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The map label for this gene is suhB [H]

Identifier: 212224194

GI number: 212224194

Start: 966620

End: 967402

Strand: Reverse

Name: suhB [H]

Synonym: TON_1045

Alternate gene names: 212224194

Gene position: 967402-966620 (Counterclockwise)

Preceding gene: 212224195

Following gene: 212224193

Centisome position: 52.36

GC content: 50.83

Gene sequence:

>783_bases
ATGGAAAAATTTGGTGAGATCTCCTGGAACGAAGTGGCCATTGAGATGGCCAAGGAAGTTGAGAAGGTTGTAATGCCCCT
CTTTGGAACCCCAAAGGCTGGGGAAACTATTGGGACTAACGTGAGCGGTGACGTCACTAAGTACGTTGACAAAGTGGCCG
AGGACATCGTCTTGAGCAGACTGCAGCCCCTCGACGTCAACGTCGTGAGCGAGGAGGTTGGACTCATAGACAACGGGAGC
GATTACACGGTTGTCGTTGATCCCATAGACGGCTCCTACAACTTCGCCGCGGGGATACCTATATTTGCTTTCAGCTTTGC
AGTCTTTGCAGGTAGAAAGCCGGTCTATGGTGCGATATATGAGTTCGTTACCAAACATTTCTATGAGGGCATTCCTGGAA
ACGGCGCCTTCATGAACGGAGAGAGGATACACGTTAGAAAGCCGGAACGTGGAAAGGAAGCACTGAGCTTCTACACGCGC
GGAAGGTGCATACGCCTCATAAAGAAGGTCAAACGCGTCCGTGTTCTTGGAGCTATAGCAGTTGAGCTGACTTACCTCGC
TAGGGGGGCTCTCGACGGCGTTCTCGACATAAGGAATTACGTTCGCCCAACGGACATAGCGGCGGGAGTTATAATTGCAA
GGGAAGCCGGCGCGATAGTGACGGATGAGAAGGGAAACGAGCTCAAGCTCAACCTCAGCGCCACGGAGACAACCAATCTA
ATAGCTGTGAATGACAGATATTTACTTGACCTAATTCTGGAGGAACTCGCCAATGATCTTTAA

Upstream 100 bases:

>100_bases
AAGATCCGGAGCTGATAAACTTCGTCAAGCTCGCAATGTTCATACTTGGCTTTGGACCCGGGACTAGGAATCTGTTGATA
ACCCTGATGGGGTGATACGT

Downstream 100 bases:

>100_bases
AGGCTCCACAATGAAATACGGGAAGGTCACAACGGCGCTCTTCGTGATTAACGTTGTCGTTTACATTTTCGAGGCCATAC
TGAGTGGTAACCCCATAGAC

Product: bifunctional inositol-1 monophosphatase/fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MEKFGEISWNEVAIEMAKEVEKVVMPLFGTPKAGETIGTNVSGDVTKYVDKVAEDIVLSRLQPLDVNVVSEEVGLIDNGS
DYTVVVDPIDGSYNFAAGIPIFAFSFAVFAGRKPVYGAIYEFVTKHFYEGIPGNGAFMNGERIHVRKPERGKEALSFYTR
GRCIRLIKKVKRVRVLGAIAVELTYLARGALDGVLDIRNYVRPTDIAAGVIIAREAGAIVTDEKGNELKLNLSATETTNL
IAVNDRYLLDLILEELANDL

Sequences:

>Translated_260_residues
MEKFGEISWNEVAIEMAKEVEKVVMPLFGTPKAGETIGTNVSGDVTKYVDKVAEDIVLSRLQPLDVNVVSEEVGLIDNGS
DYTVVVDPIDGSYNFAAGIPIFAFSFAVFAGRKPVYGAIYEFVTKHFYEGIPGNGAFMNGERIHVRKPERGKEALSFYTR
GRCIRLIKKVKRVRVLGAIAVELTYLARGALDGVLDIRNYVRPTDIAAGVIIAREAGAIVTDEKGNELKLNLSATETTNL
IAVNDRYLLDLILEELANDL
>Mature_260_residues
MEKFGEISWNEVAIEMAKEVEKVVMPLFGTPKAGETIGTNVSGDVTKYVDKVAEDIVLSRLQPLDVNVVSEEVGLIDNGS
DYTVVVDPIDGSYNFAAGIPIFAFSFAVFAGRKPVYGAIYEFVTKHFYEGIPGNGAFMNGERIHVRKPERGKEALSFYTR
GRCIRLIKKVKRVRVLGAIAVELTYLARGALDGVLDIRNYVRPTDIAAGVIIAREAGAIVTDEKGNELKLNLSATETTNL
IAVNDRYLLDLILEELANDL

Specific function: Has a broad specificity, it can act on both D and L isomers of I-1-P, on 2'-AMP, pNPP, beta-glycerol phosphate, glucose 1-P and other compounds [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=274, Percent_Identity=27.7372262773723, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI5031789, Length=192, Percent_Identity=28.6458333333333, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI221625487, Length=200, Percent_Identity=29, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1788882, Length=270, Percent_Identity=29.2592592592593, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=236, Percent_Identity=26.271186440678, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193202570, Length=239, Percent_Identity=26.3598326359833, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357303, Length=180, Percent_Identity=31.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664922, Length=211, Percent_Identity=31.7535545023697, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357329, Length=164, Percent_Identity=31.0975609756098, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664926, Length=156, Percent_Identity=30.1282051282051, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357957, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.25 [H]

Molecular weight: Translated: 28532; Mature: 28532

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFGEISWNEVAIEMAKEVEKVVMPLFGTPKAGETIGTNVSGDVTKYVDKVAEDIVLSR
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LQPLDVNVVSEEVGLIDNGSDYTVVVDPIDGSYNFAAGIPIFAFSFAVFAGRKPVYGAIY
CCCCCEEEEHHHCCCEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
EFVTKHFYEGIPGNGAFMNGERIHVRKPERGKEALSFYTRGRCIRLIKKVKRVRVLGAIA
HHHHHHHHCCCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VELTYLARGALDGVLDIRNYVRPTDIAAGVIIAREAGAIVTDEKGNELKLNLSATETTNL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCEEEEECCCCEEECCCCCEEEEEEECCCCCEE
IAVNDRYLLDLILEELANDL
EEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKFGEISWNEVAIEMAKEVEKVVMPLFGTPKAGETIGTNVSGDVTKYVDKVAEDIVLSR
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LQPLDVNVVSEEVGLIDNGSDYTVVVDPIDGSYNFAAGIPIFAFSFAVFAGRKPVYGAIY
CCCCCEEEEHHHCCCEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHH
EFVTKHFYEGIPGNGAFMNGERIHVRKPERGKEALSFYTRGRCIRLIKKVKRVRVLGAIA
HHHHHHHHCCCCCCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VELTYLARGALDGVLDIRNYVRPTDIAAGVIIAREAGAIVTDEKGNELKLNLSATETTNL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCEEEEECCCCEEECCCCCEEEEEEECCCCCEE
IAVNDRYLLDLILEELANDL
EEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 9647837; 11170378 [H]