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The map label for this gene is moeA [C]

Identifier: 212224240

GI number: 212224240

Start: 1011767

End: 1012969

Strand: Reverse

Name: moeA [C]

Synonym: TON_1091

Alternate gene names: 212224240

Gene position: 1012969-1011767 (Counterclockwise)

Preceding gene: 212224241

Following gene: 212224239

Centisome position: 54.83

GC content: 54.45

Gene sequence:

>1203_bases
ATGGCGTTCCTGAAGGTGGTTCCGCTCGAAGAAGCTCTCAAGGTTATAGACTCATTTCCGCTGAAGCCGGAGATCGAGGA
AGTTTCCCTTGAAAAAGCTCTCGGCAGGGTTCTCGCTGAGGACGTAGTCTCTCCAATAGATGTCCCACCATTTGACAGGG
CAACCGTCGATGGCTACGCCGTTAGGGCTGAGGACACGTTCATGGCGAGCGAGAGCGAACCGGTGAGGCTGAAGGTTATT
GGCGAGATAAACGCTGGTGACACGCCAACGATAGAACTCAAGCCTGGTGAGAGCGTCTACATATCCACAGGCGCACCGTT
GCCGAAGGGCGCAGATGCAGTGATACAGTTCGAGGATGTGGACAGGGAAGGCGATGAGGTTGTTATCTACAAGCCGGCCT
ATCCAAGCTTGGGTGTCATGAAGCGTGGAGCGGACATTCCGAAGGGTAGGTCTCTCCTTGAGAAAGGTACGAGGCTAGGC
TTCAAGGAGACGGCACTACTTTCGGCGGTCGGCTTCTCGAAGGTCAGAGTCTTCAGAAAGCCAAAGGTTGCTGTGATAAG
CACCGGCAACGAGGTCATTCTTCCAGGAACGGAGCTTAAATACGGTCAGATATACGACATCAACGGAAGGGCCATCGCTG
ACGCTGTAAGGGAGCTTGGCGGCGAGGCCATCTTCCTGGGAATAGCAAGGGATGACCGTGAAAGCCTGAGGGAACTGATA
CTAAGGGGTGTCGAGTGCTGTGATATTGTTCTCCTGAGCGGTGGTGCGAGCGGGGGAATAAGGGATCTCACCAGCTCGAT
AATCGAGGAGCTCGGCGAGGTGAAAATCCACGGCATAGCCATACAGCCCGGCAAACCGACAATAATAGGCCTCATTAACG
GAAAGCCCATCTTTGGCCTTCCTGGCTATCCCACGAGCTGTTTAACGAACTTCACCCTTCTCGTCGCCCCGCTCCTCAGG
AAGCTCCTTGGCAGGGAGAATGAGGTCAGGAAGGTCAAGAAGAGGCTTGCCCACAAGGTCTTTTCGGTCAAGGGCAGGAG
GCAGTTCCTTCCCGTCAGAATCGAGGGCGAAAAAGCGGTTCCAATACTCAAGGGCAGCGGAGCTGTTACGAGCTTCATCG
ATGCTGATGGCTTCATAGAGGTGTCGGAGAACGTGGAGATACTCGAGGCGGGAGAGGAGGTTGAAGTAACCTTCTTCGGT
TGA

Upstream 100 bases:

>100_bases
GGGAGATGAAGAGTGGGACGAGGAAGATGAATGGTGAGTTAAACGTTTCCTTTTACGCAACTCATTTATACGCCTGATCT
TATCTTTTCTCGGTGATAGA

Downstream 100 bases:

>100_bases
CTCTTTTTGCCGAAATGTCAAGGCGATTATCAAATTATTTTTAAACTCCAGCACCGTTCATCTCCCAGGTGAAATGCTAT
GCTGGACATAAAGCTCATCC

Product: molybdenum cofactor biosynthesis protein MoeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MAFLKVVPLEEALKVIDSFPLKPEIEEVSLEKALGRVLAEDVVSPIDVPPFDRATVDGYAVRAEDTFMASESEPVRLKVI
GEINAGDTPTIELKPGESVYISTGAPLPKGADAVIQFEDVDREGDEVVIYKPAYPSLGVMKRGADIPKGRSLLEKGTRLG
FKETALLSAVGFSKVRVFRKPKVAVISTGNEVILPGTELKYGQIYDINGRAIADAVRELGGEAIFLGIARDDRESLRELI
LRGVECCDIVLLSGGASGGIRDLTSSIIEELGEVKIHGIAIQPGKPTIIGLINGKPIFGLPGYPTSCLTNFTLLVAPLLR
KLLGRENEVRKVKKRLAHKVFSVKGRRQFLPVRIEGEKAVPILKGSGAVTSFIDADGFIEVSENVEILEAGEEVEVTFFG

Sequences:

>Translated_400_residues
MAFLKVVPLEEALKVIDSFPLKPEIEEVSLEKALGRVLAEDVVSPIDVPPFDRATVDGYAVRAEDTFMASESEPVRLKVI
GEINAGDTPTIELKPGESVYISTGAPLPKGADAVIQFEDVDREGDEVVIYKPAYPSLGVMKRGADIPKGRSLLEKGTRLG
FKETALLSAVGFSKVRVFRKPKVAVISTGNEVILPGTELKYGQIYDINGRAIADAVRELGGEAIFLGIARDDRESLRELI
LRGVECCDIVLLSGGASGGIRDLTSSIIEELGEVKIHGIAIQPGKPTIIGLINGKPIFGLPGYPTSCLTNFTLLVAPLLR
KLLGRENEVRKVKKRLAHKVFSVKGRRQFLPVRIEGEKAVPILKGSGAVTSFIDADGFIEVSENVEILEAGEEVEVTFFG
>Mature_399_residues
AFLKVVPLEEALKVIDSFPLKPEIEEVSLEKALGRVLAEDVVSPIDVPPFDRATVDGYAVRAEDTFMASESEPVRLKVIG
EINAGDTPTIELKPGESVYISTGAPLPKGADAVIQFEDVDREGDEVVIYKPAYPSLGVMKRGADIPKGRSLLEKGTRLGF
KETALLSAVGFSKVRVFRKPKVAVISTGNEVILPGTELKYGQIYDINGRAIADAVRELGGEAIFLGIARDDRESLRELIL
RGVECCDIVLLSGGASGGIRDLTSSIIEELGEVKIHGIAIQPGKPTIIGLINGKPIFGLPGYPTSCLTNFTLLVAPLLRK
LLGRENEVRKVKKRLAHKVFSVKGRRQFLPVRIEGEKAVPILKGSGAVTSFIDADGFIEVSENVEILEAGEEVEVTFFG

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=313, Percent_Identity=37.6996805111821, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI10880983, Length=313, Percent_Identity=37.6996805111821, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1787049, Length=368, Percent_Identity=38.0434782608696, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI25147659, Length=324, Percent_Identity=30.2469135802469, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=396, Percent_Identity=27.020202020202, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136978, Length=331, Percent_Identity=30.8157099697885, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24638841, Length=331, Percent_Identity=30.8157099697885, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43173; Mature: 43041

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLKVVPLEEALKVIDSFPLKPEIEEVSLEKALGRVLAEDVVSPIDVPPFDRATVDGYA
CCEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
VRAEDTFMASESEPVRLKVIGEINAGDTPTIELKPGESVYISTGAPLPKGADAVIQFEDV
EEECCEEEECCCCCEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEECC
DREGDEVVIYKPAYPSLGVMKRGADIPKGRSLLEKGTRLGFKETALLSAVGFSKVRVFRK
CCCCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCHHHEEEEEC
PKVAVISTGNEVILPGTELKYGQIYDINGRAIADAVRELGGEAIFLGIARDDRESLRELI
CCEEEEECCCEEEECCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
LRGVECCDIVLLSGGASGGIRDLTSSIIEELGEVKIHGIAIQPGKPTIIGLINGKPIFGL
HCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCEEECC
PGYPTSCLTNFTLLVAPLLRKLLGRENEVRKVKKRLAHKVFSVKGRRQFLPVRIEGEKAV
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
PILKGSGAVTSFIDADGFIEVSENVEILEAGEEVEVTFFG
EEEECCCCEEEEECCCCEEEECCCEEEEECCCEEEEEEEC
>Mature Secondary Structure 
AFLKVVPLEEALKVIDSFPLKPEIEEVSLEKALGRVLAEDVVSPIDVPPFDRATVDGYA
CEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
VRAEDTFMASESEPVRLKVIGEINAGDTPTIELKPGESVYISTGAPLPKGADAVIQFEDV
EEECCEEEECCCCCEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEECC
DREGDEVVIYKPAYPSLGVMKRGADIPKGRSLLEKGTRLGFKETALLSAVGFSKVRVFRK
CCCCCEEEEECCCCCCCHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCHHHEEEEEC
PKVAVISTGNEVILPGTELKYGQIYDINGRAIADAVRELGGEAIFLGIARDDRESLRELI
CCEEEEECCCEEEECCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHH
LRGVECCDIVLLSGGASGGIRDLTSSIIEELGEVKIHGIAIQPGKPTIIGLINGKPIFGL
HCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEECCCEEECC
PGYPTSCLTNFTLLVAPLLRKLLGRENEVRKVKKRLAHKVFSVKGRRQFLPVRIEGEKAV
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
PILKGSGAVTSFIDADGFIEVSENVEILEAGEEVEVTFFG
EEEECCCCEEEEECCCCEEEECCCEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]