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The map label for this gene is ahpC [C]

Identifier: 21226916

GI number: 21226916

Start: 964752

End: 965411

Strand: Direct

Name: ahpC [C]

Synonym: MM_0814

Alternate gene names: 21226916

Gene position: 964752-965411 (Clockwise)

Preceding gene: 21226912

Following gene: 21226917

Centisome position: 23.55

GC content: 44.09

Gene sequence:

>660_bases
ATGCCTCTCATTGGAGACGATGCCCCTTCATTTACTGCAGTAACCACACAGGGAATTATCAAATTCCCGGATGATTATAA
AGGAAAATGGGTTATTCTGTTCAGCCACCCTGCAGACTTTACACCTGTATGCACTACTGAATTCATGACTTTTGCCAGTA
TGCAGGAAGAGTTCAGGAGCATGAACACGGAACTTATAGGGCTCTCCATAGACAGCGTCTTTTCCCATATCGCCTGGCTT
AAGAGGATTGAAGAGAAAATAGAATATAAAGGAATGAAAAATCTGGAGATCAAATTCCCGGTGATAGAAGATCTGAAGAT
GGATGTTGCAAAGAAATACGGCATGGTCCAGCCAAAAGCCTCAACCACCCAGGCTGTAAGAGCGGTATTTATTATCGACC
CAGAGGCGAAAATAAGGACAATACTCTACTATCCGCAGTCAACCGGAAGGAATATGCAGGAAATCAAGAGAATAGTAGTC
GCCCTGCAGAAAAATGCAGCCGAAAAAGTTGCAACCCCGGCTAACTGGCAGCCAGGAGAAGACGTTATCATTCCACCTCC
CAGTTCAATGGAAGCAGTAAAAGAAAGGATGGGAAAAGAAGAGGAAGGAAAGCGCTGCCTTGACTGGTTTATGTGCCTGA
AAAAAGATACCCAGAAATAA

Upstream 100 bases:

>100_bases
TCAAGCACCAGTGCCTGACATCGTACTTCGGATAACGGAAAAAGATTGCAAACTAAAATGAGGTGAGAACATAATAGAAA
CAGAGTCAGAACAGATACAT

Downstream 100 bases:

>100_bases
TTTGGGTACAATAAAAACATTATTGTAACTATTCAGGTAGAGCCTTTGAAAGGCTACAATTTTTCCTCTTTTCGAGGAAA
AATTGCATATAAATTGAATC

Product: peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MPLIGDDAPSFTAVTTQGIIKFPDDYKGKWVILFSHPADFTPVCTTEFMTFASMQEEFRSMNTELIGLSIDSVFSHIAWL
KRIEEKIEYKGMKNLEIKFPVIEDLKMDVAKKYGMVQPKASTTQAVRAVFIIDPEAKIRTILYYPQSTGRNMQEIKRIVV
ALQKNAAEKVATPANWQPGEDVIIPPPSSMEAVKERMGKEEEGKRCLDWFMCLKKDTQK

Sequences:

>Translated_219_residues
MPLIGDDAPSFTAVTTQGIIKFPDDYKGKWVILFSHPADFTPVCTTEFMTFASMQEEFRSMNTELIGLSIDSVFSHIAWL
KRIEEKIEYKGMKNLEIKFPVIEDLKMDVAKKYGMVQPKASTTQAVRAVFIIDPEAKIRTILYYPQSTGRNMQEIKRIVV
ALQKNAAEKVATPANWQPGEDVIIPPPSSMEAVKERMGKEEEGKRCLDWFMCLKKDTQK
>Mature_218_residues
PLIGDDAPSFTAVTTQGIIKFPDDYKGKWVILFSHPADFTPVCTTEFMTFASMQEEFRSMNTELIGLSIDSVFSHIAWLK
RIEEKIEYKGMKNLEIKFPVIEDLKMDVAKKYGMVQPKASTTQAVRAVFIIDPEAKIRTILYYPQSTGRNMQEIKRIVVA
LQKNAAEKVATPANWQPGEDVIIPPPSSMEAVKERMGKEEEGKRCLDWFMCLKKDTQK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI4758638, Length=206, Percent_Identity=41.747572815534, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI4505591, Length=202, Percent_Identity=35.6435643564356, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI32455266, Length=202, Percent_Identity=35.6435643564356, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI32455264, Length=202, Percent_Identity=35.6435643564356, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI5453549, Length=165, Percent_Identity=36.969696969697, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI32189392, Length=185, Percent_Identity=36.7567567567568, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI5802974, Length=191, Percent_Identity=33.5078534031414, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI32483377, Length=166, Percent_Identity=34.3373493975904, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI33188454, Length=83, Percent_Identity=45.7831325301205, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1786822, Length=162, Percent_Identity=29.0123456790123, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25153706, Length=199, Percent_Identity=35.1758793969849, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI193204376, Length=189, Percent_Identity=38.6243386243386, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32565831, Length=189, Percent_Identity=38.6243386243386, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17554494, Length=161, Percent_Identity=31.6770186335404, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319407, Length=210, Percent_Identity=45.2380952380952, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6323613, Length=162, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320661, Length=160, Percent_Identity=32.5, Blast_Score=88, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=42.3280423280423, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=42.3280423280423, Blast_Score=146, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=42.3280423280423, Blast_Score=146, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24581278, Length=194, Percent_Identity=39.1752577319588, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24656348, Length=188, Percent_Identity=36.7021276595745, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17864676, Length=188, Percent_Identity=36.7021276595745, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17157991, Length=191, Percent_Identity=35.6020942408377, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24641739, Length=191, Percent_Identity=35.6020942408377, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21357347, Length=175, Percent_Identity=37.1428571428571, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17738015, Length=158, Percent_Identity=33.5443037974684, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): TDXH_METMA (Q8PYP6)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632838.1
- ProteinModelPortal:   Q8PYP6
- SMR:   Q8PYP6
- GeneID:   1479156
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0814
- NMPDR:   fig|192952.1.peg.814
- HOGENOM:   HBG493509
- OMA:   DFEARST
- ProtClustDB:   PRK13189
- BioCyc:   MMAZ192952:MM0814-MONOMER
- BRENDA:   1.11.1.15
- HAMAP:   MF_00401
- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 24946; Mature: 24815

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 44-44

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIGDDAPSFTAVTTQGIIKFPDDYKGKWVILFSHPADFTPVCTTEFMTFASMQEEFRS
CCCCCCCCCCEEEEECCCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
MNTELIGLSIDSVFSHIAWLKRIEEKIEYKGMKNLEIKFPVIEDLKMDVAKKYGMVQPKA
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCC
STTQAVRAVFIIDPEAKIRTILYYPQSTGRNMQEIKRIVVALQKNAAEKVATPANWQPGE
HHHHHEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DVIIPPPSSMEAVKERMGKEEEGKRCLDWFMCLKKDTQK
CEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLIGDDAPSFTAVTTQGIIKFPDDYKGKWVILFSHPADFTPVCTTEFMTFASMQEEFRS
CCCCCCCCCEEEEECCCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
MNTELIGLSIDSVFSHIAWLKRIEEKIEYKGMKNLEIKFPVIEDLKMDVAKKYGMVQPKA
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCC
STTQAVRAVFIIDPEAKIRTILYYPQSTGRNMQEIKRIVVALQKNAAEKVATPANWQPGE
HHHHHEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DVIIPPPSSMEAVKERMGKEEEGKRCLDWFMCLKKDTQK
CEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824