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The map label for this gene is kefC [H]

Identifier: 21227035

GI number: 21227035

Start: 1099526

End: 1101538

Strand: Reverse

Name: kefC [H]

Synonym: MM_0933

Alternate gene names: 21227035

Gene position: 1101538-1099526 (Counterclockwise)

Preceding gene: 21227038

Following gene: 21227034

Centisome position: 26.89

GC content: 44.81

Gene sequence:

>2013_bases
TTGAAATTTAAATATATATTAATGGCAACAGATCTTTTAACCGACTTACTCATTATTTTCGGGCTTTCTATTCCCGTAGT
TTTCACCTTCTCAAAGCTGAAAATAGCTCCGCTGGTGGGTTTTTTGCTTGTTGGCATCCTTGCGGGGCCTTTTGGTTTGG
GCTTGGTCCAAGATCTGGGCAATATTGAAATGCTGGCTGAGATAGGAGTCATATTGCTGCTCTTTACTATCGGGATGGAA
TTTTCCCTGCGTGAACTCCTGCAGCTTCGCAGAATAGTCATCTTTGGAGGAGGGTTGCAGCTTTTTATAACTACTCTTGC
TGCCGCTTTTATTTTCCTCATTCTTGGAATTTCCAGAGAAACTGCAATTTTCCTCGGACTCCTGGTGGCATTGAGCAGCA
CGGCAATAGTCCTTAAAATCTTGCAGGAAAAAGGGGAAATTTACAGTCTTCACGGGCGGACTTCCCTGGGGATATTGATC
TTCCAGGACGTAGCTGCAGTAATGATAATTCTCCTGATTCCTCTCCTTGCGGGAACTCAGGGAACGGAAAAATCTTTCTT
AGAACTTATCATGCAGGGATTTGGGCTCATACTGTTTACTATATTCAGCGCCAGATATGCAGTCCCTTTTATTATGTTCC
AGGTAGCAAAGACGCGTAATAGCGAACTGTTTCTCCTGAGTGTTGTGGCAATCGGACTCGCGGTTGCCTGGCTGACTTCC
ATGGTCGGTCTTTCTCTGGCTCTTGGAGCTTTTCTTGCCGGTCTGATCATTTCAGAGTCCGAATATTCGATCCAGGCTCT
TGGGAACTTAATTCCTTTCAGGGATATGTTTATGAGCATTTTTTTCATTTCAATGGGGATGCTTCTTGATCTGGGTGTAT
TAAGAGAACATTTACCCTTAATACTGGCTGCAACTCTTGGAGTGCTTATTTTGAAAGCTGCAGCGAATTCCCTTAGCACT
TTCCTTATAGGTTTTCCTTTGCACACCATGATCCTGGTCGGTTTCTCCCTCTCTCAGGTTGGGGAATTTTCACTGATTCT
TGCGAAGGTAGGCTTTACGAGCGGGCTGATAACTACTGAAATTTATCAGGAGTTTCTAGATATCGCCGTAATTTCCATGG
TACTCACTCCTTTCATAATGAGCATGGGGTATCGGACTACATCATTTGCCGAGTCTCTCCCCTTACCTTCAATAGTAAAA
ACCGGGTGGTACAGGCATTTTAAGGAGCACGTACCTCAAGATGCACCTGAAAATCATGTGATTGTAATAGGTTTCGGAAT
AAATGGGAGAAATGTCGCAGCAGCTGCAAAGTCATCTTCTATCCCCTACCGGATAATCGAGATCAATCCCGAAACCGTCA
GGCAGGAGAAACAGAAAGGAGAACATATCCTTTATGGAGACGCTGCCCAGAAAGCTGTTCTGGAACATGCAGGTATCCGG
GCTGCGAAATCGGTCGTTGTGACCGCAGGGGATCCGGTAAGTGCCAGAAGAGTTATTGAAGCTGCTAGGCGGCTAAACCC
TGAAGTCCATATTATTGCCAGGACACATTTCCTGAGCGAGCTGGATAAATTTCATATCGCCGGAGCCGATGAAGTTATTT
CGGATGAGTTTGAAAGCTCAATAGAAATTTTCACAAGAGTGCTCCACAGGTATCTGGTTCCTTCAAGTGAAATCGATTCT
CTGGGCTCAACCTTACGCTCCGACCATTACAGGATGCTTCGCAGTCCTGACATTCCCCGGAAAAAGTTCTGCGACCTGGC
TCTCGATTTTGCAGATGTGGAAATAAGGAGTATCAGGGTTGGGGAACTTTCCAGGGCGGCAGGAATGACCATTGGAGATC
TCAACGTCAGGAAAAAATATGGAGTCTCTATACTTGCAATTTCCAGAAATCATAAACTTATCTCCGAGCTGCAAGCAGAG
ACCAAAATCCATTCAAGCGATATCCTGCTTGTGATCAGCCCTCCTGAAAAGCTTGATGAAGTTAAAAAGCTTTTTGAAGA
TCAGGTGGGATAA

Upstream 100 bases:

>100_bases
TCTTTTTTCATTACTGGTCCCTCATTATTGTTTTTTCATTTTTTTCGGTTACAGATTTTCAATGTTTCGATAATAGATAA
TATGATGAAATTTATATCAT

Downstream 100 bases:

>100_bases
AGTTTCTTTATCCCGGTATTTTTCAGGTAAGGTTGAAAATAAACAATTTCAGGGATAACGCCGGAAGTCAGGATACGCGA
ATACGAATACATGAATATTT

Product: glutathione-regulated potassium-efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MKFKYILMATDLLTDLLIIFGLSIPVVFTFSKLKIAPLVGFLLVGILAGPFGLGLVQDLGNIEMLAEIGVILLLFTIGME
FSLRELLQLRRIVIFGGGLQLFITTLAAAFIFLILGISRETAIFLGLLVALSSTAIVLKILQEKGEIYSLHGRTSLGILI
FQDVAAVMIILLIPLLAGTQGTEKSFLELIMQGFGLILFTIFSARYAVPFIMFQVAKTRNSELFLLSVVAIGLAVAWLTS
MVGLSLALGAFLAGLIISESEYSIQALGNLIPFRDMFMSIFFISMGMLLDLGVLREHLPLILAATLGVLILKAAANSLST
FLIGFPLHTMILVGFSLSQVGEFSLILAKVGFTSGLITTEIYQEFLDIAVISMVLTPFIMSMGYRTTSFAESLPLPSIVK
TGWYRHFKEHVPQDAPENHVIVIGFGINGRNVAAAAKSSSIPYRIIEINPETVRQEKQKGEHILYGDAAQKAVLEHAGIR
AAKSVVVTAGDPVSARRVIEAARRLNPEVHIIARTHFLSELDKFHIAGADEVISDEFESSIEIFTRVLHRYLVPSSEIDS
LGSTLRSDHYRMLRSPDIPRKKFCDLALDFADVEIRSIRVGELSRAAGMTIGDLNVRKKYGVSILAISRNHKLISELQAE
TKIHSSDILLVISPPEKLDEVKKLFEDQVG

Sequences:

>Translated_670_residues
MKFKYILMATDLLTDLLIIFGLSIPVVFTFSKLKIAPLVGFLLVGILAGPFGLGLVQDLGNIEMLAEIGVILLLFTIGME
FSLRELLQLRRIVIFGGGLQLFITTLAAAFIFLILGISRETAIFLGLLVALSSTAIVLKILQEKGEIYSLHGRTSLGILI
FQDVAAVMIILLIPLLAGTQGTEKSFLELIMQGFGLILFTIFSARYAVPFIMFQVAKTRNSELFLLSVVAIGLAVAWLTS
MVGLSLALGAFLAGLIISESEYSIQALGNLIPFRDMFMSIFFISMGMLLDLGVLREHLPLILAATLGVLILKAAANSLST
FLIGFPLHTMILVGFSLSQVGEFSLILAKVGFTSGLITTEIYQEFLDIAVISMVLTPFIMSMGYRTTSFAESLPLPSIVK
TGWYRHFKEHVPQDAPENHVIVIGFGINGRNVAAAAKSSSIPYRIIEINPETVRQEKQKGEHILYGDAAQKAVLEHAGIR
AAKSVVVTAGDPVSARRVIEAARRLNPEVHIIARTHFLSELDKFHIAGADEVISDEFESSIEIFTRVLHRYLVPSSEIDS
LGSTLRSDHYRMLRSPDIPRKKFCDLALDFADVEIRSIRVGELSRAAGMTIGDLNVRKKYGVSILAISRNHKLISELQAE
TKIHSSDILLVISPPEKLDEVKKLFEDQVG
>Mature_670_residues
MKFKYILMATDLLTDLLIIFGLSIPVVFTFSKLKIAPLVGFLLVGILAGPFGLGLVQDLGNIEMLAEIGVILLLFTIGME
FSLRELLQLRRIVIFGGGLQLFITTLAAAFIFLILGISRETAIFLGLLVALSSTAIVLKILQEKGEIYSLHGRTSLGILI
FQDVAAVMIILLIPLLAGTQGTEKSFLELIMQGFGLILFTIFSARYAVPFIMFQVAKTRNSELFLLSVVAIGLAVAWLTS
MVGLSLALGAFLAGLIISESEYSIQALGNLIPFRDMFMSIFFISMGMLLDLGVLREHLPLILAATLGVLILKAAANSLST
FLIGFPLHTMILVGFSLSQVGEFSLILAKVGFTSGLITTEIYQEFLDIAVISMVLTPFIMSMGYRTTSFAESLPLPSIVK
TGWYRHFKEHVPQDAPENHVIVIGFGINGRNVAAAAKSSSIPYRIIEINPETVRQEKQKGEHILYGDAAQKAVLEHAGIR
AAKSVVVTAGDPVSARRVIEAARRLNPEVHIIARTHFLSELDKFHIAGADEVISDEFESSIEIFTRVLHRYLVPSSEIDS
LGSTLRSDHYRMLRSPDIPRKKFCDLALDFADVEIRSIRVGELSRAAGMTIGDLNVRKKYGVSILAISRNHKLISELQAE
TKIHSSDILLVISPPEKLDEVKKLFEDQVG

Specific function: Unknown

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=377, Percent_Identity=27.5862068965517, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1786685, Length=546, Percent_Identity=33.1501831501831, Blast_Score=243, Evalue=4e-65,
Organism=Escherichia coli, GI1789749, Length=537, Percent_Identity=29.608938547486, Blast_Score=212, Evalue=8e-56,
Organism=Escherichia coli, GI1786232, Length=540, Percent_Identity=28.7037037037037, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322367, Length=392, Percent_Identity=21.6836734693878, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 73502; Mature: 73502

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKYILMATDLLTDLLIIFGLSIPVVFTFSKLKIAPLVGFLLVGILAGPFGLGLVQDLG
CCEEEEEHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
NIEMLAEIGVILLLFTIGMEFSLRELLQLRRIVIFGGGLQLFITTLAAAFIFLILGISRE
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHH
TAIFLGLLVALSSTAIVLKILQEKGEIYSLHGRTSLGILIFQDVAAVMIILLIPLLAGTQ
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GTEKSFLELIMQGFGLILFTIFSARYAVPFIMFQVAKTRNSELFLLSVVAIGLAVAWLTS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
MVGLSLALGAFLAGLIISESEYSIQALGNLIPFRDMFMSIFFISMGMLLDLGVLREHLPL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAATLGVLILKAAANSLSTFLIGFPLHTMILVGFSLSQVGEFSLILAKVGFTSGLITTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHCCCCCHHHHH
IYQEFLDIAVISMVLTPFIMSMGYRTTSFAESLPLPSIVKTGWYRHFKEHVPQDAPENHV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCE
IVIGFGINGRNVAAAAKSSSIPYRIIEINPETVRQEKQKGEHILYGDAAQKAVLEHAGIR
EEEEECCCCCCHHHHCCCCCCCEEEEEECHHHHHHHHHCCCEEEECCHHHHHHHHHHCCH
AAKSVVVTAGDPVSARRVIEAARRLNPEVHIIARTHFLSELDKFHIAGADEVISDEFESS
HHCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
IEIFTRVLHRYLVPSSEIDSLGSTLRSDHYRMLRSPDIPRKKFCDLALDFADVEIRSIRV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEC
GELSRAAGMTIGDLNVRKKYGVSILAISRNHKLISELQAETKIHSSDILLVISPPEKLDE
CCHHHHHCCEEECCCCHHHHCEEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
VKKLFEDQVG
HHHHHHHCCC
>Mature Secondary Structure
MKFKYILMATDLLTDLLIIFGLSIPVVFTFSKLKIAPLVGFLLVGILAGPFGLGLVQDLG
CCEEEEEHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
NIEMLAEIGVILLLFTIGMEFSLRELLQLRRIVIFGGGLQLFITTLAAAFIFLILGISRE
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHH
TAIFLGLLVALSSTAIVLKILQEKGEIYSLHGRTSLGILIFQDVAAVMIILLIPLLAGTQ
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GTEKSFLELIMQGFGLILFTIFSARYAVPFIMFQVAKTRNSELFLLSVVAIGLAVAWLTS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
MVGLSLALGAFLAGLIISESEYSIQALGNLIPFRDMFMSIFFISMGMLLDLGVLREHLPL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAATLGVLILKAAANSLSTFLIGFPLHTMILVGFSLSQVGEFSLILAKVGFTSGLITTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHCCCCCHHHHH
IYQEFLDIAVISMVLTPFIMSMGYRTTSFAESLPLPSIVKTGWYRHFKEHVPQDAPENHV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCE
IVIGFGINGRNVAAAAKSSSIPYRIIEINPETVRQEKQKGEHILYGDAAQKAVLEHAGIR
EEEEECCCCCCHHHHCCCCCCCEEEEEECHHHHHHHHHCCCEEEECCHHHHHHHHHHCCH
AAKSVVVTAGDPVSARRVIEAARRLNPEVHIIARTHFLSELDKFHIAGADEVISDEFESS
HHCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
IEIFTRVLHRYLVPSSEIDSLGSTLRSDHYRMLRSPDIPRKKFCDLALDFADVEIRSIRV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEC
GELSRAAGMTIGDLNVRKKYGVSILAISRNHKLISELQAETKIHSSDILLVISPPEKLDE
CCHHHHHCCEEECCCCHHHHCEEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
VKKLFEDQVG
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 7721718 [H]