Click here to switch to the map view.

The map label for this gene is yleA [C]

Identifier: 212224708

GI number: 212224708

Start: 1428823

End: 1430100

Strand: Reverse

Name: yleA [C]

Synonym: TON_1557

Alternate gene names: 212224708

Gene position: 1430100-1428823 (Counterclockwise)

Preceding gene: 212224709

Following gene: 212224707

Centisome position: 77.4

GC content: 52.27

Gene sequence:

>1278_bases
ATGATAAAGGTTCACGTTGAGACCTACGGCTGCACCAGGAATAAAGCGGACGCCGAAATAATGGAGGCAATCCTCCTTAG
AGCGGGCTATGAGTTAGTGGAGACTCCGGAAAGTGCTGACTACGTTGTTGTGAACACCTGCGCCGTAAAGGACCCTACCG
AGAAGCACATGAGGGAGCGCATAAAAGAGCTCCTTGATTCTGGTAAAAGAGTCATCGTTACGGGTTGCCTCACACACGTC
AACCCTGATATAATAGACCCTCGCGTTTCTGGAATACTTGGAGTAAAGAGCATAGACAGAATAGCTGAGGCAATAGACCT
TGCCGAGCGCGACGGAAAGCTGGTGAGTGTTGAAGGCTGGCGCGAGAGAAGTCTTGACAAGCTTGGGCTTCCCCGCCTTT
GGAGAAGTGGCGTTGCCTTCGTGGTTCCGATAAGCGAGGGCTGCCTCAACGCGTGCACCTACTGTGCAACGCGCTTCGCT
CGTGGGGTTCTCAAGAGTTACAAACCTGAACTCGTGGTTAAGTGGGTCAAGGAGGCTTTGGCGCGCGGATACAGGGAGAT
ACAGCTTTCCAGCGAGGACACTGGCTGCTACGGCTTCGATATTGGGACCAACTTGGCGGAGCTTCTCGATGAGATAACGT
CCATAGAAGGAGAGTTCAGGATAAGGGTCGGCATGATGAACCCGAACCATGCAATAAAGTTCCTTGACGAGCTGATTGAG
GCCTATCAGGACGAGAAAGTCTACAAGTTCCTCCACCTGCCTGTTCAGAGCGGGGACAACGAAGTGCTGAGGAGAATGGG
GCGCACTTACACCGTTGAGGAGTTCGAGGAGATAGTTAACGAATTCAGAAGGAAGATTCCCGGGCTGAACCTTAACACGG
ACATCATAGTCGGCTTCCCTGGAGAGACCGAGGAAGCATTCCAGAACACAGTGGAACTGGTTAAGAGGGTGAGGCCTGAT
AAGATAAACGTTTCCCGCTATTCGCCGAGACCTGGAACGATAGCTGCCAAATGGAAGCAGCTGCCCGGCTGGAAGGTCAA
GGAGCGCTCTCGCTTGCTCCACAGGCTCAGACTCCAGATCGCCTACGAGATAAACCAGAACTACGTTGGAAGGGAGATTG
AGGTTCTCATCCACGGTGAGGGCAAAAAGGGCGGAGTGGAGGGCAGGACTTTCAACTACAAAGACATAATACTTGATGGT
GGGGCACCAGGAGAACTGATAAACGCCAGGGTCACTTGGGCAGGTTCCACATATCTTAAAGGCACTGTTTTACACTGA

Upstream 100 bases:

>100_bases
TTACTATTATACTTTTGGAACTCATTATTCATGCTTTTTGATTTTGTATCCACAGACCTGACCAGCATGCTTTTTAAACC
CCCAAGCCCAGGCGAGTGCG

Downstream 100 bases:

>100_bases
GGTATTTTTTGCAGATTCTACAATATTAATTGTTGTGCATACGATAAATTTGTGGTTCATTTGTGGAACCTACAATATCC
TACAGTGAACCAACATGGTT

Product: 2-methylthioadenine synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MIKVHVETYGCTRNKADAEIMEAILLRAGYELVETPESADYVVVNTCAVKDPTEKHMRERIKELLDSGKRVIVTGCLTHV
NPDIIDPRVSGILGVKSIDRIAEAIDLAERDGKLVSVEGWRERSLDKLGLPRLWRSGVAFVVPISEGCLNACTYCATRFA
RGVLKSYKPELVVKWVKEALARGYREIQLSSEDTGCYGFDIGTNLAELLDEITSIEGEFRIRVGMMNPNHAIKFLDELIE
AYQDEKVYKFLHLPVQSGDNEVLRRMGRTYTVEEFEEIVNEFRRKIPGLNLNTDIIVGFPGETEEAFQNTVELVKRVRPD
KINVSRYSPRPGTIAAKWKQLPGWKVKERSRLLHRLRLQIAYEINQNYVGREIEVLIHGEGKKGGVEGRTFNYKDIILDG
GAPGELINARVTWAGSTYLKGTVLH

Sequences:

>Translated_425_residues
MIKVHVETYGCTRNKADAEIMEAILLRAGYELVETPESADYVVVNTCAVKDPTEKHMRERIKELLDSGKRVIVTGCLTHV
NPDIIDPRVSGILGVKSIDRIAEAIDLAERDGKLVSVEGWRERSLDKLGLPRLWRSGVAFVVPISEGCLNACTYCATRFA
RGVLKSYKPELVVKWVKEALARGYREIQLSSEDTGCYGFDIGTNLAELLDEITSIEGEFRIRVGMMNPNHAIKFLDELIE
AYQDEKVYKFLHLPVQSGDNEVLRRMGRTYTVEEFEEIVNEFRRKIPGLNLNTDIIVGFPGETEEAFQNTVELVKRVRPD
KINVSRYSPRPGTIAAKWKQLPGWKVKERSRLLHRLRLQIAYEINQNYVGREIEVLIHGEGKKGGVEGRTFNYKDIILDG
GAPGELINARVTWAGSTYLKGTVLH
>Mature_425_residues
MIKVHVETYGCTRNKADAEIMEAILLRAGYELVETPESADYVVVNTCAVKDPTEKHMRERIKELLDSGKRVIVTGCLTHV
NPDIIDPRVSGILGVKSIDRIAEAIDLAERDGKLVSVEGWRERSLDKLGLPRLWRSGVAFVVPISEGCLNACTYCATRFA
RGVLKSYKPELVVKWVKEALARGYREIQLSSEDTGCYGFDIGTNLAELLDEITSIEGEFRIRVGMMNPNHAIKFLDELIE
AYQDEKVYKFLHLPVQSGDNEVLRRMGRTYTVEEFEEIVNEFRRKIPGLNLNTDIIVGFPGETEEAFQNTVELVKRVRPD
KINVSRYSPRPGTIAAKWKQLPGWKVKERSRLLHRLRLQIAYEINQNYVGREIEVLIHGEGKKGGVEGRTFNYKDIILDG
GAPGELINARVTWAGSTYLKGTVLH

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI93277076, Length=430, Percent_Identity=35.3488372093023, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI28872784, Length=479, Percent_Identity=27.7661795407098, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI28872782, Length=479, Percent_Identity=27.7661795407098, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1786882, Length=443, Percent_Identity=31.8284424379233, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787057, Length=450, Percent_Identity=28.8888888888889, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71996771, Length=347, Percent_Identity=34.2939481268012, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17553146, Length=465, Percent_Identity=28.6021505376344, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19922432, Length=437, Percent_Identity=36.8421052631579, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI21356207, Length=483, Percent_Identity=30.4347826086957, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006466
- InterPro:   IPR007197
- InterPro:   IPR002792 [H]

Pfam domain/function: PF04055 Radical_SAM; PF01938 TRAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 48032; Mature: 48032

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50926 TRAM ; PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVHVETYGCTRNKADAEIMEAILLRAGYELVETPESADYVVVNTCAVKDPTEKHMRER
CEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEEEEEECCCCHHHHHHHH
IKELLDSGKRVIVTGCLTHVNPDIIDPRVSGILGVKSIDRIAEAIDLAERDGKLVSVEGW
HHHHHHCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
RERSLDKLGLPRLWRSGVAFVVPISEGCLNACTYCATRFARGVLKSYKPELVVKWVKEAL
HHHCHHHCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ARGYREIQLSSEDTGCYGFDIGTNLAELLDEITSIEGEFRIRVGMMNPNHAIKFLDELIE
HCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
AYQDEKVYKFLHLPVQSGDNEVLRRMGRTYTVEEFEEIVNEFRRKIPGLNLNTDIIVGFP
HHCCCCEEHHEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECC
GETEEAFQNTVELVKRVRPDKINVSRYSPRPGTIAAKWKQLPGWKVKERSRLLHRLRLQI
CCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
AYEINQNYVGREIEVLIHGEGKKGGVEGRTFNYKDIILDGGAPGELINARVTWAGSTYLK
EEEECCCCCCCEEEEEEECCCCCCCCCCCEECCEEEEEECCCCCCEEEEEEEECCCCCCC
GTVLH
EEECC
>Mature Secondary Structure
MIKVHVETYGCTRNKADAEIMEAILLRAGYELVETPESADYVVVNTCAVKDPTEKHMRER
CEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEEEEEECCCCHHHHHHHH
IKELLDSGKRVIVTGCLTHVNPDIIDPRVSGILGVKSIDRIAEAIDLAERDGKLVSVEGW
HHHHHHCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
RERSLDKLGLPRLWRSGVAFVVPISEGCLNACTYCATRFARGVLKSYKPELVVKWVKEAL
HHHCHHHCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ARGYREIQLSSEDTGCYGFDIGTNLAELLDEITSIEGEFRIRVGMMNPNHAIKFLDELIE
HCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
AYQDEKVYKFLHLPVQSGDNEVLRRMGRTYTVEEFEEIVNEFRRKIPGLNLNTDIIVGFP
HHCCCCEEHHEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECC
GETEEAFQNTVELVKRVRPDKINVSRYSPRPGTIAAKWKQLPGWKVKERSRLLHRLRLQI
CCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
AYEINQNYVGREIEVLIHGEGKKGGVEGRTFNYKDIILDGGAPGELINARVTWAGSTYLK
EEEECCCCCCCEEEEEEECCCCCCCCCCCEECCEEEEEECCCCCCEEEEEEEECCCCCCC
GTVLH
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]