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The map label for this gene is guaAA [H]

Identifier: 21227372

GI number: 21227372

Start: 1504884

End: 1505453

Strand: Reverse

Name: guaAA [H]

Synonym: MM_1270

Alternate gene names: 21227372

Gene position: 1505453-1504884 (Counterclockwise)

Preceding gene: 21227379

Following gene: 21227370

Centisome position: 36.75

GC content: 48.42

Gene sequence:

>570_bases
ATGAGAGAACTAAAAATCCTTGTTGTGAACAACTACGGGCAGTTTTGCCACCTTATTCACAGGACTGTCCGGGACCTTGA
CATGGATACAAAAATCATTCCTAATGTAACCCCCATAGAAGAGATTCTGGCAGAAGAGCCTGACGGGCTGATCCTGAGTG
GTGGCCCCGAAATGGAAAGGGCAGGCCTTTGCTTTGACTATGTGAGGGAAATAGATGTCCCTATACTTGGAATCTGCCTG
GGGCACCAGGCAATTGCTCTCGCTTACGGAGGGCATGTTCATGCAGGCAAAAAAGGAGGCTATGCCGAAATTGAAGTAGA
GGTTCTCGAAGAAGACGACATACTCAGAGGACTTGGCCCGAAAACAACTGTATGGGCCTCGCATGCTGATGAGGTAGCCA
TTCTTCCTGACGGATTTATCCATCTTGCCCGCTCGGATGTCTGCGAGATTGAAGCCATGCGCCATCCCACAAAACCGATT
TACGGCGTTCAATGGCACCCTGAGGTTTCCCACACAAAGAAGGGAGAAGAGCTGCTCATGAATTTCTTTGAAGTTTGTGA
TCTGTATTAA

Upstream 100 bases:

>100_bases
TCCTGGAAGATACAAGAATTAAAATAGGATAAGATGGGCTAATAGGATAAGCTCAGAGCGTAAGAACATTTTATATTTGT
AAACAGGAACGGAAGGAACT

Downstream 100 bases:

>100_bases
TCCGGTCATTGATCATTATTGTCGGCTCTTCGCTGTTTCGGGTAGGTAACTTGTATTTAGTCCCTAAAATGTTGAAGTTG
CATTAAATATAGTAGGACTT

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MRELKILVVNNYGQFCHLIHRTVRDLDMDTKIIPNVTPIEEILAEEPDGLILSGGPEMERAGLCFDYVREIDVPILGICL
GHQAIALAYGGHVHAGKKGGYAEIEVEVLEEDDILRGLGPKTTVWASHADEVAILPDGFIHLARSDVCEIEAMRHPTKPI
YGVQWHPEVSHTKKGEELLMNFFEVCDLY

Sequences:

>Translated_189_residues
MRELKILVVNNYGQFCHLIHRTVRDLDMDTKIIPNVTPIEEILAEEPDGLILSGGPEMERAGLCFDYVREIDVPILGICL
GHQAIALAYGGHVHAGKKGGYAEIEVEVLEEDDILRGLGPKTTVWASHADEVAILPDGFIHLARSDVCEIEAMRHPTKPI
YGVQWHPEVSHTKKGEELLMNFFEVCDLY
>Mature_189_residues
MRELKILVVNNYGQFCHLIHRTVRDLDMDTKIIPNVTPIEEILAEEPDGLILSGGPEMERAGLCFDYVREIDVPILGICL
GHQAIALAYGGHVHAGKKGGYAEIEVEVLEEDDILRGLGPKTTVWASHADEVAILPDGFIHLARSDVCEIEAMRHPTKPI
YGVQWHPEVSHTKKGEELLMNFFEVCDLY

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=181, Percent_Identity=32.0441988950276, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788854, Length=194, Percent_Identity=34.5360824742268, Blast_Score=120, Evalue=4e-29,
Organism=Escherichia coli, GI1789760, Length=184, Percent_Identity=33.1521739130435, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1787517, Length=183, Percent_Identity=31.1475409836066, Blast_Score=61, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133901714, Length=188, Percent_Identity=30.3191489361702, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=188, Percent_Identity=30.3191489361702, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=188, Percent_Identity=30.3191489361702, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323873, Length=180, Percent_Identity=38.8888888888889, Blast_Score=121, Evalue=7e-29,
Organism=Drosophila melanogaster, GI281365319, Length=194, Percent_Identity=31.9587628865979, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 21139; Mature: 21139

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00442 GATASE_TYPE_I ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELKILVVNNYGQFCHLIHRTVRDLDMDTKIIPNVTPIEEILAEEPDGLILSGGPEMER
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
AGLCFDYVREIDVPILGICLGHQAIALAYGGHVHAGKKGGYAEIEVEVLEEDDILRGLGP
CCHHHHHHHHCCCCEEEEECCCCEEEEEECCEEECCCCCCEEEEEEEEECCCCHHHCCCC
KTTVWASHADEVAILPDGFIHLARSDVCEIEAMRHPTKPIYGVQWHPEVSHTKKGEELLM
CCEEEECCCCCEEECCCCHHHHHHCCHHHHHHHCCCCCCEECEEECCCCCCCCCHHHHHH
NFFEVCDLY
HHHHHHCCC
>Mature Secondary Structure
MRELKILVVNNYGQFCHLIHRTVRDLDMDTKIIPNVTPIEEILAEEPDGLILSGGPEMER
CCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCCC
AGLCFDYVREIDVPILGICLGHQAIALAYGGHVHAGKKGGYAEIEVEVLEEDDILRGLGP
CCHHHHHHHHCCCCEEEEECCCCEEEEEECCEEECCCCCCEEEEEEEEECCCCHHHCCCC
KTTVWASHADEVAILPDGFIHLARSDVCEIEAMRHPTKPIYGVQWHPEVSHTKKGEELLM
CCEEEECCCCCEEECCCCHHHHHHCCHHHHHHHCCCCCCEECEEECCCCCCCCCHHHHHH
NFFEVCDLY
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]