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The map label for this gene is guaAB [H]

Identifier: 21227320

GI number: 21227320

Start: 1443646

End: 1444563

Strand: Direct

Name: guaAB [H]

Synonym: MM_1218

Alternate gene names: 21227320

Gene position: 1443646-1444563 (Clockwise)

Preceding gene: 21227318

Following gene: 21227321

Centisome position: 35.24

GC content: 49.78

Gene sequence:

>918_bases
ATGGTAAAACCCGAAAAATTCATTCCGAAAGCAATTGAGAAAATAAGCAAGGAAATAAAGGACGGTAAGGCAATTATTGC
ACTCTCCGGCGGCGTGGACAGTTCTGTCTGTGCTGAGCTGGCTTACAGGGCAATTGGGGACCGGCTGCAGCCTATCTATA
TCGACACGGGGCTCATGAGAAAAGGGGAGACCGAAAGAATAAGGCACATCTTCTCTCACATGAACCTGGATGTTGTTTAT
GCAAAGGACAGGTTCCTTGCAGCCCTGGCTGGAGTTACTGACCCGGAAGAAAAAAGAAAGGCAATAGGTGAGACTTTTAT
CCGGGTGTTTGAGGAAGAGGCAAGGAAACTGGCAGCTGACTACCTGATCCAGGGCACAATTTACCCTGACAGGATAGAGT
CCGAAGGCGGCATCAAGTCTCACCACAACGTGGGAGGGCTCCCAAGCGTAATGGACTTTAAGAAAATCGTTGAGCCTATT
GAAGACCTCTACAAAGACGAGGTAAGAGAAGTTGCCTGGGCTCTCCAGCTGCCTGACGAGATCTGCGAAAGGATGCCTTT
CCCGGGTCCGGGGCTTGCTGTAAGAGTTCTCGGTGAGGTCACGGAAGAAAAGCTTGAGGTAGCAAGAGAAGCTAATTTCA
TAGTAGAAGAGGAGCTTCTTGAAAGGTTCTGCCCCTGGCAGACTTTTGCTGCCGTACTCGGCAAAGGCACTGGGGTGAAA
GGAGACGTCAGGGCTTACGGCTGGATCGTGGCTATAAGGGCTGTAGGGTCAAGAGACGGAATGACTGCGGAAGCTCTCGA
ACTCCCCTGGGAAGTGCTTAAACACCTTGAATCAAGGATCACTTCAGAGATCCCGAAAGTTGCCAGGGTAGTTTATGATA
TTACTCCCAAGCCGCCTGCAACAATTGAGTTTGAATAA

Upstream 100 bases:

>100_bases
ATATATCACATAAAAATATAACCAAATTTTCATAATTCTCATACAGTTATCGATCACTATCATTTCTCCAAAGGAAAGAT
TCACTCGAAGGAGCACTTCA

Downstream 100 bases:

>100_bases
AACCTGAAATGCAGGATAAGAGAAAATATAAGATAACAGAAGTGTAAAGTAAAGTGAAGCCTCAATTGGCTTCATCGGCT
TTTTTTGCAAACTGGATAGT

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MVKPEKFIPKAIEKISKEIKDGKAIIALSGGVDSSVCAELAYRAIGDRLQPIYIDTGLMRKGETERIRHIFSHMNLDVVY
AKDRFLAALAGVTDPEEKRKAIGETFIRVFEEEARKLAADYLIQGTIYPDRIESEGGIKSHHNVGGLPSVMDFKKIVEPI
EDLYKDEVREVAWALQLPDEICERMPFPGPGLAVRVLGEVTEEKLEVAREANFIVEEELLERFCPWQTFAAVLGKGTGVK
GDVRAYGWIVAIRAVGSRDGMTAEALELPWEVLKHLESRITSEIPKVARVVYDITPKPPATIEFE

Sequences:

>Translated_305_residues
MVKPEKFIPKAIEKISKEIKDGKAIIALSGGVDSSVCAELAYRAIGDRLQPIYIDTGLMRKGETERIRHIFSHMNLDVVY
AKDRFLAALAGVTDPEEKRKAIGETFIRVFEEEARKLAADYLIQGTIYPDRIESEGGIKSHHNVGGLPSVMDFKKIVEPI
EDLYKDEVREVAWALQLPDEICERMPFPGPGLAVRVLGEVTEEKLEVAREANFIVEEELLERFCPWQTFAAVLGKGTGVK
GDVRAYGWIVAIRAVGSRDGMTAEALELPWEVLKHLESRITSEIPKVARVVYDITPKPPATIEFE
>Mature_305_residues
MVKPEKFIPKAIEKISKEIKDGKAIIALSGGVDSSVCAELAYRAIGDRLQPIYIDTGLMRKGETERIRHIFSHMNLDVVY
AKDRFLAALAGVTDPEEKRKAIGETFIRVFEEEARKLAADYLIQGTIYPDRIESEGGIKSHHNVGGLPSVMDFKKIVEPI
EDLYKDEVREVAWALQLPDEICERMPFPGPGLAVRVLGEVTEEKLEVAREANFIVEEELLERFCPWQTFAAVLGKGTGVK
GDVRAYGWIVAIRAVGSRDGMTAEALELPWEVLKHLESRITSEIPKVARVVYDITPKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=361, Percent_Identity=29.6398891966759, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1788854, Length=317, Percent_Identity=48.5804416403785, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71992710, Length=364, Percent_Identity=32.967032967033, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992717, Length=364, Percent_Identity=32.967032967033, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI133901714, Length=365, Percent_Identity=32.8767123287671, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323873, Length=323, Percent_Identity=45.8204334365325, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI281365319, Length=346, Percent_Identity=29.7687861271676, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 34118; Mature: 34118

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKPEKFIPKAIEKISKEIKDGKAIIALSGGVDSSVCAELAYRAIGDRLQPIYIDTGLMR
CCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCC
KGETERIRHIFSHMNLDVVYAKDRFLAALAGVTDPEEKRKAIGETFIRVFEEEARKLAAD
CCCHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIQGTIYPDRIESEGGIKSHHNVGGLPSVMDFKKIVEPIEDLYKDEVREVAWALQLPDE
HHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ICERMPFPGPGLAVRVLGEVTEEKLEVAREANFIVEEELLERFCPWQTFAAVLGKGTGVK
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHCCCCCCC
GDVRAYGWIVAIRAVGSRDGMTAEALELPWEVLKHLESRITSEIPKVARVVYDITPKPPA
CCHHHHHHHHHHEECCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TIEFE
CEECC
>Mature Secondary Structure
MVKPEKFIPKAIEKISKEIKDGKAIIALSGGVDSSVCAELAYRAIGDRLQPIYIDTGLMR
CCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCC
KGETERIRHIFSHMNLDVVYAKDRFLAALAGVTDPEEKRKAIGETFIRVFEEEARKLAAD
CCCHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIQGTIYPDRIESEGGIKSHHNVGGLPSVMDFKKIVEPIEDLYKDEVREVAWALQLPDE
HHHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ICERMPFPGPGLAVRVLGEVTEEKLEVAREANFIVEEELLERFCPWQTFAAVLGKGTGVK
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHCCCCCCC
GDVRAYGWIVAIRAVGSRDGMTAEALELPWEVLKHLESRITSEIPKVARVVYDITPKPPA
CCHHHHHHHHHHEECCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TIEFE
CEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]