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The map label for this gene is serS

Identifier: 212224239

GI number: 212224239

Start: 1010315

End: 1011688

Strand: Reverse

Name: serS

Synonym: TON_1090

Alternate gene names: 212224239

Gene position: 1011688-1010315 (Counterclockwise)

Preceding gene: 212224240

Following gene: 212224237

Centisome position: 54.76

GC content: 53.57

Gene sequence:

>1374_bases
ATGCTGGACATAAAGCTCATCCGTGAAAACCCTGATCTAGTTAAGGGCGATCTCATAAAGCGCGGGGAAATTGAGAAGAT
AAAATGGATCGACGAAATCCTCGAACTCGACAAAAAGTGGCGCGAGAACCTACGGAAGATCAACCAGCTCAGGAAGGAGC
GCAACCAGCTCGCTGTGCAGATAGGAAAGCGCAAGAAGGCTGGTGAGCCGATAGACGATCTCCTTGCAAAGAGCAACGAG
ATTGTGAAGCAGATTGAGACCCTTGAGAAGGAAGTTGAGGAGCTGAGGGCAAAGATCGACTACTATCTCTGGCGCCTGCC
GAACATCACCCACGAGAGCGTTCCGATCGGCAAAGATGACAGCGAGAATGTGCCGATAAGGTTCTGGGGCAAAGCGAAGG
TCTGGGAGGGGTTCCTTGAGACGTTTAAGGAGCAGAGCCTTGGGAAGATGGACTATGAGGTTATTGACTGGAGGCCAAGG
CTCCACGTCGACATGCTCGAGATTCTTCGCGGAGCTGACATCGAGAGGGCCGCAAAGGTTAGCGGTTCAAGGTTTTACTA
CCTCCTCAACGAACTGGTCATCCTCGATCTCGCCCTCATAAGGTTTGCCCTGGATAAACTCATCGAGAAGGGTTTTATTC
CCGTCATACCGCCCTACATGGTGCGCCGCTACGTTGAAGAGGGTGTCACCAGCTTCGGTGACTTTGAAGACGTTATCTAC
AAGGTCGAGGGGGAGGATCTCTACCTTATTCCAACGGCCGAGCACCCGCTCGCTGGGATGCACGCCAACGAGATACTTGA
AGGAAAGGACCTCCCGCTCCTCTACGTTGGTATTAGCCCCTGTTTCAGGAAGGAAGCTGGAACCGCTGGAAAGGACACCA
AGGGTATCTTTAGAGTCCACCAGTTCCACAAGGTCGAGCAGTTCGTCTATTCGAGACCAGAGGAGAGCTGGGAGTGGCAC
GAAAAATTAATACAGAACGCCGAGGAGATCTTCCAGGAGCTTGAAATCCCCTACCGCGTCGTCAACATCTGTACCGGAGA
CCTCGGCTACGTTGCGGCCAAAAAGTACGACATAGAGGCATGGATGGCTGGACAGGGCAAGTTCAGGGAGGTCGTTTCGG
CGAGCAACTGTACGGAGTGGCAGGCGAGAAGGCTCAACATCCGCTACCGCGACAAGACTCACGAGAAGCCCAAGTTCGTC
CACACGCTCAACTCGACGGCGATAGCAACCTCGAGGGCTATCGTTGCTATCCTCGAAAACCACCAGACTGAGGAGGGCGT
CGTCAAGCTTCCAAAGGTCCTCTGGAAGTACACCGGATTCAAGGAGATTCTCCCGGCGCATATGAAGGAGAAGTGCTGCC
AGGGGCTTGAGTGA

Upstream 100 bases:

>100_bases
TGAAGTAACCTTCTTCGGTTGACTCTTTTTGCCGAAATGTCAAGGCGATTATCAAATTATTTTTAAACTCCAGCACCGTT
CATCTCCCAGGTGAAATGCT

Downstream 100 bases:

>100_bases
TTTCTTTTAAATTCCCCCGGCCTCCCTTACCTTTCTCCTGACGTTCGGGTCGCGGTCCGCTATGAGCTTCAGCGCTTCCT
CGAAGGTCATCCAATCGGGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLDIKLIRENPDLVKGDLIKRGEIEKIKWIDEILELDKKWRENLRKINQLRKERNQLAVQIGKRKKAGEPIDDLLAKSNE
IVKQIETLEKEVEELRAKIDYYLWRLPNITHESVPIGKDDSENVPIRFWGKAKVWEGFLETFKEQSLGKMDYEVIDWRPR
LHVDMLEILRGADIERAAKVSGSRFYYLLNELVILDLALIRFALDKLIEKGFIPVIPPYMVRRYVEEGVTSFGDFEDVIY
KVEGEDLYLIPTAEHPLAGMHANEILEGKDLPLLYVGISPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWH
EKLIQNAEEIFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMAGQGKFREVVSASNCTEWQARRLNIRYRDKTHEKPKFV
HTLNSTAIATSRAIVAILENHQTEEGVVKLPKVLWKYTGFKEILPAHMKEKCCQGLE

Sequences:

>Translated_457_residues
MLDIKLIRENPDLVKGDLIKRGEIEKIKWIDEILELDKKWRENLRKINQLRKERNQLAVQIGKRKKAGEPIDDLLAKSNE
IVKQIETLEKEVEELRAKIDYYLWRLPNITHESVPIGKDDSENVPIRFWGKAKVWEGFLETFKEQSLGKMDYEVIDWRPR
LHVDMLEILRGADIERAAKVSGSRFYYLLNELVILDLALIRFALDKLIEKGFIPVIPPYMVRRYVEEGVTSFGDFEDVIY
KVEGEDLYLIPTAEHPLAGMHANEILEGKDLPLLYVGISPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWH
EKLIQNAEEIFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMAGQGKFREVVSASNCTEWQARRLNIRYRDKTHEKPKFV
HTLNSTAIATSRAIVAILENHQTEEGVVKLPKVLWKYTGFKEILPAHMKEKCCQGLE
>Mature_457_residues
MLDIKLIRENPDLVKGDLIKRGEIEKIKWIDEILELDKKWRENLRKINQLRKERNQLAVQIGKRKKAGEPIDDLLAKSNE
IVKQIETLEKEVEELRAKIDYYLWRLPNITHESVPIGKDDSENVPIRFWGKAKVWEGFLETFKEQSLGKMDYEVIDWRPR
LHVDMLEILRGADIERAAKVSGSRFYYLLNELVILDLALIRFALDKLIEKGFIPVIPPYMVRRYVEEGVTSFGDFEDVIY
KVEGEDLYLIPTAEHPLAGMHANEILEGKDLPLLYVGISPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEESWEWH
EKLIQNAEEIFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMAGQGKFREVVSASNCTEWQARRLNIRYRDKTHEKPKFV
HTLNSTAIATSRAIVAILENHQTEEGVVKLPKVLWKYTGFKEILPAHMKEKCCQGLE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=493, Percent_Identity=38.1338742393509, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI8923421, Length=382, Percent_Identity=35.3403141361257, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI225579074, Length=370, Percent_Identity=35.9459459459459, Blast_Score=209, Evalue=5e-54,
Organism=Escherichia coli, GI1787120, Length=448, Percent_Identity=34.375, Blast_Score=274, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17539260, Length=494, Percent_Identity=37.4493927125506, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17542084, Length=403, Percent_Identity=32.258064516129, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320226, Length=456, Percent_Identity=37.719298245614, Blast_Score=286, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6321799, Length=444, Percent_Identity=35.5855855855856, Blast_Score=240, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24581334, Length=494, Percent_Identity=36.6396761133603, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17737985, Length=284, Percent_Identity=36.2676056338028, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_THEON (B6YWW5)

Other databases:

- EMBL:   CP000855
- RefSeq:   YP_002307475.1
- GeneID:   7018112
- GenomeReviews:   CP000855_GR
- KEGG:   ton:TON_1090
- HOGENOM:   HBG629391
- OMA:   VPIRFWG
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 53235; Mature: 53235

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 299-299 BINDING 306-306 BINDING 406-406

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKLIRENPDLVKGDLIKRGEIEKIKWIDEILELDKKWRENLRKINQLRKERNQLAVQ
CCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKRKKAGEPIDDLLAKSNEIVKQIETLEKEVEELRAKIDYYLWRLPNITHESVPIGKDD
HHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SENVPIRFWGKAKVWEGFLETFKEQSLGKMDYEVIDWRPRLHVDMLEILRGADIERAAKV
CCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHCCCCHHHHHHC
SGSRFYYLLNELVILDLALIRFALDKLIEKGFIPVIPPYMVRRYVEEGVTSFGDFEDVIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEE
KVEGEDLYLIPTAEHPLAGMHANEILEGKDLPLLYVGISPCFRKEAGTAGKDTKGIFRVH
EECCCEEEEEECCCCCCCCCCHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHH
QFHKVEQFVYSRPEESWEWHEKLIQNAEEIFQELEIPYRVVNICTGDLGYVAAKKYDIEA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCHHHHHHEEECCHH
WMAGQGKFREVVSASNCTEWQARRLNIRYRDKTHEKPKFVHTLNSTAIATSRAIVAILEN
EECCCCHHHHHHHCCCCCHHHHHHCCEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHC
HQTEEGVVKLPKVLWKYTGFKEILPAHMKEKCCQGLE
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDIKLIRENPDLVKGDLIKRGEIEKIKWIDEILELDKKWRENLRKINQLRKERNQLAVQ
CCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKRKKAGEPIDDLLAKSNEIVKQIETLEKEVEELRAKIDYYLWRLPNITHESVPIGKDD
HHCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SENVPIRFWGKAKVWEGFLETFKEQSLGKMDYEVIDWRPRLHVDMLEILRGADIERAAKV
CCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHCCCCHHHHHHC
SGSRFYYLLNELVILDLALIRFALDKLIEKGFIPVIPPYMVRRYVEEGVTSFGDFEDVIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEE
KVEGEDLYLIPTAEHPLAGMHANEILEGKDLPLLYVGISPCFRKEAGTAGKDTKGIFRVH
EECCCEEEEEECCCCCCCCCCHHHHCCCCCCCEEEECCCHHHHHHCCCCCCCCHHHHHHH
QFHKVEQFVYSRPEESWEWHEKLIQNAEEIFQELEIPYRVVNICTGDLGYVAAKKYDIEA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCHHHHHHEEECCHH
WMAGQGKFREVVSASNCTEWQARRLNIRYRDKTHEKPKFVHTLNSTAIATSRAIVAILEN
EECCCCHHHHHHHCCCCCHHHHHHCCEEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHC
HQTEEGVVKLPKVLWKYTGFKEILPAHMKEKCCQGLE
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA