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The map label for this gene is ndk [H]

Identifier: 212224100

GI number: 212224100

Start: 876598

End: 877110

Strand: Reverse

Name: ndk [H]

Synonym: TON_0951

Alternate gene names: 212224100

Gene position: 877110-876598 (Counterclockwise)

Preceding gene: 212224101

Following gene: 212224097

Centisome position: 47.47

GC content: 54.39

Gene sequence:

>513_bases
ATGGCGGACAAGAAGATAGAGCGCACCCTGGTTATCCTGAAGCCCGACGCCGTCGTTAGAGGCTTGATGGGCGAAATAAT
TTCCCGCTTTGAGAAGAGGGGGCTTAAAATCGTCGGAATGAAGATGATATGGATTACACGTGAGCTGGCGGAGAAGCACT
ACGAGGAGCACAAAGGCAAGCCCTTCTTTGAACCGCTGATTGACTACATAACCAAGGCTCCGAGCGTCGTCATGGTGGTT
GAAGGCCGCTATGCCATAAGCGTCGTCAGGAAGATGGCGGGTGCAACCGACCCGAAGGATGCCGAGCCCGGAAGCATAAG
GGGCGACTATGGCCTCGACGTTGGCGACGCCATATACAACGTTATCCACGCCAGCGACAGCCCGGAGAGCGCAGAGAGGG
AGATAAAGCTCTACTTCAGCGAGGACGAGATATTCGAGTACTGGAAGGCCGCCGACTGGTTCTACCACACCCACGCCAGA
GAAAAGAAGGAATACATGGACAAAATGGAGTGA

Upstream 100 bases:

>100_bases
GGAGGAAGTGATTTCTTTTTTCTTTCGTTCCCTTATTCTGCCACATGTCCTTCTCCAAAAAGCCTTTTAACCGTGCCGTC
AACTACTTCTGGTGTTGCCA

Downstream 100 bases:

>100_bases
CTTCAGACCTTCTTCATCCTCTTTTCCACGTTTGACATCACCGTTACTTCATCGTGTTTCTTGTTGGCCTTTTCCAACGC
CACTGCCTTCTTGAGCGTTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MADKKIERTLVILKPDAVVRGLMGEIISRFEKRGLKIVGMKMIWITRELAEKHYEEHKGKPFFEPLIDYITKAPSVVMVV
EGRYAISVVRKMAGATDPKDAEPGSIRGDYGLDVGDAIYNVIHASDSPESAEREIKLYFSEDEIFEYWKAADWFYHTHAR
EKKEYMDKME

Sequences:

>Translated_170_residues
MADKKIERTLVILKPDAVVRGLMGEIISRFEKRGLKIVGMKMIWITRELAEKHYEEHKGKPFFEPLIDYITKAPSVVMVV
EGRYAISVVRKMAGATDPKDAEPGSIRGDYGLDVGDAIYNVIHASDSPESAEREIKLYFSEDEIFEYWKAADWFYHTHAR
EKKEYMDKME
>Mature_169_residues
ADKKIERTLVILKPDAVVRGLMGEIISRFEKRGLKIVGMKMIWITRELAEKHYEEHKGKPFFEPLIDYITKAPSVVMVVE
GRYAISVVRKMAGATDPKDAEPGSIRGDYGLDVGDAIYNVIHASDSPESAEREIKLYFSEDEIFEYWKAADWFYHTHARE
KKEYMDKME

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI38045913, Length=152, Percent_Identity=45.3947368421053, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI4557797, Length=152, Percent_Identity=45.3947368421053, Blast_Score=143, Evalue=6e-35,
Organism=Homo sapiens, GI66392203, Length=152, Percent_Identity=45.3947368421053, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI66392227, Length=152, Percent_Identity=45.3947368421053, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI66392205, Length=152, Percent_Identity=45.3947368421053, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4505409, Length=152, Percent_Identity=45.3947368421053, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI66392192, Length=152, Percent_Identity=45.3947368421053, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI37693993, Length=151, Percent_Identity=45.0331125827815, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI4826862, Length=141, Percent_Identity=46.0992907801418, Blast_Score=133, Evalue=8e-32,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=35.2941176470588, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=35.2941176470588, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI5031951, Length=144, Percent_Identity=29.8611111111111, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI4505413, Length=139, Percent_Identity=33.0935251798561, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=31.1594202898551, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=46.7625899280576, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17506807, Length=144, Percent_Identity=43.75, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322783, Length=152, Percent_Identity=44.078947368421, Blast_Score=141, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45549037, Length=156, Percent_Identity=48.7179487179487, Blast_Score=156, Evalue=6e-39,
Organism=Drosophila melanogaster, GI18860097, Length=139, Percent_Identity=33.0935251798561, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 19650; Mature: 19519

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKIERTLVILKPDAVVRGLMGEIISRFEKRGLKIVGMKMIWITRELAEKHYEEHKGK
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC
PFFEPLIDYITKAPSVVMVVEGRYAISVVRKMAGATDPKDAEPGSIRGDYGLDVGDAIYN
CHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
VIHASDSPESAEREIKLYFSEDEIFEYWKAADWFYHTHAREKKEYMDKME
HHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADKKIERTLVILKPDAVVRGLMGEIISRFEKRGLKIVGMKMIWITRELAEKHYEEHKGK
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCC
PFFEPLIDYITKAPSVVMVVEGRYAISVVRKMAGATDPKDAEPGSIRGDYGLDVGDAIYN
CHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
VIHASDSPESAEREIKLYFSEDEIFEYWKAADWFYHTHAREKKEYMDKME
HHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA