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The map label for this gene is acs [H]

Identifier: 209696237

GI number: 209696237

Start: 3071562

End: 3073511

Strand: Direct

Name: acs [H]

Synonym: VSAL_I2833

Alternate gene names: 209696237

Gene position: 3071562-3073511 (Clockwise)

Preceding gene: 209696236

Following gene: 209696238

Centisome position: 92.37

GC content: 45.49

Gene sequence:

>1950_bases
ATGAGTGACATTCACGTATACCCAGTCAATCAAGACATCGCAAAAAATGCACATGCCGATGAAGATAAATACCGTGAAAT
GTATCAGCAATCCGTCATCAATCCCGAAGGGTTTTGGCGTGAGCACGGACAAATAGTCGACTGGATGACTCCTTATACTA
AAGTGAAAAACACCTCGTTCGATACTGGTCACGTAGACATCAAATGGTTTGAAGATGGTGAATTGAATGTCTCTGCAAAC
TGTATCGATCGCCATCTTGCTGCTCGCGGTGATGAAGTCGCGATCATCTGGGAAGGTGACGATCCACAAGATGATGCATC
AATTACCTTCAATGAGCTGCACGAACAAGTGTGTAAATTCTCAAACGCACTTAAGAGTCAAGGCGTTCGCAAAGGCGATG
TTGTGTGTATTTACATGCCAATGGTTGCAGAAGCAGCCATTGCAATGCTTGCTTGTACTCGCATTGGTGCGGTTCATACC
GTTGTTTTTGGTGGGTTCTCACCAGAAGCATTGGCGGGTCGAATCGTTGATTCAGATGCGAAAGTCGTGATTACCGCCGA
TGAAGGCGTTCGTGGCGGTCGTACCGTACCTCTAAAGAAAAACGTCGACGATGCATTAAATAACCCTGAAGTAACAACCA
TTGAAAAAGTCGTTGTATTCCAACGCACCGGTAATGATATTGATTGGAATGAAGAACGCGATGTATGGTGGCATGAAGCA
ACCGCTGTAGCTTCTGCGCATTGTGAACCAGAAGCCATGAATGCGGAAGATCCTCTTTTCATTCTTTATACCTCAGGCTC
AACAGGTAAACCAAAAGGCGTATTACACACCACTGGCGGCTACCTTGTTTATGCAGCAATGACCTTCAAATACATCTTTG
ATTACCAAGAAGGTGAGGTGTTCTGGTGTACCGCTGATGTAGGTTGGATCACTGGCCATACTTATTTAATCTACGGACCT
CTCGCTAATGGCGCAAAAACCATTCTGTTTGAAGGGGTACCAAACTACCCAAGCACTAGCCGCATGAGTGAAGTGGTCGA
TAAGCACAACGTAAATATTCTTTATACTGCGCCAACAGCCATTCGAGCACTCATGGCTCACGGTAATGACGCTGTAGAAG
GGACCTCAAGATCCTCATTACGCGTGATGGGATCCGTCGGCGAACCGATCAACCCTGAAGCATGGGAGTGGTATTACAAC
ACCATTGGTGACGCTCGCTGCCCAATCGTTGATACGTGGTGGCAAACCGAAACGGGCGGGATTTTAATCTCTCCTCTTCC
TGGTGCAACGGCTTTAAAACCGGGCTCGGCAACACGTCCTTTCTTTGGTGTTCAACCAGCTTTGGTTGATAACATGGGTA
ACCTTATTGAAGGTGCTGCCGATGGAAACCTCGTGATTACCGATTCATGGCCGGGTCAAATGCGCACCATTTATGGCGAT
CACGACCGTTTCGAACAAACTTATTTTTCAACGTTTAAAGGCATGTATTTTACCAGTGATGGTGCTCGACGTGATGAAGA
TGGTTATTACTGGATAACAGGTCGTGTTGATGATGTGCTCAATGTGTCTGGTCACCGAATGGGTACCGCTGAAGTTGAAT
CCGCCTTAGTTTCTTTCAGTAAAATTGCAGAGGCTGCCATTGTCGGTGTTCCTCATGATATTAAAGGCCAAGCGATTTAC
GCATACATCACCTTAAATTCGGGCGAATACCCAAGTGCTGAGCTCCATAAAGAAGTCAAAGATTGGGTAAGAAAAGAAAT
AGGCCCTATCGCAACACCTGATTTCTTGCATTGGACCGACTCATTACCAAAAACACGTTCAGGGAAAATAATGCGTCGAA
TTCTTCGTAAAATTGCGACGGGAGATACTTCAAATCTAGGCGATACATCCACACTTGCCGACCCTAGCGTGGTTAATAAA
CTAATTGAAGAACAAAGAAAAATTGCTTAA

Upstream 100 bases:

>100_bases
TAGCAGAAAGTAATATCAACGAAGCGCAGAACCAATGAAGGGGCTGCCATAAAATCCAGTCATAAATTGGATATTTGCTG
TATTCACAAGGAGAATCAAC

Downstream 100 bases:

>100_bases
CTGAATAGATTTAACAACATAACGGGCTAGAGCAAAAACTCAAACCGAATGAAAAAGTCGCTATTATTCGTAATAGCGAC
TTTTTTCTTGTGATTTCAAG

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSDIHVYPVNQDIAKNAHADEDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSFDTGHVDIKWFEDGELNVSAN
CIDRHLAARGDEVAIIWEGDDPQDDASITFNELHEQVCKFSNALKSQGVRKGDVVCIYMPMVAEAAIAMLACTRIGAVHT
VVFGGFSPEALAGRIVDSDAKVVITADEGVRGGRTVPLKKNVDDALNNPEVTTIEKVVVFQRTGNDIDWNEERDVWWHEA
TAVASAHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYIFDYQEGEVFWCTADVGWITGHTYLIYGP
LANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTAIRALMAHGNDAVEGTSRSSLRVMGSVGEPINPEAWEWYYN
TIGDARCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVQPALVDNMGNLIEGAADGNLVITDSWPGQMRTIYGD
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVSFSKIAEAAIVGVPHDIKGQAIY
AYITLNSGEYPSAELHKEVKDWVRKEIGPIATPDFLHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVNK
LIEEQRKIA

Sequences:

>Translated_649_residues
MSDIHVYPVNQDIAKNAHADEDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSFDTGHVDIKWFEDGELNVSAN
CIDRHLAARGDEVAIIWEGDDPQDDASITFNELHEQVCKFSNALKSQGVRKGDVVCIYMPMVAEAAIAMLACTRIGAVHT
VVFGGFSPEALAGRIVDSDAKVVITADEGVRGGRTVPLKKNVDDALNNPEVTTIEKVVVFQRTGNDIDWNEERDVWWHEA
TAVASAHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYIFDYQEGEVFWCTADVGWITGHTYLIYGP
LANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTAIRALMAHGNDAVEGTSRSSLRVMGSVGEPINPEAWEWYYN
TIGDARCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVQPALVDNMGNLIEGAADGNLVITDSWPGQMRTIYGD
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVSFSKIAEAAIVGVPHDIKGQAIY
AYITLNSGEYPSAELHKEVKDWVRKEIGPIATPDFLHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVNK
LIEEQRKIA
>Mature_648_residues
SDIHVYPVNQDIAKNAHADEDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSFDTGHVDIKWFEDGELNVSANC
IDRHLAARGDEVAIIWEGDDPQDDASITFNELHEQVCKFSNALKSQGVRKGDVVCIYMPMVAEAAIAMLACTRIGAVHTV
VFGGFSPEALAGRIVDSDAKVVITADEGVRGGRTVPLKKNVDDALNNPEVTTIEKVVVFQRTGNDIDWNEERDVWWHEAT
AVASAHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYIFDYQEGEVFWCTADVGWITGHTYLIYGPL
ANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTAIRALMAHGNDAVEGTSRSSLRVMGSVGEPINPEAWEWYYNT
IGDARCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVQPALVDNMGNLIEGAADGNLVITDSWPGQMRTIYGDH
DRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVSFSKIAEAAIVGVPHDIKGQAIYA
YITLNSGEYPSAELHKEVKDWVRKEIGPIATPDFLHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVNKL
IEEQRKIA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=664, Percent_Identity=51.6566265060241, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=677, Percent_Identity=50.6646971935007, Blast_Score=694, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=629, Percent_Identity=50.3974562798092, Blast_Score=644, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=640, Percent_Identity=36.40625, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI42544132, Length=544, Percent_Identity=28.6764705882353, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI31982927, Length=623, Percent_Identity=24.8796147672552, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI38505220, Length=518, Percent_Identity=29.1505791505791, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI122937307, Length=525, Percent_Identity=25.9047619047619, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI115511026, Length=545, Percent_Identity=26.7889908256881, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI58082049, Length=516, Percent_Identity=25.5813953488372, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=24.8062015503876, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=24.8062015503876, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=25.706940874036, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=25.706940874036, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI195947378, Length=401, Percent_Identity=26.4339152119701, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI42544134, Length=362, Percent_Identity=25.9668508287293, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI156151445, Length=543, Percent_Identity=22.0994475138122, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1790505, Length=649, Percent_Identity=72.1109399075501, Blast_Score=1021, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=639, Percent_Identity=35.8372456964006, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788107, Length=580, Percent_Identity=22.4137931034483, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI221142682, Length=515, Percent_Identity=21.5533980582524, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI145693145, Length=125, Percent_Identity=33.6, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=646, Percent_Identity=50.6191950464396, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=656, Percent_Identity=50.3048780487805, Blast_Score=647, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=635, Percent_Identity=20.7874015748031, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17559526, Length=574, Percent_Identity=23.3449477351916, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=520, Percent_Identity=22.5, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=514, Percent_Identity=22.568093385214, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=137, Percent_Identity=31.3868613138686, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=170, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=654, Percent_Identity=48.0122324159021, Blast_Score=629, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=636, Percent_Identity=47.0125786163522, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319699, Length=382, Percent_Identity=23.8219895287958, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667955, Length=657, Percent_Identity=52.8158295281583, Blast_Score=701, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=559, Percent_Identity=56.5295169946333, Blast_Score=648, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=517, Percent_Identity=57.0599613152805, Blast_Score=606, Evalue=1e-173,
Organism=Drosophila melanogaster, GI21355225, Length=647, Percent_Identity=34.7758887171561, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI18859661, Length=548, Percent_Identity=25, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24656500, Length=538, Percent_Identity=23.7918215613383, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355181, Length=519, Percent_Identity=22.1579961464355, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581924, Length=524, Percent_Identity=20.2290076335878, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71758; Mature: 71627

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIHVYPVNQDIAKNAHADEDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSF
CCCEEEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHCCCEEECCCCCHHHCCCCC
DTGHVDIKWFEDGELNVSANCIDRHLAARGDEVAIIWEGDDPQDDASITFNELHEQVCKF
CCCEEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHH
SNALKSQGVRKGDVVCIYMPMVAEAAIAMLACTRIGAVHTVVFGGFSPEALAGRIVDSDA
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEECCCC
KVVITADEGVRGGRTVPLKKNVDDALNNPEVTTIEKVVVFQRTGNDIDWNEERDVWWHEA
EEEEECCCCCCCCEEECCCCCHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEHH
TAVASAHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYIFDYQEGEV
HHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEHEEEEEEEEEECCCCE
FWCTADVGWITGHTYLIYGPLANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTA
EEEECCCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECHHH
IRALMAHGNDAVEGTSRSSLRVMGSVGEPINPEAWEWYYNTIGDARCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCCC
ILISPLPGATALKPGSATRPFFGVQPALVDNMGNLIEGAADGNLVITDSWPGQMRTIYGD
EEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECC
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVSFS
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAIVGVPHDIKGQAIYAYITLNSGEYPSAELHKEVKDWVRKEIGPIATPDFLHWTD
HHHHHHEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVNKLIEEQRKIA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDIHVYPVNQDIAKNAHADEDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSF
CCEEEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHCCCEEECCCCCHHHCCCCC
DTGHVDIKWFEDGELNVSANCIDRHLAARGDEVAIIWEGDDPQDDASITFNELHEQVCKF
CCCEEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHH
SNALKSQGVRKGDVVCIYMPMVAEAAIAMLACTRIGAVHTVVFGGFSPEALAGRIVDSDA
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEECCCC
KVVITADEGVRGGRTVPLKKNVDDALNNPEVTTIEKVVVFQRTGNDIDWNEERDVWWHEA
EEEEECCCCCCCCEEECCCCCHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEHH
TAVASAHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTFKYIFDYQEGEV
HHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEHEEEEEEEEEECCCCE
FWCTADVGWITGHTYLIYGPLANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTA
EEEECCCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECHHH
IRALMAHGNDAVEGTSRSSLRVMGSVGEPINPEAWEWYYNTIGDARCPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCCC
ILISPLPGATALKPGSATRPFFGVQPALVDNMGNLIEGAADGNLVITDSWPGQMRTIYGD
EEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECC
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVSFS
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAIVGVPHDIKGQAIYAYITLNSGEYPSAELHKEVKDWVRKEIGPIATPDFLHWTD
HHHHHHEECCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVNKLIEEQRKIA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA