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The map label for this gene is eif6

Identifier: 212224256

GI number: 212224256

Start: 1024439

End: 1025125

Strand: Reverse

Name: eif6

Synonym: TON_1107

Alternate gene names: 212224256

Gene position: 1025125-1024439 (Counterclockwise)

Preceding gene: 212224257

Following gene: 212224255

Centisome position: 55.48

GC content: 54.44

Gene sequence:

>687_bases
ATGCACATCGAAAAGCTCGATTTTGAGAATTCGCCGTACCTCGGTGTTTACGGTACCGCTACGGATAGGGTAGCCCTTAT
CAGAGAGGGCCTCGGAGAGAAGAAGCTCGAGGTTCTCCGCGAGGTTCTCAAGGTTCCGCTCATCGAGACGAGCATAATGA
AATCCAGGATAGTTGGCGTATTCGCCGCCGGCAATTCCAACGCGATAGTCGTACCCTGGTACATCTGGGACGCCGAGCTC
GAGCACATCCAGAACGAACTCAATGAACTCGACATCGATATGAGGATAGAGCCTTTCCAGAGCACGCTTACAGCCTTCGG
CAACCTGATCCTTGCCAACGATAAAGCAGCACTCATAAGCGTCAAGTTCACCCGCGAGGAAGCAAAGAAGCTCGAGGACA
TACTCGGCGTTGAGGTCGAGAGGGGAATGATAGGCGACTATCACGCGGTTGGCAGTGTGGGTGTTGTCACCAACAGGGGC
GGCCTCGTTCACCCAGAGGCCACCGATGAGGAGCTTGAGTGGCTCCGCGACCTTTTCAAGGTTGATATATACGTCGGAAC
CGCCAATATGGGCGTTCCCTTCGTCGGCTCGTGCATGCTGGCGAACTCTCACGGTGTCGTTGTCGGACACCTCACCACTG
GACCCGAGATTGTGAAGATTGAAGAGGCGTTAGGATTCCTTGACTGA

Upstream 100 bases:

>100_bases
CGCGTTAAGGTCAAGGTCGAGGAGCAGGACGGCAAGAGGGTTGCTTACGTCAACCTTGCCGACTGAATTCCTTTCCTTTT
AATTCCCACGAGGTGACGAG

Downstream 100 bases:

>100_bases
GGAGGTGTGAGGAATGGAGGTTAAGGTCTTCCGCGTTAAGGGCGTCTTTGAGAGGCTCGGAAAGAAGCAGCCGTTCACCA
AGGAATACAGGGCTCTCAAG

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MHIEKLDFENSPYLGVYGTATDRVALIREGLGEKKLEVLREVLKVPLIETSIMKSRIVGVFAAGNSNAIVVPWYIWDAEL
EHIQNELNELDIDMRIEPFQSTLTAFGNLILANDKAALISVKFTREEAKKLEDILGVEVERGMIGDYHAVGSVGVVTNRG
GLVHPEATDEELEWLRDLFKVDIYVGTANMGVPFVGSCMLANSHGVVVGHLTTGPEIVKIEEALGFLD

Sequences:

>Translated_228_residues
MHIEKLDFENSPYLGVYGTATDRVALIREGLGEKKLEVLREVLKVPLIETSIMKSRIVGVFAAGNSNAIVVPWYIWDAEL
EHIQNELNELDIDMRIEPFQSTLTAFGNLILANDKAALISVKFTREEAKKLEDILGVEVERGMIGDYHAVGSVGVVTNRG
GLVHPEATDEELEWLRDLFKVDIYVGTANMGVPFVGSCMLANSHGVVVGHLTTGPEIVKIEEALGFLD
>Mature_228_residues
MHIEKLDFENSPYLGVYGTATDRVALIREGLGEKKLEVLREVLKVPLIETSIMKSRIVGVFAAGNSNAIVVPWYIWDAEL
EHIQNELNELDIDMRIEPFQSTLTAFGNLILANDKAALISVKFTREEAKKLEDILGVEVERGMIGDYHAVGSVGVVTNRG
GLVHPEATDEELEWLRDLFKVDIYVGTANMGVPFVGSCMLANSHGVVVGHLTTGPEIVKIEEALGFLD

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=219, Percent_Identity=32.8767123287671, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI31563378, Length=219, Percent_Identity=32.8767123287671, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17506075, Length=220, Percent_Identity=29.0909090909091, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325273, Length=226, Percent_Identity=34.9557522123894, Blast_Score=135, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21492634, Length=219, Percent_Identity=32.4200913242009, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_THEON (B6YWY2)

Other databases:

- EMBL:   CP000855
- RefSeq:   YP_002307492.1
- GeneID:   7018129
- GenomeReviews:   CP000855_GR
- KEGG:   ton:TON_1107
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- ProtClustDB:   PRK04046
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 25118; Mature: 25118

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIEKLDFENSPYLGVYGTATDRVALIREGLGEKKLEVLREVLKVPLIETSIMKSRIVGV
CCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHEEEE
FAAGNSNAIVVPWYIWDAELEHIQNELNELDIDMRIEPFQSTLTAFGNLILANDKAALIS
EEECCCCEEEEEEEEECHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCEEEECCCEEEEE
VKFTREEAKKLEDILGVEVERGMIGDYHAVGSVGVVTNRGGLVHPEATDEELEWLRDLFK
EEECHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEECCCCEECCCCCHHHHHHHHHHHE
VDIYVGTANMGVPFVGSCMLANSHGVVVGHLTTGPEIVKIEEALGFLD
EEEEEEECCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEHHHCCCCC
>Mature Secondary Structure
MHIEKLDFENSPYLGVYGTATDRVALIREGLGEKKLEVLREVLKVPLIETSIMKSRIVGV
CCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHEEEE
FAAGNSNAIVVPWYIWDAELEHIQNELNELDIDMRIEPFQSTLTAFGNLILANDKAALIS
EEECCCCEEEEEEEEECHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCEEEECCCEEEEE
VKFTREEAKKLEDILGVEVERGMIGDYHAVGSVGVVTNRGGLVHPEATDEELEWLRDLFK
EEECHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEECCCCEECCCCCHHHHHHHHHHHE
VDIYVGTANMGVPFVGSCMLANSHGVVVGHLTTGPEIVKIEEALGFLD
EEEEEEECCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA