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The map label for this gene is accC [H]

Identifier: 209696240

GI number: 209696240

Start: 3074918

End: 3076261

Strand: Direct

Name: accC [H]

Synonym: VSAL_I2836

Alternate gene names: 209696240

Gene position: 3074918-3076261 (Clockwise)

Preceding gene: 209696239

Following gene: 209696241

Centisome position: 92.47

GC content: 42.56

Gene sequence:

>1344_bases
ATGTTAGATAAATTAGTTATCGCAAACCGTGGTGAAATTGCACTGCGTATCTTGCGAGCATGTAAAGAGCTTGGCATCAA
AACGGTTGCTGTGCACTCTACTGCTGACCGTGATTTAAAACACGTATTACTTGCTGATGAAACCATTTGTATCGGTCCTG
CTCGCAGTAGTGACAGCTACTTAAACATCCCACGTATTATTAGTGCGGCGGAAGTAACAGGTGCAGTTGCTGTTCACCCT
GGTTACGGTTTCTTAGCTGAAAATGCAGACTTTGCAGAGCAAGTTGAACGTTCAGGCTTTATTTTTGTTGGTCCTAAAGC
GGAAACTATTCGCATGATGGGTGACAAAGTGTCTGCGATCAGTTCAATGAAAAAAGCCGGTGTACCTTGTGTTCCGGGTT
CTGACGGCCCGTTAGATAACGATGAAGCAAAAAACAAATCATTTGCTAAGCGTATCGGCTACCCAATTATCATCAAAGCC
TCTAGCGGTGGCGGTGGTCGTGGTATGCGTGTTGTTCGTGCAGAAAAAGACCTTATTGAAGCGATTGCAATGACACGTGC
AGAAGCAACAGCGTGTTTTGGTGATGGTACGGTTTACATGGAAAAATTCCTTGAAAACCCTCGTCACATTGAAGTACAAA
TCATTGCAGATGGTCAAGGTAACGCGATTCATCTTGGCGAACGTGATTGTTCTATGCAACGTCGTCATCAAAAAGTGGTT
GAAGAAGCTCCAGCTCCTGGTATCACCGAAGAAATGCGTAAATACATTGGTGAGCGTTGTACGCGTGCTTGTGTTGATAT
CGCTTATCGTGGTGCCGGTACGTTTGAATTCCTATATGAAAATGGTGAATTCTACTTCATTGAGATGAATACTCGTATTC
AAGTTGAACACACAATTACCGAAATGGTAACGGGTATCGACTTAATCAAAGAGCAACTGCGCATTGCTGCAGGCCAACCT
CTTTCATTCACTCAAGATGATATCAAATTGCGTGGTCACTCAATTGAGTGTCGTATTAATGCTGAAGATCCTGTTCGTTT
CCTACCTTCTCCAGGTAAGATTGAACGTTTCCATGCACCAGGTGGTATGGGAGTTCGTTGGGAATCTCACATTTACACTG
GCTACACAGTACCGCCACACTACGATTCAATGATTGGTAAGCTAATTACTTACGGTGAAAACCGTGACGTAGCTATCGCA
CGTATGAAAAATGCATTAAGTGAAATGATCATTGAAGGCATCAATACAAATATCACTCTACACTTAGATATTATGAATGA
TGAAAACTTCCAACATGGTGGTGCTAATATCCACTATCTTGAGAAAAAACTGGGTCTTCAATAA

Upstream 100 bases:

>100_bases
AGCAGATAAGTCTGGTGTAGTTACTGCTATCCTAGCTGAAGACGGCCAACCGGTTGAATTCGACCAGCCACTTGTTGTGA
TCGAATAAATAGAGGTCACT

Downstream 100 bases:

>100_bases
GACACCAATTTCATTCTTTAAGTTAAAGACATAAATAAAGGCCATGAGTGATTATACTCATGGCCTTTTTCTATGATAAA
ATTCGCCGATATTTTCAACT

Product: biotin carboxylase (acetyl-CoA carboxylase subunit A)

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARSSDSYLNIPRIISAAEVTGAVAVHP
GYGFLAENADFAEQVERSGFIFVGPKAETIRMMGDKVSAISSMKKAGVPCVPGSDGPLDNDEAKNKSFAKRIGYPIIIKA
SSGGGGRGMRVVRAEKDLIEAIAMTRAEATACFGDGTVYMEKFLENPRHIEVQIIADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACVDIAYRGAGTFEFLYENGEFYFIEMNTRIQVEHTITEMVTGIDLIKEQLRIAAGQP
LSFTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAPGGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALSEMIIEGINTNITLHLDIMNDENFQHGGANIHYLEKKLGLQ

Sequences:

>Translated_447_residues
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARSSDSYLNIPRIISAAEVTGAVAVHP
GYGFLAENADFAEQVERSGFIFVGPKAETIRMMGDKVSAISSMKKAGVPCVPGSDGPLDNDEAKNKSFAKRIGYPIIIKA
SSGGGGRGMRVVRAEKDLIEAIAMTRAEATACFGDGTVYMEKFLENPRHIEVQIIADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACVDIAYRGAGTFEFLYENGEFYFIEMNTRIQVEHTITEMVTGIDLIKEQLRIAAGQP
LSFTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAPGGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALSEMIIEGINTNITLHLDIMNDENFQHGGANIHYLEKKLGLQ
>Mature_447_residues
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARSSDSYLNIPRIISAAEVTGAVAVHP
GYGFLAENADFAEQVERSGFIFVGPKAETIRMMGDKVSAISSMKKAGVPCVPGSDGPLDNDEAKNKSFAKRIGYPIIIKA
SSGGGGRGMRVVRAEKDLIEAIAMTRAEATACFGDGTVYMEKFLENPRHIEVQIIADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACVDIAYRGAGTFEFLYENGEFYFIEMNTRIQVEHTITEMVTGIDLIKEQLRIAAGQP
LSFTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAPGGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALSEMIIEGINTNITLHLDIMNDENFQHGGANIHYLEKKLGLQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.5, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=45.5981941309255, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=45.5981941309255, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=45.5981941309255, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=44.1964285714286, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=44.1964285714286, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=44.1964285714286, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI38679960, Length=505, Percent_Identity=30.4950495049505, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38679977, Length=505, Percent_Identity=30.4950495049505, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38679967, Length=505, Percent_Identity=30.4950495049505, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38679971, Length=505, Percent_Identity=30.4950495049505, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38679974, Length=505, Percent_Identity=30.4950495049505, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=29.7619047619048, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=81.65548098434, Blast_Score=758, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=186, Percent_Identity=26.3440860215054, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.27539503386, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=44.1176470588235, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=43.8752783964365, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71997163, Length=516, Percent_Identity=28.1007751937984, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=516, Percent_Identity=28.1007751937984, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=27.7551020408163, Blast_Score=191, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.7607223476298, Blast_Score=353, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=45.9090909090909, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=440, Percent_Identity=46.5909090909091, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=31.1764705882353, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=452, Percent_Identity=31.858407079646, Blast_Score=220, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=46.7120181405896, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=46.7415730337079, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=402, Percent_Identity=46.7661691542289, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=29.4820717131474, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=29.4820717131474, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=29.4820717131474, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=29.4820717131474, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49334; Mature: 49334

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARSSDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCEEEEECCCCCCCC
LNIPRIISAAEVTGAVAVHPGYGFLAENADFAEQVERSGFIFVGPKAETIRMMGDKVSAI
CCCHHHHHHHHHCCEEEECCCCCEEECCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
SSMKKAGVPCVPGSDGPLDNDEAKNKSFAKRIGYPIIIKASSGGGGRGMRVVRAEKDLIE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEEHHHHHHH
AIAMTRAEATACFGDGTVYMEKFLENPRHIEVQIIADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHHHHEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEMRKYIGERCTRACVDIAYRGAGTFEFLYENGEFYFIEMNTRIQVEHTIT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
EMVTGIDLIKEQLRIAAGQPLSFTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEECCCCCEEECCCCCCEEEEECC
GGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIARMKNALSEMIIEGINTNITL
CCCCEEEECEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
HLDIMNDENFQHGGANIHYLEKKLGLQ
EEEEECCCCCCCCCCEEEEEHHHHCCC
>Mature Secondary Structure
MLDKLVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPARSSDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCEEEEECCCCCCCC
LNIPRIISAAEVTGAVAVHPGYGFLAENADFAEQVERSGFIFVGPKAETIRMMGDKVSAI
CCCHHHHHHHHHCCEEEECCCCCEEECCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
SSMKKAGVPCVPGSDGPLDNDEAKNKSFAKRIGYPIIIKASSGGGGRGMRVVRAEKDLIE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCEEEEEHHHHHHH
AIAMTRAEATACFGDGTVYMEKFLENPRHIEVQIIADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHHHHEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEMRKYIGERCTRACVDIAYRGAGTFEFLYENGEFYFIEMNTRIQVEHTIT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
EMVTGIDLIKEQLRIAAGQPLSFTQDDIKLRGHSIECRINAEDPVRFLPSPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEEECCCCCEEECCCCCCEEEEECC
GGMGVRWESHIYTGYTVPPHYDSMIGKLITYGENRDVAIARMKNALSEMIIEGINTNITL
CCCCEEEECEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
HLDIMNDENFQHGGANIHYLEKKLGLQ
EEEEECCCCCCCCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]