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The map label for this gene is ywlC [H]

Identifier: 21227350

GI number: 21227350

Start: 1478993

End: 1480087

Strand: Reverse

Name: ywlC [H]

Synonym: MM_1248

Alternate gene names: 21227350

Gene position: 1480087-1478993 (Counterclockwise)

Preceding gene: 21227351

Following gene: 21227349

Centisome position: 36.13

GC content: 49.59

Gene sequence:

>1095_bases
GTGAAGGCAGAAAACGGAAATAAAAAAGAGACCCGGATTTTGAGGGTCTCTGAAGTGAATTTTGACGTGATTATAGACGA
GGCTGCGGAAATCATCCGGAAAGGAGGAACTGTCGCCTTCCCAACTGAGACAGTCTACGGGCTTGGGGCTGACGGGCTTA
ACCCGGATACCGTTCTGAAAATTTTTGAGGCAAAGGAACGCCCCCCGGGGAACCCTCTAAGTCTCCTTGTCCATTCCAGG
GAAGACATTAAAAAGGTTGCAAAAAATATTCCTGAAAAAGCTCTCTTGCTTATGGACACTTTCTGGCCCGGTCCCCTCAC
AATTGTGCTTGAGAAAAAAGATACTGTTCCGGAAATCACTTCGGGAAACCTGCCTACAATAGGGCTCCGCATGCCTGACC
ACAGGATCCCTCTGGAACTTATAAAAAGGGCAGGCACCCCTCTGGCTGCTCCAAGTGCTAACCTTTCAGGAAAGCCCAGT
CCCAGCCTGGCAATCCATGTCCTGGCTGACCTGGCAGGCAGGATTGATGCGGTTATTGATGGAGGGGGGACAGCCATAGG
GCTTGAGTCTACCGTTGTTGATCTGACGGTCGAACCTCCTGTCGTGCTCAGGATAGGAGCCGTAGGAATTGGCGAGCTTG
AAAAAGTTATAGGTAAAATCAGGCCCACATATGCGGGAGCCGAATACGGGTCTGGAAAGCTTATGCCTGAAAAACAGGCA
GGACAGAAGTACAGCCATTACACTCCCAATACACAGGTCGTGCTCGTCGAAGGGAAAAGCGAAGAAAAAGTTTCTGAACA
GATTGGTATTTTGCTGGAAGAACATGTGAGCAAAGGCCAGAAAGCCGGGCTTTTACTCAGTGATGAGACCGCAGGTTTTT
TTACTGCCGAAGAGTTGAATGTTCACGACTGCTTTTTACTGGGGTCCCGAAAAGAGCCGGAAGGAGCCGCAAAGAGATTA
TTTGAAGGGCTCAGGACACTTGACGCAGCAGGGCTGGACGTGATCCTTGCTGACGGTTCTTTTTCCCATTCAGGACTTGG
AGCTGCCCTTATTAACCGGTTAAGAGAAGCCGCTTCAGTAAGGCATTTTGTTTAA

Upstream 100 bases:

>100_bases
AAGTGGAAATATCGGCAGCACTATTACAGGCTGTGAACCGTGCACAGGTTTTACAAACAAAACAATAGCAAAATAACAAT
CAGTAAGGAGTTTTCCTCTG

Downstream 100 bases:

>100_bases
ATCAGGGACATCGGTTAAATTGCAAGAGTATAAGTGAGGGTTTGACAGTCAGAGTTGAGTGAAGTTTGACACCCGGATCT
GAAATTCCGATTCGAGGTTC

Product: SUA5 protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKAENGNKKETRILRVSEVNFDVIIDEAAEIIRKGGTVAFPTETVYGLGADGLNPDTVLKIFEAKERPPGNPLSLLVHSR
EDIKKVAKNIPEKALLLMDTFWPGPLTIVLEKKDTVPEITSGNLPTIGLRMPDHRIPLELIKRAGTPLAAPSANLSGKPS
PSLAIHVLADLAGRIDAVIDGGGTAIGLESTVVDLTVEPPVVLRIGAVGIGELEKVIGKIRPTYAGAEYGSGKLMPEKQA
GQKYSHYTPNTQVVLVEGKSEEKVSEQIGILLEEHVSKGQKAGLLLSDETAGFFTAEELNVHDCFLLGSRKEPEGAAKRL
FEGLRTLDAAGLDVILADGSFSHSGLGAALINRLREAASVRHFV

Sequences:

>Translated_364_residues
MKAENGNKKETRILRVSEVNFDVIIDEAAEIIRKGGTVAFPTETVYGLGADGLNPDTVLKIFEAKERPPGNPLSLLVHSR
EDIKKVAKNIPEKALLLMDTFWPGPLTIVLEKKDTVPEITSGNLPTIGLRMPDHRIPLELIKRAGTPLAAPSANLSGKPS
PSLAIHVLADLAGRIDAVIDGGGTAIGLESTVVDLTVEPPVVLRIGAVGIGELEKVIGKIRPTYAGAEYGSGKLMPEKQA
GQKYSHYTPNTQVVLVEGKSEEKVSEQIGILLEEHVSKGQKAGLLLSDETAGFFTAEELNVHDCFLLGSRKEPEGAAKRL
FEGLRTLDAAGLDVILADGSFSHSGLGAALINRLREAASVRHFV
>Mature_364_residues
MKAENGNKKETRILRVSEVNFDVIIDEAAEIIRKGGTVAFPTETVYGLGADGLNPDTVLKIFEAKERPPGNPLSLLVHSR
EDIKKVAKNIPEKALLLMDTFWPGPLTIVLEKKDTVPEITSGNLPTIGLRMPDHRIPLELIKRAGTPLAAPSANLSGKPS
PSLAIHVLADLAGRIDAVIDGGGTAIGLESTVVDLTVEPPVVLRIGAVGIGELEKVIGKIRPTYAGAEYGSGKLMPEKQA
GQKYSHYTPNTQVVLVEGKSEEKVSEQIGILLEEHVSKGQKAGLLLSDETAGFFTAEELNVHDCFLLGSRKEPEGAAKRL
FEGLRTLDAAGLDVILADGSFSHSGLGAALINRLREAASVRHFV

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=173, Percent_Identity=33.5260115606936, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI2367210, Length=137, Percent_Identity=31.3868613138686, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87081864, Length=187, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17537239, Length=237, Percent_Identity=30.8016877637131, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321269, Length=372, Percent_Identity=34.6774193548387, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI78707274, Length=188, Percent_Identity=30.8510638297872, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 38888; Mature: 38888

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAENGNKKETRILRVSEVNFDVIIDEAAEIIRKGGTVAFPTETVYGLGADGLNPDTVLK
CCCCCCCCCCEEEEEEEECCEEEEEHHHHHHHHCCCCEEECCHHEEECCCCCCCHHHHHH
IFEAKERPPGNPLSLLVHSREDIKKVAKNIPEKALLLMDTFWPGPLTIVLEKKDTVPEIT
HHHHCCCCCCCCCEEEEECHHHHHHHHHCCCHHEEEEEECCCCCCEEEEEECCCCCCCCC
SGNLPTIGLRMPDHRIPLELIKRAGTPLAAPSANLSGKPSPSLAIHVLADLAGRIDAVID
CCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEE
GGGTAIGLESTVVDLTVEPPVVLRIGAVGIGELEKVIGKIRPTYAGAEYGSGKLMPEKQA
CCCCEEECCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHC
GQKYSHYTPNTQVVLVEGKSEEKVSEQIGILLEEHVSKGQKAGLLLSDETAGFFTAEELN
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCC
VHDCFLLGSRKEPEGAAKRLFEGLRTLDAAGLDVILADGSFSHSGLGAALINRLREAASV
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
RHFV
HCCC
>Mature Secondary Structure
MKAENGNKKETRILRVSEVNFDVIIDEAAEIIRKGGTVAFPTETVYGLGADGLNPDTVLK
CCCCCCCCCCEEEEEEEECCEEEEEHHHHHHHHCCCCEEECCHHEEECCCCCCCHHHHHH
IFEAKERPPGNPLSLLVHSREDIKKVAKNIPEKALLLMDTFWPGPLTIVLEKKDTVPEIT
HHHHCCCCCCCCCEEEEECHHHHHHHHHCCCHHEEEEEECCCCCCEEEEEECCCCCCCCC
SGNLPTIGLRMPDHRIPLELIKRAGTPLAAPSANLSGKPSPSLAIHVLADLAGRIDAVID
CCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEE
GGGTAIGLESTVVDLTVEPPVVLRIGAVGIGELEKVIGKIRPTYAGAEYGSGKLMPEKQA
CCCCEEECCCEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHC
GQKYSHYTPNTQVVLVEGKSEEKVSEQIGILLEEHVSKGQKAGLLLSDETAGFFTAEELN
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCC
VHDCFLLGSRKEPEGAAKRLFEGLRTLDAAGLDVILADGSFSHSGLGAALINRLREAASV
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
RHFV
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]