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The map label for this gene is galK [H]

Identifier: 212224429

GI number: 212224429

Start: 1163925

End: 1164986

Strand: Reverse

Name: galK [H]

Synonym: TON_1280

Alternate gene names: 212224429

Gene position: 1164986-1163925 (Counterclockwise)

Preceding gene: 212224430

Following gene: 212224428

Centisome position: 63.05

GC content: 53.11

Gene sequence:

>1062_bases
ATGTATCGCGTTGATTCTCCCGGTCGGGTGAATCTTATCGGTGAGCACACTGACTACGCCCTTGGCTACGCCATGCCGAT
GGCAATAAACATCCACACGGTTCTGCATGCCAGGGAGGACGAGCAGATCTGGGTTTACTCGCAGATATTCCGTGAGGTCA
AGGAGTTCTCGCTCGATGACATCAGAAGGAGTGGGGACTGGGCGGACTACATAAAGGGAATCTTCTGGGTTCTCCGGGAA
GAAGGGCATGAAGTAGGCGGCATGAAGGGAATTCTGAATGGAGACCTGCCTATAGGCTCGGGTTTGGGTTCTTCAGCGAG
TCTTGAGCTTGCCGTTCTGGCGTTTCTCAACGAGGCATATAAACTGAGATTACTCCCCATAGAAATGGCCCTCCTGGCTC
AGAAGACCGAAAACGAGTTTGTGGGTGTCCCCTGTGGAATACTCGACCAGTTCACCATGACCCATGGAAAGAGGGGGCAC
GTCATTTTCCTTGATACTGATACGCTGAGGCACGAATACATAAAATTCCCGAGGGACATTCAGGCGATCGTCTTCTATAC
CGGTGTCAAGAGGGAGCTGGCCAACTCAGCCTACGCGGAGCGTAGGAAGGTTGCAGAAGAAACCTTAGGGCTTCTCGGTA
AGAGAACTTCCAAGGAGGTTGAGGAGGCAGAGCTGAGAAACATTCCCTCCCTCTACAGGCGCCTCTTTGGCTACATCGTT
AGAGAAAACCGGCGCGTTCTAGAGGCAAGAGATGCACTCAGGGAGGGGGATGTAGACACATTGGGAGAGCTTATTACAGC
TTCTCACTGGGATCTTGCGAGGAGCTATGATGTAAGCTGTGAAGAGTTGGACTTCTTCGTTCGTAGATCCCTCCAGCTCG
GCGCCTACGGCGCGAAGCTCACGGGAACAGGTTTCGGCGGTTCGGCCATAGCGATAGTCGATAGTGACAGGGCACTGAGC
ATTGCTAGGACAGTCTTAGAGGAGTACCAGCGTACCTTCAACTGGGAGGCCGACTACTATCTTGTCCTCCCGACCGATGG
TGTTGCTGTGAGGAGGGTTTAG

Upstream 100 bases:

>100_bases
TGGTGAGCTCAGGGGCCAAGCCCTCCAGATGGGGTGAAGTCCTTTCTTTTTCCTTCGCTATCCTTAAATATCTTCTCGCC
GAATTTTCGTGGGTGAAATC

Downstream 100 bases:

>100_bases
GGTGTCTCTCTTGTATCTTTTATCTCTCCATAAACATTGGCACTTTTCCCAAGTTCTCTCAAAGGTCGTGTTCTGAAGAG
AGAACCATCGAGATGCTTCA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MYRVDSPGRVNLIGEHTDYALGYAMPMAINIHTVLHAREDEQIWVYSQIFREVKEFSLDDIRRSGDWADYIKGIFWVLRE
EGHEVGGMKGILNGDLPIGSGLGSSASLELAVLAFLNEAYKLRLLPIEMALLAQKTENEFVGVPCGILDQFTMTHGKRGH
VIFLDTDTLRHEYIKFPRDIQAIVFYTGVKRELANSAYAERRKVAEETLGLLGKRTSKEVEEAELRNIPSLYRRLFGYIV
RENRRVLEARDALREGDVDTLGELITASHWDLARSYDVSCEELDFFVRRSLQLGAYGAKLTGTGFGGSAIAIVDSDRALS
IARTVLEEYQRTFNWEADYYLVLPTDGVAVRRV

Sequences:

>Translated_353_residues
MYRVDSPGRVNLIGEHTDYALGYAMPMAINIHTVLHAREDEQIWVYSQIFREVKEFSLDDIRRSGDWADYIKGIFWVLRE
EGHEVGGMKGILNGDLPIGSGLGSSASLELAVLAFLNEAYKLRLLPIEMALLAQKTENEFVGVPCGILDQFTMTHGKRGH
VIFLDTDTLRHEYIKFPRDIQAIVFYTGVKRELANSAYAERRKVAEETLGLLGKRTSKEVEEAELRNIPSLYRRLFGYIV
RENRRVLEARDALREGDVDTLGELITASHWDLARSYDVSCEELDFFVRRSLQLGAYGAKLTGTGFGGSAIAIVDSDRALS
IARTVLEEYQRTFNWEADYYLVLPTDGVAVRRV
>Mature_353_residues
MYRVDSPGRVNLIGEHTDYALGYAMPMAINIHTVLHAREDEQIWVYSQIFREVKEFSLDDIRRSGDWADYIKGIFWVLRE
EGHEVGGMKGILNGDLPIGSGLGSSASLELAVLAFLNEAYKLRLLPIEMALLAQKTENEFVGVPCGILDQFTMTHGKRGH
VIFLDTDTLRHEYIKFPRDIQAIVFYTGVKRELANSAYAERRKVAEETLGLLGKRTSKEVEEAELRNIPSLYRRLFGYIV
RENRRVLEARDALREGDVDTLGELITASHWDLARSYDVSCEELDFFVRRSLQLGAYGAKLTGTGFGGSAIAIVDSDRALS
IARTVLEEYQRTFNWEADYYLVLPTDGVAVRRV

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=366, Percent_Identity=35.2459016393443, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786972, Length=359, Percent_Identity=31.4763231197772, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71989053, Length=379, Percent_Identity=28.7598944591029, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 39979; Mature: 39979

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRVDSPGRVNLIGEHTDYALGYAMPMAINIHTVLHAREDEQIWVYSQIFREVKEFSLDD
CCCCCCCCEEEEEECCCCEEHHHHCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHCCHHH
IRRSGDWADYIKGIFWVLREEGHEVGGMKGILNGDLPIGSGLGSSASLELAVLAFLNEAY
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLRLLPIEMALLAQKTENEFVGVPCGILDQFTMTHGKRGHVIFLDTDTLRHEYIKFPRDI
EEEEEEHHHHHHHHHCCCCEECCCHHHHHHHHHCCCCCCCEEEEECHHHHHHHHCCCCCC
QAIVFYTGVKRELANSAYAERRKVAEETLGLLGKRTSKEVEEAELRNIPSLYRRLFGYIV
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHH
RENRRVLEARDALREGDVDTLGELITASHWDLARSYDVSCEELDFFVRRSLQLGAYGAKL
HCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCEE
TGTGFGGSAIAIVDSDRALSIARTVLEEYQRTFNWEADYYLVLPTDGVAVRRV
EECCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECC
>Mature Secondary Structure
MYRVDSPGRVNLIGEHTDYALGYAMPMAINIHTVLHAREDEQIWVYSQIFREVKEFSLDD
CCCCCCCCEEEEEECCCCEEHHHHCCEEEEEEEEEEECCCCCEEHHHHHHHHHHHCCHHH
IRRSGDWADYIKGIFWVLREEGHEVGGMKGILNGDLPIGSGLGSSASLELAVLAFLNEAY
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
KLRLLPIEMALLAQKTENEFVGVPCGILDQFTMTHGKRGHVIFLDTDTLRHEYIKFPRDI
EEEEEEHHHHHHHHHCCCCEECCCHHHHHHHHHCCCCCCCEEEEECHHHHHHHHCCCCCC
QAIVFYTGVKRELANSAYAERRKVAEETLGLLGKRTSKEVEEAELRNIPSLYRRLFGYIV
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHH
RENRRVLEARDALREGDVDTLGELITASHWDLARSYDVSCEELDFFVRRSLQLGAYGAKL
HCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCEE
TGTGFGGSAIAIVDSDRALSIARTVLEEYQRTFNWEADYYLVLPTDGVAVRRV
EECCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]