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The map label for this gene is srp54 [H]

Identifier: 21227369

GI number: 21227369

Start: 1501802

End: 1503133

Strand: Direct

Name: srp54 [H]

Synonym: MM_1267

Alternate gene names: 21227369

Gene position: 1501802-1503133 (Clockwise)

Preceding gene: 21227367

Following gene: 21227371

Centisome position: 36.66

GC content: 48.05

Gene sequence:

>1332_bases
ATGGTAATGGAAAAACTCGGAGACTCCTTACAGGGAGCACTCAAAAAGCTGATCGGCGCAGGGAGAATTGATGAGCGCAC
GGTCAATGAAGTAGTAAAGGATATTCAGCGCGCTCTGCTCCAGGCTGACGTTAACGTAAAACTTGTCATGGGGATGTCGC
AGAGAATCAAAGAGCGTGCAATGAAAGAAGACCCTCCTGCGGGTATGAACCCGAGGGAGCATGTGATCCGCATTGTGTAT
CAGGAACTGATGGAAATCATCGGGAAAGGAGCCGATATCCAGCTCAAGCCCCAGACAATCATGATGGTGGGACTTCAGGG
AAGCGGAAAGACCACAAGTGCTGCAAAACTGGCACGCTATTTCCAGAGAAAGGGGCTCAAAGCAGGTGTTGTTGCCGCAG
ATACCTTCCGGCCAGGAGCTTACCACCAGCTCAAGACTCTCTCTGAAAAGCTCAATGTGGGTTTTTACGGAGAGGAAGGA
AACCCCGATGCTGTAGAGATTACCATACATGGGCTTAAAGCACTCGAAAAATACGATATAAAAATAGTGGACACAGCAGG
CAGGCACGCCCTCGAAGCCGACCTTATCGAAGAAATGGAGAGGATCCATGCCGTTGCAAAACCTGACCACAAGTTCATGG
TTCTCGACGCGGGTATAGGGCAACAGGCAAGCCAGCAGGCTCATGCTTTCAATGATTCGGTAGGGATCACGGGCGTTATC
ATCACAAAACTGGACGGAACAGCAAAAGGTGGTGGAGCGCTTTCAGCAGTATCTGAAACAAAAGCTCCGATTGCCTTTAT
AGGAGTAGGGGAAACTCCGGAAGACTTTGAAAAGTTCGAGGCTGACAGGTTCATCTCAAGACTTCTTGGAATGGGGGACC
TCAAGAGCCTGATGGAAAAGGCAGAGGAAAGCCTGAGCGAAGAAGACGTCAATGTCGAAGCCCTTATGCAGGGGCGCTTC
ACATTGAAAGATATGTACAAGCAGCTTGAAGCAATGAATAAAATGGGCCCTCTCAAGCAGATTATGTCAATGCTCCCTAT
GGGCATGGGAGGACTGGGAGGCGTGAAATTATCAGATGAGATGTTCCAGGCTACCAGTGACAAAATGAAGAATTACAAGG
TCATTATGGACTCGATGACAGAAGATGAAATGGCTGACCCCAAGCTAATAGGCGGATCACGGATCAAAAGAATATCAAGA
GGCTCTGGCTGCAGTCCTGAAGATGTCAGGGAACTTCTAAAATATCATAAAACCATGCAGACGGCTTTGAAAGGCTTCAG
AGGCGGAAAATTCAATATCCAGAAAATGATGAAGAAGAAAATGGGGATGTAA

Upstream 100 bases:

>100_bases
CGGAAAACAACTTTGTACGCAGACGAATAAGTTAAACTCAAGATATTAAATTTAATCTATCCTTTTATCCATCCTCAAAA
TTTAGCAGGACGATTCTCAT

Downstream 100 bases:

>100_bases
TAATCCCCGAGTTCTTTTTTAGTGTTATTTTTCAATACTAAAATTTTTAGAACATATTATAAGAATAGAATCCAAAACCG
ATGAATGAAGACTTTTCTTG

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54 [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MVMEKLGDSLQGALKKLIGAGRIDERTVNEVVKDIQRALLQADVNVKLVMGMSQRIKERAMKEDPPAGMNPREHVIRIVY
QELMEIIGKGADIQLKPQTIMMVGLQGSGKTTSAAKLARYFQRKGLKAGVVAADTFRPGAYHQLKTLSEKLNVGFYGEEG
NPDAVEITIHGLKALEKYDIKIVDTAGRHALEADLIEEMERIHAVAKPDHKFMVLDAGIGQQASQQAHAFNDSVGITGVI
ITKLDGTAKGGGALSAVSETKAPIAFIGVGETPEDFEKFEADRFISRLLGMGDLKSLMEKAEESLSEEDVNVEALMQGRF
TLKDMYKQLEAMNKMGPLKQIMSMLPMGMGGLGGVKLSDEMFQATSDKMKNYKVIMDSMTEDEMADPKLIGGSRIKRISR
GSGCSPEDVRELLKYHKTMQTALKGFRGGKFNIQKMMKKKMGM

Sequences:

>Translated_443_residues
MVMEKLGDSLQGALKKLIGAGRIDERTVNEVVKDIQRALLQADVNVKLVMGMSQRIKERAMKEDPPAGMNPREHVIRIVY
QELMEIIGKGADIQLKPQTIMMVGLQGSGKTTSAAKLARYFQRKGLKAGVVAADTFRPGAYHQLKTLSEKLNVGFYGEEG
NPDAVEITIHGLKALEKYDIKIVDTAGRHALEADLIEEMERIHAVAKPDHKFMVLDAGIGQQASQQAHAFNDSVGITGVI
ITKLDGTAKGGGALSAVSETKAPIAFIGVGETPEDFEKFEADRFISRLLGMGDLKSLMEKAEESLSEEDVNVEALMQGRF
TLKDMYKQLEAMNKMGPLKQIMSMLPMGMGGLGGVKLSDEMFQATSDKMKNYKVIMDSMTEDEMADPKLIGGSRIKRISR
GSGCSPEDVRELLKYHKTMQTALKGFRGGKFNIQKMMKKKMGM
>Mature_443_residues
MVMEKLGDSLQGALKKLIGAGRIDERTVNEVVKDIQRALLQADVNVKLVMGMSQRIKERAMKEDPPAGMNPREHVIRIVY
QELMEIIGKGADIQLKPQTIMMVGLQGSGKTTSAAKLARYFQRKGLKAGVVAADTFRPGAYHQLKTLSEKLNVGFYGEEG
NPDAVEITIHGLKALEKYDIKIVDTAGRHALEADLIEEMERIHAVAKPDHKFMVLDAGIGQQASQQAHAFNDSVGITGVI
ITKLDGTAKGGGALSAVSETKAPIAFIGVGETPEDFEKFEADRFISRLLGMGDLKSLMEKAEESLSEEDVNVEALMQGRF
TLKDMYKQLEAMNKMGPLKQIMSMLPMGMGGLGGVKLSDEMFQATSDKMKNYKVIMDSMTEDEMADPKLIGGSRIKRISR
GSGCSPEDVRELLKYHKTMQTALKGFRGGKFNIQKMMKKKMGM

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=448, Percent_Identity=43.0803571428571, Blast_Score=332, Evalue=6e-91,
Organism=Homo sapiens, GI226371618, Length=386, Percent_Identity=44.0414507772021, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=49.0566037735849, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=25.0793650793651, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=25.0793650793651, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788963, Length=430, Percent_Identity=37.4418604651163, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789874, Length=205, Percent_Identity=39.0243902439024, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=39.0134529147982, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=29.3023255813954, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325345, Length=438, Percent_Identity=39.2694063926941, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6320498, Length=326, Percent_Identity=26.0736196319018, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=38.9140271493213, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48679; Mature: 48679

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMEKLGDSLQGALKKLIGAGRIDERTVNEVVKDIQRALLQADVNVKLVMGMSQRIKERA
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
MKEDPPAGMNPREHVIRIVYQELMEIIGKGADIQLKPQTIMMVGLQGSGKTTSAAKLARY
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCCHHHHHHHHH
FQRKGLKAGVVAADTFRPGAYHQLKTLSEKLNVGFYGEEGNPDAVEITIHGLKALEKYDI
HHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCEEEEEEHHHHHHHHCCE
KIVDTAGRHALEADLIEEMERIHAVAKPDHKFMVLDAGIGQQASQQAHAFNDSVGITGVI
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEE
ITKLDGTAKGGGALSAVSETKAPIAFIGVGETPEDFEKFEADRFISRLLGMGDLKSLMEK
EEECCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AEESLSEEDVNVEALMQGRFTLKDMYKQLEAMNKMGPLKQIMSMLPMGMGGLGGVKLSDE
HHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHH
MFQATSDKMKNYKVIMDSMTEDEMADPKLIGGSRIKRISRGSGCSPEDVRELLKYHKTMQ
HHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TALKGFRGGKFNIQKMMKKKMGM
HHHHHCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MVMEKLGDSLQGALKKLIGAGRIDERTVNEVVKDIQRALLQADVNVKLVMGMSQRIKERA
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
MKEDPPAGMNPREHVIRIVYQELMEIIGKGADIQLKPQTIMMVGLQGSGKTTSAAKLARY
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCCHHHHHHHHH
FQRKGLKAGVVAADTFRPGAYHQLKTLSEKLNVGFYGEEGNPDAVEITIHGLKALEKYDI
HHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCEEEEEEHHHHHHHHCCE
KIVDTAGRHALEADLIEEMERIHAVAKPDHKFMVLDAGIGQQASQQAHAFNDSVGITGVI
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEE
ITKLDGTAKGGGALSAVSETKAPIAFIGVGETPEDFEKFEADRFISRLLGMGDLKSLMEK
EEECCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AEESLSEEDVNVEALMQGRFTLKDMYKQLEAMNKMGPLKQIMSMLPMGMGGLGGVKLSDE
HHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHH
MFQATSDKMKNYKVIMDSMTEDEMADPKLIGGSRIKRISRGSGCSPEDVRELLKYHKTMQ
HHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
TALKGFRGGKFNIQKMMKKKMGM
HHHHHCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA