Click here to switch to the map view.

The map label for this gene is ribD [C]

Identifier: 21226928

GI number: 21226928

Start: 976865

End: 977551

Strand: Direct

Name: ribD [C]

Synonym: MM_0826

Alternate gene names: 21226928

Gene position: 976865-977551 (Clockwise)

Preceding gene: 21226927

Following gene: 21226934

Centisome position: 23.85

GC content: 44.69

Gene sequence:

>687_bases
ATGGACAGGCCCTTTATTTTTATAAATTCTGCTATGTCAGCTGACGGCAAGCTCTCAACAAAGGAAAGAAAGCAGGTAAA
GATCTCCGGAAAACTTGATTTTGAGAGAATGGATGAACTCAGGGCTCATGCAGATGCGATTATGGTGGGAATAGGGACCG
TACTTGCCGATGACCCCAGCCTGACAGTAAAATCCCCTGAAAGAAAGGCAGCCAGAAAAGCTGCCGGAAAAAGTGAAAAT
CCCGTAAGGGTTGTTGTTGACAGCTCAGCAAGGACACCTCTTAATGCCGATATCTTCAAAAAAGGTGAAGGGCTCAGGAT
AATTGCTGTTTCAAATTCCGCCCCTGAAGAAAAAATCAGGATGCTGGAAGAAAAAGCCCTTGTCATAAAAACAGGAGCCT
TTAGAGTTGACCTTACCGAGCTTGCAGCAAAATTAAAGGAAATGGGTATAAACAGCCTCATGGTCGAGGGAGGCGCAACC
CTGAACTGGGGCATGCTTTCCGCAGGTCTTGTTGATGAGGTATATACTTTTGTTGGAAACCTTATCATAGGAGGGAAAAC
AGCTCCAACCTTTACTGACGGGGAAGGTTTTACAGAAAACGAACTCCTCGGGCTTGAACTGTCTTCAGCTGAAAAAATTG
AAGATGGAATACTTCTGAAGTGGAAGGTCAAAGGGAAGAAGAACTGA

Upstream 100 bases:

>100_bases
TAAAAAATTAAATGGCTAAAAAATTAAACAGCTAAAAAATAAAAACGTGATTCTCAATTACGTGACTCTCAATTCAATAC
TTTTTTTCAGGAGCTAAAAA

Downstream 100 bases:

>100_bases
AAACCTTTTTTATAGAATCATTTTAAAAGTACTCTCTTTTCTTATTTTCATAGAATTATTTTAAAAATATTCTCTTTTTT
TATGTTTACAAAATTGCCTT

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: HTP reductase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MDRPFIFINSAMSADGKLSTKERKQVKISGKLDFERMDELRAHADAIMVGIGTVLADDPSLTVKSPERKAARKAAGKSEN
PVRVVVDSSARTPLNADIFKKGEGLRIIAVSNSAPEEKIRMLEEKALVIKTGAFRVDLTELAAKLKEMGINSLMVEGGAT
LNWGMLSAGLVDEVYTFVGNLIIGGKTAPTFTDGEGFTENELLGLELSSAEKIEDGILLKWKVKGKKN

Sequences:

>Translated_228_residues
MDRPFIFINSAMSADGKLSTKERKQVKISGKLDFERMDELRAHADAIMVGIGTVLADDPSLTVKSPERKAARKAAGKSEN
PVRVVVDSSARTPLNADIFKKGEGLRIIAVSNSAPEEKIRMLEEKALVIKTGAFRVDLTELAAKLKEMGINSLMVEGGAT
LNWGMLSAGLVDEVYTFVGNLIIGGKTAPTFTDGEGFTENELLGLELSSAEKIEDGILLKWKVKGKKN
>Mature_228_residues
MDRPFIFINSAMSADGKLSTKERKQVKISGKLDFERMDELRAHADAIMVGIGTVLADDPSLTVKSPERKAARKAAGKSEN
PVRVVVDSSARTPLNADIFKKGEGLRIIAVSNSAPEEKIRMLEEKALVIKTGAFRVDLTELAAKLKEMGINSLMVEGGAT
LNWGMLSAGLVDEVYTFVGNLIIGGKTAPTFTDGEGFTENELLGLELSSAEKIEDGILLKWKVKGKKN

Specific function: Converts 2,5-Diamino-6-(Ribosylamino)-4(3h)-Pyrimidinone 5'-Phosphate Into 5-Amino-6-(Ribosylamino)-2,4(1h,3h)- Pyrimidinedione 5'-Phosphate. [C]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=225, Percent_Identity=30.2222222222222, Blast_Score=83, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319629, Length=187, Percent_Identity=29.9465240641711, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006401
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF01872 RibD_C [H]

EC number: =1.1.1.193 [H]

Molecular weight: Translated: 24665; Mature: 24665

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPFIFINSAMSADGKLSTKERKQVKISGKLDFERMDELRAHADAIMVGIGTVLADDPS
CCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEHHHEEECCCC
LTVKSPERKAARKAAGKSENPVRVVVDSSARTPLNADIFKKGEGLRIIAVSNSAPEEKIR
EEEECCHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHH
MLEEKALVIKTGAFRVDLTELAAKLKEMGINSLMVEGGATLNWGMLSAGLVDEVYTFVGN
HHHHCEEEEECCCEEEEHHHHHHHHHHCCCCEEEECCCCEEECHHHHHHHHHHHHHHHCC
LIIGGKTAPTFTDGEGFTENELLGLELSSAEKIEDGILLKWKVKGKKN
EEECCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCEEEEEEECCCCC
>Mature Secondary Structure
MDRPFIFINSAMSADGKLSTKERKQVKISGKLDFERMDELRAHADAIMVGIGTVLADDPS
CCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEEHHHEEECCCC
LTVKSPERKAARKAAGKSENPVRVVVDSSARTPLNADIFKKGEGLRIIAVSNSAPEEKIR
EEEECCHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHH
MLEEKALVIKTGAFRVDLTELAAKLKEMGINSLMVEGGATLNWGMLSAGLVDEVYTFVGN
HHHHCEEEEECCCEEEEHHHHHHHHHHCCCCEEEECCCCEEECHHHHHHHHHHHHHHHCC
LIIGGKTAPTFTDGEGFTENELLGLELSSAEKIEDGILLKWKVKGKKN
EEECCCCCCCCCCCCCCCCCCEEEEEECCCHHCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]