Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 212223406

GI number: 212223406

Start: 231958

End: 232845

Strand: Reverse

Name: czcD [H]

Synonym: TON_0260

Alternate gene names: 212223406

Gene position: 232845-231958 (Counterclockwise)

Preceding gene: 212223410

Following gene: 212223403

Centisome position: 12.6

GC content: 51.46

Gene sequence:

>888_bases
ATGGGACACAAACACTCCCACAGGGCCATGAAATCCCGTATGGTCTTCTCTATAATCCTGAACTTTGTCATTACGATAGC
CGAGGTCATAGGTGGAATTCTTTCCGGAAGTTTAGCTCTCCTGAGCGACTCGCTCCACAACTTCAGCGACACTATGAGCC
TTCTGGCGAGCTACATAGCGATAAGAATCGGTGAGCGTGAAAAGAACGAAAAGTACACTTTCGGCTATAAGAGGGCCGAG
ATACTCGTCGCCTTTGTCAACTCTGCCGTCCTCGTCGGCGTTGCCCTCTTCCTGCTCGTGGAGGCCTATAAGCGCTTCAG
GAATCCCAATCCAATAGACACAGGGCTCATGCTTGTGGTGGCGGTTATTGGACTTCTGGCTAACCTTCTCTCCGTTCTCC
TCCTCCACGAGCACGCCCACGAGAGCATCAACGTTCGCTCCGCTTACCTTCATCTTGTGAGCGACACGCTGTCTTCGGTG
GCTGTGGTGGCCGGCGGTCTGGCCATAAGATACTACGACCTCGTCTGGATAGACCCACTTGTCACTGTGTTCATTTCCCT
CTACATCCTCCGCGAGGGCTACGATATACTGAAAGAAAGCGTTGATGTTCTCATGGAGGCATCGCCCGAGCTCGACTTCG
ATGCAATAAAGGCAGAACTCGAGTCAATTCCCGGCGTTAAAAATGCTCACCACTTCCACGCATGGCGCATTGGAGAAAAT
GAAACCCACTTTGAGTGCCACGTTGATGTGAACGACATGTCCCTAAGCGAGGCTCAGCGTATCATTGACGATGTCGAAAA
GATTCTGGAGAAGTATGGAGTAACCCACGTCACAGTGCAACTCGAGGTGAACCGCTGTGATGACGACGATGTGGTATGCA
AGAGTTAA

Upstream 100 bases:

>100_bases
AACCCTATGTTTATGTCTTCCCCTATCTGGGATTAAAACTTCCCAATTCTGACCTCAAAAGGCTTTTAAGTCTCCAATTA
GACCCCTCTCAGGGAGAGAA

Downstream 100 bases:

>100_bases
GCGCTTTCCTTGCCTTCGGGCTGTGCTTGGGCCATTTTCCTTTCTCTTCTTGAGAAGGTATGCAAAGGTCACTATCCCAA
GGATGGCCTTGGCTCACCTG

Product: cobalt/zinc/cadmium cation efflux pump protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MGHKHSHRAMKSRMVFSIILNFVITIAEVIGGILSGSLALLSDSLHNFSDTMSLLASYIAIRIGEREKNEKYTFGYKRAE
ILVAFVNSAVLVGVALFLLVEAYKRFRNPNPIDTGLMLVVAVIGLLANLLSVLLLHEHAHESINVRSAYLHLVSDTLSSV
AVVAGGLAIRYYDLVWIDPLVTVFISLYILREGYDILKESVDVLMEASPELDFDAIKAELESIPGVKNAHHFHAWRIGEN
ETHFECHVDVNDMSLSEAQRIIDDVEKILEKYGVTHVTVQLEVNRCDDDDVVCKS

Sequences:

>Translated_295_residues
MGHKHSHRAMKSRMVFSIILNFVITIAEVIGGILSGSLALLSDSLHNFSDTMSLLASYIAIRIGEREKNEKYTFGYKRAE
ILVAFVNSAVLVGVALFLLVEAYKRFRNPNPIDTGLMLVVAVIGLLANLLSVLLLHEHAHESINVRSAYLHLVSDTLSSV
AVVAGGLAIRYYDLVWIDPLVTVFISLYILREGYDILKESVDVLMEASPELDFDAIKAELESIPGVKNAHHFHAWRIGEN
ETHFECHVDVNDMSLSEAQRIIDDVEKILEKYGVTHVTVQLEVNRCDDDDVVCKS
>Mature_294_residues
GHKHSHRAMKSRMVFSIILNFVITIAEVIGGILSGSLALLSDSLHNFSDTMSLLASYIAIRIGEREKNEKYTFGYKRAEI
LVAFVNSAVLVGVALFLLVEAYKRFRNPNPIDTGLMLVVAVIGLLANLLSVLLLHEHAHESINVRSAYLHLVSDTLSSVA
VVAGGLAIRYYDLVWIDPLVTVFISLYILREGYDILKESVDVLMEASPELDFDAIKAELESIPGVKNAHHFHAWRIGENE
THFECHVDVNDMSLSEAQRIIDDVEKILEKYGVTHVTVQLEVNRCDDDDVVCKS

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=314, Percent_Identity=26.7515923566879, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI52352805, Length=293, Percent_Identity=29.3515358361775, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI21359890, Length=320, Percent_Identity=25, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI21361112, Length=300, Percent_Identity=27, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI222080086, Length=342, Percent_Identity=23.3918128654971, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI40255009, Length=342, Percent_Identity=23.3918128654971, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI289803013, Length=296, Percent_Identity=28.0405405405405, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI289803009, Length=296, Percent_Identity=28.0405405405405, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI289803007, Length=296, Percent_Identity=28.0405405405405, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI289803003, Length=296, Percent_Identity=28.0405405405405, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI64762489, Length=294, Percent_Identity=28.2312925170068, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI52352803, Length=131, Percent_Identity=37.4045801526718, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI52351208, Length=135, Percent_Identity=34.8148148148148, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI14210520, Length=215, Percent_Identity=26.5116279069767, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1786966, Length=282, Percent_Identity=36.5248226950355, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1790349, Length=254, Percent_Identity=25.5905511811024, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555794, Length=322, Percent_Identity=30.4347826086957, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193210990, Length=312, Percent_Identity=30.1282051282051, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17555796, Length=297, Percent_Identity=30.6397306397306, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32564488, Length=296, Percent_Identity=30.0675675675676, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550442, Length=136, Percent_Identity=30.1470588235294, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=136, Percent_Identity=30.1470588235294, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=137, Percent_Identity=35.7664233576642, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324892, Length=131, Percent_Identity=34.3511450381679, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=176, Percent_Identity=34.6590909090909, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656728, Length=352, Percent_Identity=25.8522727272727, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24656724, Length=352, Percent_Identity=25.8522727272727, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24656720, Length=352, Percent_Identity=25.8522727272727, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24656715, Length=352, Percent_Identity=25.8522727272727, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21357035, Length=352, Percent_Identity=25.8522727272727, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24645863, Length=320, Percent_Identity=25.625, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24583858, Length=317, Percent_Identity=26.813880126183, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24585900, Length=132, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585898, Length=132, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585896, Length=132, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921672, Length=132, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=29.5774647887324, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=29.5774647887324, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32916; Mature: 32785

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHKHSHRAMKSRMVFSIILNFVITIAEVIGGILSGSLALLSDSLHNFSDTMSLLASYIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
IRIGEREKNEKYTFGYKRAEILVAFVNSAVLVGVALFLLVEAYKRFRNPNPIDTGLMLVV
HHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AVIGLLANLLSVLLLHEHAHESINVRSAYLHLVSDTLSSVAVVAGGLAIRYYDLVWIDPL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VTVFISLYILREGYDILKESVDVLMEASPELDFDAIKAELESIPGVKNAHHFHAWRIGEN
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCC
ETHFECHVDVNDMSLSEAQRIIDDVEKILEKYGVTHVTVQLEVNRCDDDDVVCKS
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GHKHSHRAMKSRMVFSIILNFVITIAEVIGGILSGSLALLSDSLHNFSDTMSLLASYIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
IRIGEREKNEKYTFGYKRAEILVAFVNSAVLVGVALFLLVEAYKRFRNPNPIDTGLMLVV
HHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AVIGLLANLLSVLLLHEHAHESINVRSAYLHLVSDTLSSVAVVAGGLAIRYYDLVWIDPL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VTVFISLYILREGYDILKESVDVLMEASPELDFDAIKAELESIPGVKNAHHFHAWRIGEN
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCC
ETHFECHVDVNDMSLSEAQRIIDDVEKILEKYGVTHVTVQLEVNRCDDDDVVCKS
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]