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The map label for this gene is mtaA [H]

Identifier: 21227172

GI number: 21227172

Start: 1255824

End: 1256852

Strand: Direct

Name: mtaA [H]

Synonym: MM_1070

Alternate gene names: 21227172

Gene position: 1255824-1256852 (Clockwise)

Preceding gene: 21227169

Following gene: 21227173

Centisome position: 30.66

GC content: 51.02

Gene sequence:

>1029_bases
ATGACCGATATGAGCGAATTCACACTTAAAACAAGACTTTTAGCCGCCCTGAAAGGCGAACCTGTTGACAAAGTACCTGT
TTGTTCCGTAACCCAGACCGGAATTGTAGAACTCATGGACGTAGTCGGTGCCCCCTGGCCTGAAGCCCACACAAACCCCG
AACTCATGGCAAAGCTGGCACTCGCCAACCACGAGCTCAGCGGACTTGAAGCTGTAAGACTTCCCTACTGCCTTACCGTT
CTGGTCGAAGCAATGGGCTGTGAAATCAACATGGGTACCAAGAACAGACAGCCTTCCGTTACCGGTCACCCCTATCCCAA
GGACCTTGAAGGCGCAGCAGTCCCTGCAGACCTCCTGCAGAGGGGCAGAATTCCAGTAGTTCTTGAAGCAATTAAGATCA
TCAGGGAAAAAGTTGGACCTGACGTGCCAATCGTTGGCGGTATGGAAGGCCCTGTTACAGTCGCATCCGACCTTGTAAGT
GTCAAATCCTTCATGAAATGGTCCATCAAGAAAACCGACCTCTTAGAACAGGCTCTGGACATCGCAACCGAAGCTTCAAT
TATATATGCAAATGCAATGGTAGAAGCCGGTGCAGACGTAATTGCCATCGCAGACCCGGTCGCCTCTCCTGACCTTATGA
GCCCTGACTCCTTCAGGCAGTTCCTCAAATCAAGGCTTCAGAAGTTCGCCTCTAGCGTGAACTCCGTAACTGTCCTCCAC
ATCTGCGGAAACGTGAACCCGATCCTCAGCGACATGGCAGACTGCGGTTTTGAAGGCCTCAGCGTTGAAGAAAAGATCGG
AAGCGCAAAGAAGGGCAAGGAAGTAATCGGAACCAGAGCAAGGTTAGTAGGAAATGTTTCCAGCCCGTTCACTCTTCTGC
CCGGACCTGTTGACAAGATAAAGGCTGAAGCAAAAGAAGCTCTTGAAGGCGGAATTGATGTACTTGCACCAGGCTGTGGA
ATTGCACCCATGACCCCTCTTGAGAACGTTAAAGCTCTGGTCGCAGCAAGAGACGAATTCTACGCCTGA

Upstream 100 bases:

>100_bases
GTGTGAAACATTTTGGATTGAAAAGGTCTATATAATATTGTCAAGTAGACAATAAAATTGTAATAAAAATAAATGTACAA
GGATAAAAGTAAAAAAAGGT

Downstream 100 bases:

>100_bases
TAAGGCATAAAATCCTTTATTTTTTTTACGGGCAGATTCTGAGCCAGGGATTTTCAAGCTCTGACATCGTGCCCAATTCA
TATTTTTTTTACTTGCCGGG

Product: methylcobalamin:coenzyme M methyltransferase

Products: CO2; Coproporphyrinogen III [C]

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTDMSEFTLKTRLLAALKGEPVDKVPVCSVTQTGIVELMDVVGAPWPEAHTNPELMAKLALANHELSGLEAVRLPYCLTV
LVEAMGCEINMGTKNRQPSVTGHPYPKDLEGAAVPADLLQRGRIPVVLEAIKIIREKVGPDVPIVGGMEGPVTVASDLVS
VKSFMKWSIKKTDLLEQALDIATEASIIYANAMVEAGADVIAIADPVASPDLMSPDSFRQFLKSRLQKFASSVNSVTVLH
ICGNVNPILSDMADCGFEGLSVEEKIGSAKKGKEVIGTRARLVGNVSSPFTLLPGPVDKIKAEAKEALEGGIDVLAPGCG
IAPMTPLENVKALVAARDEFYA

Sequences:

>Translated_342_residues
MTDMSEFTLKTRLLAALKGEPVDKVPVCSVTQTGIVELMDVVGAPWPEAHTNPELMAKLALANHELSGLEAVRLPYCLTV
LVEAMGCEINMGTKNRQPSVTGHPYPKDLEGAAVPADLLQRGRIPVVLEAIKIIREKVGPDVPIVGGMEGPVTVASDLVS
VKSFMKWSIKKTDLLEQALDIATEASIIYANAMVEAGADVIAIADPVASPDLMSPDSFRQFLKSRLQKFASSVNSVTVLH
ICGNVNPILSDMADCGFEGLSVEEKIGSAKKGKEVIGTRARLVGNVSSPFTLLPGPVDKIKAEAKEALEGGIDVLAPGCG
IAPMTPLENVKALVAARDEFYA
>Mature_341_residues
TDMSEFTLKTRLLAALKGEPVDKVPVCSVTQTGIVELMDVVGAPWPEAHTNPELMAKLALANHELSGLEAVRLPYCLTVL
VEAMGCEINMGTKNRQPSVTGHPYPKDLEGAAVPADLLQRGRIPVVLEAIKIIREKVGPDVPIVGGMEGPVTVASDLVSV
KSFMKWSIKKTDLLEQALDIATEASIIYANAMVEAGADVIAIADPVASPDLMSPDSFRQFLKSRLQKFASSVNSVTVLHI
CGNVNPILSDMADCGFEGLSVEEKIGSAKKGKEVIGTRARLVGNVSSPFTLLPGPVDKIKAEAKEALEGGIDVLAPGCGI
APMTPLENVKALVAARDEFYA

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: 4.1.1.37 [C]

Molecular weight: Translated: 36280; Mature: 36148

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMSEFTLKTRLLAALKGEPVDKVPVCSVTQTGIVELMDVVGAPWPEAHTNPELMAKLA
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LANHELSGLEAVRLPYCLTVLVEAMGCEINMGTKNRQPSVTGHPYPKDLEGAAVPADLLQ
HHCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RGRIPVVLEAIKIIREKVGPDVPIVGGMEGPVTVASDLVSVKSFMKWSIKKTDLLEQALD
CCCCHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
IATEASIIYANAMVEAGADVIAIADPVASPDLMSPDSFRQFLKSRLQKFASSVNSVTVLH
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEE
ICGNVNPILSDMADCGFEGLSVEEKIGSAKKGKEVIGTRARLVGNVSSPFTLLPGPVDKI
ECCCCCHHHHHHHHCCCCCCCHHHHHCCHHCCHHHHHHHHHHHCCCCCCCEECCCCHHHH
KAEAKEALEGGIDVLAPGCGIAPMTPLENVKALVAARDEFYA
HHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDMSEFTLKTRLLAALKGEPVDKVPVCSVTQTGIVELMDVVGAPWPEAHTNPELMAKLA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LANHELSGLEAVRLPYCLTVLVEAMGCEINMGTKNRQPSVTGHPYPKDLEGAAVPADLLQ
HHCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RGRIPVVLEAIKIIREKVGPDVPIVGGMEGPVTVASDLVSVKSFMKWSIKKTDLLEQALD
CCCCHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
IATEASIIYANAMVEAGADVIAIADPVASPDLMSPDSFRQFLKSRLQKFASSVNSVTVLH
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEE
ICGNVNPILSDMADCGFEGLSVEEKIGSAKKGKEVIGTRARLVGNVSSPFTLLPGPVDKI
ECCCCCHHHHHHHHCCCCCCCHHHHHCCHHCCHHHHHHHHHHHCCCCCCCEECCCCHHHH
KAEAKEALEGGIDVLAPGCGIAPMTPLENVKALVAARDEFYA
HHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Reducing agents [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.00231 {7-COOH,} 0.00053 {8-COOH-porphyrinogen} 0.00025 {8-COOH-porphyrinogen} 0.00533 {uroporphyrinogen} 0.00256 {uroporphyrinogen} 0.00133 {uroporphyrinogen} 0.001 {uroporphyrinogen} 0.0008 {uroporphyrinogen} 0.0004 {uroporphyrino

Substrates: H+; Uroporphyrinogen III [C]

Specific reaction: (4) H+ + Uroporphyrinogen III --> (4) CO2 + Coproporphyrinogen III [C]

General reaction: Decarboxylation [C]

Inhibitor: 5, 5'-Dithiobis (2-nitrobenzoate); 7-COOH-porphyrinogenI; 7-COOH-porphyrinogen III; Butanedione; Diethyl dicarbonate; Fe2+; Iodoacetamide; p-Hydroxy mercuribenzoate; Phenyl glyoxal; Pt2+; Sn2+; UroporphyrinogenI uroporphyrinogen III; Uroporphyrinogen III;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]