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The map label for this gene is proC [H]

Identifier: 21226919

GI number: 21226919

Start: 967653

End: 968465

Strand: Reverse

Name: proC [H]

Synonym: MM_0817

Alternate gene names: 21226919

Gene position: 968465-967653 (Counterclockwise)

Preceding gene: 21226920

Following gene: 21226915

Centisome position: 23.64

GC content: 48.71

Gene sequence:

>813_bases
ATGATAAATCGAAAAATAGGATTCATTGGGGCAGGGAAAATGGGTTCTGCTCTCATGCAGGGCATAATTAAAGCCGGAAT
CGTGCAGCCTGAAAATATCGGTGCAAGCGATGTATACGAGCCTTTTTTAAAAGAGCTTCAGACAAAGCTGGGGATCAGGG
TATCAACCGATAATACCGTTATTGTCCGGGAGTCGGATATCCTCATTCTTGCAGTAAAGCCCCAGACGCTTGGTTCTGTA
CTTGAAAACCTGAAAAATGAAATTACTTCCGAAAAACTCGTAATATCAATTGCTGCAGGAGTGCCTCTTTCAACTTACGA
GGGCGCTCTTCTTGAAGGCACCAGGGTTGTCCGTGTCATGCCCAATATAGCAGCAACAGTTTCGGAGGCTGCTTCGGGAA
TTTCCCCCGGGAAGAACGCGACCCCTGAGGATATGAAAGATGCTCTTACTATCTTTTCTGCGGTTGGTACTGCAGTTCAG
GTTCCTGAATCCCTGATGGACGCAGTTACAGGTCTTTCCGGCAGTGGGCCTGCTTTCATTTTCCCTGTCATAGAGGCTAT
GGCTGACGGGGCTGTACTGGAAGGCATGGACAGGAAAAGCGCTCTTACCCTCGCAGCCCAGACCGTGCTCGGAGCCGCAA
AAATGGCACTTGAAACAGGCATGCACCCCGGAGAACTCAAAGATATGGTTACATCTCCTGCCGGTACCACTATTCAGGGA
GTTCATGCTCTCGAGGAAGCAGGAATCAGGGCAGCTTTTATGAATGCAGTTATAAGAGCAAGCGAACGCTCAAGAGAACT
CGGGAAGAAGTAA

Upstream 100 bases:

>100_bases
TTTAAGGTTAATTTAAGTTTATTTAAGTTTATTTAAGTTTATTTAAGGTCAATTTAAGTTTATTTAAGTTTATTTTTCTG
GAAATAAGGAGATTTTATAC

Downstream 100 bases:

>100_bases
TAATATCGGTTTCTTCCTTTTCTTAAATCCTCTTCCATTCATCTTTAATTCCTTTTCATCCTTTTTCTTTTTTATAAGTC
TTCAATGTGTAAATTTCTTA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MINRKIGFIGAGKMGSALMQGIIKAGIVQPENIGASDVYEPFLKELQTKLGIRVSTDNTVIVRESDILILAVKPQTLGSV
LENLKNEITSEKLVISIAAGVPLSTYEGALLEGTRVVRVMPNIAATVSEAASGISPGKNATPEDMKDALTIFSAVGTAVQ
VPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQG
VHALEEAGIRAAFMNAVIRASERSRELGKK

Sequences:

>Translated_270_residues
MINRKIGFIGAGKMGSALMQGIIKAGIVQPENIGASDVYEPFLKELQTKLGIRVSTDNTVIVRESDILILAVKPQTLGSV
LENLKNEITSEKLVISIAAGVPLSTYEGALLEGTRVVRVMPNIAATVSEAASGISPGKNATPEDMKDALTIFSAVGTAVQ
VPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQG
VHALEEAGIRAAFMNAVIRASERSRELGKK
>Mature_270_residues
MINRKIGFIGAGKMGSALMQGIIKAGIVQPENIGASDVYEPFLKELQTKLGIRVSTDNTVIVRESDILILAVKPQTLGSV
LENLKNEITSEKLVISIAAGVPLSTYEGALLEGTRVVRVMPNIAATVSEAASGISPGKNATPEDMKDALTIFSAVGTAVQ
VPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQG
VHALEEAGIRAAFMNAVIRASERSRELGKK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=43.0711610486891, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI24797097, Length=267, Percent_Identity=41.9475655430712, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI24797095, Length=267, Percent_Identity=41.9475655430712, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=41.1985018726592, Blast_Score=194, Evalue=6e-50,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=43.9114391143911, Blast_Score=215, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=46.6417910447761, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=37.2759856630824, Blast_Score=150, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6320861, Length=287, Percent_Identity=30.3135888501742, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=41.7857142857143, Blast_Score=210, Evalue=8e-55,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=45.1492537313433, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=49.7076023391813, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28071; Mature: 28071

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINRKIGFIGAGKMGSALMQGIIKAGIVQPENIGASDVYEPFLKELQTKLGIRVSTDNTV
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCEE
IVRESDILILAVKPQTLGSVLENLKNEITSEKLVISIAAGVPLSTYEGALLEGTRVVRVM
EEEECCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCCEEEEEC
PNIAATVSEAASGISPGKNATPEDMKDALTIFSAVGTAVQVPESLMDAVTGLSGSGPAFI
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHH
FPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQG
HHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHH
VHALEEAGIRAAFMNAVIRASERSRELGKK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MINRKIGFIGAGKMGSALMQGIIKAGIVQPENIGASDVYEPFLKELQTKLGIRVSTDNTV
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCCCEE
IVRESDILILAVKPQTLGSVLENLKNEITSEKLVISIAAGVPLSTYEGALLEGTRVVRVM
EEEECCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCCEEEEEC
PNIAATVSEAASGISPGKNATPEDMKDALTIFSAVGTAVQVPESLMDAVTGLSGSGPAFI
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHH
FPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQG
HHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHH
VHALEEAGIRAAFMNAVIRASERSRELGKK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]