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The map label for this gene is hemE

Identifier: 209696255

GI number: 209696255

Start: 3089204

End: 3090271

Strand: Reverse

Name: hemE

Synonym: VSAL_I2851

Alternate gene names: 209696255

Gene position: 3090271-3089204 (Counterclockwise)

Preceding gene: 209696258

Following gene: 209696254

Centisome position: 92.94

GC content: 41.76

Gene sequence:

>1068_bases
ATGACAGAATTAAAAAACGACCGTTACCTACGTGCGTTATTAAAACAACCAGTAGATTACACACCAGTTTGGATGATGCG
CCAAGCAGGCCGTTACCTACCAGAATATAAAGCCACGCGTGCAGAAGCGGGCGATTTTATGTCTTTGTGTAAGAATGCAG
GACTTGCTTCTGAAGTTACGCTTCAGCCTTTGCGCCGTTTCCCTCTAGATGCTGCGATTTTATTTTCAGATATCCTGACG
ATTCCAGATGCAATGGGTCTAGGTCTGTACTTTGAAGCTGGCGAAGGTCCTAAATTTGAACGTCCAATTACGTGTAAAGC
CGACGTCGATAAAATTGGCATTCCTGATCCTGAAGGTGAATTACAATACGTAATGAATGCCGTACGTCAGATCCGTAAAG
ATCTTAAAGGTGAAGTTCCATTGATTGGCTTCTCTGGTAGCCCGTGGACATTGGCGACTTACATGGTTGAAGGCGGAAGC
TCTAAAGCTTTTACTAAAATCAAAAAAATGATGTATGCAGAGCCTGCAATATTACATCTATTACTCGATAAATTGGCAGA
TACTGTTATTGAGTACCTTAATGCTCAAATTAAAGCCGGTGCACAATCGGTCATGGTATTTGATACATGGGGCGGTGTAT
TAACCCCTCGTGACTATAACGAGTTCTCATTACGTTATATGCATAAAATTGTCGATGCATTGATTCGTGAAAATGAAGGT
CGTCGTGTTCCTGTGACTCTATTCACAAAGAATGGTGGAATGTGGTTAGAGCAAATTGCAGCAACAGGTTGTGATGCCAT
TGGTCTGGATTGGACAATCAATATTGCTGATGCGAAGAAACGTATTGGTGATAAAGTTGCTCTGCAAGGTAACATGGATC
CATCAATCCTTTATGCACAACCTGAGCGTATTCGCCAAGAAGTTAGCACTATTCTTGAAGGGTTTGGTAATGAAGGAACA
GGCCACGTATTCAATCTAGGTCATGGTATTCATCTTGATGTACCGCCTGAAAATGCGGGTGTATTTGTTGATGCGGTTCA
TGAGTTATCAAAACCATATCATAAATAG

Upstream 100 bases:

>100_bases
TTAAGAGAACATTAAGTAAATATGATCTCGCTAGCAAAGGTAAGCTTCTGTTCAATGAATTGGATGTTACAATAGCGGGA
TCTAAGTATGGGGAAAGATC

Downstream 100 bases:

>100_bases
TAGATAGAATAAGAAAATCAAAGGGGCCTATTAGTAGAGCCTCTTTTTTTATGCTTGATAGTAAGCAGAGGTCAAAAGGA
ACACGTGAAGATAAGTGTTG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAGLASEVTLQPLRRFPLDAAILFSDILT
IPDAMGLGLYFEAGEGPKFERPITCKADVDKIGIPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMMYAEPAILHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDALIRENEG
RRVPVTLFTKNGGMWLEQIAATGCDAIGLDWTINIADAKKRIGDKVALQGNMDPSILYAQPERIRQEVSTILEGFGNEGT
GHVFNLGHGIHLDVPPENAGVFVDAVHELSKPYHK

Sequences:

>Translated_355_residues
MTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAGLASEVTLQPLRRFPLDAAILFSDILT
IPDAMGLGLYFEAGEGPKFERPITCKADVDKIGIPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMMYAEPAILHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDALIRENEG
RRVPVTLFTKNGGMWLEQIAATGCDAIGLDWTINIADAKKRIGDKVALQGNMDPSILYAQPERIRQEVSTILEGFGNEGT
GHVFNLGHGIHLDVPPENAGVFVDAVHELSKPYHK
>Mature_354_residues
TELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAGLASEVTLQPLRRFPLDAAILFSDILTI
PDAMGLGLYFEAGEGPKFERPITCKADVDKIGIPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGSS
KAFTKIKKMMYAEPAILHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDALIRENEGR
RVPVTLFTKNGGMWLEQIAATGCDAIGLDWTINIADAKKRIGDKVALQGNMDPSILYAQPERIRQEVSTILEGFGNEGTG
HVFNLGHGIHLDVPPENAGVFVDAVHELSKPYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=355, Percent_Identity=47.3239436619718, Blast_Score=325, Evalue=5e-89,
Organism=Escherichia coli, GI2367337, Length=355, Percent_Identity=81.6901408450704, Blast_Score=610, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=38.8101983002833, Blast_Score=268, Evalue=7e-73,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=41.9540229885057, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=41.9540229885057, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_ALISL (B6ENB7)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002264185.1
- GeneID:   6987947
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2851
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39507; Mature: 39376

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 328-328

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAGLASEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHH
LQPLRRFPLDAAILFSDILTIPDAMGLGLYFEAGEGPKFERPITCKADVDKIGIPDPEGE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCCHH
LQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYAEPAILHL
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDALIRENEG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKNGGMWLEQIAATGCDAIGLDWTINIADAKKRIGDKVALQGNMDPSILYAQ
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCCEEEEC
PERIRQEVSTILEGFGNEGTGHVFNLGHGIHLDVPPENAGVFVDAVHELSKPYHK
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAGLASEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHH
LQPLRRFPLDAAILFSDILTIPDAMGLGLYFEAGEGPKFERPITCKADVDKIGIPDPEGE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCCCCCCCHH
LQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYAEPAILHL
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNEFSLRYMHKIVDALIRENEG
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKNGGMWLEQIAATGCDAIGLDWTINIADAKKRIGDKVALQGNMDPSILYAQ
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCCEEEEC
PERIRQEVSTILEGFGNEGTGHVFNLGHGIHLDVPPENAGVFVDAVHELSKPYHK
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA