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The map label for this gene is hyuA [H]

Identifier: 21226170

GI number: 21226170

Start: 91254

End: 92966

Strand: Reverse

Name: hyuA [H]

Synonym: MM_0068

Alternate gene names: 21226170

Gene position: 92966-91254 (Counterclockwise)

Preceding gene: 21226171

Following gene: 21226169

Centisome position: 2.27

GC content: 49.27

Gene sequence:

>1713_bases
ATGCTAATAGGAATTGATGTAGGGGGCACCACCACGGATGCGGTGCTTATAAGGAACGGAGAGGTATACAGCACAGCCAA
GGTTCCCACGGAGCCAGGAGACCTTTTGAAGTCTCTTCTCGGTGCCCTTGATGAGGTTAGCAGAGGAGTTCCCCCGGAAC
AGTTTGAGAGGGTGGTGTTCAGTACAACTGTAATAACAAACCTTATTGCAGAGGGTAAAACCGAGAGGGTAGCTTTACTG
CTCATCCCGGGCCCTGGAGTTAACCCCGCAAGTTACGTTTTTCCCGACAGTTTCTGTATTAAGGGAGCTATGGATTACAG
GGGAAGGGAAATACAGCCCATAGACGAGGAAGAGGTTCGGGGGACTGTAAGCCGGATAAGGGATCAGGGCTTTTTAAGGG
TTGCTGTGGTAAGCAAATTCGGGCAGAGAAACCCTTCTCATGAACTCAGGATAGAAGAAATCATCAGGGAAATGCACCCG
GACTGTAAAGTGGAACTCGGTCATAAAGTTTCAGGCAAACTGAATTTCCCAAGAAGGGTCGCTACTTCTATGCTGGCATC
CGCTACAGGAGAGCATTACCAGAACTTCGTTTCTGAGATCAAAAAAGCCCTGGAGGAAAGAAAAATCCGGGCTTCTGTCT
TTATTCTTAAAGCTGATGGAGGGACTCTGCCAATTGAAAAATCAGTGGAACTCCCTGTGGAGACTATTTTTTCAGGCCCT
GCTGCAAGCACTATAGGAGCCCTTGCCATTACCCCTGAAGGGCAAACATCCGTTGTGGTGGATATAGGCGGGACGACTAC
AGACCTTGCCCTTATCCTCTCTGGAAAACCGCTTATCGCTTCCAAAGGTGCCAGGCTGGGAGATTTCCTGACCCATGTCC
GGGCTTTTGCTGTCCGCTCGATAGCTGTAGGAGGAGACAGCATTGTAAGGGTTAAAGAAACAGACAGTGGGCTCAGGACG
ATAAGCATAGGGCCTGAAAGGGTGGGTCCGGCTTACTGCATGGGAGGAAAAGAGCCAACCCCTACGGATGCTTTGAGAGT
TCTCAGGCTTGTGGAAGTAGGAGATTCTCAAAGGGCAAATGAGGCAATATCTTCTGTAGCTTCCAGTCTTGGTAAATCTG
TACTGGAAACCGCGTCCCTTATAGTGGACATAACCGCAGAAATGATTGCACAGGCAGTGAGAGAGATGTTTCTTGAATGG
GAACAGGAGCCTGCTTACAGGATATGGGAAGTTCTGCAGAAGAAAAAAGAAAGGCCTGAAAATGTGGTCGGAATAGGCGG
CGGGGCAAAGGGACTGATTGCAGGGGTTGCTGAAAAATTGAACGCTAAACCGGTTATTCCCTCCCATTCGGAGGTTGGAA
ATGCTATCGGGGCAGCCGTTGCAAGGCCTACTCTTACTCTCAACCTGCGCATTGATACCGAGCAGAAGGTCTATTCGGTA
GCCGAAGATGGAGAGATTGCAAGCCTTAAATTTACGGATATCGGGAATTTCAACAGGATGCGTTCGGAAGAAGCCGAAAC
CCTTGCAGCAAAACTTCTCAGGGACCGTGCAAAAAGGTTTGGGATTTTCGAGTACGTGGAAGAAGCCGAAGTTGTTAGCA
GCGAAGTTTTTAACATAGTGGAAGGCTGGCTTACTGTGGGGAGGCTTTTTGACGTAAGTATGCAGATCCCGGCAGGCCTC
ATTCCAGAATGGAGCAGGAGGGAAAAGGCATGA

Upstream 100 bases:

>100_bases
TAAATCAATTGAAACTGGCTACAAGCCACATTTATTATAAATTTACTAAAGTGAAATAATTGAAGATATATTCATTCAGG
TGAGGATAGGCGAATTGTGA

Downstream 100 bases:

>100_bases
AACTCGGGATCGGGAAGATTAAGGATGTACTCAAAAGCGGAGCCGGAAAAAGTACCGAATCCGGGAGAGAAGAACAAAAA
ATAGAGGAAATTGAGCCTGA

Product: N-methylhydantoinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVFSTTVITNLIAEGKTERVALL
LIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVRGTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHP
DCKVELGHKVSGKLNFPRRVATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP
AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRSIAVGGDSIVRVKETDSGLRT
ISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRANEAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEW
EQEPAYRIWEVLQKKKERPENVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV
AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIVEGWLTVGRLFDVSMQIPAGL
IPEWSRREKA

Sequences:

>Translated_570_residues
MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVFSTTVITNLIAEGKTERVALL
LIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVRGTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHP
DCKVELGHKVSGKLNFPRRVATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP
AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRSIAVGGDSIVRVKETDSGLRT
ISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRANEAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEW
EQEPAYRIWEVLQKKKERPENVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV
AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIVEGWLTVGRLFDVSMQIPAGL
IPEWSRREKA
>Mature_570_residues
MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVFSTTVITNLIAEGKTERVALL
LIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVRGTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHP
DCKVELGHKVSGKLNFPRRVATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP
AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRSIAVGGDSIVRVKETDSGLRT
ISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRANEAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEW
EQEPAYRIWEVLQKKKERPENVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV
AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIVEGWLTVGRLFDVSMQIPAGL
IPEWSRREKA

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Drosophila melanogaster, GI45550492, Length=247, Percent_Identity=28.3400809716599, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 61664; Mature: 61664

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVF
CEEEEECCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
STTVITNLIAEGKTERVALLLIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVR
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCHHHHH
GTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHPDCKVELGHKVSGKLNFPRRV
HHHHHHHCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCHHHH
ATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP
HHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHCCC
AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRS
CHHHCCEEEECCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHH
IAVGGDSIVRVKETDSGLRTISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRAN
HEECCCCEEEEEECCCCCEEEECCHHHCCCHHCCCCCCCCHHHHHHHHHHHHCCCCHHHH
EAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEWEQEPAYRIWEVLQKKKERPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
NVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV
CEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHH
AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIV
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EGWLTVGRLFDVSMQIPAGLIPEWSRREKA
HHHHHHHHHHEEHCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVF
CEEEEECCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
STTVITNLIAEGKTERVALLLIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVR
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCHHHHH
GTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHPDCKVELGHKVSGKLNFPRRV
HHHHHHHCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCHHHH
ATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP
HHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHCCC
AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRS
CHHHCCEEEECCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHH
IAVGGDSIVRVKETDSGLRTISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRAN
HEECCCCEEEEEECCCCCEEEECCHHHCCCHHCCCCCCCCHHHHHHHHHHHHCCCCHHHH
EAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEWEQEPAYRIWEVLQKKKERPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
NVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV
CEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHH
AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIV
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EGWLTVGRLFDVSMQIPAGLIPEWSRREKA
HHHHHHHHHHEEHCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]