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The map label for this gene is napA [H]

Identifier: 21226936

GI number: 21226936

Start: 984394

End: 985539

Strand: Direct

Name: napA [H]

Synonym: MM_0834

Alternate gene names: 21226936

Gene position: 984394-985539 (Clockwise)

Preceding gene: 21226935

Following gene: 21226938

Centisome position: 24.03

GC content: 44.5

Gene sequence:

>1146_bases
GTGAAATTTTTTGGTGAGATAGCAGAAAGGGCCGGAGTCCCCTCAGTTATGGGAGAAATTCTGGCTGGGATTCTGTTTGG
AGCACTTTTTCTGGATGTGGAAACCGGGATAATAACTTTTTTTGCTCAGCTAGGGTCCATTTTCCTGCTTTTTACCGCAG
GATATAAAGAAGTGAGCCTGAGGGACCTGAGACCCGCAGTACTGGTTGCCTTTATCCCTACTCTCACCCAGCTGGTTTTT
GCCTTTGCATTCGGGTTCATGCTTGGGAAAATCTTTAATTTTACATTTCTTCAAAGCCTTTTTATGGCGGTTGCTCTCAG
CCCGACAGCCATAGGAGTGGTTATCAGAATTCTTATAGACCTTAACTACCTGTCCAGCAGACCTGGCCTAGTAATGCTTT
CTTCGGCGGTTCTGGACGATATTATAGCAATATCCCTTCTCTCCCTGATTGTTACCTTTGCCCGTTTTAACCGCGCACCT
TCTGCCCTGGCAGTTCTTACAATCTCAGGAAAGATCCTGCTTTTCCTGCTGATTATGTACATCCTCGGAAAATATTTCTT
TCCCAGGCTTTTTGTCCATGCCCAGAAAATGCACGCAAAAGAAGCAGTATTTTCCCTTGTGGTTATGACAGCCCTTTTTT
CTTCCTATCTTGCAGAGTTATTTGAGCTTCATGCAACAATAGGAGCATTCATAGGAGGGATGTTAATTTCTGAAATTCCC
CTTGCAAAGATTCCTGACGTGCAGAGCAAAGTAGAGGGACTGGCTTACGGGATTTTAATCCCACTTTTTTTCGCGTTCAT
AGGATATTCAATTGATCTTTACGCCCTGGTAAAAGCAGGTATTTTCGTCCCTGTGGTCACCCTCCTGGCCCTCTCAGGAA
AGCTGATAGGGGGATTCATAGGGTCAAAAGCCATAGGGTTCAATTTTTGCGAAAGCCTCGCATTTGGGGCAGGGGTCATG
CCCAGGGCAGGAATAGAGCTTGTGATGCTGACAATAGGAAGAGGGATCGGAATTATAGGCGAAGAAATATTCTCAGCCAT
GGTGTTTATGGTTATTGTGTCCATTCTGATTTCACCTTCGGCTTTGAAATTTGCGATCCAGGCAGAAAGAAAAAACAAAA
CAGGCAATGAATTAAAGGTTGGATAA

Upstream 100 bases:

>100_bases
GTTGTAAAAGGAAATTAAAAAATAAAAACAAACGTGTAAATAAGAACCGGGGGGTAAAGCAATAAGTGCTCTGTTTCAGG
TACTGTTTCTCATTTTCAGC

Downstream 100 bases:

>100_bases
GAGTGAACAACCCGGAAGTTGAAAAGAGCAGGAGCATGAGTTTTAAGAATAGGGCACGAAAAAATACCCCTGCACCGCTT
ATAAGGTTCCCTTTAATCAG

Product: Na(+)/H(+) antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKFFGEIAERAGVPSVMGEILAGILFGALFLDVETGIITFFAQLGSIFLLFTAGYKEVSLRDLRPAVLVAFIPTLTQLVF
AFAFGFMLGKIFNFTFLQSLFMAVALSPTAIGVVIRILIDLNYLSSRPGLVMLSSAVLDDIIAISLLSLIVTFARFNRAP
SALAVLTISGKILLFLLIMYILGKYFFPRLFVHAQKMHAKEAVFSLVVMTALFSSYLAELFELHATIGAFIGGMLISEIP
LAKIPDVQSKVEGLAYGILIPLFFAFIGYSIDLYALVKAGIFVPVVTLLALSGKLIGGFIGSKAIGFNFCESLAFGAGVM
PRAGIELVMLTIGRGIGIIGEEIFSAMVFMVIVSILISPSALKFAIQAERKNKTGNELKVG

Sequences:

>Translated_381_residues
MKFFGEIAERAGVPSVMGEILAGILFGALFLDVETGIITFFAQLGSIFLLFTAGYKEVSLRDLRPAVLVAFIPTLTQLVF
AFAFGFMLGKIFNFTFLQSLFMAVALSPTAIGVVIRILIDLNYLSSRPGLVMLSSAVLDDIIAISLLSLIVTFARFNRAP
SALAVLTISGKILLFLLIMYILGKYFFPRLFVHAQKMHAKEAVFSLVVMTALFSSYLAELFELHATIGAFIGGMLISEIP
LAKIPDVQSKVEGLAYGILIPLFFAFIGYSIDLYALVKAGIFVPVVTLLALSGKLIGGFIGSKAIGFNFCESLAFGAGVM
PRAGIELVMLTIGRGIGIIGEEIFSAMVFMVIVSILISPSALKFAIQAERKNKTGNELKVG
>Mature_381_residues
MKFFGEIAERAGVPSVMGEILAGILFGALFLDVETGIITFFAQLGSIFLLFTAGYKEVSLRDLRPAVLVAFIPTLTQLVF
AFAFGFMLGKIFNFTFLQSLFMAVALSPTAIGVVIRILIDLNYLSSRPGLVMLSSAVLDDIIAISLLSLIVTFARFNRAP
SALAVLTISGKILLFLLIMYILGKYFFPRLFVHAQKMHAKEAVFSLVVMTALFSSYLAELFELHATIGAFIGGMLISEIP
LAKIPDVQSKVEGLAYGILIPLFFAFIGYSIDLYALVKAGIFVPVVTLLALSGKLIGGFIGSKAIGFNFCESLAFGAGVM
PRAGIELVMLTIGRGIGIIGEEIFSAMVFMVIVSILISPSALKFAIQAERKNKTGNELKVG

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=377, Percent_Identity=24.9336870026525, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 41076; Mature: 41076

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFGEIAERAGVPSVMGEILAGILFGALFLDVETGIITFFAQLGSIFLLFTAGYKEVSL
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RDLRPAVLVAFIPTLTQLVFAFAFGFMLGKIFNFTFLQSLFMAVALSPTAIGVVIRILID
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LNYLSSRPGLVMLSSAVLDDIIAISLLSLIVTFARFNRAPSALAVLTISGKILLFLLIMY
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHH
ILGKYFFPRLFVHAQKMHAKEAVFSLVVMTALFSSYLAELFELHATIGAFIGGMLISEIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LAKIPDVQSKVEGLAYGILIPLFFAFIGYSIDLYALVKAGIFVPVVTLLALSGKLIGGFI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSKAIGFNFCESLAFGAGVMPRAGIELVMLTIGRGIGIIGEEIFSAMVFMVIVSILISPS
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCH
ALKFAIQAERKNKTGNELKVG
HHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKFFGEIAERAGVPSVMGEILAGILFGALFLDVETGIITFFAQLGSIFLLFTAGYKEVSL
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RDLRPAVLVAFIPTLTQLVFAFAFGFMLGKIFNFTFLQSLFMAVALSPTAIGVVIRILID
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LNYLSSRPGLVMLSSAVLDDIIAISLLSLIVTFARFNRAPSALAVLTISGKILLFLLIMY
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHH
ILGKYFFPRLFVHAQKMHAKEAVFSLVVMTALFSSYLAELFELHATIGAFIGGMLISEIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LAKIPDVQSKVEGLAYGILIPLFFAFIGYSIDLYALVKAGIFVPVVTLLALSGKLIGGFI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSKAIGFNFCESLAFGAGVMPRAGIELVMLTIGRGIGIIGEEIFSAMVFMVIVSILISPS
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCH
ALKFAIQAERKNKTGNELKVG
HHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]