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The map label for this gene is lhr [C]

Identifier: 212223874

GI number: 212223874

Start: 676288

End: 678963

Strand: Reverse

Name: lhr [C]

Synonym: TON_0725

Alternate gene names: 212223874

Gene position: 678963-676288 (Counterclockwise)

Preceding gene: 212223886

Following gene: 212223871

Centisome position: 36.75

GC content: 53.92

Gene sequence:

>2676_bases
ATGTCCCTCTTCGAGACCCTCAAATCCCTCAAGTCCGAAATAGCCAAAGTTCACGTTTTTCCCCTGAGAAGCGGCGAGTT
CTCCGATTTTCGGTTTAATAACCCCGAGGTCAATTCTCTCCTTGATGAGTTAGGCTTTAAACTGTACCTGCACCAGGTTG
AGGCACTCGGAAAGCTCTACTCAGGTAAAAACATCGTGGTAACCACTCCAACCGCGAGCGGAAAGAGCGAGATTTTCAGG
CTGGCGATCTTTGACTCATACCTATCCAATCCTCGCGCGACCTACCTGCTCGTCTATCCCACCCGCGCGCTTATCAACAA
CCAGTTCGAGAAGTTCTCGCTCGAGAACCTCGCGTTCTACCGTCTAACCGGCGAGTTCATCAACGCAAGAATTCTGACGG
GCGACGTCTCGTGGGAGGAGAGGCGCGAAATACTCCGCGAGAGACCGCGAGTGATATTCACGACCCCGGATATGCTCCAT
TACACCATCCTCAGGAGATGGCGTGACTACGAGTGGCTTTTGAGGAACCTCCGCTATCTCGTCGTGGACGAGCTTCACGT
TTACCGCGGCGTCTTCGGGAGCAACGCGGCTTACCTGTTCAGACGGCTGGCCTTCAGGTTCAAGCGCCTCGGCGCGAAGC
CTCAAATAATAGCCCTTTCAGCAACACTGAGAAACCCTCGGGAGTTTGCCGAGAAGCTTTTTAGAGCTGAGTTCGAGCCG
GTAAGCGAAGCCAGGAATCCCTTTCCGAGGCGGTACTTAATCCTCTTCGAGCCCAAGAACCTCGACGAGAGACAGCTTTT
GAGGGCCGTTGTGGAGAGGCTCGCCGAGAAGAAGATCAAGACCCTAGTCTTCTTCGACTCGCGTAAAGGAACGGAGAAGC
TCATGCGCTTCCTCCTCAATTCGCCAGTCTTTCACAAGACGAGCACCTACAAGGGAACGCTGCCTAAAAACATCCGCTGG
GAGATAGAACGGGACTTCAAAGAGGGAAAGCTTCTCGTTCTCCTCACAACCAACGCTCTCGAGCTCGGCATCGACATCGG
CGATCTGGATGTAGTGATAAACTACGGCATTCCGCCCGACGGTCTCTTCTCACTCATCCAGCGCTTTGGAAGGGCTGGGA
GAAAAGCGGACAGAGAGGCTATCAACGGTATCGTCCTGAGGAAGAACGGACTCGACTATTACTACAAGGAGCACGTCGAT
GAGCTCGTCGAGAAGCTTGAGAAGGGCATAATCGAGTACATGCCAGTCAGCCTAGAGAACGAGCGCATAGCGGAAAAGCA
TCTGCACTACCTGCTCACTGAAATAGGAGTAATCGAATGGGACGAACTGGACGAGTTCGAGCGAAAGGTGATGGAGAGGC
TTGTTATAGAGCGCAGGGCCTCTCTCAGGAAGAACCCGATAACAGGCAAGCTCGAGGTCAGACCTCTGAGGCCCGCTTTC
AGCTACTCCTCCCTCCGGACGGCCACCGACGAGAGCTTCTTCCTTCTCAAGGACGAGCCCTGGATAAGGGCAAAGCTGAT
GCAGAAGCGGGATATGGGAGAGCTTCTCCGCTTCGTCAACTGGCTCAAGATCAAGGGTTACCTCATCGAGGAAGTCGATG
CCGACGAGTATCACCGCTCACTCCTCCCCGGAATGACTTACTTTTCCCGCGGAGAGCTTTATATGTCAGGAGAGCGCTTA
ACCCTTGGAAAGTTCCACTTCGTCTTCGCCAAGCAGTTAAATCGCCTCTGGGGCGTGGAGACATTCGTGAACAAGCGCGA
GGAGGTAGAGATACTTGAGACAACGGCGAGCAAAGCGTATAAGGGCGTAGAGATAGGCCTCGGCCGGCTCAGGGTAAGGC
ACATCCATACTGGCTTCGCCGTCAAGGGCAACGACGTGGGCAACTATGTGGCTGAACTGATGAGGCTGAAGGAAGCGGGA
GTCCTGAAGGGTGAAATCTATTCCCCCCTGAGCGGTGAGAGGGTCAAGGTCGATGAAGACTTCTCGATACTCAACTGGGA
AAGGTTCGCCAGGGTTGAGTTTGAGGAGCCCCACATTAGGGAGTTCGAGACTAAGGGAATCTGGCTCGTCTTCCCCGACT
GGATACGAGAGATTCCGAACGAGGAGTTCAGGGAATTTTTCAGCATAGCTGCAGAGAAAGGTAGGGAAGACCTCGCCTTC
ACCCTCTACGAGAACCTGGACAGAAAGAAGCTCTTCCCCATCTACCTCGGTGCCACAAGCCACACCATCAGGAAGGCCAT
AGGCGACGCCCTCCAGCGTTTTGGAATAAACGAGGAGGAGCTGGCCTTTGCGATAAAGAAGATGGTGGACAGCAAGGATG
GAATAGGCTCTGCCCTTCATGCCATAGAACACAACATTATCAAGATAGCGCCCATCTTCACCTACGTAGATTCACGCGAA
CTCGGCGGCTACAGCTACGCGAGTTTCCCCAATCCGCCCCACATCGGGAGGCCCCTCGTCTTCATCTATGACGGCAATGA
GTTCGGTGCCGGCCTGGCCGAGATACTCTATGAGAACGTCGAGAAGCTTATGGAAAAGAGCTACGAGCACCTGACCGGCT
GTTCCTGTAAGGACGGCTGCCCGGTCTGCGTCCTCTCGCCGAAGTGCGGCACCTTCAATGAGTTCCTTGATAAATGGATG
GCGATAAGGGTGTGGGAGAAAATTCTGGGGAAATAA

Upstream 100 bases:

>100_bases
TGATCCCCCTAATCATTCTGAGGGCGGTGTTTAAATCACTTATTGTGTTGGTGCCCTAGCCTCCAGAAATTTTTTAGCGG
TTTCCCCCAAATATACCCCC

Downstream 100 bases:

>100_bases
TGTTAACTTCGAGCGATTTTTACATACCATGTAATTTACATGAGATGTAAAAAATCACAGGCTCCTCATGAACAGCGGTC
TCAGTCTGACTCTCCCCTTA

Product: DEAD/DEAH box RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 891; Mature: 890

Protein sequence:

>891_residues
MSLFETLKSLKSEIAKVHVFPLRSGEFSDFRFNNPEVNSLLDELGFKLYLHQVEALGKLYSGKNIVVTTPTASGKSEIFR
LAIFDSYLSNPRATYLLVYPTRALINNQFEKFSLENLAFYRLTGEFINARILTGDVSWEERREILRERPRVIFTTPDMLH
YTILRRWRDYEWLLRNLRYLVVDELHVYRGVFGSNAAYLFRRLAFRFKRLGAKPQIIALSATLRNPREFAEKLFRAEFEP
VSEARNPFPRRYLILFEPKNLDERQLLRAVVERLAEKKIKTLVFFDSRKGTEKLMRFLLNSPVFHKTSTYKGTLPKNIRW
EIERDFKEGKLLVLLTTNALELGIDIGDLDVVINYGIPPDGLFSLIQRFGRAGRKADREAINGIVLRKNGLDYYYKEHVD
ELVEKLEKGIIEYMPVSLENERIAEKHLHYLLTEIGVIEWDELDEFERKVMERLVIERRASLRKNPITGKLEVRPLRPAF
SYSSLRTATDESFFLLKDEPWIRAKLMQKRDMGELLRFVNWLKIKGYLIEEVDADEYHRSLLPGMTYFSRGELYMSGERL
TLGKFHFVFAKQLNRLWGVETFVNKREEVEILETTASKAYKGVEIGLGRLRVRHIHTGFAVKGNDVGNYVAELMRLKEAG
VLKGEIYSPLSGERVKVDEDFSILNWERFARVEFEEPHIREFETKGIWLVFPDWIREIPNEEFREFFSIAAEKGREDLAF
TLYENLDRKKLFPIYLGATSHTIRKAIGDALQRFGINEEELAFAIKKMVDSKDGIGSALHAIEHNIIKIAPIFTYVDSRE
LGGYSYASFPNPPHIGRPLVFIYDGNEFGAGLAEILYENVEKLMEKSYEHLTGCSCKDGCPVCVLSPKCGTFNEFLDKWM
AIRVWEKILGK

Sequences:

>Translated_891_residues
MSLFETLKSLKSEIAKVHVFPLRSGEFSDFRFNNPEVNSLLDELGFKLYLHQVEALGKLYSGKNIVVTTPTASGKSEIFR
LAIFDSYLSNPRATYLLVYPTRALINNQFEKFSLENLAFYRLTGEFINARILTGDVSWEERREILRERPRVIFTTPDMLH
YTILRRWRDYEWLLRNLRYLVVDELHVYRGVFGSNAAYLFRRLAFRFKRLGAKPQIIALSATLRNPREFAEKLFRAEFEP
VSEARNPFPRRYLILFEPKNLDERQLLRAVVERLAEKKIKTLVFFDSRKGTEKLMRFLLNSPVFHKTSTYKGTLPKNIRW
EIERDFKEGKLLVLLTTNALELGIDIGDLDVVINYGIPPDGLFSLIQRFGRAGRKADREAINGIVLRKNGLDYYYKEHVD
ELVEKLEKGIIEYMPVSLENERIAEKHLHYLLTEIGVIEWDELDEFERKVMERLVIERRASLRKNPITGKLEVRPLRPAF
SYSSLRTATDESFFLLKDEPWIRAKLMQKRDMGELLRFVNWLKIKGYLIEEVDADEYHRSLLPGMTYFSRGELYMSGERL
TLGKFHFVFAKQLNRLWGVETFVNKREEVEILETTASKAYKGVEIGLGRLRVRHIHTGFAVKGNDVGNYVAELMRLKEAG
VLKGEIYSPLSGERVKVDEDFSILNWERFARVEFEEPHIREFETKGIWLVFPDWIREIPNEEFREFFSIAAEKGREDLAF
TLYENLDRKKLFPIYLGATSHTIRKAIGDALQRFGINEEELAFAIKKMVDSKDGIGSALHAIEHNIIKIAPIFTYVDSRE
LGGYSYASFPNPPHIGRPLVFIYDGNEFGAGLAEILYENVEKLMEKSYEHLTGCSCKDGCPVCVLSPKCGTFNEFLDKWM
AIRVWEKILGK
>Mature_890_residues
SLFETLKSLKSEIAKVHVFPLRSGEFSDFRFNNPEVNSLLDELGFKLYLHQVEALGKLYSGKNIVVTTPTASGKSEIFRL
AIFDSYLSNPRATYLLVYPTRALINNQFEKFSLENLAFYRLTGEFINARILTGDVSWEERREILRERPRVIFTTPDMLHY
TILRRWRDYEWLLRNLRYLVVDELHVYRGVFGSNAAYLFRRLAFRFKRLGAKPQIIALSATLRNPREFAEKLFRAEFEPV
SEARNPFPRRYLILFEPKNLDERQLLRAVVERLAEKKIKTLVFFDSRKGTEKLMRFLLNSPVFHKTSTYKGTLPKNIRWE
IERDFKEGKLLVLLTTNALELGIDIGDLDVVINYGIPPDGLFSLIQRFGRAGRKADREAINGIVLRKNGLDYYYKEHVDE
LVEKLEKGIIEYMPVSLENERIAEKHLHYLLTEIGVIEWDELDEFERKVMERLVIERRASLRKNPITGKLEVRPLRPAFS
YSSLRTATDESFFLLKDEPWIRAKLMQKRDMGELLRFVNWLKIKGYLIEEVDADEYHRSLLPGMTYFSRGELYMSGERLT
LGKFHFVFAKQLNRLWGVETFVNKREEVEILETTASKAYKGVEIGLGRLRVRHIHTGFAVKGNDVGNYVAELMRLKEAGV
LKGEIYSPLSGERVKVDEDFSILNWERFARVEFEEPHIREFETKGIWLVFPDWIREIPNEEFREFFSIAAEKGREDLAFT
LYENLDRKKLFPIYLGATSHTIRKAIGDALQRFGINEEELAFAIKKMVDSKDGIGSALHAIEHNIIKIAPIFTYVDSREL
GGYSYASFPNPPHIGRPLVFIYDGNEFGAGLAEILYENVEKLMEKSYEHLTGCSCKDGCPVCVLSPKCGTFNEFLDKWMA
IRVWEKILGK

Specific function: Unknown

COG id: COG1205

COG function: function code R; Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI130484567, Length=453, Percent_Identity=25.3863134657837, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI1790214, Length=368, Percent_Identity=25.2717391304348, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508543, Length=375, Percent_Identity=25.8666666666667, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320497, Length=483, Percent_Identity=30.4347826086957, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI9755332, Length=435, Percent_Identity=23.2183908045977, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321963, Length=341, Percent_Identity=23.1671554252199, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24584399, Length=330, Percent_Identity=25.7575757575758, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 103736; Mature: 103605

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFETLKSLKSEIAKVHVFPLRSGEFSDFRFNNPEVNSLLDELGFKLYLHQVEALGKLY
CCHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SGKNIVVTTPTASGKSEIFRLAIFDSYLSNPRATYLLVYPTRALINNQFEKFSLENLAFY
CCCEEEEECCCCCCHHHHEEHHHHHHHHCCCCEEEEEEECCHHHHCCCHHHHHHCCEEEE
RLTGEFINARILTGDVSWEERREILRERPRVIFTTPDMLHYTILRRWRDYEWLLRNLRYL
EEEHHHHEEEEEECCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCHHHHHHCCHHH
VVDELHVYRGVFGSNAAYLFRRLAFRFKRLGAKPQIIALSATLRNPREFAEKLFRAEFEP
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHCCCCC
VSEARNPFPRRYLILFEPKNLDERQLLRAVVERLAEKKIKTLVFFDSRKGTEKLMRFLLN
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHC
SPVFHKTSTYKGTLPKNIRWEIERDFKEGKLLVLLTTNALELGIDIGDLDVVINYGIPPD
CCCEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCEEECCEECCEEEEEECCCCCH
GLFSLIQRFGRAGRKADREAINGIVLRKNGLDYYYKEHVDELVEKLEKGIIEYMPVSLEN
HHHHHHHHHHHCCCCCCHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ERIAEKHLHYLLTEIGVIEWDELDEFERKVMERLVIERRASLRKNPITGKLEVRPLRPAF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
SYSSLRTATDESFFLLKDEPWIRAKLMQKRDMGELLRFVNWLKIKGYLIEEVDADEYHRS
CHHHHCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCHHHHHHH
LLPGMTYFSRGELYMSGERLTLGKFHFVFAKQLNRLWGVETFVNKREEVEILETTASKAY
HCCCCCCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
KGVEIGLGRLRVRHIHTGFAVKGNDVGNYVAELMRLKEAGVLKGEIYSPLSGERVKVDED
CCHHCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCC
FSILNWERFARVEFEEPHIREFETKGIWLVFPDWIREIPNEEFREFFSIAAEKGREDLAF
CCEECHHHHHEECCCCCCCHHHCCCCEEEECHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
TLYENLDRKKLFPIYLGATSHTIRKAIGDALQRFGINEEELAFAIKKMVDSKDGIGSALH
HHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
AIEHNIIKIAPIFTYVDSRELGGYSYASFPNPPHIGRPLVFIYDGNEFGAGLAEILYENV
HHHCCCEEEEEHHEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCHHCHHHHHHHHHHH
EKLMEKSYEHLTGCSCKDGCPVCVLSPKCGTFNEFLDKWMAIRVWEKILGK
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLFETLKSLKSEIAKVHVFPLRSGEFSDFRFNNPEVNSLLDELGFKLYLHQVEALGKLY
CHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SGKNIVVTTPTASGKSEIFRLAIFDSYLSNPRATYLLVYPTRALINNQFEKFSLENLAFY
CCCEEEEECCCCCCHHHHEEHHHHHHHHCCCCEEEEEEECCHHHHCCCHHHHHHCCEEEE
RLTGEFINARILTGDVSWEERREILRERPRVIFTTPDMLHYTILRRWRDYEWLLRNLRYL
EEEHHHHEEEEEECCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHCCHHHHHHCCHHH
VVDELHVYRGVFGSNAAYLFRRLAFRFKRLGAKPQIIALSATLRNPREFAEKLFRAEFEP
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHHCCCCC
VSEARNPFPRRYLILFEPKNLDERQLLRAVVERLAEKKIKTLVFFDSRKGTEKLMRFLLN
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHC
SPVFHKTSTYKGTLPKNIRWEIERDFKEGKLLVLLTTNALELGIDIGDLDVVINYGIPPD
CCCEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCEEECCEECCEEEEEECCCCCH
GLFSLIQRFGRAGRKADREAINGIVLRKNGLDYYYKEHVDELVEKLEKGIIEYMPVSLEN
HHHHHHHHHHHCCCCCCHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ERIAEKHLHYLLTEIGVIEWDELDEFERKVMERLVIERRASLRKNPITGKLEVRPLRPAF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
SYSSLRTATDESFFLLKDEPWIRAKLMQKRDMGELLRFVNWLKIKGYLIEEVDADEYHRS
CHHHHCCCCCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCHHHHHHH
LLPGMTYFSRGELYMSGERLTLGKFHFVFAKQLNRLWGVETFVNKREEVEILETTASKAY
HCCCCCCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
KGVEIGLGRLRVRHIHTGFAVKGNDVGNYVAELMRLKEAGVLKGEIYSPLSGERVKVDED
CCHHCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCC
FSILNWERFARVEFEEPHIREFETKGIWLVFPDWIREIPNEEFREFFSIAAEKGREDLAF
CCEECHHHHHEECCCCCCCHHHCCCCEEEECHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
TLYENLDRKKLFPIYLGATSHTIRKAIGDALQRFGINEEELAFAIKKMVDSKDGIGSALH
HHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
AIEHNIIKIAPIFTYVDSRELGGYSYASFPNPPHIGRPLVFIYDGNEFGAGLAEILYENV
HHHCCCEEEEEHHEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCHHCHHHHHHHHHHH
EKLMEKSYEHLTGCSCKDGCPVCVLSPKCGTFNEFLDKWMAIRVWEKILGK
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]