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The map label for this gene is tmk

Identifier: 21227213

GI number: 21227213

Start: 1304292

End: 1304912

Strand: Direct

Name: tmk

Synonym: MM_1111

Alternate gene names: 21227213

Gene position: 1304292-1304912 (Clockwise)

Preceding gene: 21227210

Following gene: 21227216

Centisome position: 31.84

GC content: 42.83

Gene sequence:

>621_bases
ATGAGAGGCAAACTGATCACACTCGAGGGTATTGATGGTTCAGGCAAAAGTACAGTTGCAAAAAAAATTCAGGAAAACCC
TGAGATTCAGGTATTTGACCCGGTATTTACCAGGGAGCCAACCAGAGGTACACTTACAGGAACTGCCGTAGAAAATGCTA
TCCAGTCTGAAACTGACCAGCTTGCTGAGCTGTTTCTTTTTACAGCGGACCATGCGGAACATCTGGCAAAGCTTGTAAAG
CCTGCACTTGCAAATGGAAAAAACGTAATTTCTGACCGCTATTCAGATAGCCGCTATGCTTATCAGGGAGTTACCCTTAA
AAGCAGGTTTGAGAATCCTCTTGAGTGGGTCAGGAGCCTGCACTCAGGATGGACAGTTGTCCCGGATCTTACTTTTCTTT
TCGATATAGAACCTGAAATCGCAGTTGAAAGGTGTGGAAAACGAGGAGAACAGACCAAATTTGAGAAAATAGAGTTTTTA
CAAAATGTCCGAGAAAATTTTCTTATCCTTGCCGCAGAAGATCCGGGTCGTTTCGTGGTAATAGATGCCTCTCGCCCCCA
GGAAGAAGTAGAGAAAAAAGTAATTAAAAAGGTTCTTGAGTTTATTCAACGTATTTCTTGA

Upstream 100 bases:

>100_bases
CCTGTTAGTTGCCACTGGCTCCTGCAGGCTATAAATACAGATAACGCGTTTCAATAAAACCTGTTAAAACCTGTTAAGAA
AAGATAAAAAGGCGGTCTTT

Downstream 100 bases:

>100_bases
GTTTATTCAACGCATTTTTTTGAGTTTATTCAACGTATTTTTTTGAGTTTATTCAACGTATTGAGTTAGATATTACGGGA
AATGAGAAACAGATACGGGA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRGKLITLEGIDGSGKSTVAKKIQENPEIQVFDPVFTREPTRGTLTGTAVENAIQSETDQLAELFLFTADHAEHLAKLVK
PALANGKNVISDRYSDSRYAYQGVTLKSRFENPLEWVRSLHSGWTVVPDLTFLFDIEPEIAVERCGKRGEQTKFEKIEFL
QNVRENFLILAAEDPGRFVVIDASRPQEEVEKKVIKKVLEFIQRIS

Sequences:

>Translated_206_residues
MRGKLITLEGIDGSGKSTVAKKIQENPEIQVFDPVFTREPTRGTLTGTAVENAIQSETDQLAELFLFTADHAEHLAKLVK
PALANGKNVISDRYSDSRYAYQGVTLKSRFENPLEWVRSLHSGWTVVPDLTFLFDIEPEIAVERCGKRGEQTKFEKIEFL
QNVRENFLILAAEDPGRFVVIDASRPQEEVEKKVIKKVLEFIQRIS
>Mature_206_residues
MRGKLITLEGIDGSGKSTVAKKIQENPEIQVFDPVFTREPTRGTLTGTAVENAIQSETDQLAELFLFTADHAEHLAKLVK
PALANGKNVISDRYSDSRYAYQGVTLKSRFENPLEWVRSLHSGWTVVPDLTFLFDIEPEIAVERCGKRGEQTKFEKIEFL
QNVRENFLILAAEDPGRFVVIDASRPQEEVEKKVIKKVLEFIQRIS

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=215, Percent_Identity=33.953488372093, Blast_Score=98, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17535647, Length=206, Percent_Identity=30.5825242718447, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322517, Length=177, Percent_Identity=31.638418079096, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_METMA (Q8PXV5)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633135.1
- ProteinModelPortal:   Q8PXV5
- SMR:   Q8PXV5
- GeneID:   1479453
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1111
- NMPDR:   fig|192952.1.peg.1111
- HOGENOM:   HBG626009
- OMA:   MLITLEG
- ProtClustDB:   PRK00698
- BioCyc:   MMAZ192952:MM1111-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23321; Mature: 23321

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKLITLEGIDGSGKSTVAKKIQENPEIQVFDPVFTREPTRGTLTGTAVENAIQSETDQ
CCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECHHHCCCCCCCCEEHHHHHHHHHHHHHH
LAELFLFTADHAEHLAKLVKPALANGKNVISDRYSDSRYAYQGVTLKSRFENPLEWVRSL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCHHHHCCCHHHHHHHH
HSGWTVVPDLTFLFDIEPEIAVERCGKRGEQTKFEKIEFLQNVRENFLILAAEDPGRFVV
HCCCEECCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCEEE
IDASRPQEEVEKKVIKKVLEFIQRIS
EECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGKLITLEGIDGSGKSTVAKKIQENPEIQVFDPVFTREPTRGTLTGTAVENAIQSETDQ
CCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECHHHCCCCCCCCEEHHHHHHHHHHHHHH
LAELFLFTADHAEHLAKLVKPALANGKNVISDRYSDSRYAYQGVTLKSRFENPLEWVRSL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCHHHHCCCHHHHHHHH
HSGWTVVPDLTFLFDIEPEIAVERCGKRGEQTKFEKIEFLQNVRENFLILAAEDPGRFVV
HCCCEECCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCEEE
IDASRPQEEVEKKVIKKVLEFIQRIS
EECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824