCP
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCCHHHHHHHHHH
LCVRNLRDAGGNIEIIDIIELVAMAMQ
HHHHHHHHCCCCEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]