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The map label for this gene is serS

Identifier: 21226967

GI number: 21226967

Start: 1021868

End: 1023136

Strand: Reverse

Name: serS

Synonym: MM_0865

Alternate gene names: 21226967

Gene position: 1023136-1021868 (Counterclockwise)

Preceding gene: 21226968

Following gene: 21226960

Centisome position: 24.98

GC content: 45.07

Gene sequence:

>1269_bases
ATGCTGGAACTTAAATTTGTACGTAACAACCCCGACATAGTTGGGCGTGCTCTTATTAGCAGGAATATGGGCACAGAGCT
TATTGATAGCCTTCTTGAATATGACGCAGCCTGGAGGGAATGTCTCATCGAGGGCGATGACCTGAAGCACAAGCGTAATG
TTGTCACCCGCGAGATAGCGCAGCTCAAGAAGGAAAATAAAGACGCTGCATCCAGAATAAATGAAATGCAGGGCATTAAC
AGCCGTATTAAAGAGCTGGATGACAAAATACGCGATTACAAATCAAAAATAAATGAAATAATGCTAAGTATTCCAAATAT
TCCTTCTGAAACCACGCCTGTAGGCAAGGATGAGAATGACAATCCGGTTGTAAGGGTAGTTGGAGAACCAAGGGAGTTCA
CATTTACTCCAAAGCCGCACTGGGAAATAGGAGAATCTCTGGATATCCTTGACTTTGAAAGAGCAGCTAAGATATCAGGC
CAGGGTTTTGCAGTCTATAAAGGTATGGGCGCAAAGCTTGAGAGAGCTCTCATAAACTTCATGCTTGATGTGCACACCAG
GCAGGGTTATCTTGAAGTTTTTCCTCCTGTGCTTATTAATGAGAAAGCCATGACTGGTACAGGCCAATTACCCAAGTTTA
AAGACGATATGTACGGATGCACTGATGGTTTCTATCTTGCGCCTACTGCAGAAGTGCCTGTAACCAACCTCTTCATGGAT
GAATATATGGAAAACCTGCCGGTATTTCTTACAGCATACACTGCCTGTTTCAGGCGTGAGGCAGGAAAACATGGTCAGGA
TACCAGAGGTATCATCCGCAACCACCAGTTCAATAAGGTTGAACTTGTTAAATTCGTAATGCCTGAAACATCCTATGAAG
AACTGGAAAAACTTACTCTTGATGCTGAAGAGATCCTCAAACTCCTTAAGTTACCATATCGGGTAGTAAGCCTCTGTACT
GGCGATCTGGGATTCTCGGCTGCCAAGACTTACGACCTCGAAGTATGGGTACCTACACAGGAAAAGTATAGAGAAATCTC
TTCGTGCTCTAATTTCGATAATTTCCAGGCAAGGAGAGCCAACATCCGCTACAGGACTCCTGAAGGGCCACAGTTCGTTC
ACACGCTCAACGGTTCGGGACTTGCTGTCGGCAGGACGGTTGTTGCAATACTGGAGAACTACCAGCGTGAAGACGGCAGT
GTCGAAATTCCGGAAGTCCTCAGGCCTTACATGGGTGGGGCAGAAGAAATTAGAAAAGTTTGCCATTGA

Upstream 100 bases:

>100_bases
TCCATTACTTATTTTTCGGGTTTTAATTTCTTGTGCAGGCTTGCAGCCTGAAAATAGTAAAATATATATTAGCTAACATG
CAGGATATCACGGGCTTAAC

Downstream 100 bases:

>100_bases
AGATAGTTTGAGCTTGCGGACTATTTCAAAAGACTCTTTCGCACAGCTGGCAGAACTATATTCCATAGTTGATACCGTAT
AAATTAAGTTAGAAATGAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLELKFVRNNPDIVGRALISRNMGTELIDSLLEYDAAWRECLIEGDDLKHKRNVVTREIAQLKKENKDAASRINEMQGIN
SRIKELDDKIRDYKSKINEIMLSIPNIPSETTPVGKDENDNPVVRVVGEPREFTFTPKPHWEIGESLDILDFERAAKISG
QGFAVYKGMGAKLERALINFMLDVHTRQGYLEVFPPVLINEKAMTGTGQLPKFKDDMYGCTDGFYLAPTAEVPVTNLFMD
EYMENLPVFLTAYTACFRREAGKHGQDTRGIIRNHQFNKVELVKFVMPETSYEELEKLTLDAEEILKLLKLPYRVVSLCT
GDLGFSAAKTYDLEVWVPTQEKYREISSCSNFDNFQARRANIRYRTPEGPQFVHTLNGSGLAVGRTVVAILENYQREDGS
VEIPEVLRPYMGGAEEIRKVCH

Sequences:

>Translated_422_residues
MLELKFVRNNPDIVGRALISRNMGTELIDSLLEYDAAWRECLIEGDDLKHKRNVVTREIAQLKKENKDAASRINEMQGIN
SRIKELDDKIRDYKSKINEIMLSIPNIPSETTPVGKDENDNPVVRVVGEPREFTFTPKPHWEIGESLDILDFERAAKISG
QGFAVYKGMGAKLERALINFMLDVHTRQGYLEVFPPVLINEKAMTGTGQLPKFKDDMYGCTDGFYLAPTAEVPVTNLFMD
EYMENLPVFLTAYTACFRREAGKHGQDTRGIIRNHQFNKVELVKFVMPETSYEELEKLTLDAEEILKLLKLPYRVVSLCT
GDLGFSAAKTYDLEVWVPTQEKYREISSCSNFDNFQARRANIRYRTPEGPQFVHTLNGSGLAVGRTVVAILENYQREDGS
VEIPEVLRPYMGGAEEIRKVCH
>Mature_422_residues
MLELKFVRNNPDIVGRALISRNMGTELIDSLLEYDAAWRECLIEGDDLKHKRNVVTREIAQLKKENKDAASRINEMQGIN
SRIKELDDKIRDYKSKINEIMLSIPNIPSETTPVGKDENDNPVVRVVGEPREFTFTPKPHWEIGESLDILDFERAAKISG
QGFAVYKGMGAKLERALINFMLDVHTRQGYLEVFPPVLINEKAMTGTGQLPKFKDDMYGCTDGFYLAPTAEVPVTNLFMD
EYMENLPVFLTAYTACFRREAGKHGQDTRGIIRNHQFNKVELVKFVMPETSYEELEKLTLDAEEILKLLKLPYRVVSLCT
GDLGFSAAKTYDLEVWVPTQEKYREISSCSNFDNFQARRANIRYRTPEGPQFVHTLNGSGLAVGRTVVAILENYQREDGS
VEIPEVLRPYMGGAEEIRKVCH

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=437, Percent_Identity=30.8924485125858, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI8923421, Length=384, Percent_Identity=32.5520833333333, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI225579074, Length=321, Percent_Identity=36.1370716510903, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=46.9767441860465, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539260, Length=450, Percent_Identity=29.1111111111111, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=374, Percent_Identity=28.8770053475936, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320226, Length=430, Percent_Identity=35.3488372093023, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6321799, Length=371, Percent_Identity=31.266846361186, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=29.5896328293737, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17737985, Length=375, Percent_Identity=31.2, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_METMA (Q8PYJ6)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632889.1
- ProteinModelPortal:   Q8PYJ6
- SMR:   Q8PYJ6
- GeneID:   1479207
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0865
- NMPDR:   fig|192952.1.peg.865
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   MMAZ192952:MM0865-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48073; Mature: 48073

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 281-281 BINDING 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELKFVRNNPDIVGRALISRNMGTELIDSLLEYDAAWRECLIEGDDLKHKRNVVTREIA
CEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QLKKENKDAASRINEMQGINSRIKELDDKIRDYKSKINEIMLSIPNIPSETTPVGKDEND
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NPVVRVVGEPREFTFTPKPHWEIGESLDILDFERAAKISGQGFAVYKGMGAKLERALINF
CCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
MLDVHTRQGYLEVFPPVLINEKAMTGTGQLPKFKDDMYGCTDGFYLAPTAEVPVTNLFMD
HHHHHCCCCHHHHCCCHHCCCCCCCCCCCCCCCHHHHCCCCCCEEECCCCCCCHHHHHHH
EYMENLPVFLTAYTACFRREAGKHGQDTRGIIRNHQFNKVELVKFVMPETSYEELEKLTL
HHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCC
DAEEILKLLKLPYRVVSLCTGDLGFSAAKTYDLEVWVPTQEKYREISSCSNFDNFQARRA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCCHHHHHC
NIRYRTPEGPQFVHTLNGSGLAVGRTVVAILENYQREDGSVEIPEVLRPYMGGAEEIRKV
CEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCHHHHHHH
CH
CC
>Mature Secondary Structure
MLELKFVRNNPDIVGRALISRNMGTELIDSLLEYDAAWRECLIEGDDLKHKRNVVTREIA
CEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QLKKENKDAASRINEMQGINSRIKELDDKIRDYKSKINEIMLSIPNIPSETTPVGKDEND
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NPVVRVVGEPREFTFTPKPHWEIGESLDILDFERAAKISGQGFAVYKGMGAKLERALINF
CCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
MLDVHTRQGYLEVFPPVLINEKAMTGTGQLPKFKDDMYGCTDGFYLAPTAEVPVTNLFMD
HHHHHCCCCHHHHCCCHHCCCCCCCCCCCCCCCHHHHCCCCCCEEECCCCCCCHHHHHHH
EYMENLPVFLTAYTACFRREAGKHGQDTRGIIRNHQFNKVELVKFVMPETSYEELEKLTL
HHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCC
DAEEILKLLKLPYRVVSLCTGDLGFSAAKTYDLEVWVPTQEKYREISSCSNFDNFQARRA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCCHHHHHC
NIRYRTPEGPQFVHTLNGSGLAVGRTVVAILENYQREDGSVEIPEVLRPYMGGAEEIRKV
CEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCHHHHHHH
CH
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824