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The map label for this gene is 21227215

Identifier: 21227215

GI number: 21227215

Start: 1305501

End: 1306223

Strand: Reverse

Name: 21227215

Synonym: MM_1113

Alternate gene names: NA

Gene position: 1306223-1305501 (Counterclockwise)

Preceding gene: 21227218

Following gene: 21227214

Centisome position: 31.89

GC content: 46.2

Gene sequence:

>723_bases
ATGTTCCGACTAGTCTTTGTAATGGACATATTTAACCGTAACGTGGTTCTCGCAAAAGGCGGAATAAGGGAAAATTACCG
GCCGGTCTCGGATTCAAGCGCTGTATGCAGGACCTCAGACCCCCTGGAGATACTTGAAATTTTACGTCCAAAAGAGGTTT
ACATCGCCGACCTTAATGTTCTTCAGGGAAAAGGTCCTCTTGATATGAATGCGGAAATTATCCGGGAGGTAAGTTTTAAA
GCGGATACCATGCTTGATTCTGGTGTATCTTCTTCAAAAGACGTTGACAGAGCACTTTCTATTGCAGGAACCGCAGTTAT
AGGCACGGAGACCGGCACTCTTGAGGTAATTAAGGATTCAATCTCCAGAAATCCGGGACGTATCAGTGTCAGCATTGATA
TAAAACATGGGAAGCTTCTGAAGCAGGATCCCAAGATCCCTGAAGACCCATTTGAAATCGTAAAAATCCTTAACAGGCTT
CCACTAAAAGACCTGATTTTTCTCGATCTCGACAGGGTAGGCACAGCTTCAGGATTTGACCCTGAGTTCCTGCGCAAACT
GGCTGAGAGCTCAGCACATGACGTCCTGCTTGCAGGGGGTGTCAGGGGTATGAAAGATCTTTTTGCTCTTGACAGTCTTG
GCATAAAGGGCGCTCTGGTGGCAACTGCAATACACTCCGGTGAGGTCTCTCCGGAAGTAATGACCCTGGGACTTAAAAAA
TAA

Upstream 100 bases:

>100_bases
GCAAACATGGAGTTAAATCTTTTACACAGTATATTCTTTAATATATACAATAACGTTTATTTTATATTTTTTTATAGGAT
GATGCAACTATCAAATAAGT

Downstream 100 bases:

>100_bases
GGTGCTGATTCGTAAATATACAGAAGATCTTTAACTCAGCTTTATGCCTCCGGTATATAAGGTATTGAGCATCTTATATA
GCCCTACAGGTATAACCCAT

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-; $phosphoribosyl)imidazole-4-carboxamide

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MFRLVFVMDIFNRNVVLAKGGIRENYRPVSDSSAVCRTSDPLEILEILRPKEVYIADLNVLQGKGPLDMNAEIIREVSFK
ADTMLDSGVSSSKDVDRALSIAGTAVIGTETGTLEVIKDSISRNPGRISVSIDIKHGKLLKQDPKIPEDPFEIVKILNRL
PLKDLIFLDLDRVGTASGFDPEFLRKLAESSAHDVLLAGGVRGMKDLFALDSLGIKGALVATAIHSGEVSPEVMTLGLKK

Sequences:

>Translated_240_residues
MFRLVFVMDIFNRNVVLAKGGIRENYRPVSDSSAVCRTSDPLEILEILRPKEVYIADLNVLQGKGPLDMNAEIIREVSFK
ADTMLDSGVSSSKDVDRALSIAGTAVIGTETGTLEVIKDSISRNPGRISVSIDIKHGKLLKQDPKIPEDPFEIVKILNRL
PLKDLIFLDLDRVGTASGFDPEFLRKLAESSAHDVLLAGGVRGMKDLFALDSLGIKGALVATAIHSGEVSPEVMTLGLKK
>Mature_240_residues
MFRLVFVMDIFNRNVVLAKGGIRENYRPVSDSSAVCRTSDPLEILEILRPKEVYIADLNVLQGKGPLDMNAEIIREVSFK
ADTMLDSGVSSSKDVDRALSIAGTAVIGTETGTLEVIKDSISRNPGRISVSIDIKHGKLLKQDPKIPEDPFEIVKILNRL
PLKDLIFLDLDRVGTASGFDPEFLRKLAESSAHDVLLAGGVRGMKDLFALDSLGIKGALVATAIHSGEVSPEVMTLGLKK

Specific function: Unknown

COG id: COG1411

COG function: function code R; Uncharacterized protein related to proFAR isomerase (HisA)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR004650
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: 5.3.1.16

Molecular weight: Translated: 26069; Mature: 26069

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLVFVMDIFNRNVVLAKGGIRENYRPVSDSSAVCRTSDPLEILEILRPKEVYIADLNV
CEEEEEEEEHHCCCEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHCCCCEEEEEECEE
LQGKGPLDMNAEIIREVSFKADTMLDSGVSSSKDVDRALSIAGTAVIGTETGTLEVIKDS
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEECCCCHHHHHHHH
ISRNPGRISVSIDIKHGKLLKQDPKIPEDPFEIVKILNRLPLKDLIFLDLDRVGTASGFD
HCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEEEHHHCCCCCCCC
PEFLRKLAESSAHDVLLAGGVRGMKDLFALDSLGIKGALVATAIHSGEVSPEVMTLGLKK
HHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHEEEHHCCCCCCHHEEEECCC
>Mature Secondary Structure
MFRLVFVMDIFNRNVVLAKGGIRENYRPVSDSSAVCRTSDPLEILEILRPKEVYIADLNV
CEEEEEEEEHHCCCEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHCCCCEEEEEECEE
LQGKGPLDMNAEIIREVSFKADTMLDSGVSSSKDVDRALSIAGTAVIGTETGTLEVIKDS
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEECCCCHHHHHHHH
ISRNPGRISVSIDIKHGKLLKQDPKIPEDPFEIVKILNRLPLKDLIFLDLDRVGTASGFD
HCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHEEEHHHCCCCCCCC
PEFLRKLAESSAHDVLLAGGVRGMKDLFALDSLGIKGALVATAIHSGEVSPEVMTLGLKK
HHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCHHHHEEEHHCCCCCCHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 1-(5-phosphoribosyl)-5-[(5-; $phosphoribosylamino)methylideneamino]imidazole-4-carboxamide

Specific reaction: 1-(5-phosphoribosyl)-5-[(5- $phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5- $[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5- $phosphoribosyl)imidazole-4-carboxamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]