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The map label for this gene is gpmI

Identifier: 21227006

GI number: 21227006

Start: 1068439

End: 1070004

Strand: Direct

Name: gpmI

Synonym: MM_0904

Alternate gene names: 21227006

Gene position: 1068439-1070004 (Clockwise)

Preceding gene: 21227003

Following gene: 21227007

Centisome position: 26.08

GC content: 46.04

Gene sequence:

>1566_bases
GTGCGGATTTCCCTTCATATGACTCAGGCAAGAAGACCTCTTATGCTTATGATCCTTGATGGCTGGGGCTACAGGGAGGA
AAAAGAAGGAAACGCTATCCTAGCAGCCAGCACTCCTCATCTTGACCGGCTGCAAAAAGAACGTCCCTCGTGCTTTTTAG
AAACATCCGGAGAAGCCGTAGGACTGCCGCAGGGCCAGATGGGAAACTCTGAAGTTGGTCATCTGAACATAGGGGCAGGA
AGAGTTGTTTACCAGGACCTTACAAAAATAAACGTCTCTATAAGAAACGGAGACTTTTTCGAAAACCCTGTTTTGCTGGA
TGCAATTTCAAATGTGAAGCTCAATAATTCGAGCCTTCACCTTATGGGACTTGTCTCTTACGGAGGCGTCCACAGTCATA
TGACCCACCTTTATGCCCTTATCAAACTTGCACAGGAAAAAGGGCTAAAAAAAGTATATATACATGTGTTTCTGGATGGG
AGAGACGTCCCCCCGAAAGCTGCATTAGGAGACGTCAAGGAGCTTGATGCGTTTTGTAAAGAAAACCAGAGTGTAAAAAT
AGCGACAGTACAGGGGCGCTACTACGCAATGGACAGAGACAAACGCTGGGAAAGAACAAAACTTGCATATGATGCCCTTA
CTCTTGGAGTCGCGCCATACAAAACCTCTGATGCCGTAACTGCAGTTTCTGAAGCTTATGAAAGGGGAGAAACTGATGAA
TTTATAAAGCCCACAATAGTTACAGACTCAGAAGGAAACCCCGAGGCAGTAATACAGGATACGGATTCGATAGTTTTCCT
TAACTTCAGACCCGATAGGGCGAGACAGCTTACCTGGGCTTTTGTAAAAGACGACTTTGAAGGCTTTACAAGGGAGAAAC
GCCCGAAAGTCCATTATGTCTGCATGGCACAGTATGATGAAACCCTGGATTTGCCCATAGCATTCCCACCTGAAGAGTTA
ACAGATGTTCTTGGCAAAGTGCTGAGCGACAGGGGGCTTATCCAGCTCCGCATTGCTGAAACCGAAAAATATGCCCATGT
AACTTTCTTCCTCAACGGCGGGCAGGAAAAATGCTATTCGGGAGAAGACCGCTGCCTTATCCCCTCACCTAAAATATCCA
CCTATGACCTCAAACCTGAAATGAGTGCATATGAAGTCACGGACGAAGTAGTAAAAAGAATCCTATCAGGAAAGTACGAT
GTGATCATACTTAATTTTGCAAATATGGACATGGTGGGGCACACAGGAGACTTTGAAGCCGCAGTAAAGGCTGTGGAGAC
GGTAGATAACTGCGTGGGAAGGATTGTAGAAGCACTGAGAACGGCAGGCGGGGCAGCACTTATAACTGCAGATCACGGGA
ACGCCGAACAGATGGAAAACTCGCATACAGGCGAGCCGCATACGGCTCATACTTCAAACCCTGTAAAGTGCATATATACA
GGAAACGGTGAAGTAAAAGCCCTTGAGAATGGGAAACTGTCCGATCTCGCTCCTACCCTTCTTGATCTTCTTGAAATCCC
AAAACCTGAAAAGATGACAGGCAGATCATTGATAGTGAGAAAATAA

Upstream 100 bases:

>100_bases
TTATATTTAAGGACAGTAGATAAATTTTCAATACATTATAAATATATAACATTTAATTTTATAAGAAGTCTCCAGATCAC
GGGAATCTATTTATTAACAT

Downstream 100 bases:

>100_bases
AAGTGGAAGAATAAAATAAACAATGAATCTCATAACGAAAAAAAGAATAGTAAAAAAACAAAGCCCGGAAGAGAATCAGT
GATTTTAAATTTTTATTACT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-independent PGAM; Phosphoglyceromutase; iPGM

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MRISLHMTQARRPLMLMILDGWGYREEKEGNAILAASTPHLDRLQKERPSCFLETSGEAVGLPQGQMGNSEVGHLNIGAG
RVVYQDLTKINVSIRNGDFFENPVLLDAISNVKLNNSSLHLMGLVSYGGVHSHMTHLYALIKLAQEKGLKKVYIHVFLDG
RDVPPKAALGDVKELDAFCKENQSVKIATVQGRYYAMDRDKRWERTKLAYDALTLGVAPYKTSDAVTAVSEAYERGETDE
FIKPTIVTDSEGNPEAVIQDTDSIVFLNFRPDRARQLTWAFVKDDFEGFTREKRPKVHYVCMAQYDETLDLPIAFPPEEL
TDVLGKVLSDRGLIQLRIAETEKYAHVTFFLNGGQEKCYSGEDRCLIPSPKISTYDLKPEMSAYEVTDEVVKRILSGKYD
VIILNFANMDMVGHTGDFEAAVKAVETVDNCVGRIVEALRTAGGAALITADHGNAEQMENSHTGEPHTAHTSNPVKCIYT
GNGEVKALENGKLSDLAPTLLDLLEIPKPEKMTGRSLIVRK

Sequences:

>Translated_521_residues
MRISLHMTQARRPLMLMILDGWGYREEKEGNAILAASTPHLDRLQKERPSCFLETSGEAVGLPQGQMGNSEVGHLNIGAG
RVVYQDLTKINVSIRNGDFFENPVLLDAISNVKLNNSSLHLMGLVSYGGVHSHMTHLYALIKLAQEKGLKKVYIHVFLDG
RDVPPKAALGDVKELDAFCKENQSVKIATVQGRYYAMDRDKRWERTKLAYDALTLGVAPYKTSDAVTAVSEAYERGETDE
FIKPTIVTDSEGNPEAVIQDTDSIVFLNFRPDRARQLTWAFVKDDFEGFTREKRPKVHYVCMAQYDETLDLPIAFPPEEL
TDVLGKVLSDRGLIQLRIAETEKYAHVTFFLNGGQEKCYSGEDRCLIPSPKISTYDLKPEMSAYEVTDEVVKRILSGKYD
VIILNFANMDMVGHTGDFEAAVKAVETVDNCVGRIVEALRTAGGAALITADHGNAEQMENSHTGEPHTAHTSNPVKCIYT
GNGEVKALENGKLSDLAPTLLDLLEIPKPEKMTGRSLIVRK
>Mature_521_residues
MRISLHMTQARRPLMLMILDGWGYREEKEGNAILAASTPHLDRLQKERPSCFLETSGEAVGLPQGQMGNSEVGHLNIGAG
RVVYQDLTKINVSIRNGDFFENPVLLDAISNVKLNNSSLHLMGLVSYGGVHSHMTHLYALIKLAQEKGLKKVYIHVFLDG
RDVPPKAALGDVKELDAFCKENQSVKIATVQGRYYAMDRDKRWERTKLAYDALTLGVAPYKTSDAVTAVSEAYERGETDE
FIKPTIVTDSEGNPEAVIQDTDSIVFLNFRPDRARQLTWAFVKDDFEGFTREKRPKVHYVCMAQYDETLDLPIAFPPEEL
TDVLGKVLSDRGLIQLRIAETEKYAHVTFFLNGGQEKCYSGEDRCLIPSPKISTYDLKPEMSAYEVTDEVVKRILSGKYD
VIILNFANMDMVGHTGDFEAAVKAVETVDNCVGRIVEALRTAGGAALITADHGNAEQMENSHTGEPHTAHTSNPVKCIYT
GNGEVKALENGKLSDLAPTLLDLLEIPKPEKMTGRSLIVRK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0696

COG function: function code G; Phosphoglyceromutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BPG-independent phosphoglycerate mutase family

Homologues:

Organism=Escherichia coli, GI1790041, Length=513, Percent_Identity=51.2670565302144, Blast_Score=569, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI32564249, Length=516, Percent_Identity=44.9612403100775, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17507741, Length=516, Percent_Identity=44.9612403100775, Blast_Score=434, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPMI_METMA (Q8PYF8)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632928.1
- ProteinModelPortal:   Q8PYF8
- SMR:   Q8PYF8
- GeneID:   1479246
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0904
- NMPDR:   fig|192952.1.peg.904
- HOGENOM:   HBG613255
- OMA:   VHFMGLV
- ProtClustDB:   PRK05434
- BioCyc:   MMAZ192952:MM0904-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_01038
- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR011258
- InterPro:   IPR006124
- InterPro:   IPR005995
- Gene3D:   G3DSA:3.40.720.10
- Gene3D:   G3DSA:3.40.1450.10
- PIRSF:   PIRSF001492
- TIGRFAMs:   TIGR01307

Pfam domain/function: PF06415 iPGM_N; PF01676 Metalloenzyme; SSF53649 Alkaline_phosphatase_core; SSF64158 BPG-indep_PGM_N

EC number: =5.4.2.1

Molecular weight: Translated: 57864; Mature: 57864

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISLHMTQARRPLMLMILDGWGYREEKEGNAILAASTPHLDRLQKERPSCFLETSGEAV
CEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEECCCCEE
GLPQGQMGNSEVGHLNIGAGRVVYQDLTKINVSIRNGDFFENPVLLDAISNVKLNNSSLH
CCCCCCCCCCCCCEEECCCCHHHEEECEEEEEEEECCCCCCCCEEEEECCCCEECCCCEE
LMGLVSYGGVHSHMTHLYALIKLAQEKGLKKVYIHVFLDGRDVPPKAALGDVKELDAFCK
EEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHCCHHHHHHHHC
ENQSVKIATVQGRYYAMDRDKRWERTKLAYDALTLGVAPYKTSDAVTAVSEAYERGETDE
CCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCCC
FIKPTIVTDSEGNPEAVIQDTDSIVFLNFRPDRARQLTWAFVKDDFEGFTREKRPKVHYV
CCCCEEEECCCCCCCEEEECCCCEEEEEECCCHHHEEEEEEEHHHHHHHHHCCCCCEEEE
CMAQYDETLDLPIAFPPEELTDVLGKVLSDRGLIQLRIAETEKYAHVTFFLNGGQEKCYS
EEEECCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEECCCCCCCC
GEDRCLIPSPKISTYDLKPEMSAYEVTDEVVKRILSGKYDVIILNFANMDMVGHTGDFEA
CCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCHHH
AVKAVETVDNCVGRIVEALRTAGGAALITADHGNAEQMENSHTGEPHTAHTSNPVKCIYT
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCEEEEEE
GNGEVKALENGKLSDLAPTLLDLLEIPKPEKMTGRSLIVRK
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MRISLHMTQARRPLMLMILDGWGYREEKEGNAILAASTPHLDRLQKERPSCFLETSGEAV
CEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEECCCCEE
GLPQGQMGNSEVGHLNIGAGRVVYQDLTKINVSIRNGDFFENPVLLDAISNVKLNNSSLH
CCCCCCCCCCCCCEEECCCCHHHEEECEEEEEEEECCCCCCCCEEEEECCCCEECCCCEE
LMGLVSYGGVHSHMTHLYALIKLAQEKGLKKVYIHVFLDGRDVPPKAALGDVKELDAFCK
EEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHCCHHHHHHHHC
ENQSVKIATVQGRYYAMDRDKRWERTKLAYDALTLGVAPYKTSDAVTAVSEAYERGETDE
CCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCCC
FIKPTIVTDSEGNPEAVIQDTDSIVFLNFRPDRARQLTWAFVKDDFEGFTREKRPKVHYV
CCCCEEEECCCCCCCEEEECCCCEEEEEECCCHHHEEEEEEEHHHHHHHHHCCCCCEEEE
CMAQYDETLDLPIAFPPEELTDVLGKVLSDRGLIQLRIAETEKYAHVTFFLNGGQEKCYS
EEEECCCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEEECCCCCCCC
GEDRCLIPSPKISTYDLKPEMSAYEVTDEVVKRILSGKYDVIILNFANMDMVGHTGDFEA
CCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCHHH
AVKAVETVDNCVGRIVEALRTAGGAALITADHGNAEQMENSHTGEPHTAHTSNPVKCIYT
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCEEEEEE
GNGEVKALENGKLSDLAPTLLDLLEIPKPEKMTGRSLIVRK
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824